Secondary instabilities are examined in compressible boundary layers at Mach numbers M(sub infinity) = 0, 0.8, 1.6, and 4.5. It is found that there is a broad-band of highly unstable 3-d secondary disturbances whose growth rates increase with increasing primary wave amplitude. At M(sub infinity) is less than or equal to 1.6, fundamental resonance dominates at relatively high (2-d) primary disturbance amplitude, while subharmonic resonance is characterized by a low (2-d) primary amplitude. At M(sub infinity) = 4.5, the subharmonic instability which arises from the second mode disturbance is the strongest type of secondary instability. The influence of the inclination, theta, of the primary wave with respect to the mean flow direction on secondary instability is investigated at M(sub infinity) = 1.6 for small to moderate values of theta. It is found that the strongest fundamental instability occurs when the primary wave is inclined at 10 deg to the mean flow direction, although a 2-d primary mode yields the most amplified subharmonic. The subharmonic instability at a high value of theta (namely, theta = 45 deg) is also discussed. Finally, a subset of the secondary instability results are compared against direct numerical simulations.