This paper summarizes the results of a NASA lead study performed to identify synergistic opportunities and concepts between human exploration initiatives and commercialization of space. The goal of this initiative, called Orbital Aggregation & Space Infrastructure Systems (OASIS), is to develop an in-space architecture and associated concepts that provide common infrastructure for enabling a large class of space missions. The concepts include communications, navigation and power systems, propellant modules, tank farms, habitats, and in-space transportation systems using several propulsion technologies. OASIS features in-space aggregation of systems and resources in support of mission objectives. The concepts feature a high level of reusability and are supported by inexpensive launch of propellant and logistics payloads from the Earth/moon system. Industry, NASA and other users could share infrastructure costs. The anticipated benefits of synergistic utilization of space infrastructure are reduced mission costs and increased mission flexibility for future space exploration and commercialization initiatives.