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PubMed Central is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).

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by Balasubramanian, P.; Jayalakshmi, K.; Vidhya, N.; Prasad, R.; Sheriff, A. Khaleefathullah; Kathiravan, G.; Rajagopal, K.; Sureban, Sripathi M.
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract Partially purified methanolic extract of Cissus quadrangularis (belonging to Vitaceae member, South Indian medicinal plant) have been explored for antiviral activity and their phytochemical characterisation. In vitro antiviral activity against HSV type1 and 2, and Vero cells at non-cytotoxic concentration were determined. HSV1 and HSV2 showed more sensitivity against the partially purified compound. Phytochemical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158892
PubMed Central
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This article is from Dialogues in Clinical Neuroscience , volume 12 . Abstract Until the mid-1960s, obsessive-compulsive disorder (OCD) was considered to be treatment-resistant, as both psychodynamic psychotherapy and medication had been unsuccessful in significantly reducing OCD symptoms. The first real breakthrough came in 1966 with the introduction of exposure and ritual prevention. This paper will discuss the cognitive behavioral conceptualizations that influenced the development of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181959
This article is from Dialogues in Clinical Neuroscience , volume 12 . Abstract Cross-species affective neuroscience studies confirm that primary-process emotional feelings are organized within primitive subcortical regions of the brain that are anatomically, neurochemically, and functionally homologous in all mammals that have been studied. Emotional feelings (affects) are intrinsic values that inform animals how they are faring in the quest to survive. The various positive affects indicate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181986
This article is from Dialogues in Clinical Neuroscience , volume 12 . Abstract More than a century since the delineation of dementia praecox by Kraepelin, the etiology, neuropathology and pathophysiology of schizophrenia remain elusive. Despite the availability of criteria allowing reliable diagnostic identification, schizophrenia essentially remains a broad clinical syndrome defined by reported subjective experiences (symptoms), loss of function (behavioral impairments), and variable patterns...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181977
PubMed Central
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract A RP-HPLC assay method has been developed and validated for cefotaxime. An isocratic RP-HPLC was developed on a SS Wakosil II- C8 column (250 mm ˜4.6 mm i.d., 5 μm) utilizing a mobile phase of ammonium acetate buffer (pH 6.8) and acetonitrile (85:15 v/v) with UV detection at wavelength 252 nm at the flow rate 0 .8 ml/min. The proposed method was validated for sensitivity, selectivity, linearity, accuracy,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158899
PubMed Central
by Klaassens, Ellen Renee
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This article is from European Journal of Psychotraumatology , volume 1 . Abstract Background: Dysregulation of the hypothalamic–pituitary–adrenal (HPA)-axis is thought to underlie stress-related psychiatric disorders such as posttraumatic stress disorder (PTSD). Some studies have reported HPA-axis dysregulation in trauma-exposed (TE) adults in the absence of psychiatric morbidity. In this dissertation we set out to unravel part of the mechanism that underlies the complex relations between...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402002
PubMed Central
by Lamchahab, Fatima Ezzahra; Beqqal, Kawtar; Guerrouj, Bouchra; Khoudri, Ibtissam; Senouci, Karima; Hassam, Badredine; Ait Ourhroui, Mohamed
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This article is from The Pan African Medical Journal , volume 7 . Abstract Introduction: Le service de Dermatologie de l’Hôpital Ibn Sina a pour mission de donner les soins en matière de dermatologie et concourt au service public de la santé au Maroc. Le but de ce travail est d’établir le profil épidémiologique et diagnostique des dermatoses en milieu hospitalier à travers cinq ans d’activité d’hospitalisation. Méthodes: Etude rétrospective menée sur une période de cinq ans...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172629
PubMed Central
by Steinberg, Avraham
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eye 158
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This article is from Rambam Maimonides Medical Journal , volume 1 . Abstract All possible pro and con arguments regarding the theory of evolution have been discussed and debated in the vast literature—scientific, religious, and lay—in the past 150 years. There is usually great zealotry in all debating parties, with mutual intolerance of ideas and concepts, disrespect toward opposing opinions and positions, and usage of very harsh language. This prejudiced approach usually does not allow for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721658
PubMed Central
by Michael, U. Adikwu; David, B. Uzuegbu; Theophine, C. Okoye; Philip, F. Uzor; Ogochukwu, Adibe Maxwell; Benson, V. Amadi
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eye 151
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract This study investigated the antidiabetic activity of the various combinations (ratios) of metformin (50 mg/kg) and aqueous extracts of the leaves of Vernonia amygdalina (100 mg/kg). The ratios of Extract to Metformin were 1:1, 2 1, and 2:1 and distilled water (control, p.o.) were given to both normoglycemic and alloxan-induced diabetic Wister albino rats. Blood was withdrawn and tested at 0, 1, 3 and 6 hours....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979188
PubMed Central
by Aviezer, Nathan
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This article is from Rambam Maimonides Medical Journal , volume 1 . Abstract Intelligent Design (ID) burst onto the scene in 1996, with the publication of Darwin’s Black Box by Michael Behe. Since then, there has been a plethora of articles written about ID, both pro and con. However, most of the articles critical of ID deal with peripheral issues, such as whether ID is just another form of creationism or whether ID qualifies as science or whether ID should be taught in public schools. It is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721655
PubMed Central
by Biswas, Kaushik; Kumar, Arun; Babaria, Bhavin A.; Prabhu, K; Setty, Ramachandra S
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eye 138
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract The 70% ethanolic extract of Peltophorum pterocarpum leaves were investigated for its hepatoprotective effect against paracetamol induced acute liver damage on albino wister rats. Paracetamol (2gm/kg, po) significantly elevated the serum levels of biochemical markers like SGPT, SGOT, ALP, bilirubin (total and direct), total cholesterol, triglycerides and depleted tissue GSH and increased the lipid peroxidation....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158896
PubMed Central
by Zhang, Yao; Fuger, Petra; Hannan, Shabab B.; Kern, Jeannine V.; Lasky, Bronwen; Rasse, Tobias M.
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This article is from Journal of Visualized Experiments : JoVE . Abstract Recent improvements in optical imaging, genetically encoded fluorophores and genetic tools allowing efficient establishment of desired transgenic animal lines have enabled biological processes to be studied in the context of a living, and in some instances even behaving, organism. In this protocol we will describe how to anesthetize intact Drosophila larvae, using the volatile anesthetic desflurane, to follow the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157860
PubMed Central
by Burke, David T.; Protopapas, Marina; Bonato, Paolo; Burke, John T.; Landrum, Rpbert F.
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eye 133
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This article is from Asian Journal of Sports Medicine , volume 2 . Abstract Purpose: To measure the time needed to teach a series of martial arts techniques to proficiency. Methods: Fifteen volunteer subjects without any prior martial arts or self-defense experience were recruited. A panel of martial arts experts selected 21 different techniques including defensive stances, arm blocks, elbow strikes, palm strikes, thumbs to eyes, instep kicks and a carotid neck restraint. The critical elements...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289195
PubMed Central
by Marduel, Marie; Carrie, Alain; Sassolas, Agnes; Devillers, Martine; Carreau, Valerie; Di Filippo, Mathilde; Erlich, Daniele; Abifadel, Marianne; Marques-Pinheiro, Alice; Munnich, Arnold; Junien, Claudine; Boileau, Catherine; Varret, Mathilde; Rabes, Jean-Pierre
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This article is from Human Mutation , volume 31 . Abstract Autosomal Dominant Hypercholesterolemia (ADH), characterized by isolated elevation of plasmatic LDL cholesterol and premature cardiovascular complications, is associated with mutations in 3 major genes: LDLR (LDL receptor), APOB (apolipoprotein B) and PCSK9 (proprotein convertase subtilisin-kexin type 9). Through the French ADH Research Network, we collected molecular data from 1358 French probands from eleven different regions in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152176
PubMed Central
by Vatankhah, Mehdi; Taghi Chitsazi, Mohammad; Mehdipour, Masoumeh; Taghavi Zenouz, Ali; Estakhri, Rasoul
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This article is from Journal of Dental Research, Dental Clinics, Dental Prospects , volume 4 . Abstract Recalcitrant gingival erythematous lichen planus lesions comprise a considerable therapeutic problem. This case of chronic desquamative gingivitis in a 25-year-old woman with erosive oral lichen planus was treated with topical and systemic corti-costeroid administration, followed by placement of a free gingival graft on right upper quadrant. Although recurrence of the lesions was observed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429958
PubMed Central
by Sanchez, Alexis; Rodriguez, Omaira; Bellorin, Omar; Sanchez, Renata; Benitez, Gustavo
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This article is from JSLS : Journal of the Society of Laparoendoscopic Surgeons , volume 14 . Abstract Failed ERCP appears to decrease the success rate of a laparoscopic approach for common bile duct exploration.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043576
PubMed Central
by Ouadnouni, Yassine; Bouchikh, Mohammed; Jahid, Ahmed; Achir, Abdellah; Smahi, Mohamed; Msougar, Yassine; Lakranbi, Marouane; Herrak, Leila; Mahassini, Najat; Benosman, Abdelatif
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This article is from The Pan African Medical Journal , volume 7 . Abstract Abstract: Les carcinomes adénoïdes kystiques (CAK), ou cylindromes, sont des tumeurs malignes de la trachée qui représentent 0,1% des cancers des voies respiratoires. Il s'agissait d'une étude rétrospective à propos de quatre patients opérés dans notre service (deux femmes et deux hommes), ayant un âge moyen de 35,8; avec un suivi moyen de 7,2 plus ou moins 3,1 ans. Ils ont été admis pour tumeur trachéale se...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172634
PubMed Central
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This article is from The Open Biomedical Engineering Journal , volume 4 . Abstract Diabetes mellitus (DM) has a growing incidence and prevalence in modern societies, pushed by the aging and change of life styles. Despite the huge resources dedicated to improve their quality of life, mortality and morbidity rates, these are still very poor. In this work, DM pathology is revised from clinical and metabolic points of view, as well as mathematical models related to DM, with the aim of justifying an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044890
PubMed Central
by Pereira, Maite; Vieira, Neiva de Souza; Brandao, Eduardo da Rosa; Ruaro, Joao Afonso; Grignet, Rodrigo Juliano; Frez, Andersom Ricardo
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This article is from Acta Ortopedica Brasileira , volume 20 . Abstract The purpose of this study was to evaluate the existence of differences in the rehabilitation of patients after ACL reconstruction using bone-patellar tendon-bone graft and the four-strand semitendinosus and gracilis tendon grafts, through a literature revision. The researched databases were MEDLINE, EMBASE, LILACS, COCHRANE and PEDro. The inclusion criteria were published studies with methodology draw from randomized...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861958
PubMed Central
by PASSALI, D.; BENEDETTO, F.; BENEDETTO, M.; CHIARAVALLOTI, F.; DAMIANI, V.; PASSALI, F.M.; BELLUSSI, L.M.; THE WORKING GROUP,
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This article is from Acta Otorhinolaryngologica Italica , volume 31 . Abstract In spite of the amount of literature demonstrating the relationship between upper and lower airways, both from the anatomical, and pathophysiological point of view, little is known about the epidemiology, diagnosis and treatment of the Rhino-Bronchial Syndrome (RBS). After the publication, in 2003, of a Consensus Report defining the Rhino-Bronchial Syndrome, an interdisciplinary group of experts made up from the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146326
PubMed Central
by Cacabelos, Ramon; Fernandez-Novoa, Lucia; Martinez-Bouza, Rocio; McKay, Adam; Carril, Juan C.; Lombardi, Valter; Corzo, Lola; Carrera, Ivan; Tellado, Ivan; Nebril, Laura; Alcaraz, Margarita; Rodriguez, Susana; Casas, Angela; Couceiro, Veronica; Alvarez, Anton
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This article is from Pharmaceuticals , volume 3 . Abstract About 80% of functional genes in the human genome are expressed in the brain and over 1,200 different genes have been associated with the pathogenesis of CNS disorders and dementia. Pharmacogenetic studies of psychotropic drug response have focused on determining the relationship between variations in specific candidate genes and the positive and adverse effects of drug treatment. Approximately, 18% of neuroleptics are substrates of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034082
PubMed Central
by Elmadil, Aziz; Bouamama, Hanan; Ramil, Mohammed; Khattal, Khalid; Afifi, Abderrahman; Bouabdallah, Youssef
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This article is from The Pan African Medical Journal , volume 7 . Abstract Abstract: La malrotaion intestinale chez l’enfant est une anomalie rare due à un arrêt des phénomènes de rotation et d’accolement de l’intestin primitif. Elle peut être grave en cas de mésentère commun incomplet en se compliquant d’un volvulus du grêle ou asymptomatique si la rotation s’arrête à 90° se déclarant ainsi par des formes atypiques d’appendicite comme c’est le cas de notre...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172621
PubMed Central
by Nirmala, R; Nam, Ki Taek; Navamathavan, R; Park, Soo-Jin; Kim, Hak Yong
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This article is from Nanoscale Research Letters , volume 6 . Abstract Polyurethane nanofibers containing calcium chloride (CaCl2) were prepared via an electrospinning technique for the biomedical applications. Polyurethane nanofibers with different concentration of CaCl2 were electrospun, and their bioactivity evaluation was conducted by incubating in biomimetic simulated body fluid (SBF) solution. The morphology, structure and thermal properties of the polyurethane/CaCl2 composite nanofibers...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102341
PubMed Central
by Ezike, Adaobi C.; Akah, Peter A.; Okoli, Charles C.; Okpala, Chinwe B.
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract The antidiabetic activity of methanol leaves extract of Cajanus cajan (L.) Millsp. (Fabaceae) was studied in alloxan-diabetic and in oral glucose loaded rats. The acute toxicity and lethality (LD50) and the phytochemical analysis of the extract were also evaluated. The results showed that the extract (400 and 600 mg/kg) significantly (P
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979181
PubMed Central
by Gharib Naseri, Mohammad Kazem; Adibpour, Neda; Namjooyan, Foroogh; Rezaee, Saeed; Shahbazi, Zahra
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 10 . Abstract The aim of this study was to investigate the effect of aerial parts of Stachys lavandulifolia Vahl. Extract on the rat ileum contractions. The crude extract was prepared by maceration method (90% methanol) followed by fractionating into chloroform, ethyl acetate, petroleum ether and water. In adult male Wistar rats, ileum was sectioned and mounted in tissue bath and their contractility was recorded is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828908
PubMed Central
by Mishra, Devendra; Joshi, Shivani; Bisht, Ganga; Pilkhwal, Sangeeta
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract The essential oil from the roots of Solidago canadensis Linn. (fam. Asteraceae) was analyzed by GC, GC/MS and NMR spectroscopy. Thirty nine constituents comprising 75.4% of the total oil were identified from the oil. Thymol constituted 20.25% of the oil followed by α-copaene (6.26%) and carvacrol (5.51%). The antimicrobial activity of the oil was evaluated using disc diffusion method. Results showed that the oil...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979189
PubMed Central
by Rajesh, P.; Latha, S.; Selvamani, P.; Kannan, V. Rajesh
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract Capparis sepiaria Linn. (Family: Capparidaceae) is a rare indigenous in South India but has widespread distribution in many tropical and sub-tropical countries. The present study intended with various phytochemical screening and toxicity studies were carried out on the leaves of the Capparis sepiaria. Preliminary phytochemical evaluation of the ethanolic extract of revealed that the presence of reducing sugar,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158893
PubMed Central
by Weyers, S.; De Sutter, P.; Hoebeke, S.; Monstrey, G.; 'T Sjoen, G.; Verstraelen, H.; Gerris, J.
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This article is from Facts, Views & Vision in ObGyn , volume 2 . Abstract The role of the gynaecologist in the treatment of female-to-male transsexual patients is largely confined to hysterectomy and vaginectomy. We showed that laparoscopic hysterectomy is feasible and safe in this group. When surgery is not performed completely, follow-up of the remaining organs is necessary.The major part of this thesis deals with the necessity and acceptability of gynaecological follow-up in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154336
PubMed Central
by Hosseini, M; Ataei, N; Aghamohammadi, A; Yousefifard, M; Taslimi, Sh; Ataei, F
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This article is from Iranian Journal of Public Health , volume 39 . Abstract Background:: The obesity and hypertension are the major risk factors of several life threatening diseases. The present study was aimed to investigate the relation between body mass index (BMI) the validated index of adiposity and different aspect of blood pressure (BP). Methods:: Systolic and diastolic blood pressures and also weight and height of 7 to 18 years old children and adolescent collected in 2002 and 2004...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481696
PubMed Central
by Kumar, Kalyan K.V; Karnati, Swathi; Reddy, Mamatha B; Chandramouli, R
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract Cell lines are the invitro models used for the drug permeability studies in the preclinical and clinical phases of the drug discovery. Cell line models are simple and quick to use and avoids the usage of animal models for pharmacological and toxicological studies and hence cost effective, produce reliable and reproducible results for understanding and evaluating the permeability characteristics of the potential...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979179
PubMed Central
by Hamidinejat, H; Shapouri, MR Seifiabad; Mayahi, M; Borujeni, M Pourmehdi
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eye 109
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This article is from Iranian Journal of Parasitology , volume 5 . Abstract Background: Coccidiosis is an intestinal disease of chickens caused by various species of protozoan parasites within the genus Eimeria. Diagnosis and genetic characterization of different species of Eimeria are central to the prevention, surveillance, and control of coccidiosis. The aim of this study was to detect different chicken Eimeria species from several areas in Khuzestan, southwest Iran. Methods: From February to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279851
PubMed Central
by Aouam, Karim; Nadia, Ben Fredj; Amel, Chaabane; Naceur, Boughattas
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eye 108
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This article is from The World Allergy Organization Journal , volume 3 . Abstract The anticonvulsant hypersensitivity syndrome, also known as drug rash eosinophilia and systemic symptoms (DRESS), is a rare but severe form of adverse cutaneous reaction. Several aromatic anticonvulsant drugs, such as carbamazepine (CBZ), phenytoin, or phenobarbital have been frequently associated with the onset of DRESS. Cross-reactivity among the aromatic anticonvulsants frequently occurs (40 to 80% of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651104
PubMed Central
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This article is from Facts, Views & Vision in ObGyn , volume 2 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154333
PubMed Central
by Al-Nimer, Marwan S.M.; Neda, Fezaa Sh.; Lateef, Zainab W. Abdul
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eye 105
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract Magnetized water showed alterations in the electrolyte potential and vibration modes. This study aimed to investigate the effect of magnetic water and physiological solutions on the UV-spectra of tramadol HCl. Distilled water as well as full strength or diluted physiological solutions are magnetized by magnetic disc. Then tramadol HCl was dissolved in each magnetic and in non-magnetic solution to obtain the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979174
PubMed Central
by Abouei Mehrizi, Ehsan; Esmaeili, Mostafa; Eslami Amirabadi, Gholamreza; Narimani, Mohammadamin
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eye 104
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This article is from Journal of Dental Research, Dental Clinics, Dental Prospects , volume 4 . Abstract Third molar eruption is an unpredictable event. Occasionally, mandibular third molars undergo angular changes in young adults. This rotational drift is of unknown etiology, is not predictable and may facilitate the eruption or may make the im-paction worse. A rare case is presented with severe rotational drift of a mesioangularly impacted mandibular third molar.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429983
PubMed Central
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This article is from IMA Fungus : The Global Mycological Journal , volume 1 . Abstract Records of Egyptian fungi, including lichenized fungi, are scattered through a wide array of journals, books, and dissertations, but preliminary annotated checklists and compilations are not all readily available. This review documents the known available sources and compiles data for more than 197 years of Egyptian mycology. Species richness is analysed numerically with respect to the systematic position and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348774
PubMed Central
by Cheli, German H.; Corley, J. C.; Bruzzone, O.; del Brio, M.; Martinez, F.; Roman, N. Martinez; Rios, I.
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This article is from Journal of Insect Science , volume 10 . Abstract This is the first study based on a planned and intensive sampling effort that describes the community composition and structure of the ground-dwelling arthropod assemblage of Península Valdés (Patagonia). It was carried out using pitfall traps, opened for two weeks during the summers of 2005, 2006 and 2007. A total of 28, 111 individuals were caught. Ants (Hymenoptera: Formicidae) dominated this community, followed by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014803
PubMed Central
by Krick, Roswitha; Bremer, Sebastian; Welter, Evelyn; Schlotterhose, Petra; Muehe, Yvonne; Eskelinen, Eeva-Liisa; Thumm, Michael
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This article is from The Journal of Cell Biology , volume 190 . Abstract Cdc48/p97/VCP plays a ubiquitin-independent role during autophagosome formation in S. cerevisiae.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101598
PubMed Central
by Kaemmerer, Harald; Mebus, Siegrun; Schulze-Neick, Ingram; Eicken, Andreas; Trindade, Pedro T; Hager, Alfred; Oechslin, Erwin; Niwa, Koichiro; Lang, Irene; Hess, John
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This article is from Current Cardiology Reviews , volume 6 . Abstract Eisenmenger syndrome is the most severe form of pulmonary arterial hypertension and arises on the basis of congenital heart disease with a systemic-to-pulmonary shunt. Due to the chronic slow progressive hypoxemia with central cyanosis, adult patients with the Eisenmenger syndrome suffer from a complex and multisystemic disorder including coagulation disorders (bleeding complications and paradoxical embolisms), renal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083816
PubMed Central
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract 3-Bromo acetyl coumarins (4a-c) on treatment with methyl and ethyl esters of nicotinic acid, isonicotinic acid (5a-d) gave 3-coumrinoyl pyridinium bromides (7a-l) and with quinoline (6) gave 3-coumarinoyl quinolinium bromides (8a-c). The structures of the final compounds were established by their spectral data. The antimicrobial activitiy of all the newly synthesized test compounds were evaluated and some of them,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158894
PubMed Central
by Caluk, Jasmin; Osmanovic, Enes; Barakovic, Fahir; Kusljugic, Zumreta; Terzic, Ibrahim; Caluk, Selma; Sofic, Amela
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This article is from Radiology and Oncology , volume 44 . Abstract Introduction: Coronary stenting is the primary means of coronary revascularization. There are two basic techniques of stent implantation: stenting with balloon predilatation of stenosis and stenting without predilatation (direct stenting). Limiting the time that a fluoroscope is activated and by appropriately managing the intensity of the applied radiation, the operator limits radiation in the environment, and this saves the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423693
PubMed Central
by Najoua, Zbiti; RhouZbiti, Hakima; Ezaitouni, Fatima; Ouzeddoune, Naima; Bayahia, Rabia; Benamar, Loubna
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eye 101
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This article is from The Pan African Medical Journal , volume 7 . Abstract Introduction: Les dysthyroïdies chez l’hémodialysé chronique sont représentées par une hypothyroïdie: dite le syndrome de basse T3, actuellement nommée “le syndrome de la maladie euthyroïdienne”. L’objectif de notre travail est de déterminer le profil thyroïdien de nos HDC afin de préciser la prévalence des différents troubles thyroïdiens dans notre population et de dégager les facteurs...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172628
PubMed Central
by Stoop, D.
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This article is from Facts, Views & Vision in ObGyn , volume 2 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154335
PubMed Central
by Templeton, Alan R.
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This article is from Rambam Maimonides Medical Journal , volume 1 . Abstract It has been argued that human evolution has stopped because humans now adapt to their environment via cultural evolution and not biological evolution. However, all organisms adapt to their environment, and humans are no exception. Culture defines much of the human environment, so cultural evolution has actually led to adaptive evolution in humans. Examples are given to illustrate the rapid pace of adaptive evolution in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721656
PubMed Central
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This article is from Philosophical transactions. Series A, Mathematical, physical, and engineering sciences , volume 368 . Abstract Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded rapidly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263808
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by Reuter, Antje; Ackermann, Andreas; Kothlow, Sonja; Rinder, Monika; Kaspers, Bernd; Staeheli, Peter
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This article is from Viruses , volume 2 . Abstract Like other pathogens that readily persist in animal hosts, members of the Bornaviridae family have evolved effective mechanisms to evade the innate immune response. The prototype of this virus family, Borna disease virus employs an unusual replication strategy that removes the triphosphates from the 5′ termini of the viral RNA genome. This strategy allows the virus to avoid activation of RIG-I and other innate immune response receptors in...
Topic: genealogy
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185651
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by Akin, Ibrahim; Kische, Stephan; Rehders, Tim C.; Nienaber, Christoph A.; Rauchhaus, Mathias; Ince, Huseyin
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This article is from Archives of Medical Science : AMS , volume 6 . Abstract A thoracic aortic aneurysm (TAA) is a potentially life-threatening condition with structural weakness of the aortic wall, which can progress to arterial dilatation and rupture. Today, both an increasing awareness of vascular disease and the access to tomographic imaging facilitate the diagnosis of TAA even in an asymptomatic stage. The risk of rupture for untreated aneurysms beyond a diameter of 5.6 cm ranges from 46%...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298329
PubMed Central
by Vijay, Priyanka; Vijayvergia, R.
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This article is from Journal of Basic and Clinical Pharmacy , volume 1 . Abstract The antioxidant activity of two plants - Hadjod i.e. Cissus quadrangularis (CQ) and Hingot i.e. Balanites aegyptiaca (BA) was determined by the thiocyanate method. The antioxidant activity of both the plants increased with increasing amount of extract (200 g-1000 g) added to the linoleic emulsion. The ethanolic extract of CQ was more effective than the other. Like antioxidant activity, the reducing power was also...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158897
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by O'Leary, Fiona; Samman, Samir
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This article is from Nutrients , volume 2 . Abstract Vitamin B12 is essential for DNA synthesis and for cellular energy production.This review aims to outline the metabolism of vitamin B12, and to evaluate the causes and consequences of sub-clinical vitamin B12 deficiency. Vitamin B12 deficiency is common, mainly due to limited dietary intake of animal foods or malabsorption of the vitamin. Vegetarians are at risk of vitamin B12 deficiency as are other groups with low intakes of animal foods or...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257642
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by Jenny, Marcel; Schrocksnadel, Sebastian; Uberall, Florian; Fuchs, Dietmar
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This article is from Pharmaceuticals , volume 3 . Abstract Phytocannabinoids present in Cannabis plants are well known to exert potent anti-inflammatory and immunomodulatory effects. Previously, we have demonstrated that the psychoactive Δ9-tetrahydrocannabinol (THC) and the non-psychotropic cannabidiol (CBD) modulate mitogen-induced Th1-type immune responses in peripheral blood mononuclear cells (PBMC). The suppressive effect of both cannabinoids on mitogen-induced tryptophan degradation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033942
PubMed Central
by Kim, Yoo-Min; Lim, Joon Seok; Kim, Jie-Hyun; Hyung, Woo Jin; Noh, Sung Hoon
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This article is from Journal of Gastric Cancer , volume 10 . Abstract Purpose: This study was done to evaluate the usefulness of preoperative computed tomography (CT) and intraoperative laparoscopic ultrasound to facilitate treatment of gastric submucosal tumors. Materials and Methods: The feasibility of laparoscopic wedge resection as determined by CT findings of tumor size, location, and growth pattern was correlated with surgical findings in 89 consecutive operations. The role of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204493
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by Hu, De-yu; Hong, Xiao; Li, Xue
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This article is from International Journal of Oral Science , volume 3 . Abstract For a long time, oral disease is one of the major problems of the public health for its high prevalence and incidence throughout the world, which is especially true for low-income populations. Since China's economic reform in 1978, great changes have taken place in China. These changes have significant impact on and have been reflected in oral disease trends in China.This paper provides an overview and assessment...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469869
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This article is from Healthcare Informatics Research , volume 16 . Abstract Objectives: The aim of this study was to develop nursing practice guidelines and algorithms for the pre- and postoperative care of gastric cancer patients. Methods: The guidelines and algorithms were developed based on a literature review and subject-matter experts' knowledge. The usefulness and applicability of the developed guidelines and algorithms were evaluated by the expert group. Results: The guidelines comprised...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092132
PubMed Central
by Lauterbach, Henning; Bathke, Barbara; Gilles, Stefanie; Traidl-Hoffmann, Claudia; Luber, Christian A.; Fejer, Gyorgy; Freudenberg, Marina A.; Davey, Gayle M.; Vremec, David; Kallies, Axel; Wu, Li; Shortman, Ken; Chaplin, Paul; Suter, Mark; O'Keeffe, Meredith; Hochrein, Hubertus
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This article is from The Journal of Experimental Medicine , volume 207 . Abstract In humans and mice, CD8α+ conventional dendritic cells are the primary source of interferon-λ released in response to the adjuvant and Toll-like receptor 3 agonist poly IC.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989774
PubMed Central
by Leal, Ermelindo C.; Martins, Joao; Voabil, Paula; Liberal, Joana; Chiavaroli, Carlo; Bauer, Jacques; Cunha-Vaz, Jose; Ambrosio, Antonio F.
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This article is from Diabetes , volume 59 . Abstract OBJECTIVE: Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy in the last decades, but its mechanisms of action are not elucidated. CaD is able to correct the excessive vascular permeability in the retina of diabetic patients and in experimental diabetes. We investigated the molecular and cellular mechanisms underlying the protective effects of CaD against the increase in blood–retinal barrier (BRB) permeability...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279541
PubMed Central
by Cacciola, Giovanna; Chianese, Rosanna; Chioccarelli, Teresa; Ciaramella, Vincenza; Fasano, Silvia; Pierantoni, Riccardo; Meccariello, Rosaria; Cobellis, Gilda
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This article is from Pharmaceuticals , volume 3 . Abstract Starting from an historical overview of lasting Cannabis use over the centuries, we will focus on a description of the cannabinergic system, with a comprehensive analysis of chemical and pharmacological properties of endogenous and synthetic cannabimimetic analogues. The metabolic pathways and the signal transduction mechanisms, activated by cannabinoid receptors stimulation, will also be discussed. In particular, we will point out the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034092
PubMed Central
by Manigrasso, Michaele B; O'Connor, J Patrick
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This article is from Acta Orthopaedica , volume 81 . Abstract Background and purpose: Cyclooxygenase-2 (COX-2) promotes inflammation by synthesizing pro-inflammatory prostaglandins from arachidonic acid. Inflammation is an early response to bone fracture, and ablation of COX-2 activity impairs fracture healing. Arachidonic acid is also converted into leukotrienes by 5-lipoxygenase (5-LO). We hypothesized that 5-LO is a negative regulator of fracture healing and that in the absence of COX-2,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216088
PubMed Central
by de Jager, Cornelis PC; van Wijk, Paul TL; Mathoera, Rejiv B; de Jongh-Leuvenink, Jacqueline; van der Poll, Tom; Wever, Peter C
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This article is from Critical Care , volume 14 . Abstract Introduction: Absolute lymphocytopenia has been reported as a predictor of bacteremia in medical emergencies. Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill patients. Methods: We retrospectively evaluated the ability of conventional infection markers, lymphocyte count and NLCR to predict bacteremia in adult patients admitted to the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219299
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This article is from Facts, Views & Vision in ObGyn , volume 2 . Abstract Objectives: To compare the value of transvaginal ultrasonographic measurement of the cervical length versus the Bishop score, prior to induction of labour, in predicting the mode of delivery within four days.Materials and Methods: This longitudinal study included 110 women (at term, singleton, vertex presentation) in whom induction of labour was performed at 37-42 weeks of gestation. Cervical length on transvaginal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090590
PubMed Central
by Liu, Hong; Di Giorgio, Anthony M; Williams, Eric S; Evans, William; Russell, Michael J
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This article is from Journal of Biomedical Research , volume 24 . Abstract Near zero stroke rates can be achieved in carotid endarterectomy (CEA) surgery with selective shunting and electrophysiological neuromonitoring. though false negative rates as high as 40% have been reported. We sought to determine if improved training for interpretation of the monitoring signals can advance the efficacy of selective shunting with electrophysiological monitoring across multiple centers, and determine if...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596694
PubMed Central
by Shen, Yan; Plane, Jennifer M.; Deng, Wenbin
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This article is from Journal of Visualized Experiments : JoVE . Abstract We describe a protocol for establishing mouse models of periventricular leukomalacia (PVL). PVL is the predominant form of brain injury in premature infants and the most common antecedent of cerebral palsy. PVL is characterized by periventricular white matter damage with prominent oligodendroglial injury. Hypoxia/ischemia with or without systemic infection/inflammation are the primary causes of PVL. We use P6 mice to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149994
PubMed Central
by Barry, Michele; van Buuren, Nicholas; Burles, Kristin; Mottet, Kelly; Wang, Qian; Teale, Alastair
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This article is from Viruses , volume 2 . Abstract Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been shown to encode BTB/kelch and ankyrin/F-box proteins that interact with cullin-3 and cullin-1 based ubiquitin ligases, respectively. Multiple members of the poxvirus family also encode...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185573
PubMed Central
by Halperin, Henry R.; Kolandaivelu, Aravindan
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This article is from Rambam Maimonides Medical Journal , volume 1 . Abstract Catheter ablation is a first-line treatment for many cardiac arrhythmias and is generally performed under X-ray fluoroscopy guidance. However, current techniques for ablating complex arrhythmias such as atrial fibrillation and ventricular tachycardia are associated with sub-optimal success rates and prolonged radiation exposure. Pre-procedure 3-D magnetic resonance imaging (MRI) has improved understanding of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678784
PubMed Central
by Wild, Jennifer; Ehlers, Anke
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This article is from European Journal of Psychotraumatology , volume 1 . Abstract Background: Research has demonstrated that Cognitive Therapy for PTSD (CT-PTSD), a version of trauma-focused cognitive-behavioural therapy developed by Ehlers and Clark's group (2000), is effective and feasible when offered in weekly and intensive daily formats. It is unknown whether patients with post-traumatic stress disorder (PTSD) could engage in and benefit from self-study assisted cognitive therapy, which...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189692
PubMed Central
by Fan, Xiyong; Kavelaars, Annemieke; Heijnen, Cobi J; Groenendaal, Floris; van Bel, Frank
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This article is from Current Neuropharmacology , volume 8 . Abstract Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase-, nitric oxide synthase-, and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080590
PubMed Central
by Desfosses, Joelle; Stip, Emmanuel; Bentaleb, Lahcen Ait; Potvin, Stephane
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This article is from Pharmaceuticals , volume 3 . Abstract The endocannabinoids anandamide and 2-arachydonoylglycerol (2-AG) are lipids naturally derived from membrane precursors which bind cannabinoid receptors (CB1, CB2). This endocannabinoid system is disturbed in schizophrenia. Indeed, there seems to be an association between schizophrenia and polymorphisms of the CB1 receptor gene. Moreover, CB1 receptors are found in higher density in the prefrontal cortex, hippocampus and basal ganglia...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034083
This article is from Journal of Injury and Violence Research , volume 3 . Abstract Background:: Suicide rates generally increase with age. A recent cross-national study, using one-year cross-sectional data on suicide rates identified regional and cross-national patterns for elderly suicide rates. However, findings from studies using one-year cross-sectional data on suicide rates may be open to bias because of random year on year fluctuations in elderly suicide rates. Methods:: One-year average...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134928
This article is from Annals of Ibadan Postgraduate Medicine , volume 8 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138766
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This article is from Sensors (Basel, Switzerland) , volume 10 . Abstract The interest in measuring physiological parameters (especially arterial blood gases) has grown progressively in parallel to the development of new technologies. Physiological parameters were first measured invasively and at discrete time points; however, it was clearly desirable to measure them continuously and non-invasively. The development of intensive care units promoted the use of ventilators via oral intubation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292138
PubMed Central
by Pezzilli, Raffaele; Morselli-Labate, Antonio Maria; Corinaldesi, Roberto
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This article is from Pharmaceuticals , volume 3 . Abstract The resulting pain is the main symptom of acute pancreatitis and it should be alleviated as soon as possible. NSAIDs are the first line therapy for pain and they are generally administered to acute pancreatitis patients upon admission to the hospital. In addition, these drugs have also been used to prevent post-endoscopic cholangiopancreatography (ERCP) acute pancreatitis. On the other hand, there are several reports indicating that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033969
PubMed Central
by Kang, Hong Soon; Okamoto, Kyoko; Kim, Yong-Sik; Takeda, Yukimasa; Bortner, Carl D.; Dang, Huaixin; Wada, Taira; Xie, Wen; Yang, Xiao-Ping; Liao, Grace; Jetten, Anton M.
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This article is from Diabetes , volume 60 . Abstract OBJECTIVE: The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. In this study, we investigate whether TAK1 functions as a regulator of lipid and energy homeostasis and has a role in metabolic syndrome. RESEARCH DESIGN AND METHODS: We generated TAK1-deficient (TAK1−/−) mice to study the function of TAK1 in the development of metabolic syndrome in aged mice and mice fed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012170
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This article is from Pharmaceutics , volume 2 . Abstract Tacrolimus is a calcineurin inhibitor immunosuppressant that has seen considerable use in both adult and pediatric solid organ transplant recipients. Though there is much pharmacokinetic data available for tacrolimus in the adult population, the literature available for children is limited. Furthermore, very little is known about the pharmacogenomic differences in the two patient groups. Based on what information is currently available,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967138
PubMed Central
by Roman, Horace; Rozsnayi, Francisc; Puscasiu, Lucian; Resch, Benoit; Belhiba, Hend; Lefebure, Benoit; Scotte, Michel; Michot, Francis; Marpeau, Loic; Tuech, Jean Jacques
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This article is from JSLS : Journal of the Society of Laparoendoscopic Surgeons , volume 14 . Abstract This study suggests that bladder and rectal dysfunction occur more frequently with colorectal resection in rectal endometriosis compared with excision of the nodules alone.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043562
PubMed Central
by Tan, SP; Suraya, A; Sa'don, S; Ruzi, A; Zahiah, M
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This article is from Biomedical Imaging and Intervention Journal , volume 6 . Abstract The authors propose a musculoskeletal (MSK) magnetic resonance imaging (MRI) protocol using selected sequences for common orthopaedic indications. Selected sequences allow optimal visualisation of the indicated pathology while screening for other common conditions. The authors emphasise the need for standard positioning of the patient and standard orientation of scan planes to facilitate comparison with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097767
PubMed Central
by Kraker, Jessica; Zivkovic, Sasa A
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This article is from Current Neuropharmacology , volume 9 . Abstract Autoimmune neuromuscular disorders affecting peripheral nerves, neuromuscular junction or muscle have a wide clinical spectrum with diverse pathogenetic mechanisms. Peripheral nervous system may be targeted in the context of complex immune reactions involving different cytokines, antigen-presenting cells, B cells and different types of T cells. Various immunomodulating and cytotoxic treatments block proliferation or activation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151594