Learning disabilities severely deteriorate the life of many NF1 patients. However, the pathogenic process for NF1-associated learning disabilities has not been fully understood and an effective therapy is not available. This study was proposed to identify genes that are deregulated in the hippocampus of the Nf1+/- mouse model by DNA microarray analysis. Characterization of these NF1-affected genes will dramatically improve our understanding of the molecular pathogenesis underlying NF1- associated learning deficits. During the 2007/2008 year of the project, we have focused on bioinformatics analyses on the NF1-affected genes and their associated molecular pathways. In addition, we also performed extensive bioinformatics analyses to identify NF1-genes that are affected by lovastatin treatment in the NF1 hippocampus.