Background: Advances in health information technology (HIT) and the use of evidence-based, clinical decision support (CDS) tools in electronic health records (EHR) hold great promise, but are relatively untested for nurses. Knowledge-Based Nursing (KBN; Lang, Hook, Akre, et al., 2006) content and evidence-based clinical decision support (CDS) tools were embedded into the EHR of one large health care system. Since then, the organization (along with many others around the country) moved quickly to utilize government incentives to purchase, design, and deploy a new comprehensive EHR to achieve effective care and meaningful use. The KBN-based content and decision-support tools were built into the system nursing policies and the new EHR. Training focused on the technical functions with passive dissemination of the evidence-based content. With the new system fully implemented, formal program evaluation will be conducted to measure the implementation of evidence-based processes and evaluate the impact of these processes on patient care outcomes. Objective/Hypotheses: The Dissemination of Evidence-based Policy Framework (Dodson, Brownson, & Weiss, 2012) guided this study. The framework proposes that dissemination strategies affects the implementation and maintenance of evidence-based policy and ultimately impacts patient outcomes. Hypothesis 1: The embedding of KBN- content into policy and EHR-based clinical decision-support (passive dissemination) has a positive effect on the adoption and implementation of evidence-based practices and the achievement of nurse-sensitive patient outcomes. Hypothesis 2: Active dissemination (optimization training) strategies with nurse leaders and staff will improve the implementation of evidence-based practices and produce measurable improvements in nursing sensitive outcomes compared to policy and EHR build (passive dissemination) alone.