The development of telemedicine/telehealth/ehealth (telemedicine for short) has reached a point where there is need to provide a synthesis of the evidence pertaining to clinical outcomes and costs to inform telemedicine policy and deployment, both nationally and internationally. This synthesis must assess the scientific adequacy of the available evidence and also suggest appropriate methodologies to guide future research. Further, there is a need to consider significant technological innovations likely to affect the reliability, efficiency, productivity, ubiquity, and appeal of telemedicine. Recognizing this, the Telemedicine Resource Center of the University of Michigan Health System will hold a symposium on Future Directions for Telemedicine. The symposium will be held in Ann Arbor, Michigan on May 20-22, 2004.