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This manuscript describes how to prepare fluidic biochips with Rainbow trout gill epithelial (RTgill-W1) cells for use in a field portable water toxicity sensor. A monolayer of RTgill-W1 cells forms on the sensing electrodes enclosed within the biochips. The biochips are then used for testing in a field portable electric cell-substrate impedance sensing (ECIS) device designed for rapid toxicity testing of drinking water. The manuscript further describes how to run a toxicity test using the...
Topics: DTIC Archive, Brennan,Linda M, U.S. Army Center for Environmental Health Research Fort Detrick...
Chinas meteoric rise has captured the attention of the United States. Adding to the complexity is China has successfully made inroads in Latin America. This reality has strategists and policy-makers at odds with one-another with respect to formulating a policy for addressing the growth of Chinese influence in Latin America. The concern is whether the rise of China and its increasing presence in Latin America signals a challenge to the influence of the United States in the Western Hemisphere....
Topics: DTIC Archive, Barron,Benito J, Joint Advanced Warfighting School Norfolk United States,...
Defense Technical Information Archive
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On the surface, the majority of Air Force units appear to be executing some form of project risk management (PRM). Deeper investigation exposes many of the PRM practices currently in place to often be ad hoc, and as such, have the potential to poorly inform decisions when risk data is escalated to the enterprise levels of the Air Force. Resultantly, there is inconsistency between the PRM processes practiced by Air Force units. This inconsistency is an indication of risk mishandling at the...
Topics: DTIC Archive, Perez,Eric J, Air Force Institute of Technology WPAFB, project management, risk...
Why GAO Did This StudyBurn pits help base commanders manage waste generated by U.S. forces overseas, but they also produce harmful emissions that military and other health professionals believe may result in chronic health effects for those exposed. Section 313 of the NDAA for FY 2015 requires the Secretary of Defense to review DOD compliance with law and guidance regarding the disposal of covered waste in burn pits. DOD submitted a report on the results of its review in March 2016.Section 313...
Topics: DTIC Archive, U.S. Government Accountability Office Washington United States, waste management,...
Our hypothesis is that combination therapy with MAPK inhibitors and immunotherapy will result in more rapid and durable control of melanoma than either modality alone. This hypothesis has gained support from several recent publications.1-4 Several proposed mechanisms for enhanced anti-tumor activity have been explored including changes in regulation of PD-L1 expression on tumor cells, changes in tumor antigen expression by tumor cells and changes in immune cell infiltration of the tumor...
Topics: DTIC Archive, Callahan,Margaret, Memorial Sloan-Kettering Cancer Center New York United States,...
Defense Technical Information Archive
by Defense Technical Information Center
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This main objective of this project is to construct an optical pump system, which would allow us to carry out optical studies of Er:GaN materials under 980 nm resonant excitation. The results obtained from the optically pumped studies will be utilized to guide crystal growth and laser design. During the supporting period, we have accomplished the following tasks: Successfully completely the installation of a high power 980 laser. The system is dedicated to the studies of the optical and lasing...
Topics: DTIC Archive, Lin,Jingyu, Texas Technical University Lubbock United States, high energy lasers,...
U.S. Army doctrine requires that commanders understand, visualize, and describe the infrastructure component of the Joint Operating Environment to accomplish the Armys missions of protecting, restoring, and developing infrastructure. The functionality of modern cities relies heavily on interdependent infrastructure systems such as those for water, power, and transportation. Disruptions often propagate within and across physical infrastructure networks and result in catastrophic consequences....
Topics: DTIC Archive, Wang,Yi, U.S. Army Engineer Research and Development Center Construction Engineering...
Non-compressible torso hemorrhage remains the leading cause of preventable death on the battlefield and a leading cause of death in civilian centers. The purpose of this project is to provide basic morphometric understanding of aortic and vena caval anatomy as it relates to the rest of the body with the goal of enabling the use of various occlusion catheters that can control bleeding in non-compressible torso injuries in the field. One year into the project, we have identified and processed the...
Topics: DTIC Archive, Wang,Stewart C, University of Michigan Ann Arbor United States, trauma, ABDOMEN,...
PURPOSE: The purpose of this report is to present preliminary data regarding the use of videography to estimate Silver Carp burst swimming speeds. The authors document the use of videotaped Silver Carp leaping behavior as a means of estimating, in-situ, burst swimming speeds, fish leap height, and horizontal distance traveled during a leap.
Topics: DTIC Archive, Parsons,Glenn R, U.S. Army Engineer Research and Development Center Vicksburg United...
Defense Technical Information Archive
by Defense Technical Information Center
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Current research at the Defense Advanced Research Projects Agency (DARPA) investigates the realm of the possible and provides insight into future force structures. DARPA is pursuing critical breakthrough technologies to enable a dispersion of assets while maintaining concentrated effects. In particular, this article presents breakthrough research in disaggregated capabilities, hypersonic strike weapons, and directed energy. These capabilities will be essential for operations in anti-access/area...
Topics: DTIC Archive, Calhoun,Paul, USAF Test Pilot School Edwards AFB United States, defense systems,...
Phase III of a research effort using the Vertical Impact Device (VID) located in Bldg 824, Wright-Patterson AFB OH., was conducted to continue research of the facility's performance capabilities. The initial performance requirements for the VID to support the WIAMan program were impact acceleration pulses over 300 G with pulse time-to-peak values in the 5 to 10 m/s range, and maximum velocity changes of greater than 32 ft/s or 9.8 m/s (Phase I), and this was followed by a new requirement to...
Topics: DTIC Archive, Perry,Chris, OAK RIDGE INST FOR SCIENCE AND EDUCATION TN OAK RIDGE, test facilities,...
This award seeks to develop high-throughput optical metabolic imaging (OMI) of primary breast tumor organoids (three-dimensional cultures of tumors) to rapidly test/screen breast cancer therapeutics as a strategy to streamline drug development and provide individualized treatment. The results outlined in this progress report indicate that OMI in primary breast tumor organoids can provide early, sensitive measures of treatment response. This system can therefore be used to streamline...
Topics: DTIC Archive, Skala,Melissa C, VANDERBILT UNIV NASHVILLE TN NASHVILLE United States, Cancer...
Defense Technical Information Archive
by Defense Technical Information Center
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This report studies how changes in job location for active duty members of the US military affect the earnings of their civilian spouses. Previous research has found that military spouses have lower earnings and employment than people with the same age, sex and education who are married to civilians, and that having experienced more military moves in the past is associated with lower spousal earnings. But military spouses may differ from civilian spouses along other dimensions that also affect...
Topics: DTIC Archive, Burke,Jeremy, RAND National Defense Research Institute Santa Monica United States,...
Defense Technical Information Archive
by Defense Technical Information Center
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The purpose of this qualitative study is to understand how the century of humiliation plays a role in the formulation of China's overarching grand strategy. Recently, a number of scholars disagree on the extent to and ways in which China is influenced by its history and culture. Gerrit Gong argues that history offers value to what individuals and countries remember and what they forget. From the context of psychological and historical perspectives, this study is anchored using a psychological...
Topics: DTIC Archive, Williams,Christopher B, US Army Command and General Staff College Fort Leavenworth...
DOD is the governments largest purchaser of contractor-provided services. In 2008, Congress required DOD to compile and review an annual inventory of its contracted services to identify the number of contractors performing services and the functions contractors performed. In 2011, Congress required DOD to use that inventory to inform certain decision-making processes, including workforce planning and budgeting. GAO has previously reported on the challenges DOD faces in compiling, reviewing, and...
Topics: DTIC Archive, U.S. Government Accountability Office Washington United States, department of...
Defense Technical Information Archive
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The overall goal of this grant is to establish the role of non-agonist PPAR-gamma ligands as potential therapeutic candidates for lung cancer. In this grant period, we have been able to identify a core gene set that is indicative of the inhibition of the phosphorylation of PPAR gamma in the setting of carboplatin treatment. Using gene set enrichment analysis, we have shown that p53 signaling and the DNA damage response is a key transcriptional target of inhibiting S273 phosphorylation. We have...
Topics: DTIC Archive, Khandekar,Melin, Massachusetts General Hospital Boston United States, lung cancer,...
Defense Technical Information Archive
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Military practitioners must be creative and critical thinkers while confronting today's broad range of traditional and nontraditional national security issues. An analysis of the current climate change policy debate demonstrates the value of considering nontraditional problem sets in an effort to enhance creative and critical thinking. When approaching complex problems such as climate change and other national security threats, policy makers should consider all available tools. One such tool is...
Topics: DTIC Archive, Heifner, Derek B, US Army School for Advanced Military Studies Fort Leavenworth...
Defense Technical Information Archive
by Defense Technical Information Center
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The FDA-approved drug pirfenidone is an anti-inflammatory/anti-fibrosis drug indicated for pulmonary fibrosis that we hypothesize can diminish scarring when applied topically to deep partial-thickness burn wounds in two animal models. The long-term objective is to learn to effectively use pirfenidone with regard to dosage, formulation and timing of treatment of burn wounds, such that animal studies will likely translate to the clinic. The objective of this proposal is to evaluate pirfenidone...
Topics: DTIC Archive, Leung,Kai, The Geneva Foundation Tacoma United States, ANTIINFLAMMATORY AGENTS,...
DOD uses both military depots and contractors to maintain many complex weapon systems and equipment. Recognizing the key role of the depots and the risk of overreliance on contractors, Section 2464 of Title 10 of the U.S. Code requires DOD to maintain a core maintenance capabilitya government-owned and operated combination of personnel, facilities, equipment, processes, and technology. Section 2464 requires DOD to provide a Biennial Core Report to Congress that includes information for the next...
Topics: DTIC Archive, U.S. Government Accountability Office Washington United States, weapon systems,...
In the prior period we obtained needed IACUC and biosafety approvals, and developed the backbone Listeria vector needed to produce the B7-H1 scFv and B7-H1-expressing Listeria vectors for follow up work. We demonstrated the significance of host B7-H1 in preventing/mitigating colitis and also colon cancer, suggesting that a B7-H1-expressing vector could be useful for clinical uses in colitis and cancer prevention. We generating a full PD-L1 KO cell line using CRISPR to optimize library screening...
Topics: DTIC Archive, Curiel,Tyler, University of Texas health Science Center at San Antonio San Antonio...
Defense Technical Information Archive
by Defense Technical Information Center
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Network knowledge synthesis (NKS) refers to effective use of network defense information for cyber assessment and management. The vision of NKS is to achieve better informed situational awareness leading to superior cyber defense. Five major components are necessary to achieve this vision: sensor placement, data collection, data filtering, data analysis and sense making, and information sharing. By reviewing the state of the art for each of these components, we identify high-priority,...
Topics: DTIC Archive, Baah,George K, MIT Lincoln Laboratory Lexington United States, relational database...
Defense Technical Information Archive
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This report details a live site demonstration project conducted by Weston Solutions at Andersen Air Force Base, Guam as part of Environmental Security Technology Certification Program (ESTCP) Munitions Response Project MR-201231. The purpose of the project was to demonstrate the effectiveness of the advanced sensor and classification methodology for identifying targets of interest (TOIs) at a military construction (MILCON) site potentially containing a diversity of munitions. A total of 2.97...
Topics: DTIC Archive, Steigerwalt,Ryan, Weston Solutions, Inc. West Chester United States
Defense Technical Information Archive
by Defense Technical Information Center
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After the October 2015 sinking of the SS EL FARO with loss of life, a Coast Guard (CG) Marine Board of Investigation (MBI) reviewed why searchers could not relocate the remains of a victim in an immersion suit. A board member requested CG Research and Development Center (RDC) help in determining the extent of previous immersion suit experiments separate from the testing requirements in 46 CFR 160 and whether the immersion suits EL FARO carried retained flotation capability after extended time...
Topics: DTIC Archive, Lewandowski,M J, COAST GUARD NEW LONDON CT NEW LONDON United States, flotation, coast...
This EA evaluates the potential environmental impacts associated with the long-term integrated management of mission-generated solid waste at Edwards AFB, California. Currently, all non-housing nonhazardous solid waste from daily operations at Edwards AFB are disposed of at the Main Base Active Landfill (MBAL). Several alternatives addressing long-term management of solid waste are evaluated, including closure of the MBAL, reducing operating days at the MBAL, and increasing the permitted...
Topics: DTIC Archive, Civil Engineer Group, Environmental Management Division Edwards AFB United States,...
Our LES modeling study of waves strongly forced by winds investigated air-sea fluxes characterized by strong air flow separation over a very steep wave field. For propagating steep wave forms with fixed shape, the dominant effect on momentum flux was geometrical steepness not the fluid speed distribution along the boundary. Adding a realistic surface wind drift current produced only a small increase in the mean wind profile, and a minor reduction in the form drag fraction. We investigated...
Topics: DTIC Archive, Banner,Michael L, University of New South Wales SYDNEY Australia, AIR SEA...
Defense Technical Information Archive
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To determine the susceptibility of aged individuals to chemical warfare nerve agents (CWNAs), we evaluated the 24-hour median lethal dose (LD50) of soman (GD) in adult (2 months of age) and aged (18 months of age) male F344 rats, Aged rats proved more sensitive to GD-induced lethality with an LD50 of 50.0 mug/kg (95% CI; 63.8-78.00). To determine the etiology of theses differences, we measured whole blood and brain acetylcholinesterase (AChE) as well as plasma carboxylesterase (CaE) activity in...
Topics: DTIC Archive, Moffett,Mark C, U.S.Army Medical Research Institute of Chemical Defense Aberdeen...
Defense Technical Information Archive
by Defense Technical Information Center
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Irans national security policy is the product of many, and sometimes competing, factors: the ideology of Irans Islamic revolution; Iranian leaderships perception of threats to the regime and to the country; long-standing Iranian national interests; and the interaction of the Iranian regimes various factions and constituencies. Some experts assert that the goal of Irans national security strategy is to overturn a power structure in the Middle East that Iran asserts favors the United States and...
Topics: DTIC Archive, Katzman,Kenneth, Congressional Research Service Washington United States, iran,...
We previously found that B cell receptor (BCR)-delivered TLR9 agonists initiate a response involving proliferation followed by abrupt cell death; furthermore, responding cells are rescued by survival cytokines. We posited this as a normal immune response-limiting mechanism that, if thwarted, may lead to persistence of self-reactive antibody-secreting cells. In this proposal we seek to characterize the pathways leading to post-proliferative death and rescue, and to determine how different forms...
Topics: DTIC Archive, Cancro,Michael P, Trustees of the University of Pennsylvania Philadelphia United...
Defense Technical Information Archive
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The impact of the use of high/medium temperature superconductors for applications to generators was investigated in an all-superconducting machine. Superconductor armature windings in electrical machines bring many design challenges that need to be addressed en route to becoming a potentially viable solution for a modern rotating equipment. Foremost amongst the challenges are the cryogenic environment and the need to address the excessive ac losses. We used an integrated design to investigate...
Topics: DTIC Archive, Bromberg,Leslie, Massachusetts Institute of Technology Cambridge United States, high...
Defense Technical Information Archive
by Defense Technical Information Center
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Our objective was to build, test, and characterize a diver-held ferrous metal detector array with real-time processing algorithms that accurately determines the position, depth, and size of magnetic anomalies from unexploded ordnance (UXO). This was accomplished by using an array of low power, miniature, total field atomic magnetometers, with a new miniaturized electronics design using a novel digital approach. We achieved order of magnitude reductions in the size and power consumption of total...
Topics: DTIC Archive, Prouty,Mark, Geometrics San Jose United States, magnetometers, uxo detection,...
Defense Technical Information Archive
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Insider threats expose every nation, state, and business entity to danger; however, most of these organizations do not realize this, or they choose to ignore it. Since most studies and technical solutions for insider threats originate from the United States, a good starting point for organizations such as the Turkish General Command of Gendarmerie (TGCG) would be to analyze lessons learned from U.S. examples to try to find ways to adapt countermeasures, considering cultural constraints. This...
Topics: DTIC Archive, Cini,Aydin, Naval Postgraduate School Monterey United States, computer network...
Factors, such as age, comorbidities, vaccine type, herd immunity, previous influenza exposure, and antigenic shift may impact the immune response to the influenza vaccine, protection against circulating strains, and antibody waning. Evaluating vaccine effectiveness (VE) is important for informing timing of vaccine administration and evaluating overall vaccine benefit. Methods: VE was assessed using febrile respiratory illness surveillance among Department of Defense non-active duty...
Topics: DTIC Archive, Radin,Jennifer M, NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA SAN DIEGO United States,...
The ability to accurately and efficiently evaluate neurocognitive status of US Warfighters exposed to diverse operational and experimental conditions is of critical importance to the ongoing mission and Force 2025 objectives of the United States military. The Automated Neuropsychological Assessment Metrics (ANAM) is a computer assisted tool for evaluating neurocognitive performance with demonstrated effectiveness for application in a wide range of military operational and research testing...
Topics: DTIC Archive, Proctor,Susan P, HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE...
Defense Technical Information Archive
by Defense Technical Information Center
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Topics: DTIC Archive, Ronai,Ze'ev, Sanford Burnham Medical Research La Jolla United States, inhibitors,...
Defense Technical Information Archive
by Defense Technical Information Center
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Today's infrastructure as a service (IaaS) cloud environments rely upon full trust in the provider to secure applications and data. Cloud providers do not offer the ability to create hardware-rooted cryptographic identities for IaaS cloud resources or sucient information to verify the integrity of systems. Trusted computing protocols and hardware like the TPM have long promised a solution to this problem. However, these technologies have not seen broad adoption because of their complexity of...
Topics: DTIC Archive, Schear,Nabil A, MIT Lincoln Laboratory Lexington United States, security, cloud...
Defense Technical Information Archive
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In Year 2 of this award we examined whether duraplasty after acute thoracic spinal cord injury (SCI) in a porcine model could improve long-term functional outcome after injury. We finalized the 12-week PTIBS analysis as well as the somatosensory-evoked potential, which was recorded at baseline, 3 hours post injury and at the final week of the study (12 weeks post SCI). Our data suggest that duraplasty surgery might improve functional recovery early after SCI compared to SCI-animals without...
Topics: DTIC Archive, Kwon,Brian K, University of British Columbia, ICORD, Blusson Spinal Cord Centre...
Injury severity in blast induced Traumatic Brain Injury (bTBI) increases with blast overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast waves were simulated in compressed gas shock-tubes in discrete increments. We evaluated 24 hour survival of rats in 0-450 kPa (0-800 Pas impulse) range at 10 discrete levels (60, 100, 130, 160, 190, 230, 250, 290, 350 and 420 kPa) and determined the mortality rate as a non-linear function of BOP. Using logistic regression model,...
Topics: DTIC Archive, Chandra,Namas, New Jersey Institute of Technology Newark United States, blast...
The purpose of this study is to investigate the role of parathyroid hormone-related protein (PTHrP) in cancer stem cell-driven triple-negative breast cancer. Our goal is to confirm PTHrP as a targetable molecular driver in order to develop better therapies against this notoriously hard-to-treat family of cancers. We have now constructed animal models with mammary epithelium fluorescent labelled cells to allow tracing of cancer stem cells from the primary mammary tumor to the metastatic site. We...
Topics: DTIC Archive, Kremer,Richard, Research Institute of McGill University Montral, QC Canada, breast...
DNA vaccine technology holds great promise as a platform for developing vaccines against both emerging and established global pathogens. Despite this potential, significant challenges impede the capacity of DNA vaccines to prevent disease in humans. Foremost amongst these, is the gap between remarkable results obtained in pre-clinical mouse models and relatively modest immunogenicity observed in humans. The present work is testing the hypothesis that skeletal muscle myocytes sense cytosolic DNA...
Topics: DTIC Archive, Zaharatos,Gerasimos J, Sir Mortimer B. Davis Jewish General Hospital Montreal H3T 1E2...
Defense Technical Information Archive
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In 2014, a Defense Science Board Task Force was convened in order to assess and explore new technologies that would aid in nuclear proliferation monitoring. One of their recommendations was for the director of National Intelligence to explore ways that crowdsourced geospatial imagery technologies could aid existing governmental efforts. Our research builds directly on this recommendation and provides feedback on some of the most successful examples of crowdsourced geospatial data (CGD).As of...
Topics: DTIC Archive, Leno,Kenyon M, NAVAL POSTGRADUATE SCHOOL MONTEREY CA MONTEREY United States, counter...
Defense Technical Information Archive
by Defense Technical Information Center
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The purpose of this MBA report is to explore and understand the issues involved in the DODs acquisition process for Unmanned Maritime Systems (UMS) in order to recommend a new acquisition approach or solutions that would allow the military to keep pace with the rapid unmanned technology development cycle found in the commercial industry. We find that current UMS acquisitions are utilizing previous acquisition reforms, but could benefit from additional contractor peer competition and peer...
Topics: DTIC Archive, Driscoll,Thomas, Naval Postgraduate School Monterey United States, military...
Defense Technical Information Archive
by Defense Technical Information Center
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The deployment of a High Energy Laser (HEL) weapon in an airborne platform is a challenging task due to size, weight, and power (SWaP) constraints. Recent technology innovations, however, promise that such HEL development may be a reality in the near future. This study models an Unmanned Combat Aerial Vehicle (UCAV) armed with a HEL weapon and simulates the laser beams atmospheric propagation. The Design of Experiments (DOE) methodology is then applied to determine the significance of the...
Topics: DTIC Archive, Lionis,Antonios, NAVAL POSTGRADUATE SCHOOL MONTEREY CA MONTEREY United States,...
Defense Technical Information Archive
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This report examines the use of an automated robotic pallet mover during resupply missions in support of forward-deployed Marine units. The pallet mover is capable of loading and unloading itself and its cargo from MV-22 and CH-53 aircraft, and subsequently transporting that cargo 3,281 feet over unimproved terrain. The report explores the operationally relevant scenarios where a robotic pallet mover could be used, to determine whether it is beneficial. The scenarios are used to quantify the...
Topics: DTIC Archive, Culp,Joshua, Naval Postgraduate School Monterey United States, systems engineering,...
Defense Technical Information Archive
by Defense Technical Information Center
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In this report we integrated the major results from our rat hemorrhagic shock model with the mechanistic details of protection from ischemia and reperfusion injury in hibernating mammals. Arousal from torpor during hibernation occurs rapidly, but there is no evidence of brain injury accompanying this extreme physiological transition. Production of the antioxidant melatonin accompanies arousal, suggesting that it plays a protective role at this time. We investigated the mechanism of melatonin...
Topics: DTIC Archive, Andrews,Matthew T, University of Minnesota Minnesota United States, hemorrhagic...
Defense Technical Information Archive
by Defense Technical Information Center
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Operation brain trauma therapy (OBTT) is a groundbreaking, rigorous, multicenter pre-clinical drug and biomarker screening consortium for traumatic brain injury (TBI). It is supported by2 closely linked grants from DoD, i.e., WH81XWH-10-1-0623 and OBTT extended studies (WH81XWH-14). As requested, this final report is restricted to work on the parent OBTT grant WH81XWH-10-1-0623. OBTT features testing in rat TBI models at the Univ. of Pittsburgh, the Univ. of Miami, and WRAIR, in a micro pig...
Topics: DTIC Archive, Kochanek,Patrick, University of Pittsburgh Pittsburgh United States, brain injuries,...
We are examining the hypothesis that mitochondrial inheritance plays a significant role in aggressiveness of prostate cancer in African Americans. In the first year of the project we identified 2,000 noncancerous tissues samples from African American men with prostate cancer and we have extracted DNA from 1,500 of them. We have validated a robust new DNA sequencing technique developed by our collaborator using single amplicon long-range PCR that permits deep coverage (10,000-20,000X on average)...
Topics: DTIC Archive, Mims,Martha, Baylor College of Medicine Houston United States, Prostate Cancer,...
Additive manufacturing is a technology taking the manufacturing revolutionizing the manufacturing industry. By creating three dimensional objects from the ground up, the technology does away with the traditional manufacturing methods used to design and create all products. This research examines the application of additive manufacturing (AM) with regards to tools and jigs in United States Air Force civil engineering (CE) operations. After testing the parts, a usability survey was conducted to...
Topics: DTIC Archive, Shields,Bradford L, AIR FORCE INSTITUTE OF TECHNOLOGY WRIGHT-PATTERSON AFB OH...
High-density lipoprotein (HDL) plays an important role in the transport and metabolism of cholesterol. Mimics of HDL are being explored as potentially powerful therapeutic agents for removing excess cholesterol from arterial plaques. Gold nanoparticles (AuNPs) functionalized with apolipoprotein A-I and with the lipids 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] have been demonstrated to be robust acceptors of...
Topics: DTIC Archive, Lai,Cheng-Tsung, NORTHWESTERN UNIV CHICAGO IL CHICAGO United States, COMPUTER...
Evidence is needed to guide prosthetic component selection for Service members, Veterans, and civilians with lower limb amputation. A randomized crossover study is conducted to compareoutcomes associated with use of modified running-specific foot (mRSF) compared to atraditional, energy-storing foot (ESF). Key outcomes include walking endurance, metabolicenergy expenditure, step activity, and self-reported mobility, fatigue, activityrestrictions, balance confidence, and satisfaction. Results...
Topics: DTIC Archive, Hafner,Brian J, University of Washington Seattle United States, prosthetics, lower...
Defense Technical Information Archive
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Optical interferometry is a technique which can be used to obtain high-resolution imagery of a distant target by interfering light collected by multiple telescopes. Image restoration from interferometric measurements poses a unique set of challenges. The first challenge is that the measurement set provides only a sparse-sampling of the objects Fourier Transform and hence image formation from these measurements is an inherently ill-posed inverse problem. Secondly, atmospheric turbulence causes...
Topics: DTIC Archive, Kurien,Binoy G, Harvard University Cambridge United States, image reconstruction,...
Aquatic habitats are among the most imperiled habitats on dryland military installations, yet they harbor a disproportionately high amount of biodiversity given the small land area they cover. Aquatic invertebrates (insects and allied taxa) constitute a major part of this biodiversity and form a critical part of the food web that sustains aquatic, riparian, and terrestrial organisms, including Federally Threatened or Endangered species. Biodiversity in dryland aquatic habitats is strongly...
Topics: DTIC Archive, Lytle,David A, University of Washington Seattle United States, aquatic organisms,...
Defense Technical Information Archive
by Defense Technical Information Center
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Protecting enterprise networks requires continuous risk assessment that automatically identifies and prioritizes cybersecurity risks, enables efficient allocation of cybersecurity resources, and enhances protection against modern cyberthreats. Lincoln Laboratory developed a foundational network security maturity model to guide development of such risk assessments and has developed practical risk metrics for the most important cyberthreats. These metrics can be computed automatically and...
Topics: DTIC Archive, Riordan,James F, MIT Lincoln Laboratory Lexington United States, cyberattacks,...
Thesis: In a period of resource austerity and complex strategic environment, the USMC's training, preparation and deployment of Security Force Assistance (SFA) is a small investment that gives the United States vital placement, access, and cultural context to developing countries. USMC SFA success has history from the Philippines through Banana Wars, WWII, Vietnam, and most recently Iraq and Afghanistan. The current de-emphasis of SFA training and deployments is an economy of force decision as...
Topics: DTIC Archive, Luccio,Douglas G, AIR WAR COLLEGE, AIR UNIVERSITY MAXWELL AFB United States,...
Defense Technical Information Archive
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The purpose of this professional studies paper is not to reinvent the multitude of existing mental health programs and tools available to squadron commanders. The intent is rather to refine the operating environment between the unit-level and base-level resources in an effort to debunk the stigma of help-seeking. The intent is also to increase awareness of the current mental health dilemma facing our post 9/11 force and to offer recommendations for commanders at multiple levels in order to...
Topics: DTIC Archive, Brown,Carlos J, Air War College, Air University Maxwell AFB United States, traumatic...
Defense Technical Information Archive
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No military officer can escape the fact that he or she is a leader. With this charge comes the great responsibility of power. Failure to understand the psychology of this power and use it judiciously deteriorates the trust in the leader/follower relationship. Degraded trust can have lasting impacts on this relationship which can cut deeply enough to negatively impact the mission. It is with this basic premise in mind that this paper provides a brief review of the Air Forces use of their...
Topics: DTIC Archive, BUTLER,MATTHEW J, AIR WAR COLLEGE MONTGOMERY United States, military education,...
Defense Technical Information Archive
by Defense Technical Information Center
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In this project, firstly, the material growth of GeSn by chemical vapor deposition (CVD) system has been investigated. The material growth mechanism was in-depth studied; secondly, the material and optical characterizations have been conducted, including SEM, TEM, XRD, Raman, PL and ellipsometry spectroscopy. The results indicated that the device level material quality was achieved; thirdly, the GeSn samples were fabricated into LEDs and photo detectors, whose operating wavelength coverd from...
Topics: DTIC Archive, Yu,Shui-Qing, University of Arkansas Fayetteville United States, chemical vapor...
We established cellular models in MDA-MB-231 and immortalized primary epithelial cells to study the effect of KHDRBS3 and SRSF12 on tumor progression and metastasis (Task1). We analyzed the effect of KHDRBS3 depletion on the growth and migration properties of the MDABD-231 cells in vitro (Task 1) and their ability to form tumors and metastasize in mouse xenograft models (Task 2). The results of similar experiments for SRPK1 were recently published and demonstrated a role for SRPK1 in migration...
Topics: DTIC Archive, Stoilov, Peter, WEST VIRGINIA UNIV RESEARCH CORP MORGANTOWN MORGANTOWN United States,...
Sympathetic postganglionic neurons (SPNs) located in sympathetic ganglia represent the final common sympathetic motor output. Even though SCI produces a profound plasticity in sympathetic autonomic function, the extent that SCI-induced dysautonomia is based on SPN changes within the thoracic paravertebral sympathetic chain is unknown. Given their strategic site in autonomic signaling to body, any plasticity is likely to be of high significance, yet there is a paucity of studies undoubtedly due...
Topics: DTIC Archive, Hochman,Shawn, Emory University Atlanta United States, spinal injuries, spinal cord,...
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Lying at the intersection of public opinion, science, and partisan politics, the debate over climate change has grown with each successive president from Richard M. Nixon to Barack H. Obama. This article argues that these two presidents, from different parties, in different eras, and with different motivations, did the most to advance federal policy. Nixon's actions laid the foundation for Obama's activism, defining the realm of possible. In a similar sense, Obama has also set the parameters of...
Topics: DTIC Archive, Flippen,J B, SOUTHEASTERN OKLAHOMA STATE UNIV DURANT DURANT, global warming, climate...
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Military personnel are tasked with providing a clean, on-spec supply of jet fuel for a large variety of aircraft and ground powered vehicles. Occasionally, fuel filters become fouled and / or fuel samples appear contaminated with particles. Fuel handlers must make several decisions based on the apparent severity of the condition. In the majority of cases the only remediation necessary is filtration and water separation. However, if the contamination is the result of a failing valve, pump, other...
Topics: DTIC Archive, Vangsness,Marlin D, AIR FORCE PETROLEUM OFFICE FORT BELVOIR VA FORT BELVOIR, fuel...
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The goal of this project was to continue to investigate methods and means to further the SERC Capstone Marketplace that was established in previous SERC research in RT-19/19a, RT-43, & RT-105. Having shown that multidisciplinary capstone programs can enhance development of systems engineering competencies, Capstone Marketplace, an online tool, intends to continue matching multi-disciplinary student teams with challenging engineering projects. While web based tools exist for matching...
Topics: DTIC Archive, SYSTEMS ENGINEERING RESEARCH CENTER HOBOKEN NJ, *ONLINE SYSTEMS, *STUDENTS, *SYSTEMS...
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This report documents work carried out by Service Thread to show that domestic technology exists which would reduce base fiber costs, versus current Nomex and Kevlar type threads and the processes and costs associated with such threads. Multifilament polyester yarn was used as a core, treated and untreated. Modified acrylic fiber (Pyro-Tex) was used as the sheath. Core to sheath ratio was 50:50. The NeC 16/2 construction offered excellent physical properties. Modified acrylic fiber shed during...
Topics: DTIC Archive, SAM M BUTLER INC LAURINBURG NC, *PERFORMANCE(ENGINEERING), *SYNTHETIC FIBERS,...
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This grant from ONR to Zwitter Technology, LLC is to develop, scale up and formulate a low-fouling and high-fouling-release marine coating by integrating nonfouling zwitterionic materials and fouling-release silicone materials together. This work facilitates the efforts to develop next-generation marine coatings exceeding the performance of existing commercial coatings. It serves to meet the long-term goal of the ONR coatings program for the development of environmentally benign, effective and...
Topics: DTIC Archive, ZWITTER TECHNOLOGY LLC SEATTLE WA, *ANTIFOULING COATINGS, *SYNTHESIS(CHEMISTRY),...
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The research reported here details a fundamental investigation of two modified germanate based glasses with a specific focus on glass stability during thermal-cycling which is representative of the steps required to fabricate a doped micro-structured germanate fiber. The investigations revealed for germanate fibres, surface crystallisation is the dominant loss mechanism, and may explain the poor performance of all published germanate fiber lasers. The research team have found a composition of...
Topics: DTIC Archive, ADELAIDE UNIV (AUSTRALIA), *GERMANATES, *GLASS FIBERS, *GLASS LASERS, DOPING,...
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This document summarizes the design features used to create a nesting area for the Common Tern (Sterna hirundo) that was incorporated as part of the maintenance repairs to the harbor breakwater located in Ashtabula, OH. The purpose of the tern nesting project was to demonstrate an option that can be used during such maintenance activities for increasing infrastructure benefits as part of the Engineering With Nature initiative (Bridges 2012). The U.S. Environmental Protection Agency's Great...
Topics: DTIC Archive, ARMY CORPS OF ENGINEERS VICKSBURG MS ENGINEER RESEARCH AND DEVELOPMENT CENTER,...
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Previous research conducted by the RE Mitchell Center for Prisoner of War Studies (REMC) has concluded that optimism proved to be the strongest predictor of health and resilience in a group of Vietnam era Repatriated Prisoners of War (RPWs). Optimism is associated with increased positive psychological health in those afflicted by extreme trauma or illness (Segovia et. al, 2012). In the follow-up study (Segovia et. al, 2015), optimism measured at repatriation was again an excellent predictor of...
Topics: DTIC Archive, NAVY MEDICINE OPERATIONAL TRAINING CENTER PENSACOLA FL, *MENTAL HEALTH, *PRISONERS OF...
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A manikin testing and modeling approach was used to predict the heat strain while wearing a Prototype Steam Suit Ensemble (PSSE) or the current U.S. Navy Submarine Steam Suit Ensemble (SSSE) and working in a steam-filled environment (88 deg C, 100% relative humidity) or a training environment (24 Degrees C, 65% relative humidity). Both ensembles were tested on a thermal manikin to measure thermal resistances. Metabolic rates during walking at 1.8 m/s (4 mph) and wearing the PSSE or the SSSE...
Topics: DTIC Archive, ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA BIOPHYSICS AND BIOMEDICAL...
Calculations are presented of vibrational and electronic excited-state absorption spectra for As-H2O complexes using density functional theory (DFT) and time-dependent density functional theory (TD-DFT). DFT and TD-DFT can provide interpretation of absorption spectra with respect to molecular structure for excitation by electromagnetic waves at frequencies within the IR and UV-visible ranges. The absorption spectrum corresponding to excitation states of As-H2O complexes consisting of relatively...
Topics: DTIC Archive, NAVAL RESEARCH LAB WASHINGTON DC MATERIALS SCIENCE AND TECHNOLOGY DIV, *ABSORPTION...
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The central hypothesis for the proposed research is that a collaborative translational autism research program with the military will result in the improved diagnosis and care of those enrolled in the study and enhance biomedical research on the diagnosis, causes, and treatment of autism spectrum disorders (ASD), in general. With approved revised Specific Aims, during this project, we enrolled 65 families (259 individuals) in the existing Central Ohio Registry for Autism, including 26 families...
Topics: DTIC Archive, NATIONWIDE CHILDREN'S HOSPITAL COLUMBUS OH RESEARCH INST, *MENTAL DISORDERS,...
This report offers details regarding the theory and mathematical formulations used within the newly developed nutrient simulation modules (NSMs) and its supporting water quality modules. The NSMs model the aquatic ecosystem by computing the changing concentrations of water quality constituents in a unit volume of water. The NSMs includes two kinetics: NSMI, NSMII. The levels of NSMs are determined by the number of interacting state variables involved in water quality simulation and the degree...
Topics: DTIC Archive, Zhang,Zhonglong, U.S. Army Engineer Research and Development Center Vicksburg United...
A key question in this project was to understand the factors and mechanisms that facilitate collaboration or antagonism; that is the sociological, religious, and cultural factors associated with close or oppositional ties between tribes, ethnic groups or sub-groups visa-vis Islamist militant groups? We focused on Nigeria in the struggle with Boko Haram, and the case of Mali vis--vis AQIM and other militant groups. The research shifted to concentrate on Nigeria (with the addition of its...
Topics: DTIC Archive, Jacobson,David, UNIVERSITY OF SOUTH FLORIDA TAMPA United States, Nigeria, TERRORISTS,...
I visited NSWC Combatant Craft Division in Norfolk. The high speed boats, including unmanned surface vehicles, are built and tested there. I investigated the recent trends of high speed boats in US and introduced the progress of our USV project. And I visited NSWC Carderock Division in Bethesda, and of course I also visited MASK facility and other basins in DTMB. I surveyed the recent high speed model tests in NSWC, and discussed whether our seakeeping and maneuvering planing boat model tests...
Topics: DTIC Archive, Kim, Dongjin, Korea Research Institute of Ships and Ocean Engineering Taejon Korea,...
Army teams operate in a complex organization that has many systems and levels. These small units (e.g., teams, squads) are generally studied from a process perspective, which posits that teams develop by progressing through a series of phases or stages (e.g., forming, storming, norming, performing). However, there is evidence that teams with standardized norms, differentiated team member roles, and interdependence among team members do not follow traditional team development processes. In...
Topics: DTIC Archive, Walker, Tywanquila L, ARMY RESEARCH INST FOR THE BEHAVIORAL AND SOCIAL SCIENCES FORT...
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Existing Navy databases do not always contain complete data about pregnancy and single parenthood in the Navy, nor do they contain information about attitudes towards birth control. Since 1988, a survey has been conducted almost biennially to obtain this data; this report presents results from the 2012-2013 administration of the survey. Overall, results are similar to previous administrations. In particular, there are currently about 14,000 single Navy fathers and 6,000 single Navy mothers;...
Topics: DTIC Archive, Uriell,Zannette A, Navy Personnel Research, Studies, and Technology Millington United...
Multiple studies have been conducted addressing intensive educational programs to determine clinical outcomes in migraine patients in headache clinics. Chronic headaches within the adolescent population have ben shown to have great morbidity on patient lives, including but no limited to missed school/work days, and loss of parental work time getting to appointments. Some studies have been completed regarding chronic adolescent headaches, but at this time nothing has been published regarding...
Topics: DTIC Archive, Ormond, Andrew J, 959th Medical Group JBSA Lackland United States