Gram-negative Klebsiella bacterial infections are of growing global public health and clinical concern. Epidemics of multidrug-resistant (MDR) gram-negative bacteria, including Klebsiella species, have occurred worldwide in the last two decades, including regions where United States (US) military forces are regularly deployed. In 2014, the incidence of all Klebsiella spp. infections increased to 83.6 cases per 100,000 eligible beneficiaries from 63.0 cases per 100,000 eligible beneficiaries in 2013 among Department of the Navy (DON) and Department of Defense (DOD) beneficiaries seeking care in the Military Health System (MHS). A pronounced gender disparity was observed for Klebsiella spp. infections; overall, DON and DOD female beneficiaries were infected more than four times as often as males. Within the MHS, Klebsiella spp. cases commonly manifested as urinary tract infections (UTIs), which was consistent with previous analysis. MDR Klebsiella spp. infections accounted for less than 5 of all Klebsiella spp. infections. Females over the age of 45 had the highest rates of MDR infections. Compared to non-MDR Klebsiella spp. infections, a higher percentage of MDR infections were healthcare-associated. Klebsiella spp. infections remained susceptible to many antibiotic classes, such as carbapenems, sulfonamides, fluoroquinolones, and cephalosporins; ciprofloxacin was the most commonly prescribed antibiotic. MDR Klebsiella spp. infections were least resistant to carbapenems.