This paper provides an overview of the Undersea Weapon Design and Optimization (UWDO) program sponsored by the United States Navy's Office of Naval Research (ONR). Progress, status, and future research directions of the UWDO program are presented. The objective of the UWDO program is to develop computational tools and simulation-based methodology to optimize undersea weaponry system designs with respect to cost and performance. The design toots and environment developed in this program continue to be improved and implemented in the ONR Torpedo Guidance & Control, Undersea Warheads/Explosive, Torpedo Stealth, and High-Speed Supercavitating Undersea Weapons programs. Specifically, the design tools and collaborative design environment are used for the design of torpedo sonar system, new warhead configurations, virtual acoustic design using active control techniques, cost analysis, and simulation of high-speed supercavitating weapons in the virtual environment. Lastly, recommendations and future research directions in UWDO are provided.