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PubMed Central is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).


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by Chen, Zheng-lin; Gu, Ping-qing; Liu, Kangsheng; Su, Ya-juan; Gao, Ling-juan
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This article is from Journal of Translational Medicine , volume 10 . Abstract Background: The globular heads of the human C1q receptor (gC1qR) localize predominantly to the mitochondrial matrix. gC1qR mediates many biological responses, including growth perturbation, morphological abnormalities and the initiation of apoptosis. The purpose of this study was to investigate the relationship between mitochondrial dysfunction, p53 status and gC1qR expression and the regulation of apoptosis in human...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567992
PubMed Central
by Min, Jing-jing; Huo, Xin-long; Xiang, ling-yun; Qin, Yan-qing; Chai, Ke-qin; Wu, Bin; Jin, Lu; Wang, Xiao-tong
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This article is from Scientific Reports , volume 4 . Abstract Cognitive impairment is a common finding in patients with chronic obstructive pulmonary disease (COPD), but little attention has been focused on therapeutic intervention for this complication. Chronic intermittent hypoxia hypercapnia (CIHH) exposure is considered to be responsible for the pathogenesis of COPD. Dl-3n-Butylphthalide (NBP), extracted from Apium graveolens Linn, has displayed a broad spectrum of neuroprotective...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080197
PubMed Central
by Huang, Yan; Lu, Yi; Zhang, Lei; Yan, Jia; Jiang, Jue; Jiang, Hong
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This article is from International Journal of Molecular Sciences , volume 15 . Abstract Recent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-inflammatory cytokines IL-6 and TNF-α. In this study, we established a rat model that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975383
PubMed Central
by Parikh, Ankur P.; Wu, Wei; Curtis, Ross E.; Xing, Eric P.
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This article is from Bioinformatics , volume 27 . Abstract Motivation: Estimating gene regulatory networks over biological lineages is central to a deeper understanding of how cells evolve during development and differentiation. However, one challenge in estimating such evolving networks is that their host cells not only contiguously evolve, but also branch over time. For example, a stem cell evolves into two more specialized daughter cells at each division, forming a tree of networks. Another...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117339
PubMed Central
by Yari, Mitra; Saeb, Morteza; Golfam, Parisa; Makhloogh, Zahra
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This article is from Journal of Injury and Violence Research , volume 5 . Abstract Background:: Anterior Cruciate Ligament (ACL) tearing is a common injury among football players. The present study aims to determine the best single-dose of intra-articular morphine for pain relief after arthroscopic knee surgery that, in addition to adequate and long-term analgesia, leads to fewer systemic side effects. Methods:: This clinical trial was conducted on 40 ASA-I athletes. After surgery, all...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683418
PubMed Central
by Roncero, Carlos; Vega, Pablo; Martinez-Raga, Jose; Barral, Carmen; Basurte-Villamor, Ignacio; Rodriguez-Cintas, Laia; Mesias, Beatriz; Grau-Lopez, Lara; Casas, Miguel; Szerman, Nestor
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This article is from International Journal of Mental Health Systems , volume 8 . Abstract Background: Since provision of integrated services for patients with dual pathology or dual disorders (coexistence of an addictive disorder and other psychiatric disorders) constitutes an important challenge, this study compared the perceptions of health-care professionals with the existing, current state of specific resources for patients with dual pathology in Spain. Methods: Epidemiological,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158069
PubMed Central
by Foote, Christopher
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This article is from BMC Research Notes , volume 7 . Abstract Contributing reviewers: The editors of BMC Research Notes would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895785
PubMed Central
by Hoffman, Sidra M; Tully, Jane E; Nolin, James D; Lahue, Karolyn G; Goldman, Dylan H; Daphtary, Nirav; Aliyeva, Minara; Irvin, Charles G; Dixon, Anne E; Poynter, Matthew E; Anathy, Vikas
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This article is from Respiratory Research , volume 14 . Abstract Background: The endoplasmic reticulum (ER) stress response participates in many chronic inflammatory and autoimmune diseases. In the current study, we sought to examine the contribution of ER stress transducers in the pathogenesis of three principal facets of allergic asthma: inflammation, airway fibrosis, and airways hyperresponsiveness. Methods: House Dust Mite (HDM) was used as an allergen for in vitro and in vivo challenge of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877992
PubMed Central
by Pafitis, Natalie
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This article is from BMC Public Health , volume 13 . Abstract Contributing reviewers: The editors of BMC Public Health would like to thank all our reviewers who have contributed to the journal in 2012.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751667
PubMed Central
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This article is from eLife , volume 3 . Abstract Deregulated expression of COX-2 has been causally linked to development, progression, and outcome of several types of human cancer. We describe a novel fundamental level of transcriptional control of COX-2 expression. Using primary human mammary epithelial cells and monocyte/macrophage cell lines, we show that the chromatin boundary/insulator factor CTCF establishes an open chromatin domain and induces expression of a long non-coding RNA within...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017649
PubMed Central
by Jahanbakhsh, Rouzbeh; Atyabi, Fatemeh; Shanehsazzadeh, Saeed; Sobhani, Zahra; Adeli, Mohsen; Dinarvand, Rassoul
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This article is from DARU Journal of Pharmaceutical Sciences , volume 21 . Abstract Background and purpose of the study: Carbon nanotubes (CNTs) are emerging drug and imaging carrier systems which show significant versatility. One of the extraordinary characteristics of CNTs as Magnetic Resonance Imaging (MRI) contrasting agent is the extremely large proton relaxivities when loaded with gadolinium ion (Gdn3+) clusters. Methods: In this study equated Gdn3+ clusters were loaded in the sidewall...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716729
PubMed Central
by Harold, Simon
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This article is from BMC Plant Biology , volume 14 . Abstract Contributing reviewers: The editors of BMC Plant Biology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897928
PubMed Central
by Chen, Wenhua; Yang, Yilin; Xing, Wei; Peng, Ya; Qiu, Jianguo; He, Zhongming; Wang, Qi
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This article is from Journal of Biomedical Research , volume 24 . Abstract Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage (SAH). The aim of our study was to assess the clinical usefulness of multislice computed tomography angiography (CTA) in the surgical and endovascular treatment of intracranial aneurysms. A total of 195 cases with 206 intracranial aneurysms underwent CTA. Fifty (24%) aneurysms underwent surgical clipping while...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596695
PubMed Central
by Chen, Dengyu; Zhang, Yunxia; Wang, Jing; Chen, Junsong; Yang, Cuiping; Cai, Kai; Wang, Xiaoying; Shi, Fangfang; Dou, Jun
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This article is from Journal of Ovarian Research , volume 6 . Abstract Background: Cancer stem cells (CSCs) are believed to be ‘seed cell’ in cancer recurrence and metastasis. MicroRNAs (miRNAs) can play an important role in the progression of primary tumor towards metastasis by regulating the epithelial-mesenchymal transition (EMT). The goal of this study was to investigate the effect of miRNA-200c overexpression on the EMT, tumorigenicity and metastasis of epithelial ovarian cancer (EOC)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729499
PubMed Central
by Huang, Li-Hui; Zhang, Luo; Tobe, Ruo-Yan Gai; Qi, Fang-Hua; Sun, Long; Teng, Yue; Ke, Qing-Lin; Mai, Fei; Zhang, Xue-Feng; Zhang, Mei; Yang, Ru-Lan; Tu, Lin; Li, Hong-Hui; Gu, Yan-Qing; Xu, Sai-Nan; Yue, Xiao-Yan; Li, Xiao-Dong; Qi, Bei-Er; Cheng, Xiao-Huan; Tang, Wei; Xu, Ling-Zhong; Han, De-Min
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This article is from BMC Health Services Research , volume 12 . Abstract Background: Neonatal hearing screening (NHS) has been routinely offered as a vital component of early childhood care in developed countries, whereas such a screening program is still at the pilot or preliminary stage as regards its nationwide implementation in developing countries. To provide significant evidence for health policy making in China, this study aims to determine the cost-effectiveness of NHS program...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353179
PubMed Central
by Krief, Sabrina; Levrero, Florence; Krief, Jean-Michel; Thanapongpichat, Supinya; Imwong, Mallika; Snounou, Georges; Kasenene, John M; Cibot, Marie; Gantier, Jean-Charles
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This article is from Malaria Journal , volume 11 . Abstract Background: Malaria parasites (Plasmodium sp.), including new species, have recently been discovered as low grade mixed infections in three wild chimpanzees (Pan troglodytes schweinfurthii) sampled randomly in Kibale National Park, Uganda. This suggested a high prevalence of malaria infection in this community. The clinical course of malaria in chimpanzees and the species of the vectors that transmit their parasites are not known. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515334
PubMed Central
by Huyen, Mai NT; Kremer, Kristin; Lan, Nguyen TN; Buu, Tran N; Cobelens, Frank GJ; Tiemersma, Edine W; de Haas, Petra; van Soolingen, Dick
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This article is from BMC Infectious Diseases , volume 13 . Abstract Background: In comparison to restriction fragment length polymorphism (RFLP) typing, variable number of tandem repeat (VNTR) typing is easier to perform, faster and yields results in a simple, numerical format. Therefore, this technique has gained recognition as the new international gold standard in typing of Mycobacterium tuberculosis. However, some reports indicated that VNTR typing may be less suitable for Beijing genotype...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568002
PubMed Central
by Cheriyan, Thomas; Schmid, Thomas M.; Spector, Myron
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This article is from Molecular Vision , volume 17 . Abstract Purpose: Lubricin is a principal boundary lubricating and anti-adhesion protein found in synovial fluid and several musculoskeletal tissues. This study investigates the presence of lubricin in the meibomian gland, lacrimal gland and ocular surface of healthy rabbits; prompted by the hypothesis that lubricin acts as boundary lubricant and anti-adhesive protein in the eye. Methods: Thirty six eyelids were resected from ten cadaveric New...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233388
PubMed Central
by Nordlund, Jessica; Backlin, Christofer L; Wahlberg, Per; Busche, Stephan; Berglund, Eva C; Eloranta, Maija-Leena; Flaegstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G; Larsson, Rolf; Palle, Josefine; Ronnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Soderhall, Stefan; Pastinen, Tomi; Gustafsson, Mats G; Lonnerholm, Gudmar; Syvanen, Ann-Christine
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This article is from Genome Biology , volume 14 . Abstract Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood. Results: We surveyed the DNA methylation levels of 435,941 CpG sites in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014804
PubMed Central
by Otterbein, Leo E
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This article is from Medical Gas Research , volume 3 . Abstract The articles contained in this review series exemplify the diverse applications and succinct biological relevance of this simple gas. Articles summarizing the important effects of carbon monoxide in preventing the rejection of an organ, in its neuroprotective properties in piglets, regulation of mycobacterial growth, in its anti-inflammatory effects in the gut and in its use in new and innovative modalities and avenues by which to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610149
PubMed Central
by Bozok, S; Ilhan, G; Yilmaz, Y; Dokumcu, Z; Tumkaya, L; Karamustafa, H; Karakisi, S Ozan; Ergene, S; Sener, E
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This article is from European Journal of Medical Research , volume 17 . Abstract Background: The role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. The objective of this study was to examine the potential protective effects of hyperbaric oxygen (HBO) and iloprost (IL) therapy on lung damage induced by limb ischemia/reperfusion injury in a rabbit model, using both biochemical and histopathological aspects. Methods: Forty New Zealand white rabbits...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406985
PubMed Central
by Kourkouta, Lambrini; Papathanasiou, Ioanna V.
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This article is from Materia Socio-Medica , volume 26 . Abstract Good communication between nurses and patients is essential for the successful outcome of individualized nursing care of each patient. To achieve this, however, nurses must understand and help their patients, demonstrating courtesy, kindness and sincerity. Also they should devote time to the patient to communicate with the necessary confidentiality, and must not forget that this communication includes persons who surround the sick...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990376
PubMed Central
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This article is from Annals of The Royal College of Surgeons of England , volume 94 . Abstract INTRODUCTION: The preliminary results of a pyrocarbon interpositional radiocarpal implant in a small cohort of patients were reviewed. As it is currently only a limited release product, we describe to potential users early complications and negative outcomes. METHODS: Patients were assessed using pain levels, ranges of motion, grip strength, type of and time to return to work as well as pre-operative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954246
PubMed Central
by Pina-Amargos, Fabian; Gonzalez-Sanson, Gaspar; Martin-Blanco, Felix; Valdivia, Abel
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This article is from PeerJ , volume 2 . Abstract Marine reserves can restore fish abundance and diversity in areas impacted by overfishing, but the effectiveness of reserves in developing countries where resources for enforcement are limited, have seldom been evaluated. Here we assess whether the establishment in 1996 of the largest marine reserve in the Caribbean, Gardens of the Queen in Cuba, has had a positive effect on the abundance of commercially valuable reef fish species in relation to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932734
PubMed Central
by Lu, H; Sun, J; Wang, F; Feng, L; Ma, Y; Shen, Q; Jiang, Z; Sun, X; Wang, X; Jin, H
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This article is from Cell Death & Disease , volume 4 . Abstract Through silencing tumor suppressor genes, epigenetic changes can activate signaling pathways important to cancer development. In this report, we found an epigenetic contribution to the aberrant activation of wnt signaling in human gastric cancer. CXXC4 (CXXC finger protein 4) was identified as a novel target of EZH2 (enhancer of zeste homolog 2), and EZH2 promotes the activation of wnt singaling by downregulating CXXC4...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763454
PubMed Central
by Leeper, Alexander D.; Farrell, Joanne; Dixon, J. Michael; Wedden, Sarah E.; Harrison, David J.; Katz, Elad
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This article is from Journal of Visualized Experiments : JoVE . Abstract Breast cancer is a leading cause of mortality in the Western world. It is well established that the spread of breast cancer, first locally and later distally, is a major factor in patient prognosis. Experimental systems of breast cancer rely on cell lines usually derived from primary tumours or pleural effusions. Two major obstacles hinder this research: (i) some known sub-types of breast cancers (notably poor prognosis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197444
PubMed Central
by Tabrizizadeh, M.; Reuben, J.; Khalesi, M.; Mousavinasab, M.; Ezabadi, MK. Ghane
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This article is from Journal of Dentistry (Tehran, Iran) , volume 7 . Abstract Objective:: Better understanding of the furcation anatomy may serve to decrease the risk of root perforation. The purpose of this study was to measure the thickness of root walls in the danger zone in mandibular first molars. Materials and Methods:: The roots of 53 extracted human mandibular first molars were sectioned in the horizontal plane 4 mm below the orifice of the mesial and distal root canals. For each cut...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184764
PubMed Central
by Cho, Dong-Sik; Woo, Sookyoung; Kim, Seonwoo; Byrne, Christopher D; Kong, Joon-Hyuk; Sung, Ki-Chul
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This article is from Cardiovascular Diabetology , volume 11 . Abstract Background: Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458889
PubMed Central
by Mohammad, Majid Malek; Dadashpour, Shahdak; Adimi, Parisa
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This article is from Tanaffos , volume 11 . Abstract Background: Cardiopulmonary exercise testing evaluates the ability of one's cardiovascular and respiratory system in maximal exercise. This was a descriptive cross-sectional pilot study conducted at Masih Daneshvari Hospital in order to determine predicted values of cardiopulmonary exercise testing in individuals with normal physical activity patterns. Materials and Methods: Thirty four individuals (14 women, 20 men) between 18-57 years of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153176
PubMed Central
by Peng, Yan; Xie, Enyi; Zheng, Kai; Fredimoses, Mangaladoss; Yang, Xianwen; Zhou, Xuefeng; Wang, Yifei; Yang, Bin; Lin, Xiuping; Liu, Juan; Liu, Yonghong
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This article is from Marine Drugs , volume 11 . Abstract Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years in Zhanjiang, Guangdong province, China. This study is the first time to investigate its chemical composition and antiviral activity. On the dry weight basis, this seaweed was constituted of ca. 35.18% ash, 11.20% protein, 1.06% lipid and 47.73% total carbohydrate, and the main carbohydrate was water-soluble polysaccharide. The protein...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564154
PubMed Central
by Hirsch, Ann M.; Alvarado, Johana; Bruce, David; Chertkov, Olga; De Hoff, Peter L.; Detter, John C.; Fujishige, Nancy A.; Goodwin, Lynne A.; Han, James; Han, Shunsheng; Ivanova, Natalia; Land, Miriam L.; Lum, Michelle R.; Milani-Nejad, Nima; Nolan, Matt; Pati, Amrita; Pitluck, Sam; Tran, Stephen S.; Woyke, Tanja; Valdes, Maria
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This article is from Genome Announcements , volume 1 . Abstract Micromonospora species live in diverse environments and exhibit a broad range of functions, including antibiotic production, biocontrol, and degradation of complex polysaccharides. To learn more about these versatile actinomycetes, we sequenced the genome of strain L5, originally isolated from root nodules of an actinorhizal plant growing in Mexico.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784783
PubMed Central
by Morawska, Magdalena
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This article is from BMC Oral Health , volume 14 . Abstract Contributing reviewers: The editors of BMC Oral Health would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921989
PubMed Central
by Moutinho, Catia; Martinez-Cardus, Anna; Santos, Cristina; Navarro-Perez, Valentin; Martinez-Balibrea, Eva; Musulen, Eva; Carmona, F. Javier; Sartore-Bianchi, Andrea; Cassingena, Andrea; Siena, Salvatore; Elez, Elena; Tabernero, Josep; Salazar, Ramon; Abad, Albert; Esteller, Manel
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This article is from JNCI Journal of the National Cancer Institute , volume 106 . Abstract Background: A major problem in cancer chemotherapy is the existence of primary resistance and/or the acquisition of secondary resistance. Many cellular defects contribute to chemoresistance, but epigenetic changes can also be a cause. Methods: A DNA methylation microarray was used to identify epigenetic differences in oxaliplatin-sensitive and -resistant colorectal cancer cells. The candidate gene SRBC...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906989
PubMed Central
by KASUYA, Kazufumi; YOSHIDA, Eiji; HARADA, Rieko; HASEGAWA, Mio; OSAKA, Hiroyuki; KATO, Masaharu; SHIBAHARA, Tomoyuki
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This article is from The Journal of Veterinary Medical Science , volume 76 . Abstract An 18-week-old female breeding Yorkshire pig displayed symptoms of astasia and subsequently died. Histologically, severe disseminated suppurative meningoencephalomyelitis was detected, as were numerous myocardial microabscesses. Gram-positive cocci were detected in these suppurative lesions, and these cocci reacted with an antibody against Streptococcus C group species. Gram-positive cocci were isolated from...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073340
PubMed Central
by Tsalafouta, A.; Papandroulakis, N.; Gorissen, M.; Katharios, P.; Flik, G.; Pavlidis, M.
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This article is from Scientific Reports , volume 4 . Abstract The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute stressors and the temporal patterns of cortisol whole body concentrations and the expression of genes involved in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078316
PubMed Central
by Morawska, Magdalena
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This article is from BMC Gastroenterology , volume 14 . Abstract Contributing reviewers: The editors of BMC Gastroenterology would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898228
PubMed Central
by Naiken, Surennaidoo P; Toso, Christian; Rubbia-Brandt, Laura; Thomopoulos, Theodoros; Roth, Arnaud; Mentha, Gilles; Morel, Philippe; Gervaz, Pascal
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This article is from BMC Surgery , volume 14 . Abstract Background: Complete pathological response occurs in 10–20% of patients with rectal cancer who are treated with neoadjuvant chemoradiation therapy prior to pelvic surgery. The possibility that complete pathological response of rectal cancer can also occur with neoadjuvant chemotherapy alone (without radiation) is an intriguing hypothesis. Case presentation: A 66-year old man presented an adenocarcinoma of the rectum with nine liver...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900671
PubMed Central
by Pavone, Vito; Bianca, Sebastiano; Grosso, Giuseppe; Pavone, Piero; Mistretta, Antonio; Longo, Maria Roberta; Marino, Silvia; Sessa, Giuseppe
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This article is from Acta Orthopaedica , volume 83 . Abstract Background and purpose: Congenital talipes equinovarus (clubfoot) can present in 2 forms: “syndromic”, in which other malformations exist, and the more common “idiopathic” form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the Sicilian population, looking for potential etiological factors. Patients and methods: Among the 801,324 live births recorded...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369158
PubMed Central
by Rohlenova, Karolina; Morand, Serge; Hyrsl, Pavel; Tolarova, Sona; Flajshans, Martin; Simkova, Andrea
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This article is from Parasites & Vectors , volume 4 . Abstract Background: The basic function of the immune system is to protect an organism against infection in order to minimize the fitness costs of being infected. According to life-history theory, energy resources are in a trade-off between the costly demands of immunity and other physiological demands. Concerning fish, both physiology and immunity are influenced by seasonal changes (i.e. temporal variation) associated to the changes of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155493
PubMed Central
by Majithia, Deesha A
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This article is from BMC Neuroscience , volume 14 . Abstract Contributing reviewers: The editors of BMC Neuroscience would like to thank all our reviewers who have contributed to the journal in Volume 13 (2012).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626905
PubMed Central
by ALTOMARE, Roberta; CACCIABAUDO, Francesco; DAMIANO, Giuseppe; PALUMBO, Vincenzo Davide; GIOVIALE, Maria Concetta; BELLAVIA, Maurizio; TOMASELLO, Giovanni; LO MONTE, Attilio Ignazio
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This article is from Iranian Journal of Public Health , volume 42 . Abstract The Mediterranean tradition offers a cousine rich in colors, aromas and memories, which support the taste and the spirit of those who live in harmony with nature. Everyone is talking about the Mediterranean diet, but few are those who do it properly, thus generating a lot of confusion in the reader. And so for some it coincides with the pizza, others identified it with the noodles with meat sauce, in a mixture of...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684452
PubMed Central
by Tan, Sheng; Ding, Keshuo; Li, Rui; Zhang, Weijie; Li, Gaopeng; Kong, Xiangjun; Qian, Pengxu; Lobie, Peter E; Zhu, Tao
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This article is from Breast Cancer Research : BCR , volume 16 . Abstract Introduction: Estrogen signaling is pivotal in the progression of estrogen receptor positive breast cancer primarily by the regulation of cell survival and proliferation. Micro (mi)RNAs have been demonstrated to be regulated by estrogen to mediate estrogenic effects. Herein, we determined the role of estrogen regulated miR-26 and its underlying molecular mechanisms associated with estrogen receptor (ER)+ breast cancer...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053242
PubMed Central
by Morawska, Magdalena
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This article is from BMC Family Practice , volume 15 . Abstract Contributing reviewers: The editors of BMC Family Practice would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121002
PubMed Central
by Citrome, Leslie; Weiden, Peter J; McEvoy, Joseph P; Correll, Christoph U.; Cucchiaro, Josephine; Hsu, Jay; Loebel, Antony
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This article is from CNS Spectrums , volume 19 . Abstract Objective: To evaluate the long-term safety and tolerability of lurasidone in schizophrenia and schizoaffective disorder patients switched to lurasidone. Method: Patients in this multicenter, 6-month open-label, flexible-dose, extension study had completed a core 6-week randomized trial in which clinically stable, but symptomatic, outpatients with schizophrenia or schizoaffective disorder were switched to lurasidone. Patients started the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140225
PubMed Central
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This article is from Bioinformatics , volume 30 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147931
PubMed Central
by Ouldim, Karim; Bouguenouch, Laila; Samri, Imane; El Otmani, Ihsan; Hamdaoui, Hasna; Bennis, Sanae; Lakhdar, Mounia Idrissi; Chaouki, Sana; Atmani, Samir; Hida, Moustapha
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This article is from The Pan African Medical Journal , volume 11 . Abstract Les syndromes microdélétionnels sont définis par la présence d’une anomalie chromosomique de taille mineure (inférieure à 5 mégabases) ou aneusomie segmentaire, décelable par cytogénétique moléculaire (FISH : Fluorescent in Situ Hybridization). Les syndromes microdélétionnels représentent des syndromes cliniques avec des phénotypes suffisamment caractéristiques pour être reconnus cliniquement....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283021
This article is from Genome Biology and Evolution , volume 5 . Abstract The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The “Rhineland hypothesis” depicts Eastern European Jews as a “population isolate” that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the “Khazarian hypothesis” suggests that Eastern European Jews descended from the Khazars, an amalgam of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595026
PubMed Central
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This article is from PLoS ONE , volume 9 . Abstract In Arabidopsis, the regulation network of the seed maturation program controls the induction of seed dormancy. Wheat EST sequences showing homology with the master regulators of seed maturation, LEAFY COTYLEDON1 (LEC1), LEC2 and FUSCA3 (FUS3), were searched from databases and designated respectively as TaL1L (LEC1-LIKE), TaL2L (LEC2-LIKE), and TaFUS3. TaL1LA, TaL2LA and TaFUS3 mainly expressed in seeds or embryos, with the expression limited...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161473
PubMed Central
by Gruning, Nana-Maria; Du, Dijun; Keller, Markus A.; Luisi, Ben F.; Ralser, Markus
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This article is from Open Biology , volume 4 . Abstract The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively respiring cells. The mechanism underlying this inhibition is illuminated by the co-crystal structure of TPI with bound PEP at 1.6 Å resolution, and by mutational studies guided by the crystallographic results. PEP is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971408
PubMed Central
by Parmar, Parveen Kaur; Agrawal, Pooja; Goyal, Ravi; Scott, Jennifer; Greenough, P Gregg
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This article is from Conflict and Health , volume 8 . Abstract Background: Human security shifts traditional concepts of security from interstate conflict and the absence of war to the security of the individual. Broad definitions of human security include livelihoods and food security, health, psychosocial well-being, enjoyment of civil and political rights and freedom from oppression, and personal safety, in addition to absence of conflict. Methods: In March 2010, we undertook a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019897
PubMed Central
by Kawai, Noriyasu; Kobayashi, Daichi; Yasui, Takahiro; Umemoto, Yukihiro; Mizuno, Kentaro; Okada, Atsushi; Tozawa, Keiichi; Kobayashi, Takeshi; Kohri, Kenjiro
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This article is from Vascular Cell , volume 6 . Abstract Background: Magnetite used in an 8-MHz radiofrequency (RF) capacitive heating device can increase the temperature of a specific site up to 45°C. When treating a metastatic lesion around large abdominal vessels via hyperthermia with magnetite, heating-induced adverse effects on these vessels need to be considered. Therefore, this study examined hyperthermia-induced damage to blood vessel walls in vitro. Methods: A large agar phantom with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128615
This article is from Trials , volume 15 . Abstract Background: Despite efforts to identify effective interventions to implement evidence-based practice (EBP), uncertainty remains. Few existing studies involve occupational therapists or resource-constrained contexts. This study aimed to determine whether an interactive educational intervention (IE) was more effective than a didactic educational intervention (DE) in improving EBP knowledge, attitudes and behaviour at 12 weeks. Methods: A matched...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061109
PubMed Central
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This article is from International Journal for Equity in Health , volume 13 . Abstract Introduction: Arabic-speaking migrants have constituted a growing population in recent years. This entails major challenges to ensure good communication in the healthcare encounter in order to provide individual and holistic healthcare. One of the solutions to ensure good communication between patient and healthcare staff who do not share the same language is to use a professional interpreter. To our...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071792
PubMed Central
by Mohammadi, Afshin; Aghasi, Mohammadreza; Jodeiry-farshbaf, Leila; Salary-Lac, Shaker; Ghasemi-rad, Mohammad
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This article is from Journal of Ovarian Research , volume 4 . Abstract : Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of childbearing age, and it seems better to consider it as an ovarian manifestation of metabolic syndrome. The aim of the current study was to evaluate early atherosclerotic findings in patients with PCOS. Methods: We enrolled 46 women with PCOS and 45 normal control subjects who were referred to our hospital's endocrinology outpatient...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212885
PubMed Central
by Marathe, Nachiket; Shetty, Sudarshan; Lanjekar, Vikram; Ranade, Dilip; Shouche, Yogesh
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This article is from BMC Microbiology , volume 12 . Abstract Background: The gut micro flora plays vital role in health status of the host. The majority of microbes residing in the gut have a profound influence on human physiology and nutrition. Different human ethnic groups vary in genetic makeup as well as the environmental conditions they live in. The gut flora changes with genetic makeup and environmental factors and hence it is necessary to understand the composition of gut flora of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511239
PubMed Central
by Figueiredo, Maria M; Amorim, Izabela FG; Pinto, Aldair JW; Barbosa, Vitor S; de Jesus Pinheiro, Lucelia; Deoti, Beatriz; Faria, Ana MC; Tafuri, Wagner L
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This article is from BMC Immunology , volume 14 . Abstract Background: Infection with parasite protozoa is a long-term health issue in tropical and subtropical regions throughout the world. The Toll-like receptor (TLR) signaling pathway is one of the first-responding defense systems against Leishmania. The aim of this study was to investigate the expression of TLR2 and TLR9 in jejunum and colon and its correlation with CD11c, CD11b, and CD14 receptors used as markers for dendritic cells and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698031
PubMed Central
by Zhu, Feng-Cai; Li, Chang-Gui; Pan, Hong-Xing; Zhang, Yi-Ju; Bi, Dan; Tang, Hai-Wen; Datta, Sanjoy
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This article is from Chinese Journal of Cancer , volume 30 . Abstract Globally, about 70% of cervical cancers are associated with human papillomavirus (HPV)-16 or HPV-18 infection. A meta-analysis of epidemiologic studies in China showed that HPV was present in 98% of cervical cancer samples. The HPV-16/18 AS04-adjuvanted vaccine Cervarix®* has shown a high level of protection against HPV-16/18 infections and associated cervical lesions. This phase I trial (NCT00549900) assessed the safety,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013406
PubMed Central
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This article is from International Journal of Fertility & Sterility , volume 4 . Abstract Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women associated with many reproductive, endocrine, metabolic and cardiovascular dysfunctions. This study aimed to determine the prevalence of PCOS among high school students in Rasht. Materials and Methods: In a cross–sectional study, 1850 students were selected by a multi-stage cluster sampling from all high...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023501
PubMed Central
by Liu, Jian-Ping; Han, Mei; Li, Xin-Xue; Mu, Yu-Jie; Lewith, George; Wang, Yu-Yi; Witt, Claudia M; Yang, Guo-Yan; Manheimer, Eric; Snellingen, Torkel; Berman, Brian; Gluud, Christian
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This article is from BMJ Open , volume 3 . Abstract Background: Clinical trials on Traditional Chinese Medicine (TCM) should be registered in a publicly accessible international trial register and report on all outcomes. We systematically assessed and evaluated TCM trials in registries with their subsequent publications. Objective: To describe the characteristics of TCM trials, estimate bias risk and outcome-reporting bias in clinical trials. Data sources and study selection: Fifteen trial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717464
PubMed Central
by Pachai, Matthew V.; Sekuler, Allison B.; Bennett, Patrick J.
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This article is from Frontiers in Psychology , volume 4 . Abstract We measured thresholds in a 1-of-10 face identification task in which stimuli were embedded in orientation-filtered Gaussian noise. For upright faces, the threshold elevation produced by the masking noise varied as a function of noise orientation: significantly greater masking was obtained with horizontal noise than with vertical noise. However, the orientation selectivity of masking was significantly less with inverted faces....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580391
PubMed Central
by Vinson, David; Ponari, Marta; Vigliocco, Gabriella
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This article is from Cognition & Emotion , volume 28 . Abstract Even single words in isolation can evoke emotional reactions, but the mechanisms by which emotion is involved in automatic lexical processing are unclear. Previous studies using extremely similar materials and methods have yielded apparently incompatible patterns of results. In much previous work, however, words' emotional content is entangled with other non-emotional characteristics such as frequency of occurrence, familiarity...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979450
PubMed Central
by Katralli, Jayasudha; Goudar, Shivaprasad S.
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This article is from Asian Journal of Sports Medicine , volume 3 . Abstract Purpose: Judo is a complex sport where different anthropological parameters determine performance. Judo, as a sport is not well known in India. There is evident lack of data concerning the anthropological determinants of judo players. This study was conducted to determine the anthropometric profile and Special Judo Fitness levels of judokas. Methods: This cross sectional study was conducted on 31 judo players....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426730
PubMed Central
by Yoo, Jung-Wan; Jo, Kyung-Wook; Kim, Mi Na; Lee, Sang Do; Kim, Woo Sung; Kim, Dong Soon; Shim, Tae Sun
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This article is from Tuberculosis and Respiratory Diseases , volume 72 . Abstract Background: The isolation of non-tuberculous mycobacteria (NTM) has been increasing in South Korea. To date, however, the cause of this increase has not been determined, and it remains unclear whether the use of liquid media has contributed to this increase. The aim of this study was to evaluate the factors associated with NTM isolation and the impact of liquid media on NTM culture. Methods: Mycobacterial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475469
PubMed Central
by Veening, Jan G; Gerrits, Peter O; Barendregt, Henk P
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This article is from Fluids and Barriers of the CNS , volume 9 . Abstract There is increasing evidence that non-synaptic communication by volume transmission in the flowing CSF plays an important role in neural mechanisms, especially for extending the duration of behavioral effects. In the present review, we explore the mechanisms involved in the behavioral and physiological effects of β-endorphin (β-END), especially those involving the cerebrospinal fluid (CSF), as a message transport system...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439317
PubMed Central
by Almanaa, Taghreed N; Geusz, Michael E; Jamasbi, Roudabeh J
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This article is from BMC Complementary and Alternative Medicine , volume 12 . Abstract Background: Many cancers contain cell subpopulations that display characteristics of stem cells. Because these cancer stem cells (CSCs) appear to provide resistance to chemo-radiation therapy, development of therapeutic agents that target CSCs is essential. Curcumin is a phytochemical agent that is currently used in clinical trials to test its effectiveness against cancer. However, the effect of curcumin on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528437
PubMed Central
by Li, Xuefei; Ren, Ruixin; Ren, Shengxiang; Chen, Xiaoxia; Cai, Weijing; Zhou, Fei; Zhang, Yishi; Su, Chunxia; Zhao, Chao; Li, Jiayu; Cheng, Ningning; Zhao, Mingchuan; Zhou, Caicun
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This article is from Translational Oncology , volume 7 . Abstract OBJECTIVE: It is important to analyze and track Epidermal Growth Factor Receptor (EGFR) mutation status for predicting efficacy and monitoring resistance throughout EGFR-tyrosine kinase inhibitors (TKIs) treatment in non-small cell lung cancer (NSCLC) patients. The objective of this study was to determine the feasibility and predictive utility of EGFR mutation detection in peripheral blood. METHODS: Plasma, serum and tumor tissue...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145390
PubMed Central
by Grover, Suchi; Leong, Darryl; Bradbrook, Craig; Walls, Angela; Mazhar, Jawad; Selvanayagam, Joseph
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045594
PubMed Central
by de la Dure-Molla, Muriel; Quentric, Mickael; Yamaguti, Paulo Marcio; Acevedo, Ana-Carolina; Mighell, Alan J; Vikkula, Miikka; Huckert, Mathilde; Berdal, Ariane; Bloch-Zupan, Agnes
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This article is from Orphanet Journal of Rare Diseases , volume 9 . Abstract Amelogenesis imperfecta (AI) is a genetically and clinically heterogeneous group of inherited dental enamel defects. Commonly described as an isolated trait, it may be observed concomitantly with other orodental and/or systemic features such as nephrocalcinosis in Enamel Renal Syndrome (ERS, MIM#204690), or gingival hyperplasia in Amelogenesis Imperfecta and Gingival Fibromatosis Syndrome (AIGFS, MIM#614253). Patients...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071802
PubMed Central
by Zhu, Xiaoxiao; Xu, Yajie; Yu, Shanshan; Lu, Lu; Ding, Mingqin; Cheng, Jing; Song, Guoxu; Gao, Xing; Yao, Liangming; Fan, Dongdong; Meng, Shu; Zhang, Xuewen; Hu, Shengdi; Tian, Yong
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This article is from Scientific Reports , volume 4 . Abstract The rapid generation of various species and strains of laboratory animals using CRISPR/Cas9 technology has dramatically accelerated the interrogation of gene function in vivo. So far, the dominant approach for genotyping of genome-modified animals has been the T7E1 endonuclease cleavage assay. Here, we present a polyacrylamide gel electrophoresis-based (PAGE) method to genotype mice harboring different types of indel mutations. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168274
PubMed Central
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This article is from Diabetes, Obesity & Metabolism , volume 15 . Abstract Aim: Assess the pharmacodynamics of lixisenatide once daily (QD) versus liraglutide QD in type 2 diabetes insufficiently controlled on metformin. Methods: In this 28-day, randomized, open-label, parallel-group, multicentre study (NCT01175473), patients (mean HbA1c 7.3%) received subcutaneous lixisenatide QD (10 µg weeks 1–2, then 20 µg; n = 77) or liraglutide QD (0.6 mg week 1, 1.2 mg week 2, then 1.8 mg; n = 71)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752965
This article is from BMC Research Notes , volume 7 . Abstract Background: Good communication is an important prerequisite for equal treatment in a healthcare encounter. One way to overcome language barriers when patients and healthcare staff do not share the same language is to use a professional interpreter. Few previous studies have been found investigating the use of interpreters, and just one previous study from the perspective of European migrants, which showed that they perceived...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915075
PubMed Central
by Sardella, Thomas CP; Polgar, Erika; Garzillo, Francesca; Furuta, Takahiro; Kaneko, Takeshi; Watanabe, Masahiko; Todd, Andrew J
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This article is from Molecular Pain , volume 7 . Abstract Background: The opioid peptide dynorphin is expressed by certain neurons in the superficial dorsal horn of the spinal cord, but little is known about the types of cell that contain dynorphin. In this study, we have used an antibody against the dynorphin precursor preprodynorphin (PPD), to reveal the cell bodies and axons of dynorphin-expressing neurons in the rat spinal cord. The main aims were to estimate the proportion of neurons in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192681
PubMed Central
by Kim, Hyeong Pil; Yusoff, Abd Rashid bin Mohd; Lee, Hee Jae; Lee, Seung Joo; Kim, Hyo Min; Seo, Gi Jun; Youn, Jun Ho; Jang, Jin
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This article is from Nanoscale Research Letters , volume 9 . Abstract We demonstrate a new solution-processed electron transport layer (ETL), zinc oxide doped with cesium carbonate (ZnO:Cs2CO3), for achieving organic photovoltaics (OPVs) with good operational stability at ambient air. An OPV employing the ZnO:Cs2CO3 ETL exhibits a fill factor of 62%, an open circuit voltage of 0.90 V, and a short circuit current density of −6.14 mA/cm2 along with 3.43% power conversion efficiency. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099096
PubMed Central
by Rabe, Kasja; Kuper, Michael; Holle, Dagny; Savidou, Irini; Kastrup, Oliver; Jahne-Blasberg, Andreas; Diener, Hans Christoph; Katsarava, Zaza; Frings, Markus
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This article is from The Journal of Headache and Pain , volume 14 . Abstract Background: Migraine with aura is associated with patent foramen ovale and right-left-shunt. Jugular venous valve insufficiency is a further vascular anomaly. It is a frequent finding in transient global amnesia which is associated with migraine. Therefore, we investigated the prevalence of jugular venous valve insufficiency in migraine. Methods: Subjects included in this study were participants of the population based...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691823
PubMed Central
by De Smet, Ive; Lau, Steffen; Ehrismann, Jasmin S.; Axiotis, Ioannis; Kolb, Martina; Kientz, Marika; Weijers, Dolf; Jurgens, Gerd
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This article is from Journal of Experimental Botany , volume 64 . Abstract In Arabidopsis thaliana, the phytohormone auxin is an important patterning agent during embryogenesis and post-embryonic development, exerting effects through transcriptional regulation. The main determinants of the transcriptional auxin response machinery are AUXIN RESPONSE FACTOR (ARF) transcription factors and AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors. Although members of these two protein families are major...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697942