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PubMed Central is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).

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The effects of high and low jumping exercise intensities combined with honey on bone and gonadotrophins were investigated in eighty four 9 week-old female rats. The experimental groups were 20 or 80 jumps per day combined with or without honey supplementation (HJ 20, HJ 80 , J 20 and J 80 ), honey supplementation (H), sedentary without supplementation control (C), and baseline control (C 0 ) groups. Study results showed that HJ 80 elicited greatest beneficial effects on tibial and femoral...
Topics: Research Article, Bone, Female rats, Gonadotropins, Honey supplementation, Jumping exercise
Source: http://www.biomedcentral.com/1472-6882/14/126
PubMed Central
Nov 16, 2014 Karlberg, Olof; Canback, Bjorn; Kurland, Charles G.; Andersson, Siv G. E.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract We propose a scheme for the origin of mitochondria based on phylogenetic reconstructions with more than 400 yeast nuclear genes that encode mitochondrial proteins. Half of the yeast mitochondrial proteins have no discernable bacterial homologues, while one-tenth are unequivocally of α-proteobacterial origin. These data suggest that the majority of genes encoding yeast mitochondrial proteins are descendants of two different...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448374
PubMed Central
Nov 16, 2014 March, Ruth
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Pharmacogenomics is defined as the study of the association between genetics and drug response. This is a rapidly expanding field with the hope that, within a few years, prospective genotyping will lead to patients being prescribed drugs which are both safer and more effective (‘the right drug for the right patient’, or personalized medicine). There are many existing examples in the literature of strong associations...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447033
PubMed Central
Nov 16, 2014 Shin, Seung Youp; Hur, Gyu Young; Ye, Young Min; Park, Hae Sim
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This article is from Journal of Korean Medical Science , volume 23 . Abstract Porcine pancreatic extracts (PPE), which are widely used as a digestive drug in Korea, are composed of α-amylase and lipase. Such enzymes are commonly described as occupational allergens. This is the first report of occupational rhinitis caused by PPE developing into occupational asthma in a hospital nurse. She showed strong positive response in the skin prick test (SPT) (5+, wheal ratio of allergen to histamine) and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526419
PubMed Central
Nov 16, 2014 Bolte, Kathrin; Kawach, Oliver; Prechtl, Julia; Gruenheit, Nicole; Nyalwidhe, Julius; Maier, Uwe-G
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This article is from BMC Plant Biology , volume 8 . Abstract Background: Cryptophytes are highly compartmentalized organisms, expressing a secondary minimized eukaryotic genome in the nucleomorph and its surrounding remnant cytoplasm, in addition to the cell nucleus, the mitochondrion and the plastid. Because the members of the nucleomorph-encoded proteome may contribute to essential cellular pathways, elucidating nucleomorph-encoded functions is of utmost interest. Unfortunately, cryptophytes...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408579
PubMed Central
Nov 16, 2014 Hong, Su-Hyung; Misek, David E.; Wang, Hong; Puravs, Eric; Hinderer, Robert; Giordano, Thomas J.; Greenson, Joel K.; Brenner, Dean E.; Simeone, Diane M.; Logsdon, Craig D.; Hanash, Samir M.
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This article is from Biomarker Insights , volume 1 . Abstract Pancreatic cancer has a poor prognosis, in part due to lack of early detection. The identification of circulating tumor antigens or their related autoantibodies provides a means for early cancer diagnosis. We have used a proteomic approach to identify proteins that commonly induce a humoral response in pancreatic cancer. Proteins from a pancreatic adenocarcinoma cell line (Panc-1) were subjected to two-dimensional PAGE, followed by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528299
PubMed Central
Nov 16, 2014 Chersich, Matthew F; Urban, Michael F; Venter, Francois WD; Wessels, Tina; Krause, Amanda; Gray, Glenda E; Luchters, Stanley; Viljoen, Dennis L
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This article is from AIDS Research and Therapy , volume 3 . Abstract Background: Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by concerns that it is teratogenic. This paper reviews evidence of efavirenz teratogenicity and considers implications in common clinical scenarios. Findings: Concerns of efavirenz-induced fetal effects stem...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1468418
PubMed Central
Nov 16, 2014 Yasui, Yutaka; Hamajima, Nobuyuki; Nakamura, Tsuneya; El-Din, Noha Sharaf; Tajima, Kazuo; Potter, John D
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This article is from Journal of Autoimmune Diseases , volume 5 . Abstract Background: Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian countries, is associated with elevated IgG antibody titers against Epstein-Barr viral capcid antigen (anti-EBVCA IgG titers). Given the 84% homology of the open reading frame BCRF1 of Epstein-Barr virus (EBV) to human interleukin 10 (hIL-10) and the remarkable Caucasian-vs.-Asian population differences in hIL-10 gene promoter...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292184
This article is from BMC Health Services Research , volume 6 . Abstract Background: This study aimed to investigate groups of patients with a relatively homogenous health status to evaluate the degree to which use of the Australian hospital system is affected by socio-economic status, locational accessibility to services and patient payment classification. Method: Records of all deaths occurring in Western Australia from 1997 to 2000 inclusive were extracted from the WA mortality register and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1555582
PubMed Central
Nov 16, 2014 Irshad, Muhammad; Canut, Herve; Borderies, Gisele; Pont-Lezica, Rafael; Jamet, Elisabeth
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This article is from BMC Plant Biology , volume 8 . Abstract Background: Cell elongation in plants requires addition and re-arrangements of cell wall components. Even if some protein families have been shown to play roles in these events, a global picture of proteins present in cell walls of elongating cells is still missing. A proteomic study was performed on etiolated hypocotyls of Arabidopsis used as model of cells undergoing elongation followed by growth arrest within a short time. Results:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551616
PubMed Central
Nov 16, 2014 Feigelson, Heather Spencer; Teras, Lauren R; Diver, W Ryan; Tang, Weining; Patel, Alpa V; Stevens, Victoria L; Calle, Eugenia E; Thun, Michael J; Bouzyk, Mark
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This article is from Breast Cancer Research : BCR , volume 10 . Abstract Introduction: Obesity has consistently been associated with postmenopausal breast cancer risk. Proteins that are secreted by adipose tissue or are involved in regulating body mass may play a role in breast tumor development. Methods: We conducted a nested case-control study among postmenopausal women from the American Cancer Society Cancer Prevention Study II Nutrition Cohort to determine whether genes associated with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575528
PubMed Central
Nov 16, 2014 Guerra, Ricardo LF; Prado, Wagner L; Cheik, Nadia C; Viana, Fabiana P; Botero, Joao Paulo; Vendramini, Regina C; Carlos, Iracilda Z; Rossi, Elizeu A; Damaso, Ana R
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This article is from Lipids in Health and Disease , volume 6 . Abstract Background: Exercise has been prescribed in the treatment and control of dyslipidemias and cholesterolemia, however, lipid responses to different training frequencies in hypercholesterolemic men have been inconsistent. We sought to verify if different frequencies of continuous moderate exercise (2 or 5 days/week, swimming) can, after 8 weeks, promote adaptations in adipocyte area and lipid parameters, as well as body weight...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933532
PubMed Central
Nov 16, 2014 Dutta, Ritaban; Dutta, Ritabrata
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This article is from BioMedical Engineering OnLine , volume 5 . Abstract Electronic Nose based ENT bacteria identification in hospital environment is a classical and challenging problem of classification. In this paper an electronic nose (e-nose), comprising a hybrid array of 12 tin oxide sensors (SnO2) and 6 conducting polymer sensors has been used to identify three species of bacteria, Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Pseudomonas aeruginosa (P. aeruginosa)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764885
PubMed Central
Nov 16, 2014 Sharma, B. C.; Saraswat, V. A.; Dhiman, R. K.; Ghoshal, U. C.; Puri, A. S.; Sikora, S. S.
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This article is from HPB Surgery , volume 9 . Abstract Extrahepatic portal vein obstruction has been reported to be associated with tumors of liver, bile ducts and pancreas. We report two cases, one with gastric leiomyosarcoma and another with Non Hodgkin’s lymphoma, complicated by portal vein block and presenting with gastric variceal bleeding. Portal vein block in both cases was due to direct vascular infiltration. Development of portal hypertension posed difficulties in management.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443092
PubMed Central
Nov 16, 2014 Schmielau, Fritz; Wong, Edward K
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This article is from Journal of NeuroEngineering and Rehabilitation , volume 4 . Abstract Background: The efficacy of treatment in hemianopic patients to restore missing vision is controversial. So far, successful techniques require laborious stimulus presentation or restrict improvements to selected visual field areas. Due to the large number of brain-damaged patients suffering from visual field defects, there is a need for an efficient automated treatment of the total visual field. Methods: A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014761
PubMed Central
Nov 16, 2014 Ghosh, Kumaresh; Adhikari, Suman; Chattopadhyay, Asoke P; Chowdhury, Purnendu Roy
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This article is from Beilstein Journal of Organic Chemistry , volume 4 . Abstract Quinoline and naphthalene-based fluororeceptors 1 and 2 have been designed and synthesized for detection of hydroxy carboxylic acids in less polar solvents. The receptor 1 shows monomer emission quenching followed by excimer emission upon hydrogen bond-mediated complexation of carboxylic acids. The excimer emission distinguishes aromatic dicarboxylic acids from aliphatic dicarboxylic acids and even long chain...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633660
PubMed Central
Nov 16, 2014 Gotay, Carolyn C; Pagano, Ian S
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This article is from Health and Quality of Life Outcomes , volume 5 . Abstract Background: The purpose of this study was to design a brief questionnaire to measure fears about recurrence and health in cancer survivors. Research involving fear of recurrence has been increasing, indicating that it is an important concern among cancer survivors. Methods: We developed and tested a six-item instrument, the Assessment of Survivor Concerns (ASC). Construct validity was examined in a multiple group...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828718
PubMed Central
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This article is from Yeast (Chichester, England) , volume 17 . Abstract We have developed a sensitive quantitative RT–PCR procedure suitable for the analysis of small samples, including single cells, and have used it to measure levels of potassium channel mRNAs in a panel of human tissues and small numbers of cells grown in culture. The method involves an initial global amplification of cDNA derived from all added polyadenylated mRNA followed by quantitative RT–PCR of individual genes using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448369
PubMed Central
Nov 16, 2014 Dunham, Ian
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This article is from Yeast (Chichester, England) , volume 17 . Abstract A recent flurry of publications and media attention has revived interest in the question of how many genes exist in the human genome. Here, I review the estimates and use genomic sequence data from human chromosomes 21 and 22 to establish my own prediction.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448377
PubMed Central
Nov 16, 2014 Nagel, M; Sprenger, A; Lencer, R; Kompf, D; Siebner, H; Heide, W
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This article is from BMC Neuroscience , volume 9 . Abstract Background: The generation of saccades is influenced by the level of "preparatory set activity" in cortical oculomotor areas. This preparatory activity can be examined using the gap-paradigm in which a temporal gap is introduced between the disappearance of a central fixation target and the appearance of an eccentric target. Methods: Ten healthy subjects made horizontal pro- or antisaccades in response to lateralized cues...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564971
PubMed Central
Nov 16, 2014 Bekarian, Nyree; Payne-Sturges, Devon; Edmondson, Stuart; Chism, Bill; Woodruff, Tracey J
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This article is from Environmental Health , volume 5 . Abstract Background: Residential-use pesticides have been shown to be a major source of pesticide exposure to people in the United States. However, little is understood about the exposures to household pesticides and the resultant health effects. One reason that little is known about home-use pesticide exposure is the lack of comprehensive data on exposures to pesticides in the home. One method to help ascertain the amount of pesticides...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534012
PubMed Central
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This article is from HPB Surgery , volume 9 . Abstract The occurrence of biliary stricutures in allografts following liver transplantation correlates with the duration of preservation time. The correlation between preservation time and biliary strictures suggests that anoxic or reperfusion injury of the bile duct epithelium causes stricture formation. However, the relative susceptibility of bile duct cells to anoxic or reoxygenation injury is unknown. Our aims were to determine the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443073
PubMed Central
Nov 16, 2014 Knoers, Nine VAM; Levtchenko, Elena N
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This article is from Orphanet Journal of Rare Diseases , volume 3 . Abstract Gitelman syndrome (GS), also referred to as familial hypokalemia-hypomagnesemia, is characterized by hypokalemic metabolic alkalosis in combination with significant hypomagnesemia and low urinary calcium excretion. The prevalence is estimated at approximately 1:40,000 and accordingly, the prevalence of heterozygotes is approximately 1% in Caucasian populations, making it one of the most frequent inherited renal tubular...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518128
PubMed Central
Nov 16, 2014 Meeren, A. Van Der; Bertho, J.-M.; Vandamme, M.; Gaugler, M.-H.
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This article is from Mediators of Inflammation , volume 6 . Abstract Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of 60Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After gamma irradiation, interleukin (IL)-1α, IL-1β and tumor necrosis factor (TNF)-α...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365835
PubMed Central
Nov 16, 2014 Lo Muzio, Lorenzo
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This article is from Orphanet Journal of Rare Diseases , volume 3 . Abstract Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms.The estimated prevalence varies from 1/57,000 to 1/256,000, with a male-to-female ratio of 1:1.Main clinical manifestations include multiple basal cell carcinomas (BCCs), odontogenic keratocysts of the jaws, hyperkeratosis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607262
PubMed Central
Nov 16, 2014 Zhang, Samuel Shao-Min; Xu, Xuming; Liu, Mu-Gen; Zhao, Hongyu; Soares, Marcelo Bento; Barnstable, Colin J; Fu, Xin-Yuan
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This article is from BMC Developmental Biology , volume 6 . Abstract Background: Between embryonic day 12 and postnatal day 21, six major neuronal and one glia cell type are generated from multipotential progenitors in a characteristic sequence during mouse retina development. We investigated expression patterns of retina transcripts during the major embryonic and postnatal developmental stages to provide a systematic view of normal mouse retina development, Results: A tissue-specific cDNA...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633734
PubMed Central
Nov 16, 2014 Kato, Jun-ichi; Hashimoto, Masayuki
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This article is from Molecular Systems Biology , volume 3 . Abstract The minimal set of genetic information necessary and sufficient to sustain a functioning cell contains not only trans-acting genes, but also cis-acting chromosomal regions that cannot be complemented by plasmids carrying these regions. In Escherichia coli (E. coli), only one chromosomal region, the origin of replication has been identified to be cis-acting. We constructed a series of mutants with long-range deletions, and the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964801
PubMed Central
Nov 16, 2014 Lin, Shin-Yu; Su, Yi-Ning; Hung, Chia-Cheng; Tsay, Woei; Chiou, Shyh-Shin; Chang, Chieh-Ting; Ho, Hong-Nerng; Lee, Chien-Nan
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This article is from BMC Medical Genetics , volume 9 . Abstract Background: Hemophilia A represents the most common and severe inherited hemorrhagic disorder. It is caused by mutations in the F8 gene, which leads to a deficiency or dysfunctional factor VIII protein, an essential cofactor in the factor X activation complex. Methods: We used long-distance polymerase chain reaction and denaturing high performance liquid chromatography for mutation scanning of the F8 gene. We designed the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442058
PubMed Central
Nov 15, 2014 Ho, Timothy B. L.; Robertson, Brian D.; Taylor, G. Michael; Shaw, Rory J.; Young, Douglas B.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The Mycobacterium tuberculosis complex is associated with a remarkably low level of structural gene polymorphism. As part of a search for alternative forms of genetic variation that may act as a source of biological diversity in M. tuberculosis, we have identified a region of the genome that is highly variable amongst a panel of unrelated clinical isolates. Fifteen of 24 isolates examined contained one or more copies of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448390
PubMed Central
Nov 15, 2014 Dicks, Jo
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Visualization of data is important for many data-rich disciplines. In biology, where data sets are becoming larger and more complex, grephical analysis is felt to be ever more pertinent. Although some patterns and trends in data sets may only be determined by sophisticated computional analysis, viewing data by eye can provide us with an extraordinary amount of information in an instant. Recent advances in bioinformatic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447042
PubMed Central
Nov 15, 2014 Wixon, Jo
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This article is from Yeast (Chichester, England) , volume 17 . Abstract This review explores the UK CropNet site. The project is aimed at aiding the comparative mapping of cereal and other crop genomes. The site provides software tools for use by those working on genome mapping, and access to an array of databases that will be of interest to all members of the plant genomics research community, using several ACeDB interfaces. All screen views from the website are reproduced with the kind...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448366
PubMed Central
Nov 15, 2014 Nasevicius, Aidas; Larson, Jon; Ekker, Stephen C.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Angiogenesis is a fundamental vertebrate developmental process that requires signalling by the secreted protein vascular endothelial growth factor-A (VEGF-A). VEGF-A functions in the development of embryonic structures, during tissue remodelling and for the growth of tumour-induced vasculature. The study of the role of VEGF-A during normal development has been significantly complicated by the dominant, haplo-insufficient...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448381
This article is from Yeast (Chichester, England) , volume 17 . Abstract The rapidly accumulating genome sequence data from the plant Arabidopsis thaliana allows more detailed analysis of genome content and organisation than ever bafore possible in plants. The genome shows a surprisingly high level of genetic redundancy, with as many as 75% of gene products showing signficant homology to another protien of A. thaliana. Many duplicated genes occur in arrays of conserved order and indicate that A....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447036
PubMed Central
Nov 15, 2014
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Alan Coulson has two main roles at the Sanger Centre, revolving around the worm and the human genome projects. Although the worm sequence is essentially finished, the tidying-up of that and the physical map is ongoing. There is also a continuous need for communication with the worm field with regard to information and materials relating to the sequence project. For example, the cosmids and YACs of the physical map continue...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447037
PubMed Central
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This article is from BMC Public Health , volume 8 . Abstract Background: With surveys suggesting that exceeding guidelines for 'sensible' alcohol intake is commonplace, the health and social impact of modifying intake on a population level is potentially considerable. If public health interventions are to be successfully implemented, it is first important to identify correlates of such behaviours, including socioeconomic disadvantage. This was the aim of the present study. Methods:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538536
PubMed Central
Nov 15, 2014 Uziel, Yosef; Feldman, Brian M; Krafchik, Bernice R; Laxer, Ronald M; Yeung, Rae SM
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This article is from Pediatric Rheumatology Online Journal , volume 5 . Abstract Background: There are neither sensitive nor specific laboratory tests for measuring disease activity in localized scleroderma (LS). Monitoring is done almost exclusively by clinical assessment. Our aim was to determine whether serum concentrations of TGFβ1 are a good biomarker of disease activity in children with LS. Methods: 55 pediatric patients with LS were divided into sub-types according to their main lesion;...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233624
PubMed Central
Nov 15, 2014 Ekker, Stephen C.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The vertebrate genome contains a predicted 50 000 100 000 genes, many of unknown function. The recent development of morpholino-based gene knock-down technology in zebrafish has opened the door to the genome-wide assignment of function based on sequence in a model vertebrate. This review describes technical aspects of morpholino use for functional genomics applications, including the potential for multigene targeting and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448384
PubMed Central
Nov 15, 2014 Haynes, Paul A.; Yates III, John R.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract In this review we examine the current state of analytical methods in proteomics. The conventional methodology using two-dimensional electrophoresis gels and mass spectrometry is discussed, with particular reference to the advantages and shortcomings thereof. Two recently published methods which offer an alternative approach are presented and discussed, with emphasis on how they can provide information not available via...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448324
PubMed Central
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Increasingly mRNA expression patterns established using a variety of molecular technologies such as cDNA microarrays, SAGE and cDNA display are being used to identify potential regulatory genes and as a means of providing valuable insights into the biological status of the starting sample. Until recently, the application of these techniques has been limited to mRNA isolated from millions or, at very best, several thousand...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448376
PubMed Central
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This article is from Yeast (Chichester, England) , volume 17 . Abstract One could almost say that it is the latest fashion to sequence a bacterial genome. However, this would belittle the efforts of those working on these important organisms, whose data will greatly help those working on the prevention of disease in the fields of medicine and agriculture. In this feature we present a guided tour of the latest additions to the ‘sequenced microbes’ club. Vibrio cholerae is the causative agent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448383
PubMed Central
Nov 15, 2014 McLysaght, Aoife; Enright, Anton J.; Skrabanek, Lucy; Wolfe, Kenneth H.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Background: Knowledge of the amount of gene order and synteny conservation between two species gives insights to the extent and mechanisms of divergence. The vertebrate Fugu rubripes (pufferfish) has a small genome with little repetitive sequence which makes it attractive as a model genome. Genome compaction and synteny conservation between human and Fugu were studied using data from public databases.Methods: Intron length...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447035
PubMed Central
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The analysis of genomics data needs to become as automated as its generation. Here we present a novel data-mining approach to predicting protein functional class from sequence. This method is based on a combination of inductive logic programming clustering and rule learning. We demonstrate the effectiveness of this approach on the M. tuberculosis and E. coli genomes, and identify biologically interpretable rules which...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448385
PubMed Central
Nov 15, 2014 Brancia, Francesco
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The general theme of the meeting was the application of mass spectrometry to pharmaceutical and biotechnological research. The majority of the oral presentations and posters were concerned with the development and application of all mass spectrometric techniques related to proteomics.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448382
PubMed Central
Nov 14, 2014 Bradnam, Keith; May, Sean
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This article is from Yeast (Chichester, England) , volume 17 . Abstract UK CropNet currently provides a range of databases (and database-mining tools) to the plant community that are all freely accessible through our website (http://ukcrop.net/). Recent upgrades have meant that we can now expand the range of available facilities (e.g. addition of new databases) whilst also strengthening and improving access to existing services (e.g. providing a BLAST search facility against sequences in our...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448389
PubMed Central
Nov 14, 2014 Fromont-Racine, Micheline; Mayes, Andrew E.; Brunet-Simon, Adeline; Rain, Jean-Christophe; Colley, Alan; Dix, Ian; Decourty, Laurence; Joly, Nicolas; Ricard, Florence; Beggs, Jean D.; Legrain, Pierre
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This article is from Yeast (Chichester, England) , volume 17 . Abstract A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces cerevisiae has identified a number of open reading frames that potentially encode structurally similar proteins termed Lsm (Like Sm) proteins. With the aim of analysing all possible interactions between the Lsm proteins and any protein...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448332
PubMed Central
Nov 14, 2014 Brosch, Roland; Gordon, Stephen V.; Buchrieser, Carmen; Pym, Alexander S.; Garnier, Thierry; Cole, Stewart T.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract On direct comparison of minimal sets of ordered clones from bacterial artificial chromosome (BAC) libraries representing the complete genomes of Mycobacterium tuberculosis H37Rv and the vaccine strain, Mycobacterium bovis BCG Pasteur, two major rearrangements were identified in the genome of M. bovis BCG Pasteur. These were shown to correspond to two tandem duplications, DU1 and DU2, of 29 668 bp and 36 161 bp,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448323
PubMed Central
Nov 14, 2014 Dow, J. M.; Daniels, M. J.
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Xylella fastidiosa, a pathogen of citrus, is the first plant pathogenic bacterium for which the complete genome sequence has been published. Inspection of the sequence reveals high relatedness to many genes of other pathogens, notably Xanthomonas campestris. Based on this, we suggest that Xylella possesses certain easily testable properties that contribute to pathogenicity. We also present some general considerations for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448391
PubMed Central
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The meeting was held on 16–20 July 2000 at the International Convention Centre in Birmingham, UK, and was co-organized by the International Union of Biochemistry and Molecular Biology (IUBMB) and the Federation of European Biochemical Societies (FEBS). Although the meeting had a broad subject area, the emphasis was firmly placed on post-genomic studies, and hence several sessions should be of interest to our readers. We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448388
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The family and motif databases, PROSITE, PRINTS, Pfam and ProDom, have been integrated into a powerful resource for protein secondary annotation. As of June 2000, InterPro had processed 384 572 proteins in SWISS-PROT and TrEMBL. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments compliment each other for grouping protein families and delineating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448387
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Nov 14, 2014 Gurvitz, Aner; Langer, Sigrid; Piskacek, Martin; Hamilton, Barbara; Ruis, Helmut; Hartig, Andreas
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The role of peroxisomal processes in the maintenance of neurons has not been thoroughly investigated. We propose using Caenorhabditis elegans as a model organism for studying the molecular basis underlying neurodegeneration in certain human peroxisomal disorders, e.g. Zellweger syndrome, since the nematode neural network is well characterized and relatively simple in function. Here we have identified C. elegans PEX-5...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448379
PubMed Central
Nov 14, 2014 Wixon, Jo
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The zebrafish has long been a favourite model for the study of vertebrate development. Here we provide an overview of the current state of knowledge and resources for the study of this fish, with comments on the future direction of zebrafish genomics from Professor Mark Fishman and Dr Stephen Wilson.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448373
PubMed Central
Nov 14, 2014
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This article is from Yeast (Chichester, England) , volume 17 . Abstract Artemis Pharmaceuticals have just announced a second saturation mutagenesis screen of the zebrafish, Danio rerio. In this interview with Stefan Schulte-Merker, who is Head of Fish Genetics at Artemis, we find out more about the purpose of the second screen and contrast it with the first screen which was carried out in Christaine Nüsslein-Volhard laboratory and which is now called ‘Tübingen One’.Stefan Schulte-Merker...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448370
PubMed Central
Nov 14, 2014 Walhout, Albertha J. M.; Boulton, Simon J.; Vidal, Marc
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The availability of complete genome sequences necessitates the development of standardized functional assays to analyse the tens of thousands of predicted gene products in high-throughput experimental settings. Such approaches are collectively referred to as ‘functional genomics’. One approach to investigate the properties of a proteome of interest is by systematic analysis of protein–protein interactions. So far, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448329
PubMed Central
Nov 14, 2014 Hunzelmann, N.; Genth, E.; Krieg, T.; Lehmacher, W.; Melchers, I.; Meurer, M.; Moinzadeh, P.; Muller-Ladner, U.; Pfeiffer, C.; Riemekasten, G.; Schulze-Lohoff, E.; Sunderkoetter, C.; Weber, M.; Worm, M.; Klaus, P.; Rubbert, A.; Steinbrink, K.; Grundt, B.; Hein, R.; Scharffetter-Kochanek, K.; Hinrichs, R.; Walker, K.; Szeimies, R.-M.; Karrer, S.; Muller, A.; Seitz, C.; Schmidt, E.; Lehmann, P.; Foeldvari, I.; Reichenberger, F.; Gross, W.L.; Kuhn, A.; Haust, M.; Reich, K.; Bohm, M.; Saar, P.; Fierlbeck, G.; Kotter, I.; Lorenz, H.-M.; Blank, N.; Grafenstein, K.; Juche, A.; Aberer, E.; Bali, G.; Fiehn, C.; Stadler, R.; Bartels, V.
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This article is from Rheumatology (Oxford, England) , volume 47 . Abstract Objective. Systemic sclerosis (SSc) is a rare, heterogeneous disease, which affects different organs and therefore requires interdisciplinary diagnostic and therapeutic management. To improve the detection and follow-up of patients presenting with different disease manifestations, an interdisciplinary registry was founded with contributions from different subspecialties involved in the care of patients with SSc.Methods....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2468885
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This article is from Journal of Insect Science , volume 6 . Abstract Experiments were conducted to study the bioefficacies of different plant/weed derivatives that affect the development of the pulse beetle, Callosobruchus maculates F. (Coleoptera: Bruchidae) fed on black gram, Vigna mungo, seeds. Plant extracts, powder, ash and oil from nishinda (Vitex negundo L.), eucalyptus (Eucalyptus globules Labill.), bankalmi (Ipomoea sepiaria K.), neem (Azadirachta indica L.), safflower (Carthamus...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990289
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Nov 12, 2014 Eickhoff, Thomas E.; Baxendale, Frederick P.; Heng-Moss, Tiffany M.
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This article is from Journal of Insect Science , volume 6 . Abstract The chinch bug, Blissus occiduus Barber (Hemiptera: Blissidae), is an important pest of buffalograss, Buchloë dactyloides (Nutall) Engelmann and potentially other turfgrass, crop, and non-crop hosts. Choice studies documented the number of B. occiduus present on selected turfgrasses, crops and weeds, and provided important insights into the host preferences of this chinch bug. Grasses with the most chinch bugs present...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990293
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Nov 12, 2014 Fielding, Dennis
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This article is from Journal of Insect Science , volume 6 . Abstract Previous analyses of diapause in insects have most often focused on the timing of the switch from non-diapausing to diapausing offspring in bivoltine populations and have assumed that diapause is irreversible or that the insect cannot survive winter if not in diapause. Many insects exhibit more flexibility in their life cycles, such as the age at which diapause begins, and facultative diapause, that may influence the evolution...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990288
This article is from Journal of Insect Science , volume 6 . Abstract A new African genus of soft scale insects, Pseudocribrolecanium gen. nov. is erected to accommodate Akermes colae Green & Laing and Cribrolecanium andersoni (Newstead). The adult females and first-instar nymphs of the two species are redescribed and illustrated. Taxonomic keys to separate the adult females and first-instar nymphs are provided. The affinity of Pseudocribrolecanium with the tribe Paralecaniini in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990287
This article is from Journal of Insect Science , volume 6 . Abstract The persistent pods of the tree, Acacia caven that do not fall from the tree provide opportunities for the appearance of a diverse group of insects the following season. Such pods collected during the spring of 1999 in Chile were indehiscent with highly sclerified pod walls. In contrast, persistent pods collected in Uruguay after a wet winter and spring (2002) were partially dehiscent, inducing the deterioration of the woody...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990294
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Nov 11, 2014 Blanco, Carlos A.; Perera, Omaththage; Ray, Jeffery D.; Taliercio, Earl; Williams, Livy
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This article is from Journal of Insect Science , volume 6 . Abstract Rhodamine B, a dye commonly used in a variety of biological studies was incorporated into the bodies of male tobacco budworm moths, Heliothis virescens (Lepidoptera: Noctuidae), by allowing them to feed freely on 0.1% rhodamine dissolved in a 10% sucrose solution. After exposing males for one to three days to this pigment, rhodamine was clearly detectable in >82% of spermatophores extracted from untreated females. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990291
PubMed Central
Nov 11, 2014 Feitosa, Fabiana M.; Calvo, Eric; Merino, Emilio F.; Durham, Alan M.; James, Anthony A.; de Bianchi, Antonio G.; Marinotti, Osvaldo; Capurro, Margareth L.
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This article is from Journal of Insect Science , volume 6 . Abstract Aedes (Stegomyia) aegypti is an important dengue vector in tropical and subtropical zones throughout the world. A transcriptome of Ae. aegypti vitellogenic fat bodies is described here. The fat body is a dynamic tissue that participates in multiple biochemical functions of intermediate metabolism. A total of 589 randomly selected cDNAs were assembled into 262 clusters based on their primary sequence similarities. The putative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990292
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Nov 11, 2014 Gibbs, Melanie; Lace, Lesley A.; Jones, Martin J.; Moore, Allen J.
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This article is from Journal of Insect Science , volume 6 . Abstract Ovipositing females are predicted to select host-plants that will maximise offspring survival and fitness. Yet hosts often differ in the component of larval fitness affected so host-selection often involves a trade-off between short development times and large size and high fecundity of offspring. If host-species can directly affect development rates and body size, and if there are gender differences in resource allocation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990290
PubMed Central
Nov 11, 2014 Weber, Donald C.; Rowley, Daniel L.; Greenstone, Matthew H.; Athanas, Michael M.
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This article is from Journal of Insect Science , volume 6 . Abstract Lebia grandis (Coleoptera: Carabidae), recorded as a parasitoid only on Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae), is capable of parasitizing the false potato beetle, L. juncta, and also L. haldemani. Historical records show that L. decemlineata, while the only recorded host, was not present in much of the original range of L. grandis, and may not have been its host prior to its expansion...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990295
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This article is from Journal of Insect Science , volume 6 . Abstract A new species of the psammophilous and brushlegged North American genus Amercaenis Provonsha and McCafferty, Amercaenis cusabo Provonsha and McCafferty, new species, is described from larvae taken from the Black River (North Carolina), the Pee Dee River (North Carolina), and the Savannah River (Georgia and South Carolina). The new species differs from the only other known species of the genus, A. ridens (McDunnough), for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990297
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Oct 29, 2014 Frikha, Zied; Abid, Leila; Abid, Dorra; Mallek, Souad; Frikha, Imed; Abdennadher, Mohamed; Rekik, Noomen; Kammoun, Samir
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This article is from Journal of Medical Case Reports , volume 5 . Abstract Introduction: Primary cardiac lymphoma is rare. Case Presentation: We report the case of a 64-year-old non-immunodeficient Caucasian man, with cardiac tamponade and paroxysmal third-degree atrioventricular block. Echocardiography revealed the presence of a large pericardial effusion with signs of tamponade and a right ventricular mass was suspected. Scanner investigations clarified the sites, extension and anatomic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180417
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This article is from Fly , volume 7 . Abstract When obtaining samples for population genetic studies, it is essential that the sampling is random. For Drosophila, one of the crucial steps in sampling experimental flies is the collection of eggs. Here an egg collection method is presented, which randomizes the eggs in a water column and diminishes environmental variance. This method was compared with a traditional egg collection method where eggs are collected directly from the medium. Within...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660287
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This article is from Molecular Pain , volume 9 . Abstract Background: IL-6 is a typical injury-induced mediator. Together with its receptors, IL-6 contributes to both induction and maintenance of neuropathic pain deriving from changes in activity of primary sensory neurons in dorsal root ganglia (DRG). We used in situ hybridization to provide evidence of IL-6 and IL-6 receptors (IL-6R and gp130) synthesis in DRG along the neuraxis after unilateral chronic constriction injury (CCI) of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844395
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Oct 29, 2014 Lee, Bo-Shyan; Huang, Si-Sheng; Hsu, Wen-Yu; Chiu, Nan-Ying
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This article is from BMC Psychiatry , volume 12 . Abstract Background: Little is known about the cause and psychopathology of delirious mania, a type of disorder where delirium and mania occur at the same time. This condition still has no formal diagnostic classification. To provide more information about this potentially life-threatening condition, we studied five patients with delirious mania. Methods: We describe the cases of five patients with delirious mania admitted to an acute inpatient...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503657
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This article is from Indian Journal of Nephrology , volume 22 . Abstract Outcome of end-stage renal disease (ESRD) in children has considerably improved since the development of dialysis and kidney transplantation. This study was conducted to evaluate the management and outcome of ESRD children in a referral pediatric center in northwest Iran. A cross-sectional study of medical records of ESRD children (glomerular filtration rate less than 15 ml/min/1.73 m2) younger than 16 years who were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391830
PubMed Central
Oct 29, 2014 Moon, Hee-Won; Kim, Bo Hyun; Park, Chul Min; Hur, Mina; Yun, Yeo-Min; Kim, Sung-Yong; Lee, Mark Hong
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This article is from The Korean Journal of Laboratory Medicine , volume 31 . Abstract Background: CD4+CD25+ regulatory T-cells (Tregs) play a critical role in immune responses. We explored the status of Tregs in neoplastic and autoimmune hematologic diseases. We also evaluated the technical aspects of Treg measurement in terms of sample type and detection markers. Methods: A total of 68 subjects were enrolled: 11 with AML, 8 with MDS, 10 with autoimmune diseases, and 39 controls. Tregs were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190000
PubMed Central
Oct 29, 2014 Leal de Godoy, Camila Haddad; da Costa Silva, Paula Fernanda; Sales de Araujo, Deise; Motta, Lara Jansiski; Biasotto-Gonzalez, Daniela Aparecida; Politti, Fabiano; Mesquita-Ferrari, Raquel Agnelli; Fernandes, Kristianne Porta Santos; Albertini, Regiane; Bussadori, Sandra Kalil
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This article is from Trials , volume 14 . Abstract Background: A number of problems involving the temporomandibular joint (TMJ) and associated structures can lead to temporomandibular disorder (TMD). The aim of the proposed study is to assess the effect of low-level laser therapy on occlusal contacts, mandibular movements, electromyography activity in the muscles of mastication and pain in adolescents with TMD. Methods/Design: A randomized, controlled, double-blind, clinical trial will be...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729421
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Oct 29, 2014 Mukherjee, Sumana; Mallick, Jayati; Pal, Prabir C; Chattopadhyay, Sarbani
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This article is from Journal of Cytology / Indian Academy of Cytologists , volume 29 . Abstract Hemangioendothelioma is a rare vascular tumor of intermediate malignancy. Cytologically, it can simulate a non-vascular malignant tumor. We report two cases of this tumor, which were misdiagnosed at cytology. In the first case, a 27-year-old man presented with an anterior abdominal wall tumor. Fine needle aspiration cytology (FNAC) of the tumor showed polygonal cells with vacuolated cytoplasm in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307467
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Oct 29, 2014 Moghaddassani, H; Mirhendi, H; Hosseini, M; Rokni, MB; Mowlavi, Gh; Kia, Eb
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This article is from Iranian Journal of Parasitology , volume 6 . Abstract Background: Strongyloidiasis is mostly an asymptomatic infection and diagnosis of latent infections is difficult due to limitations of current parasitological and serological methods. This study was conducted to set up a PCR-based method for molecular diagnosis of Strongyloides stercoralis infection by detection of copro-DNA in stool samples. Methods: A total of 782 fresh stool samples were collected and examined by agar...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279873
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Oct 29, 2014 Choi, Mi-Hye; Noh, Woo-Chang; Park, Jin-Woo; Lee, Jae-Mok; Suh, Jo-Young
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This article is from Journal of Periodontal & Implant Science , volume 41 . Abstract Purpose: Periodontal ligament (PDL) cell differentiation into osteoblasts is important in bone formation. Bone formation is a complex biological process and involves several tightly regulated gene expression patterns of bone-related proteins. The expression patterns of bone related proteins are regulated in a temporal manner both in vivo and in vitro. The aim of this study was to observe the gene expression...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175496
PubMed Central
Oct 29, 2014 Dinh Do, Nguyen; Kovalchukova, Olga; Stash, Adam; Strashnova, Svetlana
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 69 . Abstract In the title compound, {(NH4)[Ag(C5HN2O6)2(H2O)]}n, the AgI cation is seven-coordinated and is surrounded by four oxo O atoms of the 2,3,5,6-tetra­oxo-4-nitro­pyridin-4-ide species [Ag—O = 2.3848 (19), 2.4931 (18), 2.5361 (18) and 2.573 (2) Å], two nitro O atoms [Ag—O = 2.644 (2) and 2.661 (2) Å], and one water mol­ecule [Ag—O = 2.3133 (19) Å]. The pyridin-4-ide...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793704