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2014 Kallis, Aristotle A., 1970- author
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Includes bibliographical references (pages 276-305) and index
Topics: der, die, und, den, von, das, des, dem, sich, mit, und die, mit dem, von den, von der, auf die, und...
Source: http://books.google.com/books?id=8G0-AQAAMAAJ&hl=&source=gbs_api
PubMed Central
2013 Malenfant, Simon; Neyron, Anne-Sophie; Paulin, Roxane; Potus, Francois; Meloche, Jolyane; Provencher, Steeve; Bonnet, Sebastien
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This article is from Pulmonary Circulation , volume 3 . Abstract Pulmonary arterial hypertension (PAH) is a unique disease. Properly speaking, it is not a disease of the lung. It can be seen more as a microvascular disease occurring mainly in the lungs and affecting the heart. At the cellular level, the PAH paradigm is characterized by inflammation, vascular tone imbalance, pulmonary arterial smooth muscle cell proliferation and resistance to apoptosis and the presence of in situ thrombosis. At...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757823
PubMed Central
2013 Brunner, Nathan W.; Ramachandran, Krithika; Kudelko, Kristina T.; Sung, Yon K.; Spiekerkoetter, Edda; Yang, Phillip C.; Zamanian, Roham T.; Perez, Vinicio de Jesus
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This article is from Pulmonary Circulation , volume 3 . Abstract Chronic constrictive pericarditis (CP) is a relatively rare condition in which the pericardium becomes fibrotic and noncompliant, eventually resulting in heart failure due to impaired ventricular filling. The only curative treatment is pericardiectomy. Classically, CP does not usually cause severe pulmonary hypertension. When attempting to differentiate CP from restrictive cardiomyopathy, the presence of severely elevated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757841
PubMed Central
2013 Spruijt, Onno A.; Bogaard, Harm-Jan; Vonk-Noordegraaf, Anton
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This article is from Pulmonary Circulation , volume 3 . Abstract A congenital extrahepatic portosystemic venous shunt (CEPVS), also known as an Abernethy malformation, is a rare cause of pulmonary arterial hypertension (PAH). In this case series, we describe three male patients of 30, 23, and 27 years of age with PAH due to a CEPVS. In all three patients, a right heart catheterization revealed a high cardiac output. The aim of this case series is to make pulmonary hypertension physicians aware...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757842
PubMed Central
2013 Guglin, Maya; Mehra, Shabnam; Mason, Thomas J.
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This article is from Pulmonary Circulation , volume 3 . Abstract Multiple drugs are used for reversibility testing of pulmonary hypertension (PH) in advanced heart failure (HF), especially in the process of heart transplant evaluation. Effects of these drugs were never systematically compared. The aim of this meta-analysis was to compare hemodynamic effects of different drugs. We identified 20 prospective studies reporting hemodynamic variables before and after acute pharmacologic testing for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757836
PubMed Central
2013 Lange, Tobias J.; Dornia, Christian; Stiefel, Jaroslava; Stroszczynski, Christian; Arzt, Michael; Pfeifer, Michael; Hamer, Okka W.
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This article is from Pulmonary Circulation , volume 3 . Abstract Pulmonary hypertension (PH) often leads to dilatation of the pulmonary artery (PA), which can be measured on chest computed tomography (CT). While the predictive capability of PA dilatation is useful to distinguish PH (mean PA pressure ≥25 mmHg) from normal (mean PA pressure ≤ 20 mmHg), CT characteristics of borderline PH (mean PA pressure 21-24 mmHg) have not been described. We aimed to investigate whether patients with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757831
PubMed Central
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This article is from Pulmonary Circulation , volume 3 . Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is responsible for significant levels of morbidity and mortality. The estimated cumulative incidence of CTEPH is 2-4% among patients presenting with acute pulmonary thromboembolism. Currently, at the time of CTEPH diagnosis, 37.9% of the patients in an international registry were receiving at least one pulmonary arterial hypertension (PAH)-targeted therapy. Advanced medical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757827
PubMed Central
2013 Strange, Geoff; Gabbay, Eli; Kermeen, Fiona; Williams, Trevor; Carrington, Melinda; Stewart, Simon; Keogh, Anne
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This article is from Pulmonary Circulation , volume 3 . Abstract Survival rates for patients with idiopathic pulmonary arterial hypertension (IPAH) have improved with the introduction of PAH-specific therapies. However, the time between patient-reported onset of symptoms and a definitive diagnosis of IPAH is consistently delayed. We conducted a retrospective, multi-center, descriptive investigation in order to (a) understand what factors contribute to persistent diagnostic delays, and (b)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641745
PubMed Central
2013 Malhotra, Rajeev; Paskin-Flerlage, Samuel; Zamanian, Roham T.; Zimmerman, Patrick; Schmidt, Jonathan W.; Deng, Donna Y.; Southwood, Mark; Spencer, Robert; Lai, Carol S.; Parker, William; Channick, Richard N.; Morrell, Nicholas W.; Elliott, C. Gregory; Yu, Paul B.
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This article is from Pulmonary Circulation , volume 3 . Abstract The diagnosis of pulmonary arterial hypertension (PAH) is frequently delayed. We hypothesized that circulating angiogenic modulatory protein levels might correspond with vascular remodeling activity and serve as sensitive biomarkers of PAH. Levels of soluble endoglin (sEng), soluble vascular endothelial growth factor receptor-1 (sVEGFR1), N-terminal brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and other...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757832
PubMed Central
2013 Nair, Krishna Kumar Mohanan; Pillai, Harikrishnan Sivadasan; Titus, Thomas; Varaparambil, Ajitkumar; Sivasankaran, Sivasubramonian; Krishnamoorthy, Kavassery Mahadevan; Namboodiri, Narayanan; Sasidharan, Bijulal; Thajudeen, Anees; Ganapathy, Sanjay; Tharakan, Jaganmohan
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This article is from Pulmonary Circulation , volume 3 . Abstract Pulmonary artery pressure (PAP) is known to regress after successful balloon mitral valvotomy (BMV). Data of persistent pulmonary artery hypertension (PPAH) following BMV is scarce. We analyzed the clinical, echocardiographic, and hemodynamic data of 701 consecutive patients who have undergone successful BMV in our institute from 1997 to 2003. Data of 287 patients who had PPAH (defined by pulmonary artery systolic pressure [PASP]...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757839
PubMed Central
2013 Rothman, Abraham; Davidson, Stephanie; Wiencek, Robert G.; Evans, William N.; Restrepo, Humberto; Sarukhanov, Valeri; Ruoslahti, Erkki; Williams, Roy; Mann, David
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This article is from Pulmonary Circulation , volume 3 . Abstract The molecular mechanisms of pulmonary arterial hypertension (PAH) remain ill-defined. The aims of this study were to obtain sequential endoarterial biopsy samples in a surgical porcine model of PAH and assess changes in histology and mRNA expression during the disease progression. Differentially expressed genes were then analyzed as potential pharmacological targets. Four Yucatan micro-pigs underwent surgical anastomosis of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641740
PubMed Central
2013 Usatyuk, Peter V.; Kotha, Sainath R.; Parinandi, Narasimham L.; Natarajan, Viswanathan
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This article is from Pulmonary Circulation , volume 3 . Abstract Reactive oxygen species (ROS) have emerged as critical players in the pathophysiology of pulmonary disorders and diseases. Earlier, we have demonstrated that ROS stimulate lung endothelial cell (EC) phospholipase D (PLD) that generates phosphatidic acid (PA), a second messenger involved in signal transduction. In the current study, we investigated the role of PLD signaling in the ROS-induced lung vascular EC barrier dysfunction....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641713
This article is from Pulmonary Circulation , volume 3 . Abstract Pulmonary hypertension is a prevalent complication of chronic obstructive pulmonary disease (COPD) that is associated with poor prognosis. Although pulmonary hypertension is usually diagnosed in patients with advanced disease, changes in pulmonary vessels are already apparent at early disease stages, and in smokers without airflow obstruction. Changes in pulmonary vessels include intimal hyperplasia, resulting from proliferating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641725
PubMed Central
2013 Renard, Sebastien; Paulin, Roxane; Breuils-Bonnet, Sandra; Simard, Serge; Pibarot, Philippe; Bonnet, Sebastien; Provencher, Steeve
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This article is from Pulmonary Circulation , volume 3 . Abstract Provirus integration site for Moloney murine leukemia virus (Pim-1) is an oncoprotein overexpressed in lungs from pulmonary arterial hypertension (PAH) patients and involved in cell proliferation via the activation of the NFAT/STAT3 signaling pathway. We hypothesized that Pim-1 plasma levels would predict the presence of PAH and correlate with disease severity. Pim-1 plasma levels were measured at the time of catheterization in 49...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641743
PubMed Central
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This article is from Pulmonary Circulation , volume 3 . Abstract Many patients with sulfur mustard (SM) exposure present dyspnea in exertion while they have a normal pulmonary function test (PFT) and imaging. The cardiopulmonary exercise test (CPET) has been used for evaluation of dyspnea in exertion among patients with different pulmonary disorders focusing on assessing gas exchange. We evaluated subjects who were exposed to SM with normal imaging compared to the controls with CPET. A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757837
PubMed Central
2013 Adatia, Ian; Haworth, Sheila G.; Wegner, Max; Barst, Robyn J.; Ivy, Dunbar; Stenmark, Kurt R.; Karkowsky, Abraham; Rosenzweig, Erika; Aguilar, Christopher
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This article is from Pulmonary Circulation , volume 3 . Abstract Drug trials in neonates and children with pulmonary hypertensive vascular disease pose unique but not insurmountable challenges. Childhood is defined by growth and development. Both may influence disease and outcomes of drug trials. The developing pulmonary vascular bed and airways may be subjected to maldevelopment, maladaptation, growth arrest, or dysregulation that influence the disease phenotype. Drug therapy is influenced by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641736
PubMed Central
2013 Yoo, Hae Young; Zeifman, Amy; Ko, Eun A.; Smith, Kimberly A.; Chen, Jiwang; Machado, Roberto F.; Zhao, You-Yang; Minshall, Richard D.; Yuan, Jason X.-J.
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This article is from Pulmonary Circulation , volume 3 . Abstract Hypoxic pulmonary vasoconstriction (HPV) is a compensatory physiological mechanism in the lung that optimizes the matching of ventilation to perfusion and thereby maximizes gas exchange. Historically, HPV has been primarily studied in isolated perfused/ventilated lungs; however, the results of these studies have varied greatly due to different experimental conditions and species. Therefore, in the present study, we utilized the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757835
PubMed Central
2013 Glynos, Constantinos; Athanasiou, Chariclea; Kotanidou, Anastasia; Korovesi, Ioanna; Kaziani, Katerina; Livaditi, Olga; Dimopoulou, Ioanna; Maniatis, Nikolaos A.; Tsangaris, Iraklis; Roussos, Charis; Armaganidis, Apostolos; Orfanos, Stylianos E.
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This article is from Pulmonary Circulation , volume 3 . Abstract Pulmonary endothelium is a major metabolic organ affecting pulmonary and systemic vascular homeostasis. Brain death (BD)-induced physiologic and metabolic derangements in donors’ lungs, in the absence of overt lung pathology, may cause pulmonary dysfunction and compromise post-transplant graft function. To explore the impact of BD on pulmonary endothelium, we estimated pulmonary capillary endothelium-bound (PCEB)-angiotensin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757838
PubMed Central
2013 Kingrey, John F.; Panos, Ralph J.; Ying, Jun; Meganathan, Karthikeyan; Vandivier, Robin; Elwing, Jean M.
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This article is from Pulmonary Circulation , volume 3 . Abstract PH occurs alone or in association with many disorders. Many patients with transthoracic echocardiography (TTE) findings suggesting PH never receive additional evaluation. Patient characteristics and echocardiographic data associated with increased recognition of PH have not been fully evaluated. We evaluated TTE reports at the Cincinnati Veterans Affairs Medical Center from 2005 to 2006 retrospectively for findings highly...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757834
PubMed Central
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This article is from Pulmonary Circulation , volume 3 . Abstract MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional gene regulation activity by targeting messenger RNAs. miRNAs have been found to be involved in various fundamental biological processes and deregulation of miRNAs is known to result in pathological conditions. In this review, we provide an overview of recent discoveries on the role played by this class of molecules in lung development and in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757825
PubMed Central
2013 Tonelli, Adriano R.; Haserodt, Sarah; Aytekin, Metin; Dweik, Raed A.
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This article is from Pulmonary Circulation , volume 3 . Abstract Nitric oxide (NO) is a diffusible gas with diverse roles in human physiology and disease. Significant progress in the understanding of its biological effects has taken place in recent years. This has led to a better understanding of the pathobiology of pulmonary hypertension (PH) and the development of new therapies. This article provides an overview of the NO physiology and its role in the pathobiology of lung diseases,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641730
PubMed Central
2013 Grieve, Andy P.; Chow, Shien-Chung; Curram, John; Dawe, Stephen; Harnisch, Lutz O.; Henig, Noreen R.; Hung, Hsien Ming J.; Ivy, D. Dunbar; Kawut, Steven M.; Rahbar, Mohammad H.; Xiao, Shen; Wilkins, Martin R.
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This article is from Pulmonary Circulation , volume 3 . Abstract In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clinical trial designs in pulmonary hypertension and here discusses their merits, limitations and challenges to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641733
PubMed Central
2013 Austin, Eric D.; Lahm, Tim; West, James; Tofovic, Stevan P.; Johansen, Anne Katrine; MacLean, Margaret R.; Alzoubi, Abdallah; Oka, Masahiko
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This article is from Pulmonary Circulation , volume 3 . Abstract Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this “estrogen paradoxȍ of enhanced female survival despite increased female susceptibility remains a mystery, recent progress has begun to shed light upon the interplay of sex hormones, the pathogenesis of pulmonary hypertension,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757824
PubMed Central
2012 Delaney, Cassidy; Cornfield, David N.
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This article is from Pulmonary Circulation , volume 2 . Abstract In utero, pulmonary blood flow is closely circumscribed and oxygenation and ventilation occur via the placental circulation. Within the first few breaths of air-breathing life, the perinatal pulmonary circulation undergoes a dramatic transition as pulmonary blood flow increases 10-fold and the pulmonary arterial blood pressure decreases by 50% within 24 hours of birth. With the loss of the placental circulation, the increase in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342743
PubMed Central
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This article is from Pulmonary Circulation , volume 2 . Abstract We aimed to investigate the role of endothelin-mediated vasoconstriction following acute pulmonary thromboembolism (APTE). Thirteen anesthetized piglets (~25 kg) were ventilated with 0 PEEP. Cardiac output (Qt) and wedge pressure (Pw) were measured by a Swan Ganz catheter, along with arterial and venous blood gases. APTE was induced by autologous blood clots (~0.8 g/kg, 12-16 pieces) via a jugular venous catheter at time = 0...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342751
PubMed Central
2012 Tang, Beverly T.; Pickard, Sarah S.; Chan, Frandics P.; Tsao, Philip S.; Taylor, Charles A.; Feinstein, Jeffrey A.
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This article is from Pulmonary Circulation , volume 2 . Abstract Previous clinical studies in pulmonary arterial hypertension (PAH) have concentrated predominantly on distal pulmonary vascular resistance, its contribution to the disease process, and response to therapy. However, it is well known that biomechanical factors such as shear stress have an impact on endothelial health and dysfunction in other parts of the vasculature. This study tested the hypothesis that wall shear stress is reduced...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555417
PubMed Central
2012 Stenmark, Kurt R.; Frid, Maria G.; Yeager, Michael; Li, Min; Riddle, Suzette; McKinsey, Timothy; El Kasmi, Karim C.
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This article is from Pulmonary Circulation , volume 2 . Abstract Experimental data indicate that the adventitial compartment of blood vessels, in both the pulmonary and systemic circulations, like the connective tissue stroma in tissues throughout the body, is a critical regulator of vessel wall function in health and disease. It is clear that adventitial cells, and in particular the adventitial fibroblast, are activated early following vascular injury, and play essential roles in regulating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342746
PubMed Central
2012 Brittain, Evan L.; Janz, David R.; Monahan, Kenneth J.; Sevin, Carla M.
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This article is from Pulmonary Circulation , volume 2 . Abstract Acute massive pulmonary embolism results in a rise in pulmonary vascular resistance and acute right ventricular dilation and systolic dysfunction. In unstable patients who cannot safely undergo computed tomography, echocardiography can often provide direct and indirect evidence of pulmonary embolism. We present a case in which clinical and echocardiographic evidence provided sufficient evidence of PE to initiate treatment. Dynamic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555424
PubMed Central
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This article is from Pulmonary Circulation , volume 2 . Abstract During the progression of pulmonary hypertension (PH), proximal pulmonary arteries (PAs) undergo remodeling such that they become thicker and the elastic modulus increases. Both of these changes increase the vascular stiffness. The increase in pulmonary vascular stiffness contributes to increased right ventricular (RV) afterload, which causes RV hypertrophy and eventually failure. Studies have found that proximal PA stiffness or...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555422
PubMed Central
2012 Zeng, Wei-Jie; Sun, Yun-Juan; Gu, Qing; Xiong, Chang-Ming; Li, Jian-Jun; He, Jian-Guo
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This article is from Pulmonary Circulation , volume 2 . Abstract The survival rates of Chinese patients with idiopathic pulmonary arterial hypertension (IPAH) and familial pulmonary arterial hypertension (PAH) on conventional therapy at 1 and 3 years were 68.0% and 38.9%, respectively. Our aim was to update recent knowledge on the demographics, clinical course, hemodynamic features, disease management, and survival of adult patients with IPAH. This retrospective and observational study was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487306
This article is from Pulmonary Circulation , volume 2 . Abstract Increased pulmonary blood flow (PBF) is widely thought to provoke pulmonary vascular obstructive disease (PVO), but the impact of wall shear stress in the lung is actually poorly defined. We examined information from patients having cardiac lesions which impact the pulmonary circulation in distinct ways, as well as experimental studies, asking how altered hemodynamics impact the risk of developing PVO. Our results are as follows:...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487301
PubMed Central
2012 Papamatheakis, Demosthenes G.; Patel, Jay J.; Blood, Quintin; Merritt, Travis T.; Longo, Lawrence D.; Wilson, Sean M.
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This article is from Pulmonary Circulation , volume 2 . Abstract Membrane depolarization is critical to pulmonary arterial (PA) contraction. Both L-type Ca2+ channels (CaL) and Rho-kinase are important signaling components of this process and mitochondrial and non-mitochondrial generated superoxides can be part of the signaling process. Maturation and long-term hypoxia (LTH) each can modify depolarization-dependent contraction and the role of superoxides. By the use of wire myography, we tested...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342748
PubMed Central
2012 Maliyasena, Videshinie A.; Hopkins, Peter M. A.; Thomson, Bruce M.; Dunning, John; Wall, Douglas A.; Ng, Benjamin J.; McNeil, Keith D.; Mullany, Daniel; Kermeen, Fiona D.
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This article is from Pulmonary Circulation , volume 2 . Abstract The objective of this study was to report the outcome of pulmonary endarterectomy (PEA) surgery performed for chronic thromboembolic pulmonary hypertension (CTEPH) at a single tertiary center. The prospective study consisted of 35 patients with surgically amenable CTEPH undergoing PEA between September 2004 and September 2010. The main outcome measures were Functional (New York Heart Association [NYHA] class, 6-Minute Walk...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487304
PubMed Central
2012 Anjum, Fatima; Lazar, Jason; Zein, Joe; Jamaleddine, Ghassan; Demetis, Spiro; Wadgaonkar, Raj
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This article is from Pulmonary Circulation , volume 2 . Abstract Endothelial dysfunction plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH) in sickle cell disease (SCD). A variety of evidence suggests that circulating endothelial progenitor cells (EPCs) play an integral role in vascular repair. We hypothesized that SCD patients with PAH are deficient in EPCs, potentially contributing to endothelial dysfunction and disease progression. The number of circulating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342749
PubMed Central
2012 Pham, Isabelle; Wuerzner, Gregoire; Richalet, Jean-Paul; Peyrard, Severine; Azizi, Michel
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This article is from Pulmonary Circulation , volume 2 . Abstract Hypoxia-induced pulmonary vasoconstriction in patients with a medical history of high-altitude pulmonary edema (HAPE) may involve activation of the endothelin-1 (ET-1) pathway. We, therefore, compared the effect of the ETA/ETB receptor antagonist, bosentan, on pulmonary artery systolic pressure (PASP) in healthy subjects with (HS: HAPE subjects, n=5) or without a HAPE-history (CS: Control subjects, n=10). A double-blind,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342745
PubMed Central
2012 Nicolls, Mark R.; Mizuno, Shiro; Taraseviciene-Stewart, Laima; Farkas, Laszlo; Drake, Jennnifer I.; Al Husseini, Aysar; Gomez-Arroyo, Jose G.; Voelkel, Norbert F.; Bogaard, Herman J.
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This article is from Pulmonary Circulation , volume 2 . Abstract In spite of treatment, severe angioproliferative pulmonary arterial hypertension (PAH) remains a disease characterized by great morbidity and shortened survival. New treatment strategies for patients with PAH are needed, and after drug development, preclinical studies are best conducted in animal models which present with pulmonary angio-obliterative disease and right heart failure. A rat model of severe pulmonary hypertension and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555413
PubMed Central
2012 Talati, Megha; Seeley, Erin; Ihida-Stansbury, Kaori; Delisser, Horace; McDonald, Hayes; Ye, Fei; Zhang, Xueqiong; Shyr, Yu; Caprioli, Richard; Meyrick, Barbara
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This article is from Pulmonary Circulation , volume 2 . Abstract The pathogenesis of idiopathic pulmonary hypertension is poorly understood. This paper utilized histology-based Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) to identify as-yet unknown proteins that may be associated with the structural changes in the pulmonary arterial walls of patients with IPAH. The technology identified significant increases in two fragments of histone H1 in the IPAH cases compared...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487302
PubMed Central
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This article is from Pulmonary Circulation , volume 2 . Abstract Pulmonary arterial hypertension (PAH) is a chronic, progressive disease of the pulmonary vasculature with a high morbidity and mortality. Its pathobiology involves at least three interacting pathways – prostacyclin (PGI2), endothelin, and nitric oxide (NO). Current treatments target these three pathways utilizing PGI2 and its analogs, endothelin receptor antagonists, and phosphodiesterase type-5 (PDE-5) inhibitors. Inhaled...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401867
PubMed Central
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This article is from Pulmonary Circulation , volume 2 . Abstract Endothelial cell (EC) apoptosis and apoptosis resistant proliferation have been proposed to play crucial roles in the development of featured plexiform lesions in the pathogenesis of pulmonary hypertension (PH). Subsequently, EC injury associated smooth muscle cell (SMC) proliferation facilitates vascular remodeling and eventually leads to narrowed vascular lumen, increased pulmonary vascular resistance, increased pulmonary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555411
PubMed Central
2012 Hansmann, Georg; Fernandez-Gonzalez, Angeles; Aslam, Muhammad; Vitali, Sally H.; Martin, Thomas; Mitsialis, S. Alex; Kourembanas, Stella
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This article is from Pulmonary Circulation , volume 2 . Abstract Clinical trials have failed to demonstrate an effective preventative or therapeutic strategy for bronchopulmonary dysplasia (BPD), a multifactorial chronic lung disease in preterm infants frequently complicated by pulmonary hypertension (PH). Mesenchymal stem cells (MSCs) and their secreted components have been shown to prevent BPD and pulmonary fibrosis in rodent models. We hypothesized that treatment with conditioned media (CM)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401871
PubMed Central
2012 Fessel, Joshua P.; Hamid, Rizwan; Wittmann, Bryan M.; Robinson, Linda J.; Blackwell, Tom; Tada, Yuji; Tanabe, Nobuhiro; Tatsumi, Koichiro; Hemnes, Anna R.; West, James D.
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This article is from Pulmonary Circulation , volume 2 . Abstract Pulmonary arterial hypertension (PAH) is a progressive and fatal disease of the lung vasculature for which the molecular etiologies are unclear. Specific metabolic alterations have been identified in animal models and in PAH patients, though existing data focus mainly on abnormalities of glucose homeostasis. We hypothesized that analysis of the entire metabolome in PAH would reveal multiple other metabolic changes relevant to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401874
PubMed Central
2012 Dereddy, Narendra; Huang, Jing; Erb, Markus; Guzel, Sibel; Wolk, John H; Sett, Suvro S; Gewitz, Michael H; Mathew, Rajamma
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This article is from Pulmonary Circulation , volume 2 . Abstract Endothelial caveolin-1 loss is an important feature of pulmonary hypertension (PH); the rescue of caveolin-1 abrogates experimental PH. Recent studies in human PH suggest that the endothelial caveolin-1 loss is followed by an enhanced expression of caveolin-1 in smooth muscle cells (SMC) with subsequent neointima formation. In order to evaluate caveolin-1 expression in infants with PH, we examined the available clinical histories,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555420
PubMed Central
2012 Ryan, John J.; Thenappan, Thenappan; Luo, Nancy; Ha, Thanh; Patel, Amit R.; Rich, Stuart; Archer, Stephen L.
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This article is from Pulmonary Circulation , volume 2 . Abstract Pulmonary hypertension (PH) is defined as a resting mean pulmonary artery pressure greater than 25 mmHg. The World Health Organization (WHO) classifies PH into five categories. The WHO nomenclature assumes shared histology and pathophysiology within categories and implies category-specific treatment. Imaging of the heart and pulmonary vasculature is critical to assigning a patient's PH syndrome to the correct WHO category and is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342739
PubMed Central
2012 Singla, Sunit; Jacobson, Jeffrey R.
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This article is from Pulmonary Circulation , volume 2 . Abstract Acute lung injury (ALI) is a devastating clinical condition associated with pulmonary and systemic inflammation and characterized by incompetence of the pulmonary microvascular barrier culminating in noncardiogenic pulmonary edema. An understanding of the mechanisms underlying endothelial barrier dysfunction in ALI has been facilitated by study of the effects of statins in relevant cellular and animals models. Many of the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555410
PubMed Central
2012 George, Peter M.; Cunningham, Morven E.; Galloway-Phillipps, Neil; Badiger, Rekha; Alazawi, William; Foster, Graham R.; Mitchell, Jane A.
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This article is from Pulmonary Circulation , volume 2 . Abstract Endothelin-1 is a potent vasoconstrictor and a therapeutic target in pulmonary arterial hypertension. Endothelial cells are the physiological source of endothelin-1 but in vitro data from our group shows that interferons (IFNα, IFNβ or IFNγ) induce endothelin-1 in pulmonary vascular smooth muscle cells. IFNs are integral to innate immunity and their antiviral and immunomodulatory capability has been harnessed therapeutically;...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555421
PubMed Central
2012 Maniatis, Nikolaos A.; Kardara, Matina; Hecimovich, Dan; Letsiou, Eleftheria; Castellon, Maricela; Roussos, Charalambos; Shinin, Vasily; Votta-Vellis, E. Gina; Schwartz, David E.; Minshall, Richard D.
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This article is from Pulmonary Circulation , volume 2 . Abstract Caveolin-1 is a key regulator of pulmonary endothelial barrier function. Here, we tested the hypothesis that caveolin-1 expression is required for ventilator-induced lung injury (VILI). Caveolin-1 gene-disrupted (Cav-1-/-) and age-, sex-, and strain-matched wild-type (WT) control mice were ventilated using two protocols: volume-controlled with protective (8 mL/kg) versus injurious (21 mL/Kg) tidal volume for up to 6 hours; and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555415
PubMed Central
2012 Louis, Lam; Bair, Nancy; Banjac, Svetlana; Dweik, Raed A.; Tonelli, Adriano R.
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This article is from Pulmonary Circulation , volume 2 . Abstract Prostacyclin analogs therapy has been associated with development of thrombocytopenia. Little is known whether this treatment increases the risk of intracranial hemorrhage in pulmonary artery hypertension (PAH) patients. We queried the Cleveland Clinic billing database to identify cases of nontraumatic sudural hematoma (SDH) in patients with PAH. We identified those individuals who were receiving prostacyclin analogs therapy at...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555423
PubMed Central
2012 Farha, Samar; Sharp, Jacqueline; Asosingh, Kewal; Park, Margaret; Comhair, Suzy A. A.; Tang, W. H. Wilson; Thomas, Jim; Farver, Carol; Hsieh, Fred; Loyd, James E.; Erzurum, Serpil C.
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This article is from Pulmonary Circulation , volume 2 . Abstract A proliferation of mast cells around the small pulmonary blood vessels and the alveolar septae has been noted in models of pulmonary hypertension, and in plexiform lesions of pulmonary arterial hypertension (PAH) in patients. Here, we hypothesize that total mast cell numbers and activation are increased in PAH and that they contribute to vascular remodeling through cellular and soluble proangiogenic effectors. To test this, blood...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401876
PubMed Central
2011 Long, Jason; Russo, Mark J.; Muller, Charlie; Vigneswaran, Wickii T.
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This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary hypertension (PH) is a serious and progressive disorder that results in right ventricular dysfunction that lead to subsequent right heart failure and death. When untreated the median survival for these patients is 2.8 years. Over the past decade advances in disease specific medical therapy considerably changed the natural history. This is reflected in a threefold decrease in the number of patients undergoing lung...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224424
PubMed Central
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This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary hypertension (PH) is a relatively misunderstood disease, partly related to the fact that many perceive PH to be a singular diagnosis. An unintended consequence of this is the misapplication of the role of the Doppler-Echocardiographic (DE) examination, as well as an underappreciation for its ability to help discern PH pathophysiology prior to right heart catheterization. Since DE often serves as the “gatekeeper” to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198642
PubMed Central
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This article is from Pulmonary Circulation , volume 1 . Abstract Intracellular Ca2+ plays a fundamental role in regulating cell functions in pulmonary arterial smooth muscle cells (PASMCs). A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) triggers pulmonary vasoconstriction and stimulates PASMC proliferation. [Ca2+]cyt is increased mainly by Ca2+ release from intracellular stores and Ca2+ influx through plasmalemmal Ca2+-permeable channels. Given the high concentration of intracellular Cl- in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198647
PubMed Central
2011 Malhotra, Rajeev; Hess, Dean; Lewis, Gregory D.; Bloch, Kenneth D.; Waxman, Aaron B.; Semigran, Marc J.
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This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary vasodilator testing is currently used to guide management of patients with pulmonary arterial hypertension (PAH). However, the utility of the pulmonary vascular response to inhaled nitric oxide (NO) and oxygen in predicting survival has not been established. Eighty patients with WHO Group I PAH underwent vasodilator testing with inhaled NO (80 ppm with 90% O2 for 10 minutes) at the time of diagnosis. Changes in right...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183738
PubMed Central
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This article is from Pulmonary Circulation , volume 1 . Abstract Biophysically-based computational models provide a tool for integrating and explaining experimental data, observations, and hypotheses. Computational models of the pulmonary circulation have evolved from minimal and efficient constructs that have been used to study individual mechanisms that contribute to lung perfusion, to sophisticated multi-scale and -physics structure-based models that predict integrated structure-function...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198640
This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary hypertension (PH) is associated with structural and mechanical changes in the pulmonary vascular bed that increase right ventricular (RV) afterload. These changes, characterized by narrowing and stiffening, occur in both proximal and distal pulmonary arteries (PAs). An important consequence of arterial narrowing is increased pulmonary vascular resistance (PVR). Arterial stiffening, which can occur in both the proximal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198648
This article is from Pulmonary Circulation , volume 1 . Abstract Mutations in the bone morphogenetic protein type II receptor gene (BMPR-II) are the major cause of heritable pulmonary arterial hypertension (PAH). Although both endothelial and smooth muscle cell BMPR-II dysfunction have been seen to contribute to pulmonary hypertension in vivo, little is known about the impact of BMPR-II mutation on the interaction between these two important cell types. We employed adenoviral vectors to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198633
PubMed Central
2011 Firth, Amy L.; Remillard, Carmelle V.; Platoshyn, Oleksandr; Fantozzi, Ivana; Ko, Eun A.; Yuan, Jason X.-J.
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This article is from Pulmonary Circulation , volume 1 . Abstract The activity of voltage-gated ion channels is critical for the maintenance of cellular membrane potential and generation of action potentials. In turn, membrane potential regulates cellular ion homeostasis, triggering the opening and closing of ion channels in the plasma membrane and, thus, enabling ion transport across the membrane. Such transmembrane ion fluxes are important for excitation–contraction coupling in pulmonary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173772
PubMed Central
2011 Porres-Aguilar, Mateo; Fernandez, Genaro; Elliott, C. Greogery
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This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary vein stenosis (PVS) post radiofrequency ablation for chronic atrial fibrillation poses a diagnostic challenge for the clinician. PVS presents with nonspecific symptoms, signs and radiographic features, and may be associated with significant pulmonary vascular involvement. Interestingly, others have described variation of the pulmonary artery wedge pressure between sites of the lung as a clue to pulmonary veno-occlusive...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329080
PubMed Central
2011 George, M. Patricia; Champion, Hunter C.; Pilewski, Joseph M.
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This article is from Pulmonary Circulation , volume 1 . Abstract Although medical therapies for pulmonary arterial hypertension have greatly improved, it remains a chronic and fatal disease. For patients who are refractory to medical therapy, lung transplantation is an important treatment option. This review discusses issues pertaining to indications for transplant, preparation for transplant and listing, operative issues, and outcomes for patients with pulmonary arterial hypertension.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198646
PubMed Central
2011 Damy, Thibaud; Lesault, Pierre-Francois; Guendouz, Soulef; Eddahibi, Saadia; Tu, Ly; Marcos, Elisabeth; Guellich, Aziz; Dubois-Rande, Jean-Luc; Teiger, Emmanuel; Hittinger, Luc; Adnot, Serge
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This article is from Pulmonary Circulation , volume 1 . Abstract To evaluate the vasoconstrictor component of PH in CHF by investigating the hemodynamic response to inhaled nitric oxide (iNO) and to determine whether this response was influenced by the phosphodiesterase 5 gene (PDE5) G(1142)T polymorphism. CHF patients underwent right heart catheterization at rest and after 20 ppm of iNO and plasma cGMP and PDE5 G(1142)T polymorphism determinations. Of the 72 included CHF patients (mean age,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224429
PubMed Central
2011 Duong, Heng T.; Comhair, Suzy A.; Aldred, Micheala A.; Mavrakis, Lori; Savasky, Benjamin M.; Erzurum, Serpil C.; Asosingh, Kewal
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This article is from Pulmonary Circulation , volume 1 . Abstract Proliferative pulmonary vascular remodeling is the pathologic hallmark of pulmonary arterial hypertension (PAH) that ultimately leads to right heart failure and death. Highly proliferative endothelial cells known as endothelial colony-forming cells (ECFC) participate in vascular homeostasis in health as well as in pathological angiogenic remodeling in disease. ECFC are distinguished by the capacity to clonally proliferate from a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329078
PubMed Central
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This article is from Pulmonary Circulation , volume 1 . Abstract The acute respiratory distress syndrome (ARDS) is a complex disorder of heterogeneous etiologies characterized by a consistent, recognizable pattern of lung injury. Extensive epidemiologic studies and clinical intervention trials have been conducted to address the high mortality of this disorder and have provided significant insight into the complexity of studying new therapies for this condition. The existing clinical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198645
PubMed Central
2011 Joshi, Sachindra R.; McLendon, Jared M.; Comer, Brian S.; Gerthoffer, William T.
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This article is from Pulmonary Circulation , volume 1 . Abstract During normal lung development and in lung diseases structural cells in the lungs adapt to permit changes in lung function. Fibroblasts, myofibroblasts, smooth muscle, epithelial cells, and various progenitor cells can all undergo phenotypic modulation. In the pulmonary vasculature occlusive vascular lesions that occur in severe pulmonary arterial hypertension are multifocal, polyclonal lesions containing cells presumed to have...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224427
PubMed Central
2011 Thamm, Melanie; Voswinckel, Robert; Tiede, Henning; Lendeckel, Friederike; Grimminger, Friedrich; Seeger, Werner; Ghofrani, Hossein A.
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This article is from Pulmonary Circulation , volume 1 . Abstract Our aim was to determine what proportion of patients with pulmonary hypertension (PH) has undertaken air travel contrary to the general medical advice and to characterize these patients according to disease severity and medical treatment. In cooperation with Pulmonale Hypertonie e.V., the German patient organization, a questionnaire was distributed. In total, 430 of 720 questionnaires were returned completed. Of the 179 patients...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198644
PubMed Central
2011 Kim, Gene H.; Ryan, John J.; Marsboom, Glenn; Archer, Stephen L.
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This article is from Pulmonary Circulation , volume 1 . Abstract Epigenetics refers to changes in phenotype and gene expression that occur without alterations in DNA sequence. Epigenetic modifications of the genome can be acquired de novo and are potentially heritable. This review focuses on the emerging recognition of a role for epigenetics in the development of pulmonary arterial hypertension (PAH). Lessons learned from the epigenetics in cancer and neurodevelopmental diseases, such as...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224426
PubMed Central
2011 Fessel, Joshua P.; Loyd, James E.; Austin, Eric D.
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This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary arterial hypertension (PAH) is a rapidly progressive and fatal disease for which there is an ever-expanding body of genetic and related pathophysiological information on disease pathogenesis. The most common single culprit gene known is BMPR2, and animal models of the disease in several forms exist. There is a wealth of genetic data regarding modifiers of disease expression, penetrance, and severity. Despite the rapid...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224422
PubMed Central
2011 Newman, John H.; Holt, Timothy N.; Hedges, Lora K.; Womack, Bethany; Memon, Shafia S.; Willers, Elisabeth D.; Wheeler, Lisa; Phillips, John A.; Hamid, Rizwan
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This article is from Pulmonary Circulation , volume 1 . Abstract High-altitude pulmonary hypertension (HAPH) is a consequence of chronic alveolar hypoxia, leading to hypoxic vasoconstriction and remodeling of the pulmonary circulation. Brisket disease in cattle is a naturally occurring animal model of hypoxic pulmonary hypertension. Genetically susceptible cattle develop severe pulmonary hypertension and right heart failure at altitudes >7,000 ft. No information currently exists regarding...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329076
PubMed Central
2011 Stamm, Jason A.; Risbano, Michael G.; Mathier, Michael A.
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This article is from Pulmonary Circulation , volume 1 . Abstract There have been tremendous strides in the management of pulmonary hypertension over the past 20 years with the introduction of targeted medical therapies and overall improvements in surgical treatment options and general supportive care. Furthermore, recent data shows that the survival of those with pulmonary arterial hypertension is improving. While there has been tremendous progress, much work remains to be done in improving the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198638
PubMed Central
2011 Kumar, Bhupesh; Puri, Goverdhan D.; Manoj, Rohit; Gupta, Kirti; Shyam, K. S.
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This article is from Pulmonary Circulation , volume 1 . Abstract Although mild increase in pulmonary vascular resistance following intracardiac repair of tetralogy of Fallot is often seen in the early postoperative period, it usually subsides without any sequel. Persistent severe pulmonary artery hypertension after total correction is rare. We report a child with tetralogy of Fallot and Down's syndrome, who developed severe pulmonary hypertension and low cardiac output syndrome following an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198627
PubMed Central
2011 Lane, Kirk L.; Talati, Megha; Austin, Eric; Hemnes, Anna R.; Johnson, Jennifer A.; Fessel, Joshua P.; Blackwell, Tom; Mernaugh, Ray L.; Robinson, Linda; Fike, Candice; Roberts, L. Jackson; West, James
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This article is from Pulmonary Circulation , volume 1 . Abstract Hereditary pulmonary arterial hypertension (PAH) is usually caused by mutations in BMPR2. Mutations are found throughout the gene, and common molecular consequences of different types of mutation are not known. Knowledge of common molecular consequences would provide insight into the molecular etiology of the disease. The objective of this study was to determine the common molecular consequences across classes of BMPR2 mutation....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167174
PubMed Central
2011 Andersen, Charlotte U.; Hilberg, Ole; Mellemkjaer, S?ren; Nielsen-Kudsk, Jens E.; Simonsen, U.
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This article is from Pulmonary Circulation , volume 1 . Abstract Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right ventricular function. Despite progress in pharmacological therapy, there is still no cure for PAH. The peptide apelin and the G-protein coupled apelin receptor (APLNR) are expressed in several tissues throughout the organism. Apelin is localized in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224425
PubMed Central
2011 Lammers, Astrid E.; Adatia, Ian; del Cerro, Maria Jesus; Diaz, Gabriel; Freudenthal, Alexandra Heath; Freudenthal, Franz; Harikrishnan, S.; Ivy, Dunbar; Lopes, Antonio A.; Raj, J. Usha; Sandoval, Julio; Stenmark, Kurt; Haworth, Sheila G.
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This article is from Pulmonary Circulation , volume 1 . Abstract The members of the Pediatric Task Force of the Pulmonary Vascular Research Institute (PVRI) were aware of the need to develop a functional classification of pulmonary hypertension in children. The proposed classification follows the same pattern and uses the same criteria as the Dana Point pulmonary hypertension specific classification for adults. Modifications were necessary for children, since age, physical growth and maturation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161406
PubMed Central
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This article is from Pulmonary Circulation , volume 1 . Abstract We have shown previously that acute hypoxia downregulates protein kinase G (PKG) expression and activity in ovine fetal pulmonary vessels and pulmonary arterial smooth muscle cells (SMC). Here, we report that acute hypoxia also reduces the expression of leucinezipper-positive MYPT1 (LZ+MYPT1), a subunit of myosin light chain (MLC) phosphatase, in ovine fetal pulmonary arterial SMC. We found that in hypoxia, there is greater...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329079
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Topics: Gladstone, W. E. 1809-1896, Vatican Council 1869-1870), Popes, Allegiance
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Topic: Catholic Church
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Topic: Catholic Church