the response in all may be the conversion of a naturally occurring britain -- brain protein, tau a the law high hyperphosphorylated form that is toxic to nerve cells and their connections. while our research shows that this abnormal accumulation of tau is widespread throughout the individuals -- throughout the brains of individuals with cte, is immediately concentrated in medial temporal lobe structures and thus leads to a clinical triad of recent memory failure, and extreme degrees dementia, depression, and lack of impulse control. all cte has been mostly reported in the world's literature in boxers, and for the longest period of time, over 80 years, nearly 20 cases and all i several years have been reported from individuals that formerly played in the nfl. in our group, we've recently reported a case of cte in a man who only played football at the college level. obviously some of these individuals have entered the nfl already within said that if not full blown cte. but the -- with a incipient, if not full-blown, cte. now that we are aggressively looking for cte, there has been a 40%