The effects of aerodynamic uncertainties on the handling qualities of the space shuttle orbiter were investigated with the use of six-degree-of-freedom, nonlinear equations of motion on the hybrid computer system. Flight condition characteristics for Mach numbers of 1.5 and .6 for the nominal and off nominal angle of attack conditions were selected for this investigation. Results revealed that at the low Mach number condition (.6), only a few problems existed for the angle of attack range considered and the many combinations of large aerodynamic variations considered. Moreover, none of these problems were considered to be related to poor handling qualities. For the angle of attack conditions considered at the high Mach number (1.5) problems existed with reduction of roll rate which can result in roll reversal conditions. In many cases, sideslip became proverse and increased rudder deflections and yaw jets were required.