The integration of multiple bioinformatics tools into an integrated suite poses many software engineering, social, and research challenges. We present our work on Bio-SPICE, an integrated open-source framework of tools for modern biology. SRI led the integration tasks, bringing together a community of researchers and practitioners to agree on a set of standards and practices that enabled multiple tools from multiple institutions to be brought to bear on problems of interest to biologists working on DoD-relevant problems. Working through communication and cultural barriers, the Bio-SPICE community developed good working relationships and built a series of impressive use cases, highlighting the effectiveness of combinations of computational tools from multiple sources working together on a common problem. This report documents the efforts at SRI International in leading the integration and combining research efforts across the Bio-SPICE program, including the development of the Bio-SPICE user interface, standards, and community working groups.