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This paper in concerned with Educating the youth to market their talents. Youth are not useless but used less in the society. They need learn to solve their problems and market their talents in a constructive way. The behavior of youth is to be carefully observed by the teacher and counselors. This paper focuses on the problem solving components of risk taking behavior of adolescents and their social implications including business field. During risk taking situations, youth are expected to go...
Topics: Demographic and Social Factors, Cognitive Style, Genetic and Biological Factors, Risk Taking...
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x, 377 pages : 24 cm
Topics: Biotechnologie, Aufsatzsammlung, biochemie, biotechnologie, biochemistry, chemische industrie,...
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xi, 376 pages : 24 cm
Topics: Straftat, Soziobiologie, Verbrechen, Ursache, Aufsatzsammlung, Kongress, Genetics, Behavioral,...
Source: removedNEL
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xiii, 348 pages : 21 cm
Topics: Produits naturels -- Biotechnologie -- Congrès, Médicaments -- Composition -- Congrès,...
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v, 218 pages ; 24 cm
Topics: Biological products -- Standards, Vaccines -- Biotechnology, Biological Factors -- standards
For many devastating combat and civilian injuries where conventional reconstruction is inadequate, vascularized composite allotransplantation (VCA) has become a viable alternative. However, the toxicities and adverse effects of high dose immunosuppressive drugs have curtailed wider application. Thus the purpose of this project is to develop novel clinically relevant immunosuppression sparing regimens allowing for immunomodulation and tolerance induction after VCA using a translational large...
Topics: DTIC Archive, Brandacher,Gerald, Johns Hopkins University Baltimore United States, wounds and...
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5.0
May 7, 2020
05/20
by
Morss, John R
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xviii, 262 pages
Topics: Darwin, Charles, 1809-1882, Developmental psychology -- History, Child development, Child...
The on-going research is to test the central hypothesis that post-SCI administration of the catalytic oxidoreductant BuOE will inhibit neuropathic pain after SCI. The research in years1-3 focused on the goals of aims 1-3, to test the hypothesis that post-SCI administration of BuOE decreases inflammation and ROS activation in a rat, mouse and porcine model of SCI. The main finding of our work in this year was to evaluate the dose-effect curve of post-SCI administration of BuOE on the outcomes...
Topics: DTIC Archive, Floyd,Candace L, University of Alabama at Birmingham Birmingham United States, spinal...
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Apr 22, 2020
04/20
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International Symposium on Molecular and Cellular Networks for Cancer Therapy (1988 : Osaka, Japan)
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x, 269 pages : 25 cm
Topics: Immunstimulans, Cytokines -- Therapeutic use, Krebs Medizin, Kongress, Cancer -- Immunologie --...
Citrullination, catalysed by peptidylarginine deiminase (PAD), is a post-translational modification of arginine to citrulline, which contributes to the pathogenesis of rheumatoid arthritis (RA). We show that citrullinated epithelial-derived neutrophil-activating peptide78/CXCL5 (cit-ENA-78/CXCL5) is significantly higher in RA synovial fluids (SFs) compared to osteoarthritis (OA) and other inflammatory rheumatic diseases (OD) SFs, and its concentration correlates with RA disease activity....
Topics: DTIC Archive, Fox,David A, Regents of the University of Michigan Ann Arbor United States,...
Monkeypox virus (MPXV) is an emerging/re-emerging zoonotic infection endemic to Central Africa that produces a human disease similar to smallpox. Since the cessation of active vaccination and the global eradication of smallpox, monkeypox has emerged as a potential biological threat due to the vast number of unvaccinated individuals worldwide. Given the adverse events associated with current vaccination strategies, and a lack of fully licensed therapeutic options, there has been sustained...
Topics: DTIC Archive, Lin,Kenny L, Uniformed Services University Of The Health Sciences Bethesda United...
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xxi, 729 pages : 25 cm
Topics: Rheumatology -- Treatment, Rheumatic Diseases -- therapy, Biological Factors -- therapeutic use,...
The three primary methods typical laboratories use for detection/diagnostics of infectious agents is:(1) cultivation of a viable agent,(2) use of the infected host to obtain evidence of infection (typically a serological response or other host response such as encephalitis), and(3) direct detection of the agent using laboratory methods such as amplification of the infectious agents nucleic acids or an immunoassay targeted toward the infectious agents proteins. May this manual provide you a...
Topics: DTIC Archive, Wolcott, Mark J, ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD...
Transforming growth factor beta (TGFB) signaling regulates key reproductive events via TGFBR1/TGFBR2. To determine potential effect of overactivation of TGFB signaling in the oocyte, we generated a mouse model containing a constitutively active TGFBR1 using growth differentiation factor 9 (Gdf9)-Cre (i.e., TGFBR1-gCA). Follicle counting demonstrated that the number of primordial, primary, and secondary follicles was reduced in TGFBR1-gCA ovaries compared with controls at P7. Concomitantly,...
Topics: DTIC Archive, Li,Qinglei, Texas A and M Agrilife Research College Station United States, ovarian...
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Apr 21, 2020
04/20
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Organization, World Health
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1 online resource (203 pages)
Topics: Vaccines -- Developing countries -- Prevention, Communicable diseases in children -- Developing...
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1 online resource (x, 748 pages) :
Topics: Natural products -- Dictionaries, Biomolecules -- Dictionaries, Metabolites -- Dictionaries,...
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2787 pages : 29 cm
Topics: Drugs -- Dictionaries, Biological Factors, Catalogs, Drug as Topic, Drugs, Geneesmiddelen, United...
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Dec 16, 2020
12/20
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International Workshop on Cytokines (2nd : 1989 : Hilton Head Island, S.C.)
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xli, 570 p. : 24 cm
Topics: Cytokines -- Congresses, Biological Factors -- physiology -- congresses
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1 online resource (xx, 332 pages) :
Topics: Biological products -- Therapeutic use, Cancer -- Immunotherapy, HEALTH & FITNESS -- Diseases...
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xv, 479 p., [8] p. of plates : 27 cm
Topics: Peptides -- Physiological effect, Peptides -- physiology, Biological Factors -- physiology
This Technical Reference Manual (TRM) serves as a supplement to Allied Medical Publication 7.5 (AMedP-7.5), documenting the analyses, rationale, and underlying data utilized in the development of the methodology. This document provides information beyond the scope of AMedP-7.5 that will allow for transparency and verification of the methodology.
Topics: DTIC Archive, Oxford,Sean M, INSTITUTE FOR DEFENSE ANALYSES ALEXANDRIA VA ALEXANDRIA United States,...
Current methods to fabricate multifunctional textiles to provide multiple facets of protection to the Warfighter are restrictive and not efficient. To address this challenge, previous work by the FORCE ProTex effort encapsulated a narrow-spectrum antimicrobial, the bacteriocin nisin, in a photocatalytic matrix, titanium dioxide (titania), on fabric to evaluate the creation of a multifunctional textile in unison. This report summarizes preliminary investigations to leverage this work by...
Topics: DTIC Archive, Stote,Robert, Biological Sciences and Technology, ARMY NATICK SOLDIER RESEARCH...
Recent discoveries have demonstrated that the expression of LIGHT molecules within the tumor milieu counteracts cancer immune-evasion mechanisms and instigates activation and migration of T-cells into the tumor; however the delivery of LIGHT to the tumor microenvironment has been a challenge. The overall goal of this project is to develop a targeted therapy that will deliver LIGHT to the tumor microenvironment by generating bispecific fusion proteins that are one-part LIGHT and one-part...
Topics: DTIC Archive, Kast,Wijbe M, UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES United States, cell line,...
Little information is available on the novel treatment for abiraterone (Abi)- and MDV3100 (MDV)-resistant disease. G protein-coupled receptor 30(GPR30) is a seven-transmembrane estrogen receptor and activation by its specific agonist G-1 inhibited growth in multiple castration-resistant prostate cancer (CRPC) xenograft models that were resistant to the first-generation androgen deprivation therapy. More importantly, GPR30 is an androgen-repressed target and its expression increased in clinical...
Topics: DTIC Archive, Hung-Ming,Lam, University of Washington Seattle United States, prostate cancer, body...
The use of chemically or thermally inactivated biothreat toxins in detection methodologies can prove problematic when the resulting toxoids become attenuated or altered to the point that they are no longer recognizable by the antibody-based test methods for which they were intended. Recombinant technology was used to assess whether a nontoxic surrogate could be developed that retains the relative epitopes for antibody-based detection platforms. Here, three small batches of staphylococcal...
Topics: DTIC Archive, Calm,Alena, ARMY EDGEWOOD CHEMICAL BIOLOGICAL CENTER APG MD ABERDEEN PROVING GROUND...
Asthma incidence is increasing worldwide and disproportionately affects disadvantaged and minority populations. There is overrepresentation in the Active Duty military of low income and minority populations, including African Americans and Latinos. These populations experience the greatest social adversities and have significant asthma burden. The etiology of asthma-related disparities is multifactorial and known to be affected by poverty and its associated exposures. Chronic exposure to social...
Topics: DTIC Archive, Thakur,Neeta, University of California San Francisco San Francisco United States,...
Despite earlier detection and improved therapies, prostate cancer remains a leading cause of cancer-related death among men in the US. Castration resistant prostate cancer (CRPC) represents the most dangerous and presently incurable stage of the disease. In this grant, weexplore a new strategy to block the activity of a clinically relevant target known as Hedgehog proteins (Hhs). Hhs comprise a family of extracellular signaling proteins that contribute to the development and progression of...
Topics: DTIC Archive, Callahan,Brian, State University of New York at Binghamton Binghamton United States,...
The overarching goal of this grant is to characterize differential splicing of oncogenes in African American (AA) versus Caucasian American (CA) prostate cancer (PCa). We focused our efforts on two oncogenes, phosphatidylinositol-4,5-bisphosphate 3-kinase delta(PIK3CD) and fibroblast growth factor receptor 3 (FGFR3). We cloned novel short (-S) splice variants PIK3CD-S (missing exon 20 due to exon skipping event) and FGFR3-S (missing exon 14) that are enriched in AA PCa specimens. PCa cell lines...
Topics: DTIC Archive, Lee, Norman H, George Washington University School of Medicine Washington United...
We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM (Primary Tumor Microenvironment of Metastases) contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HI/p-ATF2LO/E-cadhLO could identify motile early-progressed tumor...
Topics: DTIC Archive, Aguirre-Ghiso,Julio, Mount Sinai School of Medicine New York, United States,...
The overall goal of this project is to characterize the beluga immune response at the molecular level utilizing archived and fresh blood and skin samples collected in association with different stressors. In the long term, selected biomarkers found to be informative will be utilized in skin, potentially eliminating the need for blood sampling from wild populations.
Topics: DTIC Archive, Romano,Tracy, Sea Research Foundation, Inc Mystic United States, biological markers,...
The present grant proposes to look at the effects of blast on the eye of the mouse looking at phenotypic changes in the eye and in the changes in gene expression following a 50psi blast. We are using these data to define biomarkers to predict the severity of the injury and to predict eventual outcomes. We have examined the phenotypic changes in the eye in the BXD strains before and 5 days after a 50psi blast and have observed no strain specific change in either the cornea or the IOP. We have...
Topics: DTIC Archive, Geisert, Eldon E, Emory University Atlanta United States, eye, retinal diseases, eye...
Bcl10 is a key signaling intermediate in the TCR-to-NF-B pathway in Tlymphocytes. It is currently believed that, once activated, Bcl10 functions within a multiprotein signaling complex that activates the IKK complex. Bcl10 is thought to regulate this signaling complex, but how it transmits its signal through the complex is unknown. A thorough knowledge of Bcl10 biology is critical to understanding how Bcl10 functions and how it regulates its binding partners. In this study, we used mutational...
Topics: DTIC Archive, Langel,Felicia D, Uniformed Services University Of The Health Sciences Bethesda...
The proposal addresses a very important area of bone fracture healing that is a major health and financial burden in the United States. Towards developing an effective approach to cure segmental bone fractures, it is essential to understand additional mechanisms that play a crucial role in bone healing through participation of cells other than osteoblasts, osteoclasts and their respective progenitors. Bone fractures heal with overlapping phases of inflammation, cell proliferation, and bone...
Topics: DTIC Archive, Ponnazhagan,Selvarangan, The University of Alabama at Birmingham Birmingham United...
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5.0
May 15, 2020
05/20
by
Stratton, Kathleen R
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1 online resource (476 pages)
Topics: Immunization -- Research -- United States -- Planning, Vaccines -- Research -- United States --...
Eye injuries require immediate and effective treatment to prevent corneal opacification, neovascularization, irregularity and occasionally ulceration of the cornea, which can be potentially blinding. Eye injuries are generally treated with eye drops for 4-8 times per day, which may not be feasible in critically injured patients in intensive care. This research project aims to develop a nanowafer drug delivery system that can deliver the drug to the eye for longer periods of time to treat eye...
Topics: DTIC Archive, Pflugfelder, Stephen C, Baylor College of Medicine Houston United States, health...
The overall goal for the Johns Hopkins RTR Consortium is to advance translational research of the most clinically pertinent issues of Restorative Transplantation through a multidisciplinary collaboration among highly experienced and accomplished partners. The Consortium has thus assembled three complimentary, multidisciplinary research projects from Johns Hopkins, Massachusetts General Hospital and University of Pittsburgh. Each of the individual projects has made significant progress during...
Topics: DTIC Archive, Lee,W P, Johns Hopkins University Baltimore United States, biomedical research,...
In the Chemical, Biological, Radiological-Nuclear and Explosives Research and Technology Initiative(CRTI) Project 09-509TD, a persistent, highly realistic, game-based synthetic environment (SE) for incident commanders and first responders to conduct individual and/or team training and collaboration (at the tactical and/or strategic levels) to address deliberate or accidental Chemical, Biological, Radiological, Nuclear and Explosives (CBRNE) releases in an urban environment has been proposed....
Topics: DTIC Archive, Lien,Fue-Sang, Waterloo CFD Engineering Consulting Inc. (WATCFD) Waterloo, Ontario...
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Nov 12, 2018
11/18
by
None
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ix, 223 pages : 24 cm
Topics: Brain -- Differentiation -- Congresses, Brain -- Sex differences -- Congresses, Sex differences...
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1 online resource
Topics: Biosynthesis, Biological Factors, SCIENCE -- Life Sciences -- Genetics & Genomics, Chemistry
Sleep deprivation has been associated with an increase in overall mortality and morbidity. Mechanistically, a loss of brain mass, due to neuronal death, has been observed after chronic sleep deprivation. Sleep deprivation also has enormous impacts on metabolic homeostasis, with increased prevalence of weight gain and obesity. Interestingly, perturbation of gut microbiota presents a pattern of metabolic abnormalities mirroring those induced by sleep deprivation. In this study, perturbation of...
Topics: DTIC Archive, Soto,Armando, AIR FORCE RESEARCH LAB WRIGHT PATTERSON AFB OH HUMAN PERFORMANCE WING...
This study will recruit wounded warriors with severe extremity trauma, which places them at high risk for heterotopic ossification (HO); bone formation at abnormal sites, which causes pain, limits motion and/or limits the use of a prosthetic device. There are three goals: 1) to understand the mechanisms involved in HO;2) to define accurate and practical methods to predict where HO will develop; and 3) to define potential therapies for prevention or mitigation of HO.
Topics: DTIC Archive, Forsberg,Jonathan, The Geneva Foundation Tacoma United States, extremities, wounds...
This project is focused on Systemic Sclerosis (SSc), a progressive fibrotic disease characterized by skin fibrosis and damage to internal organs. While a wide range of environmental and biological triggers have been proposed, no definitive etiologic agents have yet been identified. Metagenomic analysis of non-human sequences in SSc RNA-seq data was used to detect microbial sequences in human tissues in an unbiased, quantitative manner. Our studies suggest that disease pathogenesis includes a...
Topics: DTIC Archive, Whitfield,Michael L, The Trustees of Dartmouth College Hanover United States,...
Traumatic brain injury (TBI) is a significant worldwide problem with an estimated incidence of at least 200 cases per 100,000 people per year. Due to recent military conflicts in the Middle East, a tremendous spike in the incidence of combat related brain injury has occurred over the past decade. Over the last 30 years, preclinical research focused on evaluating potential pharmacologic therapeutic agents has produced multiple promising candidates; however, to date no single drug intervention...
Topics: DTIC Archive, Budinich,Craig S, UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD BETHESDA...
Introduction: Dental implant technology has evolved into a predictable treatment option for the restoration of edentulous sites. However, peri-implantitis is an emerging complication leading to increased morbidity or mortality of osseointegrated implants. The prevalence of peri-implant diseases has been reported to range from 12% to 80% of patients. Treatment of peri-implantitis requires thorough debridement and decontamination of the implant surface
Topics: DTIC Archive, Quintero,David G, Uniformed Services University of the Health Sciences Bethesd United...
Alphaviral vectors have been used as vaccines for immunization against several viral infections. However, these vectors typically induce rapid cytopathic effects in mammalian cells. The cytopathicity of these vectors allow for only transient expression of transgenes. In viral models where long-term expression may be needed to induce adequately differentiated immune responses, the current wild-type alphaviral vectors may not be sufficiently immunogenic. This thesis describes development of...
Topics: DTIC Archive, Defang,Gabriel N, Uniformed Services University Of The Health Sciences Bethesda...
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27 volumes 26 cm
Topics: Materia medica -- Dictionaries, Drugs -- Dictionaries, Biological products -- Dictionaries,...
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xxxiii, 957 pages : 31 cm
Topics: Communicable diseases in animals -- Diagnosis, Veterinary biologicals, Vaccination of animals,...
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5.0
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1 online resource (xi, 742 pages) :
Topics: HEALTH & FITNESS -- Diseases -- Cancer, Biomédecine, Sciences de la vie, Biological response...
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2465, [6] pages : 29 cm
Topics: Pharmaceutical Preparations, Biological Factors, United States, Pharmacology -- Dictionaries, Drugs...
The main objective of the grant was to develop and characterize new materials that are useful as energetic components while releasing highly potent biocidal combustion products. These materials are intended to replace or supplement metal fuel powders in the current energetic formulations. The goal is to make them stable, easy to handle, and compatible with the other formulation components. Beyond the material development and characterization scope, this study aimed at extensively testing the...
Topics: DTIC Archive, Grinshpun,Sergey A, University of Cincinnati Newark United States, BIOLOGICAL...
