Despite existing measures to prevent and control arthropod-borne diseases in military units, these diseases continue to be serious threats to deployed troops. Due to a shrinking list of safe, cost-effective pesticides for control of disease vectors, new and improved toxicants and methods for delivery are needed by the armed forces, Since 2004, the USDA Agricultural Research Service (ARS) has participated in the Department of Defense (DOD) - sponsored Deployed War-Fighter Protection (DWFP) program to identify and develop new tools for combating pest and vector species that impact deployed war-fighters. Ongoing research at the USDA-ARS Center for Medical, Agricultural and Veterinary Entomology (CMAVE) laboratory involves the discovery, evaluation, development, and optimization of: (a) new pesticides effective against mosquitoes and flies; (b) new personal protection products effective in preventing mosquito and fly bites, and (c) new application and personal protection methodologies and strategies. Products of this research are designed to protect military troops from mosquito and fly borne diseases but will be also be available to International and US. Public Health agencies and Mosquito and Vector Control Districts to prevent disease transmission. Here we describe a brief summary of the DWFP mosquito control research conducted at the CMAVE.