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PubMed Central is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM).

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Nov 19, 2019 Bass, Willa S.; Oswald, Karl M.
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This article is from Advances in Cognitive Psychology , volume 10 . Abstract Proactive interferencebuilds up with exposure to multiple lists of similar items with a resulting reduction in recall. This study examined the effectiveness of using a proactive strategy of the method of loci to reduce proactive interference in a list recall paradigm of categorically similar words. While all participants reported using some form of strategy to recall list words, this study demonstrated that young...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116757
PubMed Central
Jun 26, 2019 Dreon, Marcos S.; Fernandez, Patricia E.; Gimeno, Eduardo J.; Heras, Horacio
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This article is from PLoS Neglected Tropical Diseases , volume 8 . Abstract Background: The spread of the invasive snail Pomacea canaliculata is expanding the rat lungworm disease beyond its native range. Their toxic eggs have virtually no predators and unusual defenses including a neurotoxic lectin and a proteinase inhibitor, presumably advertised by a warning coloration. We explored the effect of egg perivitellin fluid (PVF) ingestion on the rat small intestine morphology and physiology....
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063725
PubMed Central
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This article is from Frontiers in Psychology , volume 5 . Abstract There is a gap between proposed theoretical attachment theory frameworks, measures of attachment in the assessment phase and their relationship with changes in outcome after a psychodynamic oriented psychotherapy. Based on a clinical case study of a young woman with Panic Attack Disorder, this paper examined psychotherapy outcome findings comparing initial and post-treatment assessments, according to the mental functioning in S...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138773
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 69 . Abstract Practical chemistry courses at universities very frequently propose the synthesis and characterization of [Co(CO3)(NH3)4]NO3, but this goal is never achieved since students only obtain the hemihydrated form. The anhydrous form can be prepared, however, and its structure is presented here. Similar to the hemihydrate form, the anhydrous phase contains the CoIII ion in an octahedral O2N4...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772400
This article is from Social History of Medicine , volume 27 . Abstract Public fears of widespread venereal disease led in 1913 to the appointment of The Royal Commission on Venereal Diseases (RCVD). In 1916 its Final Report offered only a single cautious and somewhat imprecise summary statement about the likely prevalence of venereal diseases in England and Wales. Although the significance of contemporary attitudes to venereal disease has attracted a good deal of historiographic attention, no...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109696
PubMed Central
Jul 28, 2017 Galati, Giovanni; De Vincentis, Antonio; Vespasiani-Gentilucci, Umberto; Gallo, Paolo; Vincenti, Donatella; Solmone, Maria Carmela; Dell'Unto, Chiara; Picardi, Antonio
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This article is from BMC Gastroenterology , volume 14 . Abstract Background: Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitutions in the HBsAg sequences of the Hepatitis B Virus (HBV) genome able to explain an immunological escape variant.HBV genome has a very compact coding organization, with four partially overlapping open reading frames...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031327
PubMed Central
Nov 1, 2016 Joksic, Gordana; Spasojevic-Tisma, Vera; Antic, Ruza; Nilsson, Robert; Rutqvist, Lars E
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This article is from Harm Reduction Journal , volume 8 . Abstract Background: Epidemiological studies suggest that smokeless tobacco in the form of Swedish snus has been used by many smokers in Scandinavia to quit smoking, but the efficacy of snus has so far not been evaluated in controlled clinical trials. Methods: We conducted a randomized, double-blind, placebo-controlled, clinical trial aimed at assessing the efficacy of snus to help adult cigarette smokers in Serbia to substantially...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186733
PubMed Central
Jul 6, 2016 Ferguson, Lydia; Agoulnik, Alexander I.
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This article is from Frontiers in Endocrinology , volume 4 . Abstract The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by various genetic and developmental factors. While in some cases the association with genetic abnormalities and environmental causes has been shown, the etiology of cryptorchidism...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602796
PubMed Central
Jun 22, 2016 Tsang, Siu Wai; Zhang, Hongjie; Lin, Chengyuan; Xiao, Haitao; Wong, Michael; Shang, Hongcai; Yang, Zhi-Jun; Lu, Aiping; Yung, Ken Kin-Lam; Bian, Zhaoxiang
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This article is from PLoS ONE , volume 8 . Abstract Pancreatic fibrosis, a prominent histopathological feature of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma, is essentially a dynamic process that leads to irreversible scarring of parenchymal tissues of the pancreas. Though the exact mechanisms of its initiation and development are poorly understood, recent studies suggested that the activation of pancreatic stellate cells (PSCs) plays a critical role in eliciting such active...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849497
PubMed Central
Dec 4, 2015 Bauer, Michael; Fetherstonhaugh, Deirdre; Tarzia, Laura; Nay, Rhonda; Beattie, Elizabeth
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This article is from BMC Geriatrics , volume 14 . Abstract Background: Sexuality is a key component of quality of life and well-being and a need to express one’s sexuality continues into old age. Staff and families in residential aged care facilities often find expressions of sexuality by residents, particularly those living with dementia, challenging and facilities often struggle to address individuals’ needs in this area. This paper describes the development of an assessment tool which...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085662
PubMed Central
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This article is from BMC Health Services Research , volume 11 . Abstract Health planners and managers make decisions based on their appreciation of causality. Social audits question the assumptions behind this and try to improve quality of available evidence. The method has its origin in the follow-up of Bhopal survivors in the 1980s, where “cluster cohorts” tracked health events over time. In social audit, a representative panel of sentinel sites are the framework to follow the impact of...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397387
PubMed Central
Jun 23, 2015 Cheng, Yi-Shing Lisa; Rees, Terry; Wright, John
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This article is from Clinical and Translational Medicine , volume 3 . Abstract Using saliva for disease diagnostics and health surveillance is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945802
PubMed Central
Jun 23, 2015 Jurel, Sunit Kumar; Gupta, Durga Shanker; Singh, Raghuwar D.; Singh, Mrinalini; Srivastava, Shilpi
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This article is from Indian Journal of Human Genetics , volume 20 . Abstract Oral cancers have been one of the leading causes of deaths particularly in the developing countries. Prime reason for this high mortality and morbidity is attributed to the delay in diagnosis and prompt treatment. Relentless research in the field of oncology has led to the advent of novel procedures for the early detection of oral cancers. Molecular biology is highly promising in this regard. It is a procedure that...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065477
PubMed Central
May 2, 2015 Johnston, Rowena; Barre-Sinoussi, Francoise
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This article is from Journal of the International AIDS Society , volume 15 . Abstract Background: Antiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs. Discussion: Most efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients, with the notable exception of a stem cell transplant...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334674
PubMed Central
Dec 14, 2014 Pereira, Maite; Vieira, Neiva de Souza; Brandao, Eduardo da Rosa; Ruaro, Joao Afonso; Grignet, Rodrigo Juliano; Frez, Andersom Ricardo
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This article is from Acta Ortopedica Brasileira , volume 20 . Abstract The purpose of this study was to evaluate the existence of differences in the rehabilitation of patients after ACL reconstruction using bone-patellar tendon-bone graft and the four-strand semitendinosus and gracilis tendon grafts, through a literature revision. The researched databases were MEDLINE, EMBASE, LILACS, COCHRANE and PEDro. The inclusion criteria were published studies with methodology draw from randomized...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861958
PubMed Central
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This article is from BMC Pregnancy and Childbirth , volume 11 . Abstract Background: The inequity in emergency obstetric care access in Tanzania is unsatisfactory. Despite an existing national obstetric referral system, many birthing women bypass referring facilities and go directly to higher-level care centres. We wanted to compare Caesarean section (CS) rates among women formally referred to a tertiary care centre versus self-referred women, and to assess the effect of referral status on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160415
PubMed Central
- Kim, Hyungtae; Sung, Si Chan; Kim, Si-Ho; Chang, Yun Hee; Ahn, Hyo Yeong; Lee, Hyoung Doo
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This article is from The Korean Journal of Thoracic and Cardiovascular Surgery , volume 44 . Abstract Background: The intramural coronary artery has been known as a risk factor for early death after an arterial switch operation (ASO). We reviewed the morphological characteristics and evaluated the early and mid-term results of ASO for patients with an intramural coronary artery. Materials and Methods: From March 1994 to September 15th 2010, 158 patients underwent ASO at Dong-A and Pusan...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249286
PubMed Central
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This article is from BMC Family Practice , volume 13 . Abstract Background: Standing orders programs (SOPs) allow non-physician medical staff to assess eligibility and administer vaccines without a specific physician's order. SOPs increase vaccination rates but are underutilized. Method: In 2009, correlates of SOPs use for influenza vaccine and pneumococcal polysaccharide vaccination (PPV) were assessed in a nationally representative, stratified random sample of U.S. physicians (n = 880) in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324392
PubMed Central
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This article is from Molecular Pain , volume 8 . Abstract Background: Galanin is expressed in a small percentage of intact small diameter sensory neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of the dorsal horn of the spinal cord. The neuropeptide modulates nociception demonstrating dose-dependent pro- and anti-nociceptive actions in the naïve animal. Galanin also plays an important role in chronic pain, with the anti-nociceptive actions enhanced in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404965
PubMed Central
- Patil, Sandeep S; Gentschev, Ivaylo; Nolte, Ingo; Ogilvie, Gregory; Szalay, Aladar A
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This article is from Journal of Translational Medicine , volume 10 . Abstract Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed. Several oncolytic viruses including adenovirus strains, canine distemper virus and vaccinia virus strains have been used for canine cancer therapy in preclinical studies. However, in contrast to human studies, clinical trials with oncolytic viruses for canine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398296
PubMed Central
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This article is from Brazilian Journal of Microbiology , volume 43 . Abstract Cordyceps is a fastidious pathogenic fungus infecting insects, and recent years have witnessed rapid progress in its medical properties. In this study, a wild isolate, C. cicadae MP12, was characterized through in vitro cultivation and its nuclear small-subunit (SSU) ribosomal DNA (rDNA) data. In vitro culture of C. cicadae MP12 was established by growing its fruiting bodies in a solid matrix. C. cicadae MP12 was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768836
This article is from Addiction & Health , volume 5 . Abstract Background: Substance abuse is a social, and health problem in Middle Eastern countries such as Iran. One of its most devastating effects is domestic violence against children. This study examined the association between the history of parental substance abuse, and rate of child abuse in Ahvaz, Iran. Methods: This was a case-control study. The study population included all parents with high school children in Ahwaz within the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905474
PubMed Central
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This article is from The Indian Journal of Medical Research , volume 138 . Abstract Sialic acids (Sias) are nine-carbon keto sugars primarily present on the terminal residue of cell surface glycans. Sialic acid binding immunoglobulins (Ig)-like lectins (siglecs) are generally expressed on various immune cells. They selectively recognize different linkage-specific sialic acids and undertake a variety of cellular functions. Many pathogens either synthesize or acquire sialic acids from the host....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928697
PubMed Central
- Kapitaniak, Marcin; Lazarek, Mateusz; Nielaczny, Michal; Czolczynski, Krzysztof; Perlikowski, Przemyslaw; Kapitaniak, Tomasz
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This article is from Scientific Reports , volume 4 . Abstract Synchronization occurs widely in natural and technological world, but it has not been widely used to extend the life time of the desirable behavior of the coupled systems. Here we consider the globally coupled system consisting of n units and show that the initial synchronous state extends the lifetime of desired behavior of the coupled system in the case when the excitation of one or few units is suddenly (breakdown of energy...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955919
PubMed Central
- Morof, Diane F; Kerber, Kate; Tomczyk, Barbara; Lawn, Joy; Blanton, Curtis; Sami, Samira; Amsalu, Ribka
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This article is from Conflict and Health , volume 8 . Abstract Background: Over 40% of all deaths among children under 5 are neonatal deaths (0–28 days), and this proportion is increasing. In 2012, 2.9 million newborns died, with 99% occurring in low- and middle-income countries. Many of the countries with the highest neonatal mortality rates globally are currently or have recently been affected by complex humanitarian emergencies. Despite the global burden of neonatal morbidity and mortality...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057580
PubMed Central
- Lastoria, Joel Carlos; de Abreu, Marilda Aparecida Milanez Morgado
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This article is from Anais Brasileiros de Dermatologia , volume 89 . Abstract Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056695
PubMed Central
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This article is from Environmental Health , volume 13 . Abstract Background: There is a need to evaluate complex interaction effects on human health, such as those induced by mixtures of environmental contaminants. The usual approach is to formulate an additive statistical model and check for departures using product terms between the variables of interest. In this paper, we present an approach to search for interaction effects among several variables using boosted regression trees. Methods: We...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120739
PubMed Central
- Park, Seon-Young; Lim, Sung-Ook; Ki, Ho-Seok; Jun, Chung-Hwan; Park, Chang-Hwan; Kim, Hyun-Soo; Choi, Sung-Kyu; Rew, Jong-Sun
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This article is from Gut and Liver , volume 8 . Abstract Background/Aims: Synchronous/metachronous gastric epithelial neoplasias (GENs) in the remaining lesion can develop at sites other than the site of endoscopic resection. In the present study, we aimed to investigate the predictive value of serum pepsinogen for detecting multiple GENs in patients who underwent endoscopic resection. Methods: In total, 228 patients with GEN who underwent endoscopic resection and blood collection for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026645
PubMed Central
- Chubukov, Victor; Uhr, Markus; Le Chat, Ludovic; Kleijn, Roelco J; Jules, Matthieu; Link, Hannes; Aymerich, Stephane; Stelling, Jorg; Sauer, Uwe
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This article is from Molecular Systems Biology , volume 9 . Abstract Regulation of enzyme expression is one key mechanism by which cells control their metabolic programs. In this work, a quantitative analysis of metabolism in a model bacterium under different conditions shows that expression alone cannot explain the majority of the observed metabolic changes.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039378
PubMed Central
- Honeyman, Alexander; Browning, James; Hertzberg, Jean; Schroeder, Joyce D; Stalder, Aurelien F; Kern Buckner, J; Fenster, Brett
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042372
PubMed Central
- Chen, Qi; Sjolander, Arvid; Runeson, Bo; D'Onofrio, Brian M; Lichtenstein, Paul; Larsson, Henrik
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This article is from BMJ : British Medical Journal , volume 348 . Abstract Objective To investigate the association between drug treatment for attention-deficit/hyperactivity disorder (ADHD) and risk of concomitant suicidal behaviour among patients with ADHD.Design Register based longitudinal study using within patient design.Setting Linkage of multiple national registers in Sweden.Participants 37 936 patients with ADHD born between 1960 and 1996 and followed from 2006 to 2009 for treatment...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062356
PubMed Central
- Brunet-LLobet, Lluis; Miranda-Rius, Jaume; Lahor-Soler, Eduard; Mrina, Ombeni; Nadal, Alfons
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This article is from The Open Dentistry Journal , volume 8 . Abstract Pyogenic granuloma is defined as a benign neoplasm of vascular phenotype. This case describes the clinical and histopathological features of a gigantic mucogingival pyogenic granuloma, in a 14-year-old healthy black boy. This exophytic gray-purple mass, related to a toothpick injury, had more than twelve-month evolution on the anterior mandible involving lingual area besides to the floor of the mouth pressing the right...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076627
PubMed Central
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This article is from Journal of the advanced practitioner in oncology , volume 3 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093341
PubMed Central
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This article is from Journal of Contemporary Brachytherapy , volume 6 . Abstract Magnetic resonance imaging (MRI) represents the reference imaging modality for image guided adaptive brachytherapy (IGABT) of cervix cancer. Accurate interpretation of pre-treatment MRI is required for proper understanding of the tumor extent and topography at IGABT. Planning and optimal timing of the application begins already before treatment, and may need to be adapted during external beam irradiation (EBRT)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105647
PubMed Central
- Li, Jia; Tang, Yaohui; Wang, Yongting; Tang, Rongbiao; Jiang, Weifang; Yang, Guo-Yuan; Gao, Wei-Qiang
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This article is from Stem Cell Reports , volume 3 . Abstract The concept of the “neurovascular unit,” emphasizing the interactions between neural and vascular components in the brain, raised the notion that neural progenitor cell (NPC) transplantation therapy aimed at neural repair may be insufficient for the treatment of ischemic stroke. Here, we demonstrate that enhanced neurovascular recovery via cotransplantation of NPCs and embryonic stem cell-derived vascular progenitor cells (VPCs)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110773
This article is from Archives of Public Health , volume 72 . Abstract Background: Information is needed at all stages of the policy making process. The Health Survey for England (HSE) is an annual cross-sectional health examination survey of the non-institutionalised general population in England. It was originally set up to inform national policy making and monitoring by the Department of Health. This paper examines how the nurse collected physical and biological measurement data from the HSE...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128608
PubMed Central
- Levaggi, Rosella; Montoya, Isaac; Ivanitskaya, Lana; Liang, Bryan A; Mackey, Tim K
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This article is from Journal of Medical Internet Research , volume 14 . Abstract Background: Unprecedented drug shortages announced by the US Food and Drug Administration (FDA) have severely affected therapeutic access, patient safety, and public health. With continued shortages, patients may seek drugs online. Objective: To assess the prevalence of online marketing for current FDA shortage drugs and potential patient safety risks. Methods: We performed a descriptive study of the prevalence of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374535
PubMed Central
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This article is from Journal of Korean Neurosurgical Society , volume 51 . Abstract Objective: Traumatic epidural hematomas (EDHs) in children are a relatively unusual occurrence. The cause and outcome vary depending on period and region of study. The aims of this analysis were to review the cause and outcome of pediatric EDHs nowadays and to discuss outcome-related variables in a large consecutive series of surgically treated EDH in children. Methods: This is a retrospective review of 29...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377878
PubMed Central
- Casa, Roberto Della; Ungaro, Carla; Acampora, Emma; Pignata, Claudio; Vajro, Pietro; Salerno, Mariacarolina; Santamaria, Francesca; Parenti, Giancarlo
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This article is from Italian Journal of Pediatrics , volume 38 . Abstract We report on a female patient affected by galactosemia in whom the diagnosis was obscured by the concomitant presence of manifestations suggesting a cow’s milk intolerance. This case exemplifies the problems in reaching a correct diagnosis in patients with metabolic diseases.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462687
PubMed Central
- Donnell, Deborah J; Hall, H Irene; Gamble, Theresa; Beauchamp, Geetha; Griffin, Angelique B; Torian, Lucia V; Branson, Bernard; El-Sadr, Wafaa M
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This article is from The Open AIDS Journal , volume 6 . Abstract Introduction:: Modeling studies suggest intensified HIV testing, linkage-to-care and antiretroviral treatment to achieve viral suppression may reduce HIV transmission and lead to control of the epidemic. To study implementation of strategy, population-level data are needed to monitor outcomes of these interventions. US HIV surveillance systems are a potential source of these data. Methods:: HPTN065 (TLC-Plus) Study is evaluating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462339
PubMed Central
- Bae, Song-I; Yeon, Jong Eun; Lee, Jong Mee; Kim, Ji Hoon; Lee, Hyun Jung; Lee, Sun Jae; Suh, Sang Jun; Yoon, Eileen L.; Kim, Hae Rim; Byun, Kwan Soo; Seo, Tae-Seok
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This article is from Clinical and molecular hepatology , volume 18 . Abstract Necrotizing pancreatitis is one of the rare complications of transcatheter arterial chemoembolization (TACE). Necrotizing pancreatitis after TACE may result from the development of ischemia caused by regurgitation of embolic materials into the vessels supplying the pancreas. We report a case of post-TACE necrotizing pancreatitis with abscess formation in a patient with hepatocellular carcinoma. The patient had...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467437
PubMed Central
- Kim, Seok-Jun; Shin, Ji-Young; Lee, Kang-Duck; Bae, Young-Ki; Sung, Ki Woong; Nam, Seok Jin; Chun, Kyung-Hee
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This article is from Breast Cancer Research : BCR , volume 14 . Abstract Introduction: C-C chemokine receptor type 7 (CCR7) plays an important role in chemotactic and metastatic responses in various cancers, including breast cancer. In the present study, the authors demonstrated that microRNA (miRNA) let-7a downregulates CCR7 expression and directly influences the migration and invasion of breast cancer cells. Methods: The expression of CCR7, its ligand CCL21, and let-7a was detected in breast...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496131
PubMed Central
- Attia, Walid; Orief, Tamer; Almusrea, Khaled; Alfawareh, Mohamed; Soualmi, Lahbib; Orz, Yasser
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This article is from Asian Spine Journal , volume 6 . Abstract Study Design: A retrospective analysis of 7 patients with traumatic rotatory atlanto-axial subluxation. Overview of Literature: Cases of traumatic rotatory atlantoaxial subluxation in children are difficult to be stabilized. Surgical challenges include: narrow pedicles, medial vertebral arteries, vertebral artery anomalies, fractured pedicles or lateral masses, and fixed subluxation. The use of O-arm and computer-assisted navigation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530701
This article is from Nucleic Acids Research , volume 41 . Abstract The RNA exosome is responsible for a wide variety of RNA processing and degradation reactions. The activity and specificity of the RNA exosome is thought to be controlled by a number of cofactors. Mtr4 is an essential RNA-dependent adenosine triphosphatase that is required for all of the nuclear functions of the RNA exosome. The crystal structure of Mtr4 uncovered a domain that is conserved in the RNA exosome cofactors Mtr4 and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592479
PubMed Central
- Xi, Chunhua; Zhu, Youling; Zhu, Chunyan; Song, Daohui; Wang, Yongguang; Wang, Kai
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This article is from Behavioral and Brain Functions : BBF , volume 9 . Abstract Background: Previous studies have indicated that the temporal lobe is involved in theory of mind (ToM). However, little attention has been paid to ToM in patients with cerebral infarction. In this study, we investigated the ability of ToM in patients with temporal lobe cerebral infarction (TLCI) using a variety of tests. Methods: In the study, 19 patients with TLCI and 20 healthy controls (HC) were examined using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646669
PubMed Central
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This article is from Evolutionary Applications , volume 6 . Abstract A number of theoretical models, experimental studies and time-series studies of wild fish have explored the presence and magnitude of fisheries-induced evolution (FIE). While most studies agree that FIE is likely to be happening in many fished stocks, there are disagreements about its rates and implications for stock viability. To address these disagreements in a quantitative manner, we conducted a meta-analysis of FIE rates...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684740
PubMed Central
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This article is from BMJ Open , volume 3 . Abstract Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Chinese herbal medicine has been used for the treatment of PCOS, but the evidence for its efficacy and safety is minimal. Tanshinones are a class of bioactive molecules isolated from Salvia miltiorrhiza, a commonly used herb in Traditional Chinese Medicine. This study aims to evaluate the efficacy of tanshinones on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808776
This article is from Journal of Neuroinflammation , volume 10 . Abstract Background: Induction of pro-inflammatory factors is one of the characteristics of microglia activation and can be regulated by numerous active components of Chinese traditional herbs. Suppression of pro-inflammatory factors is beneficial to alleviate microglia-mediated cell injury. The present study aims to investigate the effect and possible mechanism of 2,3,4’,5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG) on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854509
PubMed Central
- Damiani, Gianfranco; Federico, Bruno; Anselmi, Angela; Bianchi, Caterina Bianca Neve Aurora; Silvestrini, Giulia; Iodice, Lanfranco; Navarra, Pierluigi; Da Cas, Roberto; Raschetti, Roberto; Ricciardi, Walter
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This article is from BMC Health Services Research , volume 14 . Abstract Background: Statins are among the most commonly prescribed drugs worldwide in the prevention of cardiovascular diseases and their effectiveness is largely acknowledged. The consumption of statins increased four-fold during the 2000–2010 decade in Italy and national and regional control policies were developed. Restrictions to reimbursement were fixed at the national level, whereas co-payment was introduced in some, but...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893493
PubMed Central
- Southworth, Lizabeth O.; Holick, Michael F.; Chen, Tai C.; Kunz, Thomas H.
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This article is from Dermato-endocrinology , volume 5 . Abstract It has long been accepted that most vertebrate animals meet their vitamin D requirements from exposure of skin to UV-B (UV-B) radiation. Many factors affect this endogenous synthesis of vitamin D, including season, latitude, time of day, age, presence of hair, and degree of skin pigmentation. Most bats roost in dark places by day and forage at night, and thus have little or no potential for sunlight exposure. Notwithstanding, some...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897589
This article is from PLoS ONE , volume 9 . Abstract Colony-stimulating factor 2 (CSF2), also known as granulocyte macrophage colony-stimulating factor, facilitates mammalian embryonic development and implantation. However, biological functions and regulatory mechanisms of action of porcine endometrial CSF2 in peri-implantation events have not been elucidated. The aim of present study was to determine changes in cellular activities induced by CSFs and to access CSF2-induced intracellular...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919804
PubMed Central
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This article is from International Journal of Environmental Research and Public Health , volume 11 . Abstract Smoking-related diseases can be attributed to the inhalation of many different toxins, including heavy metals, which have a host of detrimental health effects. The current study reports the levels of arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), and lead (Pb) in cigarettes obtained from adult smokers participating in the 2009 wave of the ITC United States Survey (N = 320). The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924441
PubMed Central
- TAKASHIMA, Yasuhiro; TAKASU, Masaki; YANAGIMOTO, Isao; HATTORI, Naoki; BATANOVA, Tatiana; NISHIKAWA, Yoshifumi; KITOH, Katsuya
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This article is from The Journal of Veterinary Medical Science , volume 75 . Abstract Bovine abortion caused by the Apicomplexan parasite Neospora caninum is a major economic problem in the livestock industry worldwide. Our study measured the prevalence and temporal changes in levels of antibodies specific for two N. caninum derived antigens, NcSAG1 and NcGRA7, to determine an appropriate strategy for serodiagnosis. Using an enzyme-linked immunosorbent assay (ELISA), blood samples showed that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942981
This article is from Frontiers in Psychology , volume 5 . Abstract In three experiments we manipulated the resolution of novel complex objects in visual working memory (WM) by changing task demands. Previous studies that investigated the trade-off between quantity and resolution in visual WM yielded mixed results for simple familiar stimuli. We used the contralateral delay activity as an electrophysiological marker to directly track the deployment of visual WM resources while participants...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975110
PubMed Central
- Valencia Pacheco, Guillermo J; Pinzon Herrera, Francisc; Cruz Lopez, Juan J; Vera Gamboa, Ligia del Carmen; Pavia Ruiz, Norma; Santos Rivero, Adrian; Sanchez Lugo, Saulo; Puerto, Fernando
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This article is from Colombia Médica : CM , volume 44 . Abstract Introduction:: TLR´s play a role in host defense in HIV infection recognizing the viral DNA or RNA. Their activation induces a signaling pathway that includes the proteins MyD88, IRAK4, TRAF6 and the transcription factor NF-kBp65. Objective:: To determine the expression of TLR7, TLR8 and TLR9, and activation of its signaling pathway in monocytes from patients infected with HIV. Methods. Expression of TLR7, TLR8 and TLR9 was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002021
PubMed Central
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This article is from PLoS ONE , volume 9 . Abstract Through the descriptive and rheological characterization of worm-like micelles formed by N-hexadecyl-N-methylpyrrolidinium bromide and sodium laurate, the formation and properties of the worm-like micelles were affected by the concentrations of sodium laurate and temperature. Additionally, cryogenic transmission electron microscopy images further validated the formation of worm-like micelles.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097072
PubMed Central
- M'Dahoma, Said; Bourgoin, Sylvie; Kayser, Valerie; Barthelemy, Sandrine; Chevarin, Caroline; Chali, Farah; Orsal, Didier; Hamon, Michel
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This article is from PLoS ONE , volume 9 . Abstract In humans, spinal cord lesions induce not only major motor and neurovegetative deficits but also severe neuropathic pain which is mostly resistant to classical analgesics. Better treatments can be expected from precise characterization of underlying physiopathological mechanisms. This led us to thoroughly investigate (i) mechanical and thermal sensory alterations, (ii) responses to acute treatments with drugs having patent or potential...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096923
PubMed Central
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This article is from PLoS Computational Biology , volume 10 . Abstract Neuronal activity in cortex is variable both spontaneously and during stimulation, and it has the remarkable property that it is Poisson-like over broad ranges of firing rates covering from virtually zero to hundreds of spikes per second. The mechanisms underlying cortical-like spiking variability over such a broad continuum of rates are currently unknown. We show that neuronal networks endowed with probabilistic synaptic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102400
This article is from PLoS ONE , volume 9 . Abstract Clinical trials on fracture repair have challenged the effectiveness of bone morphogenetic proteins (BMPs) but suggest that delivery of mesenchymal stem cells (MSCs) might be beneficial. It has also been reported that BMPs could not increase mineralization in several MSCs populations, which adds ambiguity to the use of BMPs. However, an exogenous supply of MSCs combined with vascular endothelial growth factor (VEGF) and BMPs is reported to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105618
PubMed Central
- Karthikeyan, G; Paul-Satyaseela, Maneesh; Dhatchana Moorthy, Nachiappan; Gopalaswamy, Radha; Narayanan, Shridhar
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This article is from F1000Research , volume 2 . Abstract Candida albicans is a mucosal commensal organism capable of causing superficial (oral and vaginal thrush) infections in immune normal hosts, but is a major pathogen causing systemic and mucosal infections in immunocompromised individuals. Azoles have been very effective anti-fungal agents and the mainstay in treating opportunistic mold and yeast infections. Azole resistant strains have emerged compromising the utility of this class of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111124
PubMed Central
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This article is from Sexually Transmitted Infections , volume 86 . Abstract Background: Documentation of the long-term impact of supportive supervision using a monitoring tool in STI intervention with sex workers, men who have sex with men and injection-drug users is limited. The authors report methods and results of continued quality monitoring in a large-scale STI services provided as a part of a broader HIV-prevention package in six Indian states under Avahan, the India AIDS Initiative....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252614
PubMed Central
- Christina, Ambrose; Christapher, Varghese; Bhore, Subhash J.
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This article is from Pharmacognosy Reviews , volume 7 . Abstract World human population is increasing with an alarming rate; and a variety of new types of health issues are popping up. For instance, increase in number of drug-resistant bacteria is a cause of concern. Research on antibiotics and other microbial natural products is pivotal in the global fight against the growing problem of antibiotic resistance. It is necessary to find new antibiotics to tackle this problem. The use of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731874
PubMed Central
- Wang, Tian; Pelletier, Matthew H; Bertollo, Nicky; Crosky, Alan; Walsh, William R
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This article is from The Open Orthopaedics Journal , volume 7 . Abstract Background:: Shape-closed cemented implants rely on a stronger bond and have displayed inferior clinical outcomes when compared to force-closed designs. Implant contamination such as saline, bone marrow and blood prior to cement application has the potential to affect the cement-implant bond. The consequences of implant contamination were investigated in this study. Methods:: Fifty Titanium alloy (Ti-6Al-4V) dowels were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722542
PubMed Central
- Kim, Taehwan; Shin, Ji Hoon; Kim, Jinoo; Yoon, Hyun-Ki; Ko, Gi-Young; Gwon, Dong-Il; Yang, Heechul; Sung, Kyu-Bo
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This article is from Yonsei Medical Journal , volume 55 . Abstract Purpose: To evaluate the technical feasibility and clinical outcome of bilateral uterine artery embolization (UAE) as a first-line therapeutic option for bleeding uterine arteriovenous malformation (AVM). Materials and Methods: Between 2002 and 2012, 19 patients were diagnosed with acquired uterine AVM clinically and through imaging studies. The clinical characteristics, angiographic features, technical success rate of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936651
This article is from BMC Biotechnology , volume 13 . Abstract Background: Halotolerant bacteria are excellent sources for selecting novel enzymes. Being intrinsically stable and active under high salinities, enzymes from these prokaryotes have evolved to function optimally under extreme conditions, making them robust biocatalysts with potential applications in harsh industrial processes. Results: A halotolerant strain LY19 showing lipolytic activity was isolated from saline soil of Yuncheng...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029450
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title mol­ecule, C18H12O4, the phenyl ring is twisted by 23.2 (1)° from the mean plane of the chromene system. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds link mol­ecules into zigzag chains extending in the [010] direction. An intra­molecular O—H⋯O hydrogen bond is also present.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213638
PubMed Central
- Zaidi, Tanweer; Reidy, Thomas; D'Ortona, Samantha; Fichorova, Raina; Pier, Gerald; Gadjeva, Mihaela
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This article is from Scientific Reports , volume 1 . Abstract Eye trauma and contact lens wear are the main factors that predispose to the development of infectious keratitis. The existing therapies fail to control the inflammation-driven tissue damage that occurs during Pseudomonas aeruginosa infection. Antibiotic treatment reduces bacterial burdens, but better interventions are needed to alleviate tissue damage resulting from local inflammation. We have previously documented that inhibition...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216545
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title compound, [Zn(CH3CO2)2(C8H7N3)]n, the ZnII atom is coordinated by one N atom from a 4-(1H-pyrazol-3-yl)pyridine ligand and three O atoms from two bridging and one terminal acetate ligands, forming a distorted tetra­hedral geometry. The bridging acetate ligands link the Zn atoms into a chain along [001]. N—H⋯O hydrogen bonds and π–π inter­actions between the pyridine and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246942
PubMed Central
- Browne, G; Nesbitt, H; Ming, L; Stein, G S; Lian, J B; McKeown, S R; Worthington, J
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This article is from British Journal of Cancer , volume 107 . Abstract Background:: We have previously shown that hypoxia selects for more invasive, apoptosis-resistant LNCaP prostate cancer cells, with upregulation of the osteogenic transcription factor RUNX2 and the anti-apoptotic factor Bcl-2 detected in the hypoxia-selected cells. Following this observation, we questioned through what biological mechanism this occurs. Methods:: We examined the effect of hypoxia on RUNX2 expression and the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493869
PubMed Central
- Sagar, Sunil; Kaur, Mandeep; Radovanovic, Aleksandar; Bajic, Vladimir B
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This article is from Journal of Cheminformatics , volume 5 . Abstract Background: Natural products are considered a rich source of new chemical structures that may lead to the therapeutic agents in all major disease areas. About 50% of the drugs introduced in the market in the last 20 years were natural products/derivatives or natural products mimics, which clearly shows the influence of natural products in drug discovery. Results: In an effort to further support the research in this field, we...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608955
PubMed Central
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This article is from Iranian Journal of Pediatrics , volume 23 . Abstract Objective: There are different methods for measuring bilirubin concentration; however, it is quite important for practitioners to know which method should be used in certain clinical situations. The present prospective study aimed to compare three different methods for measuring neonatal bilirubin concentrations. Methods: All full term neonates who were either brought into emergency departments or admitted to the neonatal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684480
PubMed Central
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This article is from Oncology Letters , volume 7 . Abstract Spontaneous regression of cancer is a partial or complete disappearance of malignant tumor without specific treatment. Spontaneous regression of hepatocellular carcinoma (HCC) is a rare condition, and the mechanism underlying it is unclear. This report presents a rare case of spontaneous complete regression of HCC, as revealed by tumor markers and imaging studies. A 64-year-old Korean male patient with hepatitis B virus-associated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961391
PubMed Central
- Choi, Kwan-Woo; Woo, Jong-Min; Kim, Youl-Ri; Lee, Seung-Hwan; Lee, Sang-Yeol; Kim, Eui-Jung; Chung, Sang-Keun; Kang, Eun-Ho; Lee, Jae-Hon; Yu, Bum-Hee
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This article is from Clinical Psychopharmacology and Neuroscience , volume 10 . Abstract Objective: Panic disorder is characterized by recurrent panic attacks, persistent concerns about additional attacks, and worry about the implications of the attack or significant changes in behavior related to the attacks. We examined the efficacy of 24-week naturalistic, open-label escitalopram treatment in terms of the response and remission rates and functional disability in 119 adult Korean patients...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569153
This article is from Journal of Physical Therapy Science , volume 26 . Abstract [Purpose] This study aimed to validate the postural control characteristics of individuals with a history of ankle sprain during single leg standing by using a gravicorder and head and foot accelerometry. [Subjects] Twenty subjects with and 23 subjects without a history of ankle sprain (sprain and control groups, respectively) participated. [Methods] The anteroposterior, mediolateral, and total path lengths, as well...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976024
PubMed Central
- Phan, Hoang Trong; Hause, Bettina; Hause, Gerd; Arcalis, Elsa; Stoger, Eva; Maresch, Daniel; Altmann, Friedrich; Joensuu, Jussi; Conrad, Udo
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This article is from PLoS ONE , volume 9 . Abstract Fusion protein strategies are useful tools to enhance expression and to support the development of purification technologies. The capacity of fusion protein strategies to enhance expression was explored in tobacco leaves and seeds. C-terminal fusion of elastin-like polypeptides (ELP) to influenza hemagglutinin under the control of either the constitutive CaMV 35S or the seed-specific USP promoter resulted in increased accumulation in both...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051685