A fixture to apply compressive loads to composite specimens during an impact event was used to assess the effect of prestresses on the compression-after-impact (CAI) strength of 16 ply quasi-isotropic carbon/epoxy test coupons. Advanced design of experiments techniques were used to evaluate a range of prestresses and impact energies on two material systems, T300/934 and IM7/8551-7. An instrumented drop tower supplied impact energies between 1 and 9 Joules for the T300/934 material and between 4 and 16 Joules for the IM7/8551-7 material. The prestress values varied between a low of 5.7 Wa and a high of 287 NDa. Results showed some change in CAI strength that could be attributed to the prestresses on the specimens.