In this paper, the problem of active vibration control of multi-degree-of-freedom structures is considered. ANFIS Controller and PID Controller are designed to suppress structural vibrations against earthquakes under the non-linear soil-structure interaction. The advantage of the ANFIS Controller and PID Controller approach is the ability to handle the non-linear behavior of the system. Non-linear behavior of the soil is modeled in the dynamics of the structural system with non-linear hysteric restoring forces. The ANFIS Controller and PID Controller are designed for getting the maximum response reduction under different types of earthquake excitations. A structural system was simulated against the ground motion of the destructive Gadha earthquake (Mw = 6.9) in Jabalpur, India on 21 May 1997. At the end of the study the time history of the storey displacements and accelerations and the frequency responses of both the uncontrolled and the ANFIS Controller and PID Controller based controlled structures are presented. These results show that the proposed ANFIS Controller and PID Controller have great potential in active structural control. In another situation two MR dampers were used as multiple control devices and a scaled five-story building model was selected as an example structure. A clipped-optimal control algorithm was compared with the proposed ANFIS Controller and PID Controller. After numerical simulation, it has been verified that the ANFIS Controller and PID Controller can present better control performance compared to the clipped-optimal control algorithm in reducing both displacement and acceleration responses. Also in this paper, conventional (MR Damper), PID controllers and ANFIS+PID controllers, respectively denoted by PID controllers and ANFIS+PID controllers, are designed to suppress vibrations of a three - story building against earthquake. The structural system is simulated against the ground accelerations of the Gadha-Jabalpur earthquake in India on May 21th, 1997; the Northridge earthquake in USA on January 17th, 1994 and the Kobe earthquake in Japan on January 16th, 1995. The control effects of PID controllers and ANFIS+PID controllers are compared via the time history of the story displacements of the structure.