Concepts and hypothesis of basic aging processes / Edward J. Masoro -- Free radicals and differentiation: the interrelationship of development and aging / Robert G. Allen -- Basic free radical biochemistry / Robert A. Floyd -- Oxidative damage by free radicals and lipid peroxidation in aging / Byung Pal Yu -- DNA damage and aging / Harris Bernstein and Helen L. Gensler -- Free radicals in glycation / Simon P. Wolff -- Age-related alterations in antioxidant defense / Mitsuyoshi Matsuo -- Free radicals, exercise and aging / Mohsen Meydani and William J. Evans -- Free radicals and age-related diseases / Denham Harman -- Free radicals, the aging brain, and age-related neurodegenerative disorders / Randy Strong, Michael B. Mattamal and Anne C. Andorn -- Oxygen radicals and cancer / Terry D. Oberley and Larry W. Oberley -- Future directions of free radical research in aging / Richard Weindruch, Huber R. Warner and Pamela E. Starke-Reed