Excessive consumption of dietary fat may enhance the rate of breast cancer metastasis. In addition, it is generally accepted that the upregulation of endothelial cell adhesion molecules is involved in the formation of blood-borne metastasis. Among different adhesion molecules, evidence indicates that intracellular adhesion molecule-1 (ICAM-1) may play a critical role in breast cancer metastatic formation. Our studies have demonstrated that dietary fatty acids can exert highly specific effects on NF-KB activation and expression of adhesion molecules in human endothelial cells. In addition, we indicated that linoleic acid induces ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1) expression through the activation of NF-KB. More importantly, because the ability of cancer cells to interact with the endothelium appears to be a prerequisite for the potential of distant metastasis and because ICAM-1 and VCAM-1 are considered to be a crucial adhesion molecule in this process, the present study may have significant therapeutic implications in developing a novel strategy against cancer metastasis.