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xv, 352 p. : 24 cm
Topics: Microsatellites (Genetics), Genetic markers
http://uf.catalog.fcla.edu/uf.jsp?st=UF023010644&ix=pm&I=0&V=D&pm=1
Topics: Honeybee, Genetic markers, Insect populations.
National Institutes of Health Library
128
128
Apr 12, 2016
04/16
by
Petrakis, Peter L; National Institute on Alcohol Abuse and Alcoholism; Editorial Experts, Inc
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"Contract no. ADM 281-84-0006 to Editorial Experts, Inc."
Topics: Alcoholism, Alcoholism, Genetic Markers, Risk Factors
578
578
Aug 25, 2019
08/19
by
Tudor Parfitt, Chris Hale, David Espar, Cicada Films., WGBH (Television station : Boston, Mass.), WGBH Video (Firm)
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1 videocassette (60 min.) : 1/2 in South Africa's Lemba people claim to be descendants of Jews and one of the lost tribes of Israel. In this program, anthropologist Tudor Parfitt investigates the Lemba's claim through genetic testing and attempts to retrace their migration. VHS format Videocassette release of a program from the PBS series, Nova Narration writer, David Espar ; film editor, David Hill ; executive producer, Paula S. Apsell ; narrator, Liev Schreiber Narrator, Liev Schreiber
Topics: nova (television program), genetic markers, Lemba (South African people), lost tribes of Israel,...
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Oct 16, 2018
10/18
by
Gutkind, Lee
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237 pages ; 23 cm
Topics: Genetic screening, Medical genetics, Genetic markers, Medical technology, Genetic markers, Genetic...
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xi, 269 p. : 24 cm
Topics: Chromosome polymorphism -- Laboratory manuals, Human genetics -- Variation -- Laboratory manuals,...
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xx, 465 p. : 26 cm
Topics: Cancer -- Genetic aspects, Cancer -- Molecular aspects, Cancer -- Diagnosis, Human cytogenetics,...
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192 p. : 27 cm
Topics: Tumors in children -- Immunodiagnosis, Tumor markers -- Diagnostic use, Genetic Markers, Neoplasms...
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xiv, 464 p. : 27 cm
Topics: Chromosome polymorphism -- Laboratory manuals, Human genetics -- Variation -- Laboratory manuals,...
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Topics: Biochemical markers, Genomics, Proteomics, Biological Markers -- analysis, Biological Markers --...
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1 online resource (164 pages) :
Topics: Recombinant microorganisms -- Ecology, Recombinant microorganisms -- Identification, Genetics,...
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vii, 175 p. : 25 cm
Topics: Cancer -- Genetic aspects -- Animal models, Cancer -- Risk factors -- Animal models, Neoplasms --...
Prostate cancer (PCa) is the most common cancer and the second leading cause of cancer death among men in the United States. While most prostate cancer patients have an indolent form of the disease that may not even require treatment, about 10-15% of PCa patients have an aggressive form that may progress to metastases and death, thus requiring intensive treatment. Several clinical variables such as PSA levels, Gleason grade and TNM stage are good predictors for disease with poor clinical...
Topics: DTIC Archive, WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF HEALTH SCIENCES, *GENETIC MARKERS,...
Food allergies are complex, multifactorial traits that pose great risk to health and operational success. Latent food allergies could manifest catastrophic outcomes during missions, resulting in potential failure and loss of life. Understanding an individuals risk of developing severe allergies is one of many components that can make up a high-quality surveillance and public health/preventive medicine program.
Topics: DTIC Archive, Chapleau, Richard R, USAFSAM/FHT Wright-Patterson AFB United States, ALLERGY AND...
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1 online resource (vi, 84 pages) :
Topics: Cancer -- Research -- United States, Cancer -- Genetic aspects, HEALTH & FITNESS -- Diseases --...
Genome-wide association studies (GWAS) of breast cancer have been completed among populations of European ancestry, and several regions have been identified that appear to contribute susceptibility to this cancer. However, recent data suggest that not all risk alleles for common cancers will be revealed by studies limited to Whites of European ancestry, and that similar efforts in other racial and ethnic populations will be needed to identify the full spectrum of common risk alleles that...
Topics: DTIC Archive, UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES, *AFRICAN AMERICANS, *BREAST CANCER,...
The increasing incidence of obesity and Type 2 Diabetes (T2D) confers significant burden on the US civilian and military healthcare system. It is hypothesized that the risk of future obesity and T2D can be mitigated by targeted interventions during early adulthood which are based on individual biological variability (e.g., personalized medicine using genetic biomarkers).
Topics: DTIC Archive, AIR FORCE MEDICAL WING (59TH) WILFORD HALL AMBULATORY SURGICAL CENTER LACKLAND AFB...
Circulating tumor-derived extracellular vesicles (EVs) have emerged as a promising source for identifying cancer biomarkers for early cancer detection. However, the clinical utility of EVs has thus far been limited by the fact that most EV isolation methods are tedious, nonstandardized, and require bulky instrumentation such as ultracentrifugation (UC). Here, we report a size-based EV isolation tool called ExoTIC (exosome total isolation chip), which is simple, easy-to-use, modular, and...
Topics: DTIC Archive, Utkan ,Demirci, Leland Stanford Junior University Palo Alto United States, genetic...
We have performed a high throughput, in vivo genetic screen to identify kinases that permit androgen-dependent transformed prostate epithelial cells (LHSR-AR cells) to form tumors in female animals. In addition to known prostate cancer oncogenes and mediators of androgen independence (mutated KRAS, constitutively active MEK, RAF1, ERBB2, AKT1, PIM1 and PIM2), overexpression of the Never In Mitosis A (NIMA) related kinase 6 (NEK6) reproducibly yielded androgen-independent tumors. NEK6 is...
Topics: DTIC Archive, Choudhury, Atish, Dana-Farber Cancer Institute Boston United States, prostate cancer,...
To classify a disease samples using high throughput genomic and proteomic data, it is essential to decide which toll like receptors and CDmarker should be included in a predictor list. Too few markers may not be enough to discriminate and classify an exposure. Having toomany Markers is not optimal either, as some of these markers may be irrelevant to the diagnosis and may reduce the information decisivefactor due to adding noise. Efforts are made to select an optimal set of targets for which to...
Topics: DTIC Archive, Muhie,Seid, Georgetown University Georgetown University United States, algorithms,...
A multimodal MRI, MRS and MEG (magnetoencephalography) design is employed in cohorts of boys with XYY, who are symptomatic for ASD and control cohorts of idiopathic ASD (ASD-I) and typical development (TD). Targeted recruitment for year 1 totaled 30 enrolled. At the point of this report, 25 subjects have been enrolled, 5 were eliminated for not meeting inclusion criteria upon clinical assessment, 19 have completed data acquisition, and 1 is pending imaging completion. Three of the 19 are...
Topics: DTIC Archive, Ross, Judith, Childrens Hospital of Philadelphia Philadelphia United States, autism,...
Here we report major findings for our project aimed at studying the expression of Discoidin Domain Receptors (DDRs) in breast cancer (BrCa) tissues and their functional contribution to the formation of BrCa bone metastases. We also aim at testing the feasibility of targeting DDRs for the treatment of BrCa bone metastases. During the first funding period, we performed immunohistochemical analysis of DDR1 in 120 samples of invasive BrCa cases with different molecular subtypes, and found a...
Topics: DTIC Archive, Bonfil,Ricardo D, Wayne State University Detroit United States, breast cancer,...
We proposed that induction of the ERRalpha/gamma signaling pathway can enhance mitochondrial functionin both cell and animal models of mitochondrial disease. Our major findings include;1)We recently compared in detail the different mitochondrial disease animal models (under review in Cell Metabolism). We found that the compound Ant1-/-ND6 mutant mouse model exhibited the earliest and strongest mitochondrial cardiomyopathy phenotype and therefore provided the best therapeutic window for our...
Topics: DTIC Archive, Wallace,Douglas C, Childrens Hospital of Philadelphia Philadelphia United States,...
MicroDNAs are extra chromosomal circular DNA present in normal mammalian somatic cells. To find the prostate tissue-specific microDNA a panel of human prostrate (LnCap (PSA, hK2 and AR positive), C4-2, and PC-3 (non-tranformed prostate epithelium)) and ovarian (ES2 and OVCAR-8) cancer cell lines were examined for microDNA. The identified microDNAs in all the cell lines were mostly approximately 200bp or approximately 400bp in size, arising from the GC rich regions in the genome, and mostly...
Topics: DTIC Archive, VIRGINIA UNIV CHARLOTTESVILLE, *GENETIC MARKERS, *PROSTATE CANCER, CELLS(BIOLOGY),...
During the project, strategies for the preparation of new globular polymers (dendrimers) were introduced and methods for their rapid synthesis were pioneered. Both achievements address long-standing shortcomings of this field that have hindered translation to the clinic. Structure-activity relationships revealed design criteria for achieving high water solubility necessary for therapeutic application. Methods were surveyed for attaching varied functional groups including the therapeutic...
Topics: DTIC Archive, Simanek,Eric, Texas Christian Universtiy Fort Worth United States, prostate cancer,...
We used various methods to perform a test for an excess of prostate cancer among males sharing the same Y chromosome. Methodology is being refined by comparing 2 competing methods and selecting the preferred model. This analysis identified a ranked list of Y chromosomes from the UPDB resource. A set of 20 samples representing the top 10 high risk and 10 low-risk Y chromosomes for genotyping with a set of 16,000 Y SNPs, and Y chromosome full genome sequencing was submitted. We used available...
Topics: DTIC Archive, Cannon-Albright, Lisa A, University of Utah Salt Lake City United States,...
We pinpointed the hyperexcitable hot spots in the brain responsible for epileptic activities after TBI. These are located in the anterior portion of the injured neocortex in the S1 somatosensory cortex and in the functionally connected somatosensory portion of the thalamus. We found two anatomical and physiological biomarkers of the hot spots: 1) a massive upregulation of the C1q molecule, and 2) a reduced synaptic inhibition in these hot spots. These discoveries we made during the first funded...
Topics: DTIC Archive, Paz, Jeanne, The J. David Gladstone Institutes San Francisco United States, brain...
This is a Clinical Exploration Award funding a clinical trial for patients with metastatic, castration resistant prostate cancer (CRPC). For patients with metastatic CRPC, there are few established therapeutic options and the prognosis remains dire. The overarching goal of this award is to build on concept that under the selective pressure of androgen receptor (AR) targeted therapies, prostate cancer adapts. One way it adapts is by upregulating another hormone receptor, the glucocorticoid...
Topics: DTIC Archive, Szmulewitz,Russell, University of Chicago Chicago United States, health services,...
Purpose: To test the hypothesis that the replacement of tissue-resident alveolar macrophages with monocyte-derived macrophages in response to repeated injury over the lifespan explains the delayed onset of lung fibrosis until the later decades of life. We will use our experimental findings in mice to guide an unbiased assessment of macrophage heterogeneity in normal human lungs and lungs from patients with pulmonary fibrosis. The overarching goal of these studies is to identify clinically...
Topics: DTIC Archive, Misharin,Alexander, Northwestern University Chicago United States, BIOLOGICAL AGING,...
Many factors are known to contribute to the development of lung cancer; one of the important contributing ones is genetic mutations. For example, KRAS mutations account for 22% lung cancer cases. Thus, researchers have be entrying hard to develop drugs against mutant KRAS. However, to date no effective pharmacological inhibitors targeting mutant RAS have reached the clinic for various reasons. Therefore, the search is still going on. Synthetic lethal approach is a new concept that RAS mutant...
Topics: DTIC Archive, Yin-Yuan, Mo, University of Mississippi Medical Center Jackson United States, lung...
Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; currently, chemotherapy and targeted therapies are the main treatment modalities for TNBC, but one-third of patients develop recurrence and drug resistance within 3 years of therapy. Recently, we have discovered that LINK-A (Lipid-Interacting Noncoding RNA for Kinase Activation), a breast cancer-upregulated lncRNA, interacts with PtdIns (3,4,5)P3. In vitro and in vivo experiments...
Topics: DTIC Archive, Yang,Liuqing, University of Texas MD Anderson Center Houston United States,...
The Genitourinary Cancer Biorepository at the University of Washington joined the Prostate Cancer Pathology Resource Network (PCBN) September 30th 2014. The purpose of this interaction is to provide high quality, well annotated specimens that can be used by prostate cancer researchers through the PCBN. The University of Washington Biorepository has a focuson advanced stage disease. Specimens provided by the University of Washington site includes blood (serum, plasma, and buffy coat),...
Topics: DTIC Archive, Morrissey, Colm, University of Washington Seattle United States, prostate cancer,...
Dystrophic or non-dystrophic forms of scoliosis are skeletal manifestations of Neurofibromatosis type 1 (NF1). Dystrophic scoliosis has a more progressive and debilitating course than non-dystrophic scoliosis, often requiring substantial surgical intervention. Experts have recommended early intervention for better outcomes but clinical tools for early detection of dystrophic scoliosis have not been developed. The first goal of this study was to develop a validated radiographic tool for...
Topics: DTIC Archive, Polly,David Jr W, University of Minnesota Minneapolis United States, genetic...
In this program project, 72 brains were examined, including 32 brains of subjects with idiopathic autism (unknown etiology), 12 brains of individuals with autism associated with chromosome15 duplication (dup15) and 28 brains of control subjects from 2 to 65 years of age. The study revealed several correlations between structural and biochemical changes and autistic phenotype. 1. The deficit of neuron volume detected in all 16 brain structures and 15 of 19 of their anatomical subdivisions in 4-8...
Topics: DTIC Archive, RESEARCH FOUNDATION FOR MENTAL HYGIENE INC STATEN ISLAND NY, *BRAIN, *GENETIC...
Monoclonal antibodies are drugs that can specifically bind targets present on tumor cells. The highly aggressive triple-negative subtype of breast cancer does not have specific antibody drugs like Herceptin, and there is considerable need for targeted therapeutics and diagnostic biomarkers. We have developed a new technique allowing for discovery of new antibodies that disrupt a key process in cancer progression termed epithelial to mesenchymal transition or EMT. This process is important in...
Topics: DTIC Archive, Smider, Vaughn V, The Scripps Research Institute La Jolla United States, breast...
We are developing computational tools for improved visual exploration and spatial analysis of DNA profiles, with accompanying photo-identification records or telemetry tracks of marine mammals. Referred to as geneGIS, the computational tools provide the ability to display, browse, select, filter and summarize spatio-temporal relationships of these individual-based records and associated data from molecular markers and ecomarkers (e.g., stable isotopes). A toolbox of software applications allows...
Topics: DTIC Archive, OREGON STATE UNIV NEWPORT HATFIELD MARINE SCIENCE CENTER, *DATA BASES, *WHALES,...
We are conducting a five-year population-based case-control breast cancer study to identify how various breast cancer risk factors differ in their relationships to different molecular subtypes of breast cancer and to further characterize molecular differences between these subtypes. To address the existing research gaps regarding the etiologies of different molecular subtypes of breast cancer we will employ state of the art multidisciplinary approaches to advance our understanding of the...
Topics: DTIC Archive, University of Michigan Ann Arbor United States, breast cancer, clinical trials,...
This grant focuses on identifying molecular features of prostatic adenocarcinomas (PrCa) from African Americans (AAs) which we hypothesize may differ from the molecular features of PrCas from European Americans (EAs). We give priority to characteristics found to be associated with PrCa aggressiveness, because the differential expression of those characteristics may, in part, explain why AAs tend to have more aggressive PrCa than EAs. Genes involved in fatty acid transport and metabolism have...
Topics: DTIC Archive, ALABAMA UNIV IN BIRMINGHAM, *AFRICAN AMERICANS, *MALES, *PROSTATE CANCER, BIOPSY,...
Hypothesis: Plasma proteins, clinical data, and patient characteristics can be used to prospectively identify severely burned patients who are at risk for developing sepsis and other infections. Measurement of already identified biomarkers alongside novel biomarkers identified with discovery proteomics can improve identification of risk for infection and identify the early stages of infection prior to clinical detection. This multicenter study will enable us to identify novel biomarkers,...
Topics: DTIC Archive, Finnerty,Celeste C, The University of Texas Medical Branch at Galveston Galveston...
Food allergy is a harmful immune reaction driven by uncontrolled type-2 immune responses. Current knowledge provide limited insights into why only some, rather than all food allergic individuals are prone to develop life-threatening anaphylaxis. We have identified a novel multi-functional IL-9-producing mucosal mast cells (MMC9s) that produce large amounts of IL-9, IL-13, and mast cell mediators. The objective of this proposal is to identify the factors that regulate MMC9 induction, which...
Topics: DTIC Archive, Wang,Yui H, Childrens Hospital Medical Center Cincinnati United States, ALLERGY AND...
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3.0
May 20, 2020
05/20
by
Nobel Symposium (80th : 1990 : Bjorkborn, Sweden)
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xiii, 316 pages : 25 cm
Topics: Medical genetics -- Congresses, Génétique médicale -- Congrès, Cartes chromosomiques,...
This project collected data to genetically map superior intelligence in the military working dog. A behavioral testing regimen was developed by canine cognitive expert Dr Karen Overall (UPENN) which enabled quantitative intelligence testing of individual dogs and blood samples were taken, and genome-wide SNP typing completed by means of the Affymetrix Canine SNP (single nucleotide polymorphism) Array v2. In order to identify SNP markers for mapping of small-effect-sized genes that contribute to...
Topics: DTIC Archive, HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE WRIGHT-PATTERSON...
From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms (SNPs) meet the stringent threshold for genome-wide significance (meta-p-value 5x10-8), and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all...
Topics: DTIC Archive, Rosenstein,Barry S, Icahn School of Medicine at Mount Sinai New York United States,...
From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms (SNPs) meet the stringent threshold for genome-wide significance (meta-p-value 5x10-8), and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all...
Topics: DTIC Archive, Ostrer,Harry, Albert Einstein College of Medicine of Yeshiva University Bronx United...
Repetitive mild TBI leads to chronic traumatic encephalopathy (CTE), but the underlying molecular changes remain unclear. Here, biochemical and genetic studies that deepen our understanding of the pathogenesis of CTE will be performed, facilitating diagnosis and therapeutic development.
Topics: DTIC Archive, Crary, John F, Icahn School of Medicine at Mount Sinai New York United States,...
Hypothesis: Plasma proteins, clinical data, and patient characteristics can be used to prospectively identify severely burned patients who are at risk for developing sepsis and other infections. Measurement of already identified biomarkers alongside novel biomarkers identified with discovery proteomics can improve identification of risk for infection and identify the early stages of infection prior to clinical detection. This multicenter study will enable us to identify novel biomarkers,...
Topics: DTIC Archive, Finnerty, Celeste C, The University of Texas Medical Branch at Galveston Galveston...
The objective of the study is to validate pupillary light reflex (PLR), saccadic and convergence eye movements as objective biomarkers for the identification of Warfighters with acute mild traumatic brain injury (mTBI) using commercial-off-the-shelf (COTS) instruments: infrared pupillometers, King-Devick (KD) test and near point of convergence (NPC) rule, respectively. Hundred mTBI and 100 age-matched non-TBI (controls) military personnel are to be recruited from the patient population at...
Topics: DTIC Archive, Capo-Aponte,Jose E, Geneva Foundation Tacoma United States, eye movements, traumatic...
During this reporting period we completed an 8 week DMM experiment, in the presence and absence of the AF-28 antibody. This experiment revealed a trend for an AF-28-mediated reduction in knee hyperalgesia, but not mechanical allodynia, in mice at 8 weeks post-surgery. This trend was not statistically significant, however, we are looking forward to results from the next time point, at 16 weeks post-surgery. The hind limbs from the 8 week study, from mice with and without AF-28 treatment, have...
Topics: DTIC Archive, Fosang,Amanda J, The University of Melbourne Dept of Pediatrics Parkville Australia,...
We propose to perform a phase I/II study comparing two nutraceuticals and placebo that target mediators identified in our prior dynamic modeling study of Gulf War Illness (GWI). We will repeat the dynamic modeling before treatment and on therapy to assess our modeling and the impact of the interventions on the homeostatic networks we have identified, with an added focus on the glutathione/redox system. In our prior study Dynamic Modeling in GWI we used an exercise stress model (rest, peak VO2,...
Topics: DTIC Archive, Deth, Richard C, Nova Southeastern University Fort Lauderdale United States, PERSIAN...
Our prior award generated evidence that some syndromes involving unexplained chronic multisymptom illness (CMI) and chronic widespread pain (CWP), including Gulf War Illness (GWI), may involve small-fiber polyneuropathy (SFPN). Objective diagnostic measures suggest that some veterans with GWI may have longstanding, persistent early-onset SFPN. We are developing and evaluating generally applicable tools that can better screen and test Veterans with GWI for such long-standing, early-onset SFPN....
Topics: DTIC Archive, Oaklander,Anne L, Massachusetts General Hospital Boston United States,...
