Legal, cultural, and ethical considerations impact decisions of organizations and those of the individuals who aspire to assume their rightful role in them as students enrolled at universities or as aspiring employees in business firms. An ongoing question emerges, however, concerning the barriers and cultural attitudes toward women (and minorities) versus men. The specific area of study undertaken examined the relationship between several categories of data and the persistence of men and women students in completing their self-selected college major as preparation for employed life after graduation. Implications and challenges of career choices for women wishing to pursue careers in science and math or business management are discussed.