Phase 1's primary objective was a handheld, multi-analyte, wet-chemistry instrument design that could measure a wide range of chemicals, proteins, viruses, bacteria and biological fragments at concentrations ranging to below one part per billion. This was to be accomplished through an integration of state-of-the-art digital and analog circuitry with novel miniaturized fluid handling technologies, optics, and highly specific antibody-based assay techniques. Successful implementation of a dot-style immunoassay strategy was demonstrated on a prototype molded polystyrene optical element. Experimental tests strongly substantiated the design strategy. A 5-channel electro-optic module was constructed that produced signal levels well within the measurement ability of state-of-the-art PIN photodiode technology, and experimental binding curves for model assays were remarkably smooth, lacking in noise, and exhibited no optical cross-talk between channels.