The need to improve information-sharing capabilities across all five primary Defense Security Enterprise (DSE) domains (i.e., physical, personnel, industrial, information, and operational) has been tragically highlighted by events such as the shootings at Fort Hood, TX, in November 2009, at the Washington Navy Yard, DC, in September 2013, again at Fort Hood in April 2014, and most recently the shootings in Chattanooga, TN. Currently, defense security information sharing requests are sent manually via email, telephone calls, PowerPoint briefings, and other non-automated processes. These are neither effective nor efficient methods of accessing defense security-related information. This information is available within the DSE domains and must be readily accessible to prevent, protect, mitigate, or respond to security-related incidents. When the aforementioned events occurred, neither installations in the surrounding area nor U.S. Northern Command (USNORTHCOM) were notified. Had any of these shootings been part of a coordinated attack, U.S. installations were unprepared to prevent, protect, mitigate, or respond to another simultaneous or secondary incident. This lack of preparedness directly impacts broader mission assurance interests, goals, and objectives. The DSEA-Backbone is a Joint Office of the Secretary of Defense (OSD) Research and Development (RDT and E) initiative addressing vertical and horizontal information sharing across the DSE domains, missions, and functions (e.g., Special Access Program security policy, critical program information protection policy, and security training). The plan is to align with counterintelligence, information assurance, foreign disclosure, security cooperation, technology transfer, export control, cyber security, nuclear physical security, chemical and biological agent surety and security, antiterrorism, force protection, and mission assurance policy.