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by Roncero, Carlos; Vega, Pablo; Martinez-Raga, Jose; Barral, Carmen; Basurte-Villamor, Ignacio; Rodriguez-Cintas, Laia; Mesias, Beatriz; Grau-Lopez, Lara; Casas, Miguel; Szerman, Nestor
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This article is from International Journal of Mental Health Systems , volume 8 . Abstract Background: Since provision of integrated services for patients with dual pathology or dual disorders (coexistence of an addictive disorder and other psychiatric disorders) constitutes an important challenge, this study compared the perceptions of health-care professionals with the existing, current state of specific resources for patients with dual pathology in Spain. Methods: Epidemiological,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158069
PubMed Central
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This article is from United European Gastroenterology Journal , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070603
PubMed Central
by Rice, Catherine M
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This article is from BMC Genomics , volume 14 . Abstract Contributing reviewers: The editors of BMC Genomics would like to thank all our reviewers who have contributed to the journal in volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642022
PubMed Central
by Solera, Dafne
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This article is from BMC Cancer , volume 14 . Abstract Contributing reviewers: The editors of BMC Cancer would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909450
PubMed Central
by Harold, Simon
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This article is from BMC Plant Biology , volume 14 . Abstract Contributing reviewers: The editors of BMC Plant Biology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897928
PubMed Central
by Pafitis, Natalie
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This article is from BMC Public Health , volume 13 . Abstract Contributing reviewers: The editors of BMC Public Health would like to thank all our reviewers who have contributed to the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751667
PubMed Central
by Morawska, Magdalena
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This article is from BMC Gastroenterology , volume 14 . Abstract Contributing reviewers: The editors of BMC Gastroenterology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898228
PubMed Central
by Foote, Christopher
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This article is from BMC Research Notes , volume 7 . Abstract Contributing reviewers: The editors of BMC Research Notes would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895785
PubMed Central
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This article is from Annals of The Royal College of Surgeons of England , volume 94 . Abstract INTRODUCTION: The preliminary results of a pyrocarbon interpositional radiocarpal implant in a small cohort of patients were reviewed. As it is currently only a limited release product, we describe to potential users early complications and negative outcomes. METHODS: Patients were assessed using pain levels, ranges of motion, grip strength, type of and time to return to work as well as pre-operative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954246
PubMed Central
by Spiegler, Stefanie; Najm, Juliane; Liu, Jian; Gkalympoudis, Stephanie; Schroder, Winnie; Borck, Guntram; Brockmann, Knut; Elbracht, Miriam; Fauth, Christine; Ferbert, Andreas; Freudenberg, Leonie; Grasshoff, Ute; Hellenbroich, Yorck; Henn, Wolfram; Hoffjan, Sabine; Huning, Irina; Korenke, G Christoph; Kroisel, Peter M; Kunstmann, Erdmute; Mair, Martina; Munk-Schulenburg, Susanne; Nikoubashman, Omid; Pauli, Silke; Rudnik-Schoneborn, Sabine; Sudholt, Irene; Sure, Ulrich; Tinschert, Sigrid;...
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This article is from Molecular Genetics & Genomic Medicine , volume 2 . Abstract Cerebral cavernous malformations (CCM) are prevalent vascular malformations occurring in familial autosomal dominantly inherited or isolated forms. Once CCM are diagnosed by magnetic resonance imaging, the indication for genetic testing requires either a positive family history of cavernous lesions or clinical symptoms such as chronic headaches, epilepsy, neurological deficits, and hemorrhagic stroke or the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960060
PubMed Central
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This article is from United European Gastroenterology Journal , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070608
PubMed Central
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This article is from Frontiers in Neuroscience , volume 8 . Abstract Spinal muscular atrophy (SMA) is the most common genetic disease causing infant death, due to an extended loss of motoneurons. This neuromuscular disorder results from deletions and/or mutations within the Survival Motor Neuron 1 (SMN1) gene, leading to a pathological decreased expression of functional full-length SMN protein. Emerging studies suggest that the small GTPase RhoA and its major downstream effector Rho kinase...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148024
PubMed Central
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This article is from International Journal of Clinical Pediatric Dentistry , volume 5 . Abstract Restoration of primary incisors, which have been severely damaged by rampant caries or trauma, is a difficult task for the pediatric dentist. With the introduction of new adhesive systems and restorative materials, alternative approaches for treating these teeth have been proposed. This paper discusses the restoration of carious primary maxillary incisors using composite resin restoration reinforced...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148739
PubMed Central
by Mota-Rolim, Sergio A.; Targino, Ze H.; Souza, Bryan C.; Blanco, Wilfredo; Araujo, John F.; Ribeiro, Sidarta
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This article is from Frontiers in Human Neuroscience , volume 7 . Abstract During sleep, humans experience the offline images and sensations that we call dreams, which are typically emotional and lacking in rational judgment of their bizarreness. However, during lucid dreaming (LD), subjects know that they are dreaming, and may control oneiric content. Dreaming and LD features have been studied in North Americans, Europeans and Asians, but not among Brazilians, the largest population in Latin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857923
PubMed Central
by Helfrich, Christian D; Blevins, Dean; Smith, Jeffrey L; Kelly, P Adam; Hogan, Timothy P; Hagedorn, Hildi; Dubbert, Patricia M; Sales, Anne E
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This article is from Implementation Science : IS , volume 6 . Abstract Background: There is widespread interest in measuring organizational readiness to implement evidence-based practices in clinical care. However, there are a number of challenges to validating organizational measures, including inferential bias arising from the halo effect and method bias - two threats to validity that, while well-documented by organizational scholars, are often ignored in health services research. We describe...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157428
PubMed Central
by Harris, Philippa K
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This article is from BMC Microbiology , volume 13 . Abstract Contributing reviewers: The editors of BMC Microbiology would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576289
PubMed Central
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This article is from Virology Journal , volume 11 . Abstract : The editors of Virology Journal would like to thank all our reviewers who have contributed to the journal in Volume 10 (2013). The success of any scientific journal depends on an effective and strict peer review process and Virology Journal could not operate without your contribution. We are grateful to the large number of reviewers (1026 to be exact!), who have done a great job in not only lifting the quality of the journal’s...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898089
PubMed Central
by Ferreira, Charles Francisco; Bernardi, Juliana Rombaldi; Bosa, Vera Lucia; Schuch, Ilaine; Goldani, Marcelo Zubaran; Kapczinski, Flavio; Salum, Giovanni Abrahao; Dalmaz, Carla; Manfro, Gisele Gus; Silveira, Patricia Pelufo
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This article is from Lipids in Health and Disease , volume 13 . Abstract Background: Although several studies have reported an association between mental disorders and serum levels of brain-derived neurotrophic factor (BDNF), this association is still poorly understood. The study of factors associated with both BDNF levels and mental disorders, such as n-3 polyunsaturated fatty acids (n-3 PUFAs), may help to elucidate the mechanisms mediating the relationship between the two variables....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974009
PubMed Central
by Sands, Timothy R
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This article is from BMC Systems Biology , volume 8 . Abstract Contributing reviewers: The editors of BMC Systems Biology would like to thank all our reviewers who have contributed to the journal in Volume 7 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914848
PubMed Central
by Lenguerrand, Erik; MacLennan, Graeme; Siassakos, Dimitrios; Draycott, Timothy; Bhattacharya, Siladitya; Norrie, John
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This article is from Trials , volume 14 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980426
PubMed Central
by Koe, Chwee Tat; Li, Song; Rossi, Fabrizio; Wong, Jack Jing Lin; Wang, Yan; Zhang, Zhizhuo; Chen, Keng; Aw, Sherry Shiying; Richardson, Helena E; Robson, Paul; Sung, Wing-Kin; Yu, Fengwei; Gonzalez, Cayetano; Wang, Hongyan
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This article is from eLife , volume 3 . Abstract The control of self-renewal and differentiation of neural stem and progenitor cells is a crucial issue in stem cell and cancer biology. Drosophila type II neuroblast lineages are prone to developing impaired neuroblast homeostasis if the limited self-renewing potential of intermediate neural progenitors (INPs) is unrestrained. Here, we demonstrate that Drosophila SWI/SNF chromatin remodeling Brahma (Brm) complex functions cooperatively with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944433
PubMed Central
by CHEN, JIAN-PING; XU, DE-GUO; YU, XIAO-YI; ZHAO, FENG-MING; XU, DONG-QING; ZHANG, XU; CAI, BAO-CHANG; WANG, MING-YAN
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This article is from Oncology Letters , volume 7 . Abstract Morroniside is a water-soluble compound extracted from the fruit of Cornus officinalis and is used to protect lung activity against aging. In the present study, the manner in which morroniside regulates normal lung and cancer cells was examined. The human embryonic lung fibroblast (HELF) cell line and lung cancer A549 cell line, and their responses to morroniside treatment, were examined. Results showed that morroniside reverses the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961276
PubMed Central
by Child, Nicholas; Muhr, Tina; Sammut, Eva; Dabir, Darius; Ucar, Eduardo Arroyo; Bueser, Tootie; Gill, Jaswinder; Carr-White, Gerry; Nagel, Eike; Puntmann, Valentina O
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract Background: Myocardial crypts are discrete clefts or fissures in otherwise compacted myocardium of the left ventricle (LV). Recent reports suggest a higher prevalence of crypts in patients with hypertrophic cardiomyopathy (HCM) and also within small samples of genotype positive but phenotype negative relatives. The presence of a crypt has been suggested to be a predictor of gene carrier status. However, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164788
PubMed Central
by Nache, Marius; Scheier, Rico; Schmidt, Heiner; Hitzmann, Bernd
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This article is from Journal of Cheminformatics , volume 6 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980082
PubMed Central
by Molina-Pinelo, Sonia; Carnero, Amancio; Rivera, Fernando; Estevez-Garcia, Purificacion; Bozada, Juan Manuel; Limon, Maria Luisa; Benavent, Marta; Gomez, Javier; Pastor, Maria Dolores; Chaves, Manuel; Suarez, Rocio; Paz-Ares, Luis; de la Portilla, Fernando; Carranza-Carranza, Andres; Sevilla, Isabel; Vicioso, Luis; Garcia-Carbonero, Rocio
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This article is from BMC Cancer , volume 14 . Abstract Background: MicroRNAs (miRNAs) are involved in numerous biological and pathological processes including colorectal cancer (CRC). The aim of our study was to evaluate the ability of miRNA expression patterns to predict chemotherapy response in a cohort of 78 patients with metastatic CRC (mCRC). Methods: We examined expression levels of 667 miRNAs in the training cohort and evaluated their potential association with relevant clinical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167263
PubMed Central
by Fan, Yunxia; Ji, Muhuo; Zang, Lina; Wang, Wenhui; Yin, Qi; Xu, Jian; Yang, Jianjun
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This article is from Upsala Journal of Medical Sciences , volume 116 . Abstract Background: To test the hypothesis that 5 mg/mL tramadol is superior to 3 μg/mL fentanyl when combined with 0.125% ropivacaine in parturients undergoing labor during epidural analgesia. Methods: Sixty-one parturients undergoing labor selected for delivery with epidural analgesia were randomized into two groups: Group tramadol (0.125% ropivacaine plus tramadol 5 mg/mL) and Group fentanyl (0.125% ropivacaine plus...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207300
PubMed Central
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This article is from BMC Health Services Research , volume 12 . Abstract Background: Computed tomography (CT) is a major source of ionizing radiation exposure in medical diagnostic. Compared to adults, children are supposed to be more susceptible to health risks related to radiation. The purpose of a cross-sectional survey among office-based physicians in Germany was the assessment of medical practice in paediatric CT referrals and to investigate physicians' knowledge of radiation doses and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306200
PubMed Central
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This article is from International Journal of Pediatric Endocrinology , volume 2012 . Abstract Background: Pediatric risk factors predict adult cardiovascular disease (CVD) and type 2 diabetes (T2DM), but whether they predict events independently of adult risk factors is not fully known. Objective: Assess whether risk factors for CVD and T2DM retained from childhood to adulthood predict CVD and T2DM in young adulthood. Study design: 770 schoolchildren, ages 5–20 (mean age 12), 26-yr...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466140
PubMed Central
by Daams, Marita; Schuitema, Ilse; van Dijk, Bob W; van Dulmen-den Broeder, Eline; Veerman, Anjo JP; van den Bos, Cor; de Sonneville, Leo MJ
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This article is from BMC Neurology , volume 12 . Abstract Background: Prophylaxis to prevent relapses in the central nervous system after childhood acute lymphoblastic leukemia (ALL) used to consist of both intrathecal chemotherapy (CT) and cranial irradiation (CRT). CRT was mostly abolished in the eighties because of its neurotoxicity, and replaced with more intensive intrathecal CT. In this study, a group of survivors treated with CRT before 1983 and another group treated without CRT...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517522
PubMed Central
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This article is from Blood research , volume 49 . Abstract Hypercoagulability can result from a variety of inherited and, more commonly, acquired conditions. Testing for the underlying cause of thrombosis in a patient is complicated both by the number and variety of clinical conditions that can cause hypercoagulability as well as the many potential assay interferences. Using an algorithmic approach to hypercoagulability testing provides the ability to tailor assay selection to the clinical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090343
PubMed Central
by Yi, Ling; Zhao, Yanlin; Wang, Xiaojue; Dai, Min; Hellstrom, Karl Erik; Hellstrom, Ingegerd; Zhang, Hongtao
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This article is from PLoS ONE , volume 9 . Abstract Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the action of agonistic and antagonistic anti-CD137 mAbs we have mapped the binding region of the CD137 ligand (CD137L) to human and mouse CD137. By...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897701
PubMed Central
by Harold, Simon
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This article is from BMC Genetics , volume 15 . Abstract Contributing reviewers: The editors of BMC Genetics would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984743
PubMed Central
by Mizumoto, Kyoichi; Gosho, Masahiko; Zako, Masahiro
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This article is from Clinical Ophthalmology (Auckland, N.Z.) , volume 8 . Abstract We examined associations between optic nerve head structural parameters and glaucomatous visual field indices. The study population included patients with glaucomatous optic neuropathy who were evaluated at Aichi Medical University, Nagakute, Aichi, Japan, from October 2010 to January 2011. A total of 57 eyes from 33 patients were assessed. We measured visual field using a Humphrey field analyzer, peripapillary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077864
PubMed Central
by Zebrauskas, Andrius; Birskute, Ruta; Maciulskiene, Vita
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This article is from Journal of Oral & Maxillofacial Research , volume 5 . Abstract Objectives: To determine prevalence of dental erosion among competitive swimmers in Kaunas, the second largest city in Lithuania. Material and Methods: The study was designed as a cross-sectional survey, with a questionnaire and clinical examination protocols. The participants were 12 - 25 year-old swimmers regularly practicing in the swimming pools of Kaunas. Of the total of 132 participants there were 76...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115598
PubMed Central
by Huenges, Bert; Gulich, Markus; Bohme, Klaus; Fehr, Folkert; Streitlein-Bohme, Irmgard; Ruttermann, Viktor; Baum, Erika; Niebling, Wilhelm-Bernhard; Rusche, Herbert
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This article is from GMS Zeitschrift für Medizinische Ausbildung , volume 31 . Abstract During their studies to become medical professionals, all students are obliged to become familiar with various aspects of primary care. The aim is to provide all students with a high quality training which ensures the best possible cooperation across all sectors of the medical system. Primary care comprises the primary use of the medical service by an unfiltered set of patients as well as continued patient...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152999
PubMed Central
by Belmondo, Simone; Fiorilli, Valentina; Perez-Tienda, Jacob; Ferrol, Nuria; Marmeisse, Roland; Lanfranco, Luisa
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This article is from Frontiers in Plant Science , volume 5 . Abstract Arbuscular mycorrhizal fungi (AMF), which form an ancient and widespread mutualistic symbiosis with plants, are a crucial but still enigmatic component of the plant micro biome. Nutrient exchange has probably been at the heart of the success of this plant-fungus interaction since the earliest days of plants on land. To characterize genes from the fungal partner involved in nutrient exchange, and presumably important for the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153046
PubMed Central
by Cornacchia, Catia
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This article is from BMC Pulmonary Medicine , volume 14 . Abstract Contributing reviewers: The editors of BMC Pulmonary Medicine would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923386
PubMed Central
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This article is from Biomedical Optics Express , volume 3 . Abstract The spectrally constrained diffuse optical tomography (DOT) method relies on incorporating spectral prior information directly into the image reconstruction algorithm, thereby correlating the underlying optical properties across multiple wavelengths. Although this method has been shown to provide a solution that is stable, the use of conventional Tikhonov-type regularization techniques can lead to additional crosstalk between...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447547
PubMed Central
by Agterberg, Martijn J. H.; Hol, Myrthe K. S.; Van Wanrooij, Marc M.; Van Opstal, A. John; Snik, Ad F. M.
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This article is from Frontiers in Neuroscience , volume 8 . Abstract Direction-specific interactions of sound waves with the head, torso, and pinna provide unique spectral-shape cues that are used for the localization of sounds in the vertical plane, whereas horizontal sound localization is based primarily on the processing of binaural acoustic differences in arrival time (interaural time differences, or ITDs) and sound level (interaural level differences, or ILDs). Because the binaural...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082092
PubMed Central
by Maharramov, Abel M.; Mardanova, Vusala I.; Chyraqov, Famil M.; Gurbanov, Atash V.; Ng, Seik Weng
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract The CuII atom in the title compound, [Cu(C12H11N2O4)2(C10H14N2O)(H2O)]n, lies in a square plane defined by the O atoms of the carboxyl­ate ions, the N atom of the N-heterocycle and the water mol­ecule. Coordination by an amido O atom of an adjacent N-heterocycle in the apical direction leads to a polymeric chain running along [01]. The chain motif is consolidated by hydrogen bonds involving...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274867
PubMed Central
by Fulde, Marcus; Willenborg, Joerg; Huber, Claudia; Hitzmann, Angela; Willms, Daniela; Seitz, Maren; Eisenreich, Wolfgang; Valentin-Weigand, Peter; Goethe, Ralph
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This article is from Frontiers in Cellular and Infection Microbiology , volume 4 . Abstract The arginine-ornithine antiporter (ArcD) is part of the Arginine Deiminase System (ADS), a catabolic, energy-providing pathway found in a variety of different bacterial species, including the porcine zoonotic pathogen Streptococcus suis. The ADS has recently been shown to play a role in the pathogenicity of S. suis, in particular in its survival in host cells. The contribution of arginine and arginine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129364
PubMed Central
by Yang, Chan Kyu; Jang, Woo Sung; Choi, Eun-Suk; Cho, Sungkyu; Choi, Kwangho; Nam, Jinhae; Kim, Woong-Han
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This article is from The Korean Journal of Thoracic and Cardiovascular Surgery , volume 47 . Abstract Background: The Damus-Kaye-Stansel (DKS) procedure is a method for mitigating the risk of systemic ventricular outflow tract obstruction (SVOTO). However, there have been few reports on which surgical technique shows a better outcome. The objective of this study was to compare the outcome of the DKS procedure according to the surgical technique used. Methods: We retrospectively reviewed 12...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157496
PubMed Central
by Lee, Hyoung-Song; Kim, Min Jee; Ko, Duck Sung; Jeon, Eun Jin; Kim, Jin Young; Kang, Inn Soo
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This article is from Clinical and Experimental Reproductive Medicine , volume 40 . Abstract Objective: Preimplantation genetic diagnosis (PGD) is an assisted reproductive technique for couples carrying genetic risks. Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy, with a prevalence rate of 1/2,500. In this study, we report on our experience with PGD cycles performed for CMT types 1A and 2F. Methods: Before clinical PGD, we assessed the amplification rate and allele...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913895
PubMed Central
by Mazaki, Tetsuro; Shiozaki, Yasuyuki; Yamane, Kentaro; Yoshida, Aki; Nakamura, Mariko; Yoshida, Yasuhiro; Zhou, Di; Kitajima, Takashi; Tanaka, Masato; Ito, Yoshihiro; Ozaki, Toshifumi; Matsukawa, Akihiro
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This article is from Scientific Reports , volume 4 . Abstract Osteochondral injuries remain difficult to repair. We developed a novel photo-cross-linkable furfurylamine-conjugated gelatin (gelatin-FA). Gelatin-FA was rapidly cross-linked by visible light with Rose Bengal, a light sensitizer, and was kept gelled for 3 weeks submerged in saline at 37°C. When bone marrow-derived stromal cells (BMSCs) were suspended in gelatin-FA with 0.05% Rose Bengal, approximately 87% of the cells were viable...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964514
PubMed Central
by Hommelsheim, Carl Maximilian; Frantzeskakis, Lamprinos; Huang, Mengmeng; Ulker, Bekir
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This article is from Scientific Reports , volume 4 . Abstract Designer transcription-activator like effectors (TALEs) is a promising technology and made it possible to edit genomes with higher specificity. Such specific engineering and gene regulation technologies are also being developed using RNA-binding proteins like PUFs and PPRs. The main feature of TALEs, PUFs and PPRs is their repetitive DNA/RNA-binding domains which have single nucleotide binding specificity. Available kits today allow...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031481
PubMed Central
by Cheng, Yi-Shing Lisa; Rees, Terry; Wright, John
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This article is from Clinical and Translational Medicine , volume 3 . Abstract Using saliva for disease diagnostics and health surveillance is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945802
PubMed Central
by Monirpoor, Nader; Gholamyzarch, Morteza; Tamaddonfard, Mohsen; Khoosfi, Helen; Ganjali, Ali Reza
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This article is from International Journal of High Risk Behaviors & Addiction , volume 1 . Abstract Background: Primary maladaptive schemas, which are the basis of high-risk behavior and psychological disorders, result from childhood experiences with significant objects, such as fathers, in different developmental phases. Objectives: This endeavor examined the role of the father in predicting these schemas. Patients and Methods: A total of 345 Islamic Azad University students (Qom Branch)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070103
PubMed Central
by Gengenbacher, Martin; Vogelzang, Alexis; Schuerer, Stefanie; Lazar, Doris; Kaiser, Peggy; Kaufmann, Stefan H. E.
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This article is from mBio , volume 5 . Abstract The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV+ newborns. We previously reported improved preclinical efficacy and safety of the recombinant vaccine candidate BCG ΔureC::hly, which secretes the pore-forming listeriolysin O of Listeria monocytogenes. Here, we evaluate a second-generation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049106
PubMed Central
by Crossley, Samantha; Reid, Jenny; McLatchie, Rachel; Hayton, Judith; Clark, Clair; MacDougall, Margaret; Andrews, Peter JD
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This article is from Critical Care , volume 18 . Abstract Introduction: Research into therapeutic hypothermia following traumatic brain injury has been characterised by small trials of poor methodological quality, producing variable results. The Cochrane review, published in 2009, now requires updating. The aim of this systematic review is to assess the effectiveness of the application of therapeutic hypothermia to reduce death and disability when administered to adult patients who have been...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056614
PubMed Central
by RIEGER, JOHANNES; BAHR, OLIVER; MAURER, GABRIELE D.; HATTINGEN, ELKE; FRANZ, KEA; BRUCKER, DANIEL; WALENTA, STEFAN; KAMMERER, ULRIKE; COY, JOHANNES F.; WELLER, MICHAEL; STEINBACH, JOACHIM P.
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This article is from International Journal of Oncology , volume 44 . Abstract Limiting dietary carbohydrates inhibits glioma growth in preclinical models. Therefore, the ERGO trial (NCT00575146) examined feasibility of a ketogenic diet in 20 patients with recurrent glioblastoma. Patients were put on a low-carbohydrate, ketogenic diet containing plant oils. Feasibility was the primary endpoint, secondary endpoints included the percentage of patients reaching urinary ketosis, progression-free...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063533
This article is from BMC Public Health , volume 12 . Abstract Background: Achieving universal coverage as an objective needs to confront the reality of multiple mechanisms, with healthcare financing and provision occurring in both public and private settings. South Africa has both large and mature public and private health systems offering useful insights into how they can be effectively harmonized to optimise coverage. Private healthcare in South Africa has also gone through many phases and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381693
PubMed Central
by Navidghasemizad, Sahar; Takala, Timo M; Alatossava, Tapani; Saris, Per EJ
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This article is from Bioengineered , volume 4 . Abstract In this study the growth of genetically modified Lactobacillus casei LAB6, overexpressing proline iminopeptidase PepI and its capacity to increase free proline was investigated during ripening of Edam cheese. The strain successfully survived 12 weeks of ripening period in cheese. The food-grade plasmid pLEB604, carrying the pepI gene, was stable, and PepI enzyme was active in LAB6 cells isolated at different stages of the ripening...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937202
PubMed Central
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This article is from ZooKeys . Abstract AbstractEight apterous species of the paederine genus Lathrobium Gravenhorst, 1802 from the Chinese province Sichuan are described, illustrated, and distinguished from closely related and/or geographically close congeners: Lathrobium erlangense Peng & Li sp. n. (Erlang Shan), Lathrobium blandum Peng & Li sp. n. (Labahe N. R.), Lathrobium yelense Peng & Li sp. n. (Yele), Lathrobium obscurum Peng & Li sp. n. (Yele), Lathrobium yinziweii Peng...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689065
PubMed Central
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This article is from Ecology and Evolution , volume 3 . Abstract Genetic correlations among traits alter evolutionary trajectories due to indirect selection. Pleiotropy, chance linkage, and selection can all lead to genetic correlations, but have different consequences for phenotypic evolution. We sought to assess the mechanisms contributing to correlations with size at maturity in the cyclic parthenogen Daphnia pulicaria. We selected on size in each of four populations that differ in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586631
PubMed Central
by Fleury, Eduardo de Faria Castro; Assuncao-Queiros, Maria do Carmo Guedes Alcoforado; Roveda, Decio
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This article is from Breast Cancer : Targets and Therapy , volume 6 . Abstract Background: This study assessed factors influencing the sonoelastographic presentation of breast carcinoma. Methods: A prospective collaborative study was conducted by the Santa Casa de São Paulo and CTC-Center, on 540 breast lesions in women referred for percutaneous breast biopsy. Eighty-four carcinomas showing lesions on ultrasonography were included. These lesions were classified into four sonoelastographic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128690
This article is from Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease , volume 2 . Abstract Background: Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase‐II (Arg‐II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through uncoupling of endothelial nitric oxide synthase and activation of macrophage inflammation. The function of Arg‐II in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828809
PubMed Central
by Meng, Qiong; Bai, Xiangning; Zhao, Ailan; Lan, Ruiting; Du, Huamao; Wang, Tao; Shi, Changyou; Yuan, Xuejiao; Bai, Xuemei; Ji, Shaobo; Jin, Dong; Yu, Bo; Wang, Yan; Sun, Hui; Liu, Kai; Xu, Jianguo; Xiong, Yanwen
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This article is from BMC Microbiology , volume 14 . Abstract Background: Shiga toxin-producing Escherichia coli (STEC) is recognized as an important human diarrheal pathogen. Swine plays an important role as a carrier of this pathogen. In this study we determined the prevalence and characteristics of STEC from healthy swine collected between May 2011 and August 2012 from 3 cities/provinces in China. Results: A total of 1003 samples, including 326 fecal, 351 small intestinal contents and 326...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893481
PubMed Central
by Seifirad, Soroush; Ghaffari, Alireza; Amoli, Mahsa M.
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This article is from Frontiers in Physiology , volume 5 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094884
PubMed Central
by Alijahan, Rahele; Hazrati, Sadegh; Mirzarahimi, Mehrdad; Pourfarzi, Farhad; Ahmadi Hadi, Peymaneh
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This article is from Iranian Journal of Reproductive Medicine , volume 12 . Abstract Background: Preterm birth is a leading cause of perinatal mortality and long-term morbidity as well as the long-term health consequences and cognitive outcomes. Objective: Present study was conducted to determine prevalence and risk factors associated with preterm birth in Ardabil, Iran.Materials and Methods: A case control study was conducted between Nov 2010 and July 2011 in all three maternal hospitals in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009588
PubMed Central
by Hommel, Marcel
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This article is from Malaria Journal , volume 13 . Abstract Contributing reviewers: Malaria Journal would like to thank all reviewers who have contributed to the journal in 2013.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917501
PubMed Central
by Bhattacharya, Soumee; Haertel, Christin; Maelicke, Alfred; Montag, Dirk
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This article is from PLoS ONE , volume 9 . Abstract The plant alkaloid galantamine is an established symptomatic drug treatment for Alzheimer’s disease (AD), providing temporary cognitive and global relief in human patients. In this study, the 5X Familial Alzheimer’s Disease (5XFAD) mouse model was used to investigate the effect of chronic galantamine treatment on behavior and amyloid β (Aβ) plaque deposition in the mouse brain. Quantification of plaques in untreated 5XFAD mice showed a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931790
PubMed Central
by Taniguchi, Keiichi; Takii, Takemasa; Yamamoto, Saburo; Maeyama, Jun-ichi; Iho, Sumiko; Maruyama, Mitsuo; Iizuka, Narushi; Ozeki, Yuriko; Matsumoto, Sohkichi; Hasegawa, Tomohiro; Miyatake, Yuuji; Itoh, Saotomo; Onozaki, Kikuo
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This article is from Immunity & Ageing : I & A , volume 10 . Abstract Background: Mycobacterium bovis bacillus Calmette Guérin (BCG) vaccine, which has been inoculated to more than one billion people world-wide, has significant effect in preventing tuberculous meningitis and miliary tuberculosis (TB) in neonate and early childhood. However, BCG fails to adequately protect against pulmonary TB and reactivation of latent infections in adults. To overcome this problem, adequate booster is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704610
PubMed Central
by Ponsuwanna, Patrath; Kumpornsin, Krittikorn; Chookajorn, Thanat
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This article is from PLoS ONE , volume 9 . Abstract Even though antigenic variation is employed among parasitic protozoa for host immune evasion, Tetrahymena thermophila, a free-living ciliate, can also change its surface protein antigens. These cysteine-rich glycosylphosphatidylinositol (GPI)-linked surface proteins are encoded by a family of polymorphic Ser genes. Despite the availability of T. thermophila genome, a comprehensive analysis of the Ser family is limited by its high degree of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136848
PubMed Central
by Bouchentouf, Rachid; Bouaity, Brahim; Touati, Mohamed; Benjelloun, Amine; Aitbenasser, Moulay Ali
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This article is from The Pan African Medical Journal , volume 14 . Abstract La localisation nasosinusienne de la tuberculose est rare. Elle est caractérisée par une présentation clinique polymorphe et non spécifique, posant souvent un problème de diagnostic différentiel. Le diagnostic repose sur l'examen anatomopathologique et bactériologique avec examen direct et culture. Le traitement est essentiellement médical à base d'antibacillaires.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597901
This article is from Frontiers in Aging Neuroscience , volume 5 . Abstract Cognitive training and aerobic training are known to improve cognitive functions. To examine the separate and combined effects of such training on cognitive performance, four groups of healthy older adults embarked on a 4 months cognitive and/or mild aerobic training. A first group [n = 33, mean age = 80 (66–90)] engaged in cognitive training, a second [n = 29, mean age = 81 (65–89)] in mild aerobic training, a third...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607803
PubMed Central
by Grulkowski, Ireneusz; Liu, Jonathan J.; Potsaid, Benjamin; Jayaraman, Vijaysekhar; Lu, Chen D.; Jiang, James; Cable, Alex E.; Duker, Jay S.; Fujimoto, James G.
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This article is from Biomedical Optics Express , volume 3 . Abstract We demonstrate swept source OCT utilizing vertical-cavity surface emitting laser (VCSEL) technology for in vivo high speed retinal, anterior segment and full eye imaging. The MEMS tunable VCSEL enables long coherence length, adjustable spectral sweep range and adjustable high sweeping rate (50–580 kHz axial scan rate). These features enable integration of multiple ophthalmic applications into one instrument. The operating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493240
PubMed Central
by Kim, Dae-Won; Staples, Meaghan; Shinozuka, Kazutaka; Pantcheva, Paolina; Kang, Sung-Don; Borlongan, Cesar V.
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This article is from International Journal of Molecular Sciences , volume 14 . Abstract Wharton’s jelly (WJ) is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as displaying the stemness phenotype is the mesenchymal stromal cells (MSCs). Because MSCs’ stemness and immune properties appear to be more robustly expressed and functional which are more comparable with fetal than adult-derived...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709752
PubMed Central
by Hao, Yanwei; Wang, Xinyu; Li, Xian; Bassa, Carole; Mila, Isabelle; Audran, Corinne; Maza, Elie; Li, Zhengguo; Bouzayen, Mondher; van der Rest, Benoit; Zouine, Mohamed
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This article is from Journal of Experimental Botany , volume 65 . Abstract Members of the TOPLESS gene family emerged recently as key players in gene repression in several mechanisms, especially in auxin perception. The TOPLESS genes constitute, in ‘higher-plant’ genomes, a small multigenic family comprising four to 11 members. In this study, this family was investigated in tomato, a model plant for Solanaceae species and fleshy fruits. Six open reading frames predicted to encode...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935560
PubMed Central
by Felis, Thomas; McGregor, Helen V.; Linsley, Braddock K.; Tudhope, Alexander W.; Gagan, Michael K.; Suzuki, Atsushi; Inoue, Mayuri; Thomas, Alexander L.; Esat, Tezer M.; Thompson, William G.; Tiwari, Manish; Potts, Donald C.; Mudelsee, Manfred; Yokoyama, Yusuke; Webster, Jody M.
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This article is from Nature Communications , volume 5 . Abstract Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ18O for Last Glacial Maximum and deglacial corals that show a considerably steeper meridional SST gradient than the present day in the central GBR. We find a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082631
PubMed Central
by Nishihara, Ken; Kawai, Hisashi; Hayashi, Hiroyuki; Naruse, Hideo; Kimura, Akihiko; Gomi, Toshiaki; Hoshi, Fumihiko
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This article is from Clinical Interventions in Aging , volume 9 . Abstract Background: The skeletal muscle echo intensity (EI) during ultrasound imaging has been investigated to evaluate the muscle quality. However, EI fluctuates according to the scanning conditions. Methods: The motor functions and ultrasound images of 19 elderly (73±3.2 years) and 19 young (22±1.5 years) individuals were investigated and an EI frequency component was assessed for more reliable evaluations. Healthy elderly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160316
PubMed Central
by Ramirez, Oscar; Motta-Mena, Laura B.; Cordova, Amanda; Garza, Kristine M.
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This article is from PLoS ONE , volume 9 . Abstract Synthesis of compound libraries and their concurrent assessment as selective reagents for probing and modulating biological function continues to be an active area of chemical biology. Microwave-assisted solid-phase Dötz benzannulation reactions have been used to inexpensively synthesize 2, 3-disubstituted-1, 4-naphthoquinone derivatives. Herein, we report the biological testing of a small library of such compounds using a murine fibroblast...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157788
PubMed Central
by Shipley, Tim
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This article is from BMC Neurology , volume 14 . Abstract Contributing reviewers: The editors of BMC Neurology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973960
PubMed Central
by Meyer, Norbert; Nuss, Sarah Janine; Rothe, Thomas; Siebenhuner, Alexander; Akdis, Cezmi A; Menz, Gunter
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This article is from Journal of Asthma and Allergy , volume 7 . Abstract Background: Asthma is a heterogeneous disease characterized by different clinical phenotypes and the involvement of multiple inflammatory pathways. During airway inflammation, many cytokines and chemokines are released and some are detectable in the sera. Objective: Serum chemokines and cytokines, involved in airway inflammation in asthma patients, were investigated. Methods: A total of 191 asthma patients were classified...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008293
PubMed Central
by Verhaeghe, J.; Gheysen, R.; Enzlin, P.
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This article is from Facts, Views & Vision in ObGyn , volume 5 . Abstract Pheromones are substances which are secreted to the outside by an individual and received by a second individual of the same species. Many examples exist in animals but their role in humans remains uncertain since adults have no functioning vomeronasal organ, which processes pheromone signals in animals. Yet pheromones can be detected by the olfactory system although humans under develop and underrate their smelling...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987372
PubMed Central
by van de Crommenacker, Janske; Komdeur, Jan; Burke, Terry; Richardson, David S
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This article is from The Journal of Animal Ecology , volume 80 . Abstract 1.Fluctuations in the quality of the habitat in which an animal lives can have major consequences for its behaviour and physiological state. In poor-quality habitat with low food availability, metabolically intensive foraging activity is likely to result in increased generation of reactive oxygen species, while scarcity of food can lead to a weakening of exogenously derived antioxidant defences. The consequent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107423