The development of a reusable and space-based orbital transfer vehicle (OTV) necessitates an integral approach toward structural and propulsion subsystems design. A single engine installation necessitates moving the engine further aft and/or relocation of the engine gimbal point to accommodate vehicle control requirements. Penalties associated with gimbal point relocation without increasing stage length or modifying typical advanced engine concepts, as well as a method for minimizing such penalties, are presented for a single engine toroidal tank OTV configuration. Alternative integrated vehicle structure/engine concepts are also presented for multi-engine configurations. Features of these potential concepts are given which indicate the need for substantial additional study of feedline gimbal alternatives before firmly establishing advanced engine design. The issue of vehicle/engine integration is addressed in three areas: interfaces (physical and functional), installation requirements, and reliability apportionment (i.e., number of engines required to assure mission completion).