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Attorney Docket No.: 96.27US 



PATENT 




J/ 

^jeaajS^^n re Application of: Pelle et al. 



IN THE UNITED STATES PATENT AND TRADEMARK OFFICE 



Serial No.: 08/865,821 

Filed: May 30, 1997 

For: Lipid Mix for Lip Product 



Group Art Unit: 1615 
Examiner: Faulkner, Diedra 



DECLARATION UNDER 37 C.F.R. §1.132 



I, Philip Wesley Wertz, declare and say that: 
L I am a citizen of the United States and I reside at 1412 Laurel Street, Iowa City, IA 
52240. 

2. I am a professor at the University of Iowa, College of Dentistry located in Iowa City, 
IA, and I have an A.B. degree in Biochemistry from Rutgers University, New Brunswick, 
NJ and a Ph.D. degree in Biochemistry from the University of Wisconsin, Madison, WI. A 
copy of my curriculum vitae is attached hereto. 

3. For over 20 years, I have taught, published and conducted research in the field of 
skin lipids. I have published numerous book chapters and articles related to skin lipids, 
including, in particular, the subject of the structure and function of lipids in the skin. I am 
very familiar with the scientific principles and issues related to the different structures and 
physiological roles of lipids in the skin and related to skin lipid research. 

4. I have read U.S. Patent No. Zysman, U.S. Pat. No. 5,618,523 (hereinafter referred to as 
v: the '523 reference" 5 ) entitled "Ceramides, Process for Their Preparation and Their 
Applications in the Cosmetic and Dermopharmaceutical Fields" which relates to ceramides 
having a particular structure and compounds containing the ceramide. One of the 
compositions can be an aqueous dispersion of lipid spherules composed of organized 
molecular layers made of the ceramide and another lipid compound. The other lipid 
compound can be cholesterol, or cholesteryl sulphate or phosphate. I understand that the 



Examiner in the present application has asserted that "cholesteryl esters are encompassed by 
the generic term, cholesterol" in this reference. 

5. In my opinion, the Examiner's statement is incorrect. One of ordinary skill in the art 
recognizes that cholesteryl esters, cholesterol, and cholesteryl sulphate and phosphate are 
distinct compounds and treats each of these compounds as non-equivalent compounds due 
to their distinct distribution in the stratum corneum as well as their different functions in the 
stratum comeum. The '523 reference does not make a generic disclosure of cholesterol 
derivatives and the '523 reference does not disclose cholesteryl esters. More specifically, as 
applied directly to the Examiner's statement, it is my opinion that the mere recitation of the 
term "cholesterol" or "cholesteryl sulphate and phosphate" does not encompass cholesteryl 
esters. 

6. Cholesterol is a major constituent of the stratum corneum, and it is believed to play 
a major role in the stratum corneum by contributing to the epidermal permeability barrier 
function and mediating desquamation of the skin. Moreover, cholesterol is a major 
component of the intercellular membrane system in the cornified layer of the epidermis. 
This intercellular membrane system provides the permeability barrier of the skin. In 
contrast, the cholesterol esters found in the cornified layer are not membrane forming lipids, 
and at a physiologic temperature they are liquid. The cholesterol esters in the cornified layer 
are thought to separate into isolated liquid phase pockets, and therefore, it is thought that 
cholesterol esters do not function as components of the intercellular membrane system. 

7. Those skilled in the art also do not consider cholesterol and cholesteryl esters to be 
interchangeable. More specifically, because of the different functions of the compounds in 
the skin, one skilled in the art, on reading about a particular use for one of these compounds, 
would not assume that one of the other compounds would also function for the same 
purpose. This is evidenced by the separate treatment, both structurally and functionally, of 
cholesterol and cholesteryl esters in the scientific literature, especially literature pertaining 
to dermatology. 

8. With respect to biochemistry and biology, one of ordinary skill in the physiological 
and/or dermatological arts recognizes that cholesterol, and cholesteryl sulphate and 



9627DEC.DOC 



phosphate, as disclosed in the '523 reference, are each individual compounds having 
individual qualities and functions in a physiological and/or dermatological system. 
Therefore, one of ordinary skill in the art would not interpret or imply that cholesterol, as it 
is disclosed in the ' 523 reference, includes cholesteryl ester nor would one of ordinary skill 
in the art be led to substitute cholesterol with cholesteryl esters. 

9. In my opinion, based on the compositions taught in the '523 reference, it would not 
have been obvious to one of ordinary skill in the art to replace the cholesterol in the 
compositions of the '523 reference with the cholesteryl ester in the lipid mixture of the 
present invention. 

10. The undersigned declares further that all statements made herein of his own 
knowledge are true and that all statements made on information and belief are believed to 
be true; and further that these statements were made with the knowledge that willful false 
statements and the like so made are punishable by fine or imprisonment, or both, under 
Section 1001 of Title 18 of the United States Code and that such willful false statements 
may jeopardize the validity of the application or any patents issuing thereon. 





9627DEC.DOC 



3 



FACULTY PROFESSIONAL BIOGRAPHY 
College of Dentistry 
University of Iowa 

Date of preparation 



Personal Data 



1 . Name Philip Wesley Wertz 
3. Birth Date 10/25/49 



5. Present Rank 



Professor 



12/12/98 



2. Social Security # 173-42-0860 

4. Department Oral Pathology. Radiology & 
Medicine 

6. Date appointed to present rank 7/93 

Mo./Yr. 



Higher Education , formal programs (most recent first) 



Date Awarded 
(Mo./Yr.) 

1976 
1971 



Degree 



Ph.D. 
A.B. 



Major 



Biochemistry 
Biochemistry 



Institution 



Dates Attended 



University of Wisconsin 1 97 1 - 1 976 
Rutgers University 1 967- 1971 



Professional Employment : Appointments (most recent first) 
Mo./Yr. Rank/Title 



Institution 



1993- 
present 

1990- 
1993 

1984- 
1990 



1981- 
1984 



1979- 
1981 

1976- 
1979 



Professor 

Associate Professor 
Assoc. Research Sci. 

Assist. Research Sci. 

Assoc. of the Laboratory 
Postdoctoral Fellow 



University of Iowa College of Dentistry 
Dows Institute for Dental Research 

University of Iowa College of Dentistry and 
Dows Institute for Dental Research 

University of Iowa College of Medicine 
Department of Dermatology University of Iowa Iowa 
City, Iowa 

University of Iowa College of Medicine 
Department of Dermatology University of Iowa Iowa 
City, Iowa 

McArdle Laboratory for Cancer Research 
University of Wisconsin 

McArdle Laboratory for Cancer Research 
University of Wisconsin 



Facility Professional Biography -2- Philip Wesley Wertz 

IV. Certification and Licensure (Eligibility, stage of completion) 

Board Date 



V. Honors and Awards (most recent first) 

Certificate of appreciation for lecture delivered at Catholic University Graduate School, Seoul, Korea 
(1996) 

Certificate of appreciation for presentation at the annual meeting of the Cosmetic Chemists Society 
(1994) 

Certificate of appreciation from NIH for participation in minority apprenticeship program (1992) 
A.B. with highest honors (1971) 
Phi Beta Kappa (1970) 

VI. Professional Appointments (consultantships, editorships, review panels, etc.; most recent first) 

Year Tjtle 



Reviewer for: 

Biochimica et Biophysica Acta 
Canadian Journal of Microbiology 
Chemistry and Phisics of Lipids 
Journal of Investigative Dermatology 
Journal of Lipid Research 
Journal of Nutritional Biochemistry 
Lipids 

and others 

1992- Director of the Research Seminar Series 

1992 External Reviewer for: 

Advisory Board for Research 

College of Dentistry 

The University of Illinois at Chicago 

1991 Consultant for: 

Functions of Lipids in the Skin. 
Program Director: Donald T. Downing 
Department of Dermatology 
University of Iowa College of Medicine 
Program Project Grant Application not funded 



Fatuity Professional Biography -3- Philip Wesley Wertz 

1991- Ceramide Metabolism & Transport in Keratinocyte Cultures 

Principal Investigator: Kathi Madison 
Department of Dermatology 
University of Iowa College of Medicine 
RO-1 application — active 

1991- Effect of Nicotine on Inflammatory Mediators 

Principal Investigator: Georgia Johnson 
Department of Periodontics & Dows Institute 
University of Iowa College of Dentistry 
R-29 application — active 

1991- Effect of Nicotine on Inflammatory Mediators 

Principal Investigator: Georgia Johnson 
Department of Periodontics & Dows Institute 
University of Iowa College of Dentistry 
Funded by Smokeless Tobacco Council — completed 

1987 External Grant Reviewer for NIH 

General Medicine A Study Section 



VH. Committees (include chair and officer positions; most recent first) 
Year Committee 



National : 
1995 

1987 

University : 
1996-1998 
1992-1993 



Organization 



Session Chairman, Presenter and Workshop Co-chairman at the Gordon 
Conference on the Barrier Function of the Skin 

Session Co-chairman; Gordon Conference; 
Epithelial Differentiation and 
Keratinaization: The Cell Periphery. 



Ethics and Scientific Misconduct Commitee 



Biological Sciences Committee 
(Advisory Committee to the Vice 
President for Research) Pew Proposal 
Review Subcommittee (1992-1993) 



1997-1998 



Biological Sciences Committee 
(Convener) 



) 



Fatuity Professional Biography -4- Philip Wesley Wertz 

1991-1997 Committee B (Human Subjects) 

1997- Committee A 

1 997- 1 998 Library Committee 

Collegiate : 

1998 - Senior Faculty Peer Review Committee 

1998 Periodontics Department Self Study Review Committee 

1996 Basic Science Subcommittee of the Curriculum Committee 

1991-1994 Research Committee 

1 99 1 - Student Dental Research Committee 

Special Advisory Subcommittee on Design and 

Conduct of Retrospective and Prospective 

Clinical Studies (1992- ) 



VIIL Professional Memberships (include offices held; most recent first) 



Year Organization 

1992- Secretary/Treasurer of Iowa Chapter of AADR 
1993 

1992- ASBMB Congressional Correspondent 

1991- American Association for Dental Research 

1989- American Society for Biochemistry and Molecular Biology 

1981- American Oil Chemists Society 

1981- Society for Investigative Dermatology 

1997- American Association of Pharmaceutical Scientists 

1998- Controlled Release Society 



DC. Areas of Research 



Lipids of skin and oral epithelium — structures, functions and metabolism 
Epithelial permeability and drug delivery 
Biochemistry of carcinogenesis 
Essential fatty acids 

X. Current Projects 



. . ) 

Faculty Professional Biography -5- Philip Wesley Wertz 

Compositions and structures of lipids from oral mucosa and skin 

Isolation and characterization of membrane coating granules 

Lipid alteration in hyperplasia 

Biochemical basis for oral mucosal drug delivery 

Preparation of liposomes for drug delivery 

Comparative enzymology of skin and oral epithelium. 

Quantitative morphology of oral epithelia 

Role of alcohol dehydrogenase in oral carcinogenesis 

XI. Financial Resources (Grants and Contracts; include funded, pending, and approved but not funded 
applications; list most recent first in each category) 

Role on Project 

Title (eg: PL Co-Pi consultant) Dates Amount 

Federal: 

A Tissue Engineered Skin Model Contractor/Investigator 02/0 1/00- 

(ROl) 01/31/03 
Source: NIH 
Status: Pending 

Principal Investigator: Bozena Michniak 
Salary Support for PWW: 1 1% 
Comment: This is an ROl 
Submitted from the University 
of South Carolina. 

Local Effects of Alcohol, Aldehyde Investigator 
And Tobacco Carcinogens in the 
Pathogenesis of Oral Cancer 
Source: NIH/NIDR 
Status: Pending 

Principal Investigator: Christopher Squier 
Salary Support for PWW: 10% 
Comment: 

This is a component of a PPG. 

Production of Carcinogens by Investigator 08/01/99- 

Oral Candida Strains 03/3 1/04 

Source: NIH/NIDR 
Status: Pending 

Principal Investigator: David Soli 
Salary Support for PWW: 5% 
Comment: 

This is a component of a PPG. 



08/01/99- 
03/31/04 



Stratum Corneum Lipid 
Disks: A Novel Skin Model 



Contractor/Collaborator 



1-/01/99- 
09/30/02 



Faculty Professional Biography 



-6- 



Philip Wesley Wertz 



Source: NIH 
Status: Pending 

Principal Investigator: Bozena B. 
Michniak 

Salary Support for PWW: 25% 
Comment: This is an ROl 
submitted from the University 
of South Carolina. The major 
focus is a series of studies on 
mechanisms of penetration 
enhancer action using lipid 
disks prepared at UI. Some EPR 
spectra and TEM work will also 
be done at Iowa. 

Tissue Engineering, Biomimetics Investigator 08/01/98- 
And Medical Implant Science 07/01/03 
Source: NIH 
Status: Active 

Principal Investigator: Jackie 
Bickenbach 

Salary Support for PWW: 5% 



Source: NIH/NIDR 
Status: Active 

Principal Investigator: Christopher 
A. Squier 

Salary Support for PWW: 20% 
Comment: The proposed 
experiments would identify the 
physiochemical parameters required 
for effective drug delivery through 
the oral mucosa and would identify 
permeability enhancers for use in 
oral mucosal drug delivery systems. 

Effects Of Alcohol On Oral Principal Investigator 07/01/95- $70,835 

Mucosal Permeability. 06/3 1/97 

Source: NIH/NIDR 

Status: Approved but not funded 



Comment: Lipid composition will be 
one of several markers used to judge 
epithelial differentiation in several 
bioengineered systems. 



Biological Basis For Oral 
Mucosal Drug Delivery. 



Investigator 



07/01/95- 
06/31/98 



$474,624 



Faculty Professional Biography 

Principal Investigator: Philip W. Wertz 
Salary Support for PWW: 15% 
Comment: The effects of alcohol on 
oral mucosal permeability to 
the tobacco carcinogen NNN 
would be examined. These 
studies could provide a 
mechanistic explanation 
for the association of alcohol 
and tobacco use with oral cancer. 



) 



Faculty Professional Biography 



-8- 



Philip Wesley Wertz 



Transmucosal Peptide Delivery. 



Investigator 



07/01/95- 
06/31/97 



$100,000 



Source: NIH/NIDR 



Status: Approved but not funded 
Principal Investigator: William Abraham 
Salary Support for PWW: 5% 
Comment: This is a Small Business 
Technology Transfer application. 
If funded we would collaborate with 
Cygnus Therapeutics Inc of Redwood CA 
on the development of trans oral 
mucosal peptide delivery systems. 

Lipids And The Permeability Principal Investigator 09/01/93- $403,504 

Barrier of Oral Epithelium. 08/3 1/97 

Source: NIH-NIDR 
Status: Active 

Salary Support for PWW: 30% 
Comment: This grant would support 
studies on the formation, structure, 
permeability barriers. 
It would also include studies on 
the perturbation of barrier 
function by essential fatty acid 
deficiency. 

Epithelial Permeability; The Investigator 07/01/92- $328,61 1 

Effects Of Age and Alcohol. 06/30/95 
Source: NIH-NIDR 
Status: Completed 

Principal Investigator: Christopher A. Squier 
Salary Support for PWW: 20% 
Comment: This grant supports 
work on the structure, lipid 
composition and permeability of 
human epithelia and the effects of 
aging on these parameters. Also, the 
effects of alcohol consumption 
on oral epithelial properties and 
carcinogenesis will be studied. 



Faculty Professional Biography 



.9. 



Philip Wesley Wertz 



Structure And Function of 
Polar Lipids In Human Skin. 



Investigator 



12/01/83- 
07/01/90 



$725,000 



Source: NIH-NIADDK 

Principal Investigator: Donald T. Downing 

Salary support for PWW: 60% 

Comment: PWW was involved in all 

phases of planning and execution of this 

project. This included 

extraction, isolation and analysis 

of epidermal lipids, synthesis of 

novel lipids, planning of metabolic 

experiments and formulation and 

testing of topical treatments. 

Evaluation Of Pathogenic Investigator 04/15/81- $1,341,000 

Factors In Acne Vulgaris. 07/0 1 190 

Source: NIH-NIADDK 

Principal Investigator: John S.Strauss 

Salary support for PWW: 40% 

Comment: As an Inversigator 

on this project, PWW was 

specifically responsible for isolation 

and analysis of polar lipids from 

normal skin and from patients with 

acne and scaling dermatoses. 

College of Dentistry: 
none 



Source: Cellegy Pharmaceuticals 
Status: Active 

Comment: This project is linked 
To a US Patent application on 
Mucoadhesive liposomes. 
($30,000) 

Lipid Dermatophysiology. Principal Investigator 10/30/91- $105,00 

Source: ConvaTec - 1 2/3 1/94 

Bristol-Myers Squibb 

Status: Completed ($56,900 in account) 

Comment: This project 

focuses on the effects of 

sebaceous lipids, synthetic 

lipids and liposomes on 



Other: 

Mucoadhesive Liposomes 



Principal Investigator 



08/30/98- 
04/30/99 



Faculty Professional Biography 



Philip Wesley Wertz 



properties of the skin surface 
including permeability and 
adhesive performance. It is 
renewable on an annual basis 
at $3 5,000 per year. 

Ceramides & Ceramidases of Skin Principal Investigator 01/01/95- 

12/31/95 

Source: Gist-brocades 
Status: Completed ($1,788 remaining) 
Comment: This project involved several 
experiments in which the penetration of 
ceramides into stratum corneum was 
monitored, and the activity of ceramidase 
in epidermal homogenates was assayed. 
(Total costs - $5,000) 

Lipid Analytical Service Principal Investigator 11/15/90 - 

Source: Various Agencies 
Status: Active on an intermittant basis 
($40,000 currently in account) 
This is a service with 
prospects of long term 
continuity and accumulation 
of small amounts of money in 
exchange for occasional advise 
or analytical services. 

Roles of Lipids In Desquamation. Co-Principal Investigator 07/01/86- $300,00 

Source: The Procter & Gamble ' 07/0 1/90 

Company 

Co-Principal Investigators: Donald T. 
Downing & Philip W. Wertz 
Comment: This contract was renewed 
on an annual basis at $75,000 per year. 



Roles Of Lipids In Cosmetic Investigator 4/15/81- $200,000 

Properties of The Skin. 6/30/86 
Source: Richardson Vicks Inc. 
Principal Investigator: John S. Strauss 
Comment: PWW was 

an investigator on this contract, ■— - - 

which provided partial salary 
support during 1981-1983 and 
supplemented funds available 
through federal grants. The 



Faculty Professional Biography 



Philip Wesley Wertz 



contract was renewed on an 
annual basis. It started at 
$25,000 per year, and ended 
at $75,000 per year. 



XII. Bibliography (attach sections in the following order, with authors in sequence; most recent first; list 

work that is published or "in press" Submitted work may also be listed; include journal title and date of 
submission; manuscripts in progress should not be included) 

1 . Books and/or Chapters 

Wertz PW, MichniakBB: Epidermal lipid metabolism and barrier function of stratum corneum. In: 
BIOMEDICAL MODULATIONS OF SKIN REACTIONS IN DERMAL AND 
TRANSDERMAL DRUG DELIVERY, JJ Wille, A. Kydonieus (Eds), CRC Press, Boca 
Raton, 1999, in press 

Michniak BB, Wertz PW: Ceramides and lipids. In: HANDBOOK OF COSMETIC SCIENCE 
AND TECHNOLOGY, HI Maibach, A Barel, M Paye (Eds.), Marcel Dekker, New York, 
1999, in press 

Wertz PW: Integral lipids of hair and stratum corneum. In Hair: Biology And Structure, H. Zahn 
and P. Jolles, Eds., Birkhauser Yerlag, Basel,, 1996, pp 227-238. 

Wertz PW: Skin lipids in health and disease. In Phospholipids: Characterization, Metabolism and 
Novel Biological Applications, G. Cevc, F. Paltauf, Eds., AOCS Press, Champaign, IL, pp 
141-160, 1996. 

Wertz PW: Percutaneous absorption: Role of lipids, In Dermatotoxicology - 5th Edition, H.I. 
Maibach and F.N. Marzulli, Eds., Taylor and Francis, Washington DC, pp 29-32, 1996 

Wertz PW, Hoogstraate AJ, Squier CA: Biochemical basis of the permeability barrier in skin and 
oral mucosa. In Oral Mucosa Drug Delivery, MJ. Rathbone and J. Hadgraft, Eds., Marcel 
Dekker, Inc., New York, pp 27-49, 1996 

Squier CA, Wertz PW: Structure and function of the oral mucosa and implications for drug 

delivery. In Oral Mucosal Drug Delivery, MJ Rathbone, Ed., AAI Inc, Wilmington, pp 1-26, 
1996 

Wertz PW, Squier CA: Biochemical Basis of the Permeability Barrier in Skin and Oral Mucosa. In 
Oral Mucosal Drug Delivery, MJ Rathbone, Ed., AAI Inc, Wilmington, pp 1-26, 1996 

Squier CA, Wertz PW, Williams DM, Cruchley AT: Permeability of oral mucosa and skin with age. 
In The Effect Of Aging In Oral Mucosa And Skin, CA. Squier and M.W. Hill, Eds., CRC 
Press, Boca Raton, pp 91-98, 1994. 



Faculty Professional Biography 



-12- 



Philip Wesley Wertz 



Wertz PW, Karthigasan J, Hill MW; Effects of Aging on Epithelial Metabolism. In The Effect of 
Aging In Oral Mucosa And Skin, C. A. Squier and M.W. Hill, Eds., CRC Press, Boca Raton, 
pp 107-112, 1994. 

Downing DT, Stewart ME, Wertz PW, Strauss JS: Lipids of the epidermis and the sebaceous 

glands. In Dermatology In General Medicine, 4th edition, TB Fitzpatrick, AZ Eisen, K Wolff, 
KF Austen (eds.) McGraw-Hill, Inc., New York, 210-21 1, 1993. 

Wertz PW, Downing DT: Biology and biochemistry of the epidermis. In Biochemistry And 

Physiology Of The Skin, 2nd edition, LA Goldfsmith (Ed.) Oxford University Press, New 
York, 1992. 

Wertz PW: Liposome dermatics - chemical aspects of the skin lipid approach. In: Liposome 

Dermatics, O. Braun-Falco, HC Korting, HI Maibach (Eds.), Springer- Verlag, Berline, 1992, 
pp 38-43. 

Wertz PW, Swartzendruber DC, Downing DT: The role of the corneocyte lipid envelope in the 
structure and function of the epidermal barrier. In Proceedings Of The Conference On 
Prediction Of Percutaneous Penetration, RC Scott, J Hadgraft, RH Guy, J McDougal (Eds.), 
IBC Technical Services Ltd., London, 1990, pp. 405-41 1. 

Downing DT, Stewart ME, Wertz PW, Strauss JS: The effect of sebum on epidermal lipid 
composition. In Acne And Related Disorders, R Marks, G Plewig (Eds.) Martin Dunitz, 
London, 1989. 

Wertz PW, Downing DT: Stratum corneum: biological and biochemical considerations. In 
Transdermal Delivery Systems, J Hadgraft, RH Guy (Eds.), Marcel Dekker, NY, 1988. 

Wertz PW: Lipids of keratinized tissues. In Biology Of The Integument, Vol. 2. J Bereiter-Hahn, 
GAMatoltsy, KS Richards (Eds.), Springer- Verlag, Berlin, 1986. 

Wertz PW: Effects of phorbol esters on phospholipid metabolism in vitro. In Arachidonic Acid 
Metabolism And Tumor Promotion, Vol. 3. TJ Slaga, SM Fisher (Eds.), Martinas Nijhoff 
Publishing, Boston, 1985. 

2. Journal Articles (include initial and final page numbers) 

Di Nardo A, Wertz PW, Giannetti A, Seidenari S: Ceramide and cholesterol composition of the skin 
of patients with atopic dermatitis. Acta Derm Venereol (Stockh) 78:27-30, 1998 

Madison KC, Sando GN, Howard EJ, True CA, Gilbert D, Swartzendruber DC, Wertz PW: 
Lamellar granule biogenesis: a role for ceramide glucosyltransferase, lysosomal enzyme 
transport, and the golgi. J Invest Dermatol Symp Proc 3:80-86, 1998 

Kuempel D, Swartzendruber DC, Squier CA, Wertz PW: In vitro reconstitution of stratum 
corneum lipid lamellae. Biochim Biophys Acta 1372:135-140, 1998 



Faculty Professional Biography 



-13- 



Philip Wesley Wertz 



Wertz PW, van den Bergh BAI: The Physical, chemical and functional properties of lipids in the 
skin and other biological barriers. Chem Phys Lipids 91 :85-96, 1998 

van den Bergh BAI, Bouwstra JA, Junginger HE, Wertz PW: Interaction of flexible liquid-state 
niosomes with hairless mouse skin, assessed by electron microscopy, in vivo, and by 
diffusion studies in vitro. Proceed Int Symp Control Rel Bioact Mater 25:18-19, 1998 

Law S, Fotos PG, Wertz PW: Skin surface lipids inhibit adherence of Candida albicans to stratum 
corneum. Dermatology 195:220-223, 1997 

Whittle S, Swartzendruber DC, Kremer M, Squier CA, Wertz PW: Lipids of hamster cheek pouch 
epithelium. Lipids 32:961-964, 1997 

Hoogstraate AJ, Wertz PW, Squier CA, Bos-van Geest A, Abraham W, Garrison MD, Verhoef JC, 
Junginger HE, Bodde HE: Effects of the penetration enhancer glycodeoxycholate on the lipid 
integrity in porcine buccal epithelium in vitro. Euro J Pharm Sci 5:189-198, 1997 

Atar PS, Wertz PW, McArthur M, Imakado S, Bickenbach JR, Roop DR: Inhibition of retinoid, 
signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function. 
Molecular Endocrin 11:792-800, 1997 

Squier CA, Kremer M, Wertz PW: Continuous flow mucosal cells for measuring the in vitro 
permeability of small tissue samples. J Pharm Sci, 86:82-84, 1997 

Di Nardo A, Sugino K, Ademola J, Wertz PW, Maibach HI: Role of ceramides in proclivity to 
toluene and xylene-induced skin irritation. Dermatosen 44:1 19-125, 1996 

Di Nardo A, Sugino K, Ademola J, Wertz PW, Maibach HI: Sodium lauryl sulfate (SLS) induced 
irritant contact dermatitis: a correlation study between ceramides and in vivo parameters of 
irritation. Contact Dermatitis. 35:86-91,1996 

Law S, Wertz PW, Swartzendruber DC, Squier CA: Regional variation in content, composition 
and organization of porcine epithelial barrier lipids revealed by thin-layer chromatography and 
transmission electron microscopy. Archs oral Biol 40:1085-1091, 1995 

Swartzendruber DC, Manganaro A, Madison KC, Kremer M, Wertz PW, Squier CA: Organization 
of the intercellular spaces of porcine epidermal and palatal stratum corneum: a Quantitative 
study employing ruthenium tetroxide. Cell & Tissue Res 279:271-276, 1995. 

Swartzendruber DC, Burnett IH, Wertz PW, Madison KC, Squier CA: Osmium tetroxide and 

ruthenium tetroxide are complementary reagents for the preparation of epidermal samples for 
transmission electron microscopy. J Invest Dermatol, 104:417-420, 1995. 

Vargas K, Wertz PW, Drake D, Morrow B, Squier CA, Soil DR: Differences in adhesion of the 
switch phenotypes of Candida albicans strain 3 153 A to buccal epithelium and stratum 
corneum. Infection and Immunity, 62:1328-1335, 1994. 



Faculty Professional Biography 



-14- 



Philip Wesley Wertz 



Johnson GK, Poore TK, Squier CA, Wertz PW, Reinhardt RA, Vincent SD: Prostaglandin E2 and 
interleukin-1 levels in smokeless tobacco-induced oral mucosal lesions. J Periodont Res, 29: 
430-438, 1994. 

Abraham W, Wertz PW, Potts RO, Garrison MD: Investigation of phase transition in oral mucosa 
by fluorescent spectroscopy. Proc Internat Symposium Control Release Bioact Mater, 
21:557-558, 1994. 

Steen Law SL, Squier C A, Wertz PW: Free sphingosine in oral epithelium. Comp Biochem 
Physiol, 110B:51 1-513, 1994. 

Chang F, Wertz PW, Squier CA: Localization of p-glucosidase activity within keratinizing 
epithelia. Comp Biochem Physiol, 105A:251-253, 1993. 

Chang F, Swartzendruber DC, Wertz PW, Squier C A: Covalently bound lipids in keratinizing 
epithelia. Biochim Biophys Acta 1 150:98-102,1993. 

Abrams K, Harvell J, Shriner D, Wertz P, Maibach H, Maibach HI, Rehfeld SJ: Effect of organic 
solvents on in vitro human skin water barrier function. J Invest Dermatol 101:609-613, 1993. 

Di Nardo A, Sugino K, Wertz PW, Ademola J, Maibach HI: Cutaneous reactions to the organic 
solvents toluene and xylene: determination of surface lipids and instrumental determination of 
inflammatory reaction. Determatologia Oggi 2:17-21, 1993. 

Wertz PW, Kremer M, Squier CA: Comparison of lipids from epidermal and palatal stratum 
corneum. J Invest Dermatol, 98:375-378, 1992. 

Squier CA, Cox P, Wertz PW: Lipid content and water permeability of skin and oral mucosa. J 
Invest Dermatol, 96:123-126, 1991. 

Chang F, Wertz PW, Squier C A: Comparison of glycosidase activities in epidermis, palatal 
epithelium and buccal epithelium. Comp Biochem Physiol, 100B: 137-139, 1991. 

Squier CA, Wertz PW, Cox P: Thin-layer chromatographic analyses of lipids in different layers of 
porcine epidermis and oral epithelia. Arch Oral Biol, 36:647-653, 1991. 

Wertz PW, Downing DT: Metabolism of topically applied fatty acid methyl esters in BALB/c 
mouse epidermis. Journal of Dermatologic Science 1:33-38, 1990. 

Wertz PW, Downing DT: Free sphingosine in human epidermis. J Invest Dermatol 94: 159-161, 
1990. 

Bortz JT, Wertz PW, Downing DT: Composition of cerumen lipids. J Amer Acad Dermatol, 
23:845-849, 1990. 

Wertz PW, Downing DT: Ceramidase activity in porcine epidermis. FEBS Letters, 268: 110-1 12, 
1990. 



Faculty Professional Biography -15- Philip Wesley Wertz 

Wertz PW, Downing DT: Metabolism of linoleic acid in porcine epidermis. J Lipid Res 31: 1839- 
1844, 1990. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Sphingolipid metabolism in 
organotypic mouse keratinocyte cultures. J Invest Dermatol, 95:657-664, 1990. 

Wertz PW, Madison KC, Downing DT: Covalently bound lipids of human stratum corneum. J 
Invest Dermatol 91:109-1 1 1, 1989. 

Takamura T, Wertz PW, Sato K: Free fatty acids and sterols of human eccrine sweat. Brit J 
Dermatol 120:43-47, 1989. 

Swartzendruber DC, Wertz PW, Kitko DJ, Madison KC, Downing DT: Molecular models of the 
intercellular lipid lamellae in mammalian stratum corneum. J Invest Dermatol 92:251-257, 
1989. 

Wertz PW, Downing DT: Integral lipids of mammalian hair. Comp Biochem Biophys 92B:759- 
761, 1989. 

Wertz PW, Downing DT: w-Hydroxyacid derivatives in the epidermis of several mammalian 
species. Comp Biochem Physiol 93B:265-269, 1989. 

Wertz PW, Downing DT: b-Glucosidase activity in porcine epidermis. Biochim Biophys Acta 
1001:115-119,1989. 

Wertz PW, Downing DT: Free sphingosine in porcine epidermis. Biochim Biophys Acta 
1002:213-217, 1989. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Murine keratinocyte cultures grown 
at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during 
differentiation. J Invest Dermatol 93:10-17, 1989. 

Wertz PW. Swartzendruber DC, Kitko DJ, Madison KC, Downing DT: The role of the corneocyte 
lipid envelopes in cohesion of the stratum corneum. J Invest Dermatol 93:169-172, 1989. 

Bortz JT, Wertz PW, Downing DT: On the origin of alkanes found in human skin surface lipids. J 
Invest Dermatol 93:723-727, 1989. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Lamellar granule extrusion and 
stratum corneum intercellular lamellae in murine keratinocyte cultures. J Invest Dermatol 
90:110-116, 1988. 



Hedberg CL, Wertz PW, Downing DT: 
90:225-229, 1988. 



The nonpolar lipids of pig epidermis. J Invest Dermatol 



Faculty Professional Biography 



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Philip Wesley Wertz 



Abraham W, Wertz PW, Downing DT; Fusion patterns of liposomes formed from stratum corneum 
lipids. J Invest Dermatol 90:259-262, 1988. 

Perisho KM, Wertz PW, Madison KC, Stewart ME, Downing DT: Fatty acids of acylceramides 
from comedones and from the skin surface of acne patients and control subjects. J Invest 
Dermato 90:350-353, 1988. 

Abraham W, Wertz PW, Downing DT: Effect of epidermal acylglucosylceramides and 

acylceramides on the morphology of liposomes prepared from stratum corneum lipids. 
Biochim Biophys Acta 939:403-408, 1988. 

Hedberg CL, Wertz PW, Downing DT: The time course of lipid biosynthesis in pig epidermis. J 
Invest Dermatol 91:169-174, 1988. 

Wertz PW, Downing DT: Hydroxyacid derivatives in human epidermis. Lipids 23:415-418, 1988. 

Wertz PW, Downing DT: Integral lipids of human hair. Lipids 23:878-881, 1988. 

Swartzendruber DC, Kitko DJ, Wertz PW, Downing DT: Isolation of corneocyte envelopes from 
porcine epidermis. Arch Dermatol Res 280:424-429, 1988. 

Wertz PW, Downing DT: Covalently bound co-hydroxyacylsphingosine in the stratum corneum. 
Biochim Biophys Acta 917:108-1 1 1, 1987. 

Abraham W, Wertz PW, Landmann L, Downing DT: Stratum corneum lipid liposomes: calcium- 
induced transformation into lamellar sheets. J Invest Dermatol 88:212- 214, 1987. 

Abraham W, Wertz PW, Burken RR, Downing DT: Glucosylsterol and acylglucosylsterol of snake 
epidermis. J Lipid Res 28:446-449, 1987. 

Wix MA, Wertz PW, Downing DT: Polar lipid composition of mammalian hair. Comp Biochem 
Biophys 86B:671-673, 1987. 

Swartzendruber DC, Wertz PW, Madison KC, Downing DT: Evidence that the corneocyte has a 
chemically bound lipid envelope. J Invest Dermatol 88:709-713, 1987. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Presence of intact intercellular 
lamellae in the upper layers of the stratum corneum. J Invest Dermatol 88:714-718, 1987. 

Wertz PW, Swartzendruber DC, Madison KC, Downing DT. The composition and morphology of 
epidermal cyst lipids. J Invest Dermatol 89:419-425, 1987. 

Melton JL, Wertz PW, Swartzendruber DC, Downing DT: Effects of essential fatty acid deficiency 
on 0-acylsphingoIipids and transepidermal water loss in young pigs. Biochim Biophys Acta 
921:191-197, 1987. 



Faculty Professional Biography 



-17- 



Philip Wesley Wertz 



Ranasinghe AW, Wertz PW, Downing DT, Mackenzie IC: Lipid composition of cohesive and 
desquamated corneocytes from mouse ear skin. J Invest Dermatol 86:187-190, 1986. 

Wertz PW, Cox PS, Squier CA, Downing DT: Lipids of epidermis and keratinized and non- 
keratinized oral epithelia. Comp Biochem Physiol 83B:529-531, 1986. 

Wertz PW, Downing DT: Linoleate content of epidermal acylglucosylceramide in newborn, 
growing, and mature mice. Biochim Biophys Acta 876:469-473, 1986. 

Wertz PW, Downing DT: Covalent attachment of co-hydroxyacid derivatives to epidermal 

macromolecules: a prelimnary characterization. Biochem Biophys Res Comm 137-992-997, 
1986. 

Wertz PW, Stover PM, Downing DT: A survey of polar and nonpolar lipids from epidermis and 
epidermal appendages of the chicken ( Gallus domesticus ). Comp Biochem Physiol 84B:203- 
206, 1986. 

Wertz PW, Stover PM, Abraham W, Downing DT: Lipids of chicken epidermis. J Lipid Res 
27:427-435, 1986. 

Madison KC, Wertz PW, Strauss JS, Downing DT: Lipid composition of cultured murine 
keratinocytes. J Invest Dermatol 87:253-259, 1986. 

Squier CA, Cox PS, Wertz PW, Downing DT: The lipid composition of porcine epidermis and oral 
epithelium. Archs Oral Biol 31:741-747, 1986. 

Merrill AH Jr., Wang E, and Wertz PW: Differences in long chain (sphingoid) base composition of 
sphingomyelin from rats bearing Morris hepatoma 7777. Lipids 21 :529-530, 1986. 

Downing DT, Wertz PW, Stewart ME: The role of sebum and epidermal lipids in the cosmetic 
properties of the skin. Int J Cosmetic Sci 8:1 15-123, 1986. 

Wertz PW, Abraham W, Landmann L, Downing DT: Preparation of liposomes from stratum 
corneum lipids. J Invest Dermatol 87:582-584, 1986. 

Stewart ME, Grahek MO, Cambier LS, Wertz PW, Downing DT: Dilutional effect of increased 
sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in 
epidermal acylceramides. J Invest Dermatol 87:733- 736, 1986. 

Downing DT, Stewart ME, Wertz PW, Strauss JS: Essential fatty acids and acne. J Amer Acad 
Dermatol 14:221-225, 1986. 

Wertz PW, Abraham W, Cho ES, Downing DT: Linoleate-rich O-acylsphingolipids of mammalian 
epidermis: structures and effects of essential fatty acid deficiency. Prog Lipid Res 25:383- 
389, 1986. 



Faculty Professional Biography - 1 8- Philip Wesley Wertz 

Burken RR, Wertz PW, Downing DT: The effects of lipids on transepidermal water permeation in 
snakes. Comp Biochem Physiol 81 A:213-216, 1985. 

Burken RR, Wertz PW, Downing DT: A survey of polar and nonpolar lipids extracted from snake 
skin. Comp Biochem Physiol 81B:315-318, 1985. 

Wertz PW, Miethke MC, Long SA, Strauss JS, Downing DT: The composition of the ceramides 
from human stratum corneum and from comedones. J Invest Dermatol 84:410-412, 1985. 

Long SA, Wertz PW, Strauss JS, Downing DT: Human stratum corneum polar lipids and 
desquamation. Arch Dermatol Res 277:284-287, 1985. 

Abraham W, Wertz PW, Downing DT: Linoleate-rich acylglucosylceramides from pig epidermis; 
structure determination by proton magnetic resonance. J Lipid Res 26:761-766, 1985. 

Schoephoerster RT, Wertz PW, Madison KC, Downing DT: A survey of polar and nonpolar lipids 
of mouse organs. Comp Biochem Physiol 82B:229-232, 1985. 

Wertz PW, Abraham W, Stover PM, Downing DT: Uropygiols: confirmation of structure by 
proton magnetic resonance. J Lipid Res 26:1333-1337, 1985. 

Wertz PW, Downing DT, Freinkel RK, Traczyk TN: Sphingolipids of the stratum corneum and 
lamellar granules of fetal rat epidermis. J Invest Dermatol 83:193- 195, 1984. 

Frost ML, Colton SW 6th, Wertz PW, Downing DT: Structures of the dienoic lactones of horse 
sebum. Comp Biochem Physiol 78B:549-552, 1984. 

Wertz PW, Downing DT: Cholesteryl sulfate: the major polar lipid from horse hoof. J Lipid Res 
25:1320-1323, 1984. 

Landmann L, Wertz PW, Downing DT: Acylglucosylceramide causes flattening and stacking of 
liposomes: an analogy for assembly of the epidermal permeability barrier. Biochim Biophys 
Acta 778:412-418, 1984. 

Wertz PW Colton SW, VI, Downing DT: Comparison of the hydroxyacids from the epidermis and 
the sebaceous glands of the horse. Comp Biochem Physiol 75B:217- 220, 1983. 

Wertz PW, Downing DT: Acylglucosylceramides of pig epidermis: structure determination. J 
Lipid Res 24:753-758, 1983. 

Wertz PW, Downing DT: Ceramides of pig epidermis: structure determination. J Lipid Res 
24:759-765, 1983. 

Wertz PW, Cho ES, Downing DT: Effects of essential fatty acid deficiency on the epidermal 
sphingolipids of the rat. Biochim Biophys Acta 753:350-355, 1983. 



Faculty Professional Biography 



-19- 



Philip Wesley Wertz 



Wertz PW, Downing DT: Glucosylceramides of pig epidermis: structure determination. J Lipid 
Res 24:1135-1139, 1983. 

Downing DT, Stewart ME, Wertz PW, Colton SW 6th, Strauss JS: Skin lipids. Comp Biochem 
Physiol 76B: 673-678, 1983. 

Wertz PW, and Mueller GC: A possible role for protein alkylation in phorbol ester action. 
Carcinogenesis 7:499-511, 1982. 

Birkby CS, Wertz PW, Downing DT: The polar lipids from keratinized tissues of some 
vertebrates. Comp Biochem Physiol 73B:239-242, 1982. 

Wertz PW, Downing DT: Glycolipids in mammalian epidermis: structure and function in the water 
barrier. Science 217:1261-1262, 1982. 

Mueller GC, Wertz PW, Kwong CH, Anderson KA, and Wrighton SA: Dissection of the early 
molecular events in the activation of lymphocytes by 12-0- tetradecanoylphorbol- 13 -acetate. 
Jerusalem Symposia on Quantum Chemistry and Biochemistry 13:319-333, 1981. 

Wertz PW, Garver JC, and Anderson L: The anatomy of a complex mutarotation. J Amer Chem 
Soc 103:3916-1922, 1981. 

Wertz PW and Mueller GC: Inhibition of 1 2-0-tetradecanoylphorobol- 13 -acetate accelerated 
phospolipid metabolism by 5,8,1 1,1 4-eicosatetraynoic acid. Cancer Res 40:776-781, 1980. 



Verma AK, Slaga TJ, Wertz PW, Mueller GC, and Boutwell RK: Inhibition of skin tumor 

promotion by retinoic acid and its metabolite 5,6-epoxyretinoic acid. Cancer Res 40:2367- 
2371, 1980. 

Wertz PW, Kensler TW, Mueller GC, Verma AK, and Boutwell RK: 5,6-Epoxyretinoic acid 

opposes the effects of 12-0-tetradecanoylphorbol-13-acetate in bovine lymphocytes. Nature 
277:227-229, 1979. 

Kensler TW, Wertz PW, and Mueller GC: Inhibition of phorbol ester accelerated amino acid 
transport in bovine lymphocytes. Biochim Biophys Acta 585:43-52, 1979. 

Wertz PW, and Mueller GC: Rapid stimulation of phospholipid metabolism in bovine lymphocytes 
by tumor-promoting phorbol esters. Cancer Res 38:2900-2904, 1978. 

Wertz PW, Kensler TW, and Mueller GC: Inhibition of phorbol ester action in lymphocytes by 5,6- 
epoxy-P-ionone. Biochem Biophys Res Commun 83:138-143, 1978. 

3. Reviews 

Wertz PW: Sebum. In: DRUGS VS. COSMETICS: COSMECEUTICALS?, HI Maibach, P Eisner 
(Eds.), Marcel Dekker, New York, 1999, in press 



Faculty Professional Biography -20- Philip Wesley Wertz 

Hoogstraate AJ, Garza J, Wertz PW: Barrier lipids from epidermis and oral epithelium. Recent 
Develop Lipids Res, 1999, in press 

Hoogstraate AJ, Wertz PW: Drug delivery via the buccal mucosa. Pharm Sci Tech Today 1 :309- 
316, 1998 

Wertz PW: The nature of the epidermal barrier: biochemical aspects. Advan Drug Delivery Rev 
18:283-294, 1996 

Book Review (Lipids ~ Molecular Organization, Physical Functions And Technical Applications 
Kare Larsson, The Oily Press, Dendee, Scotland, 1994) for Chemistry and Physics of Lipids, 
in press, 1994. 

Soil DR, Morrow B, Srikantha T, Vargas K, Wertz PW: The developmental and molecular biology 
of switching in Candida albicans . Oral Surgery, Oral Medicine and Oral Pathology, 78:194- 
201, 1994. 

Wertz PW, Swartzendruber DC, Squier CA: Regional variation in the structure and permeability of 
oral mucosa and skin. Advanced Drug Delivery Reviews, 12:1-12, 1993. 

Squier CA, Wertz PW: Permeability and the pathophysiology of oral mucosa. Advanced Drug 
Delivery Reviews, 12:13-24, 1993. 

Wertz PW: Epidermallipids. Seminars in Dermatology, 11:106-113, 1992. 

Book review (Interfacial Phenomena In Biological Systems M. Bender, Ed., Marcel Dekker Inc., 
New York, 1991) for Inform - a publication of the American Oil Chemists' Society. Inform 
3:835, 1992. 

Wertz PW, Squier CA: Cellular and molecular basis of permeability barrier function in oral 
epithelium. Crit Rev Ther Drug Carrier Sys, 8:237-269, 1991. 

Wertz PW, Swartzendruber DC, Abraham A, Madison KC, Downing DT: Essential fatty acids and 
epidermal integrity. Arch Dermatol 123:1381-1384, 1987. 

Downing DT, Stewart ME, Wertz PW, Colton SW 6th, Abraham W, Strauss JS: Skin lipids: An 
update. J Invest Dermatol 88:2s-6s, 1987. 

4. Abstracts 

Gilbert D, MA KC, Sando GN, Squier CA, Wertz PW: (3-Glucocerebrosidase in lamellar 
granules. J Dent Res, 7S:719, 1999 

Squire D, Squier CA, Wertz PW: Effects of protease inhibitors on desquamation from buccal 
mucosa. J Dent Res, 78: 536, 1999 

Garza J, Madison KC, Sando GN, Wertz PW: N-Butyldeoxygalactonojirimycin inhibits glycolipid 
and ceramide synthesis and permeability barrier formation. J Dent Res, 78:719, 1999 



Faculty Professional Biography 



Philip Wesley Wertz 



Ahmad M, Hoogstraate AJ, Squier CA, Wertz PW: Effects of potential permeability enhancers 
on buccal epithelial integrity. J Dent Res, 78:719, 1999 

Howard M, Swartzendruber DC, Squier CA, Wertz PW: In vitro reconstitution of epidermal and 
palatal stratum corneum lipid lamellae. J Dent Res, 536, 1999 

Guo R, Swartzendruber DC, Squier CA, Wertz: Quantitative morphology of the intercellular 
spaces of superficial buccal epithelium. J Dent Res, 78:719, 1999 

Kremer MJ, Denel S, Kas SH, Wertz PW, Squier CA: Oral mucosal drug delivery: Chitosanm as 
vehicle and permeabilizer. J Dent Res, 78:719, 1999 

Zantua JB, Kremer MJ, Lafoon JE, Squier CA, Wertz PW: Role of mucin glycoproteins in the 
permeability of oral mucosa. J Dent Res, 78:719, 1999 

Wade TL, Vargas MA, Wertz PW: Effect of preparation and acid conditioning on dentin collagen. 
J Dent Res 77:177, 1998 

Squire D, Squier CA, Wertz PW: Effects of SDS and a protease inhibitor on desquamation. J 
Dent Res 77:293, 1998 

Gilbert D, Swartzendruber DC, Squier CA, Wertz PW: Lipid composition of isolated lamellar 
granules. J Dent Res 77:293, 1998 

Ahmad M, Hoogstraate AJ, Krema C, Squier CA, Wertz PW: Size limit and pathway for glucan 
diffusion across buccal mucosa. J Dent Res 77:293, 1998 

Whittle S, Quinn J, Squier CA, Wertz PW: Sphingomyelinase activity in epidermis and oral 
epithelium. J Dent Res 77:293, 1998 

Garza J, Swartzendruber DC, Vincent S, Squier CA, Wertz PW: Membrane structures in human 
buccal epithelium. J Dent Res 77:293, 1998 

Kuempel D, Swartzendruber DC, Squier CA, Wertz PW: In vitro reconstitution of stratum 
corneum lipid lamellae. J Dent Res 77:294, 1998 

Kremer MJ, Squier CA, Wertz PW: Absorption and release of triamcinolone in oral mucosa. J 
Dent Res 76:361, 1997 

Kuempel D, Swartzendruber, DC, Kremer M, Wertz PW, Squier CA: Reconstruction of epithelial 
membrane systems. J Dent Res 76:361, 1 997 

Lund TM, Wertz PW, Drake DR: Development of an in vitro Candida albicans oral infection 
model. J Dent Res 76: 1 2 1 , 1 997 



Faculty Professional Biography -22- Philip Wesley Wertz 

Jarpa P, Johnson GK, Squier CA, Wertz PW: Effects of smokeless tobacco products on pH. J Dent 
Res 76:448, 1997 

Grau M, Donly KJ, Wertz PW: In vitro degradation of a guided tissue regeneration matrix barrier. 
J Dent Res 76:444, 1997 

Squire D, Wertz PW, Squier CA: A model system for studies of desquamation from buccal 
epithelium. J Dent Res 76:362, 1997 

Du X, Kremer M, Wertz PW, Squier CA: Oral epithelial flux and reservoir function following brief 
exposure to ethanol. J Dent Res 76:362, 1997 

Whittle S, Du X, Squier CA, Wertz PW: Effects of hyperplasia on stratum corneum barrier function 
and lipids. J Dent Res 76:362, 1 997 

Lafoon JE, Squier CA, Wertz PW, Barrieshi K, Kremer MJ: Role of vascularized rete pegs in 
permeability of oral mucosa. J Dent Res 76:362, 1997 

Ortale K, Hall E, Squier CA, Wertz PW: Patterns of DNA fragmentation during epithelial 
differentiation. J Dent Res 76:362, 1997 

Ortale K, Fromm R, Wertz PW, Squier CA: Adherence of positively charged liposomes to buccal 
mucosa, J Dent Res 75:330, 1996 

Whittle S, Squier CA, Kremer M, Swartzendruber DC, Johnson GK, Wertz PW: Alteration of oral 
epithelial lipids in hyperplasia, J Dent Res 75:260,1996 

Lund T, Drake DR, Wertz PW: Liposomal modification of mucosal surfaces and adherence of 
Candida albicans, J Dent Res 75:1 14, 1996 

Alves J, Barrieshi K, Walton R, Wilcox L, Wertz PW, Drake DR: Endotoxin penetration from 
mixed culture through obturated post-prepared canals, J Dent Res 75:373, 1996 

Kremer M, Squier CA, Wertz PW: Mucosal permeability is best predicted by flow through perfusion 
chambers, J Dent Res 75:330, 1996 

Gell G, Drake DR, Wertz PW: Peridex and lauric acid exhibit a synergistic effect on Streptococcus 
mutans. Annual meeting of the American Association for Dental Research, J Dent Res 74:76, 
1995 

Ortale K, Wertz PW, Squier CA: Preparation of liposomes from buccal barrier lipids. Annual 
meeting of the American Association for Dental Research, J Dent Res 74:59, 1995 

Steen Law SL, Wertz PW, Squier CA: Regional variation in content and composition of epithelial 
barrier lipids. Annual meeting of the American Association for Dental Research J Dent Res, 
74:62, 1995 



Faculty Professional Biography 



-23- 



Philip Wesley Wertz 



Bayati P, Wertz PW, Swartzendruber DC, Squier CA: Relationship of orientation to electron 
microscopic images of lamellar granules. Annual meeting of the American Association for 
Dental Research, J Dent Res 74:62, 1995 

Bickenbach JR, Attar PS, Imakado S, Rothnagel J A, Wertz PW, Roop DR: Dominant negative 
retinoic acid receptor produces loss of epidermal barrier function in transgenic mice. J Invest 
Dermatol, in press, 1995 

Quinn J, Cox P, Squier CA, Wertz PW: Epithelial sphingomyelin and sphingomyelinase. Annual 
meeting of the American Association for Dental Research, J Dent Res 73:108, 1994 

Steen Law SL, Squier CA, Wertz PW: Free sphingosine in oral epithelium. Annual meeting of the 
American Association for Dental Research, J Dent Res 73:108, 1994 

Williams DM, Cruchley AT, Wertz PW, Squier CA: The lipid composition of human oral 

epithelium. Annual meeting of the American Association for Dental Research, J Dent Res 
73:168, 1994 

Bayati P, Chang F, Swartzendruber DC, Madison KC, Johnson GK, Squier CA, Wertz PW: 
Organization of human epithelial permeability barriers. Annual meeting of the American 
Association for Dental Research, J Dent Res 73:168, 1994 

Johnson GK, Poore TK, Wertz PW, Organ CC, Reinhardt RA: IL-1 and PGE2 levels in smokeless 
tobacco-induced lesions. Annual meeting of the American Association for Dental Research, J 
Dent Res 73:359, 1994 

Cannon CL, Neal PJ, Kulilus J, Klausner M, Swartzendruber DC, Squier CA, Kremer MJ, Wertz 
PW: Lipid and ultrastructural characterization of a new epidermal model shows good 
correspondence to normal human epidermis. Annual meeting of the Society for Investigative 
Dermatology, J Invest Dermatol 102:600, 1994 

Swartzendruber DC, Manganaro A, Ahonkhai A, Wertz PW, Squier CA: Organization of epithelial 
permeability barriers. Annual meeting of the American Association for Dental Research, J 
Dent Res 72:166, 1993. 

Manganaro A, Wertz PW, Squier CA: Enhancement of buccal permeability by oleic acid. Annual 
meeting of the American Association for Dental Research, J Dent Res 72:103, 1993. 

Chang F, Swartzendruber DC, Wertz PW, Squier CA: Covalently bound lipids in oral epithelia. 
Annual meeting of the American Association for Dental Research, J Dent Res 72:165, 1993. 

Kremer M, Hu L, Wertz PW, Squier CA: Method for isolation of the buccal permeability barrier. 
Annual meeting of the American Association for Dental Research, J Dent Res 72:166, 1993. 

Gell G, Drake D, Wertz PW: Antimicrobial effects of epithelial lipids. Annual meeting of the 
American Association for Dental Research, J Dent Res 72:399, 1993. 



Faculty Professional Biography 



-24- 



Philip Wesley Wertz 



Wertz PW, Squier CA: Glycosylceramides of buccal epithelium - structure determination. Annual 
meeting of the American Association for Dental Research, J Dent Res 72:166, 1993. 

Squier CA, Kremer M, Wertz PW, Squier SU: Penetration of ovalbumin across nonkeratinized oral 
epithelia. Annual meeting of the American Association for Dental Research, J Dent Res 
72:166, 1993. 

Law SS, Fotos PG, Wertz PW: Effects of lipids on adherence of Candida albicans to a keratinized 
epithelial surface. Annual meeting of the American Association for Dental Research, J Dent 
Res 72:300, 1993. 

Di Nardo. A, Sugino K, Wertz PW, Ademola J, Maibach HI: Irritation induced by organic solvents: 
An in vivo study of the effects of toluene and xylene in man. Third Congress of the European 
Academy of Dermatology and Venereology, Denmark, 1993 

Di Nardo A, Sugino K, Wertz PW, Ademola J, Maibach HI: Evaluation with noninvasive methods 
of irritation by xylene and toluene and analysis of superficial lipids. 68th National Congress of 
the Itallian Society of Dermatology and Venereology, Pisa, 1993 

Kremer MJ, Shade WB II, Holbrook NS, Wertz PW, Squier CA: Morphologic Location of the 
Buccal Permeability Barrier. Annual meeting of the American Association for Dental 
Research, 1992. J Dent Res 71 :213, 1992. 

Wertz PW, Kremer M, Squier CA: A Comparison of Lipids From Epidermal and Palatal Stratum 
Corneum. Annual meeting of the American Association for Dental Research, J Dent Res 
71:214, 1992. 

Chang F, Wertz PW, Squier CA: Distribution of b-Glucosidase in Keratinizing Epithelia. Annual 
meeting of the American Association for Dental Research, J Dent Res 71:214, 1992. 

Kremer MJ, Shade WB II, Holbrook NS, Wertz PW, Squier C A: Morphologic Location of the 
Buccal Permeability Barrier. Annual meeting of the American Association for Dental 
Research, 1992. J Dent Res 71:213, 1992. 

Wertz PW, Kremer M, Squier CA: A Comparison of Lipids from Epidermal and Palatal Stratum 
Corneum. Annual meeting of the American Association for Dental Research, J Dent Res 
71:214, 1992. 

Chang F, Wertz PW, Squier CA: Distribution of b-Glucosidase in Keratinizing Epithelia. Annual 
meeting of the American Association for Dental Research, J Dent Res 71 :214, 1992. 

Squier CA, Wertz PW, Laflfoon J, Kremer M: Lipid Lamellae and the Permeability Barrier in Oral 
Epithelium. Annual meeting of the International Association for Dental Research, 1992. 

Abrams K, Harvell J, Shriner D, Wertz P, Maibach HI, Rehfeld SJ: The effect of various solvent 
systems on in vitro human skin barrier function. Annual meeting of the Society for 
Investigative Dermatology, 1992. J Invest Dermatol 98:641, 1992. 



Faculty Professional Biography 



-25- 



Philip Wesley Wertz 



Chang F, Squier CA, Wertz PW: Glycosidases in skin and oral mucosa. Annual meeting of the 
International Association for Dental Research, 1991. J Dent Res 70:513, 1991. 

Wertz PW, Downing DT: The time course of linoleate metabolism in pig epidermis in vivo. 

Annual meeting of the Society for Investigative Dermatology, 1990. Clin Res 38:603 A, 1990. 

Wertz PW, Downing DT: Epidermal ceramide hydrolase. Annual meeting of the Society for 
Investigative Dermatology, 1990: Clin Res 38:640A, 1990. 

Swartzendruber DC, Boysen DP, Wertz PW, Downing DT: The ultrastructure of lipid lamellae in 
avian epidermis. Annual meeting of the Society for Investigative Dermatology, 1990. Clin 
Res38:640A, 1990. 

Madison KC, Swatzendruber DC, Wertz PW, Downing DT: Characterization of the ceramides of 
mouse epidermis and organotypic murine keratinocyte cultures. Annual meeting of the 
Society for Investigative Dermatology, 1990. Clin Res 38:685A, 1990. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: De novo synthesis of ceramides in 
organotypic mouse epidermal cultures. Annual meeting of the American Federation for 
Clinical Research, 1989. Clin Res 37:353A, 1989. 

Bortz JT, Wertz PW, Downing DT: On the originin of paraffin hydrocarbons found in skin surface 
lipids. Annual meeting of the Society for Investigative Dermatology, 1989. Clin Res 
37-.617A, 1989. 

Hedberg CL, Wertz PW, Downing DT: Glucose is not a substrate for epidermal lipid biosynthesis 
in vivo. Annual meeting of the Society for Investigative Dermatology, 1989. Clin Res 
37:675A, 1989. 

Swartzendruber DC, Wertz PW, Madison KC, Downing DT: Modelling the molecular architecture 
of stratum corneum lipid lamellae. Annual meeting of the Society for Investigative 
Dermatology, 1989. Clin Res 37:680A, 1989. 

Golden G, Francoeur ML, Potts RO, Abraham W, Wertz PW, Downing DT: Cedramides provide 
for the "solid-like" properties of stratum corneum intercellular lipids. Annual meeting of the 
Society for Investigative Dermatology, 1989. Clin Res 37:617A, 1989. 

Wertz PW, Downing DT: Free sphingosine in porcine epidermis. Annual meeting of the Society 
for Investigative Dermatology, 1989. Clin Res 37:622A, 1989. 

Downing DT, Stewart ME, Wertz PW, Strauss JS: The effect of sebum on epidermal lipid 
composition. International symposium on acne and related disorders, 1988. 

Downing DT, Stewart ME, Wertz PW, Strauss JS: Diet and acne. International symposium on 
acne and related disorders, 1988. 



I 



Faculty Professional Biography -26- Philip Wesley Wertz 

Wertz PW, Downing DT: Integral lipids of human hair. Annual meeting of the Society for 
Investigative Dermatology, 1988. Clin Res 36:703 A, 1988. 

Abraham W, Wertz PW, Downing DT: Preparation of liposomes and lamellar sheets from the total 
stratum corneum extracts. Annual meeting of the Society for Investigative Dermatology, 

1988. Clin Res 36:629A, 1988. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Lipid composition and metabolism in 
murine keratinocyte cultures grown at the air/medium interface. Annual meeting of the 
Society for Investigative Dermatology, 1988. Clin Res 36:670A, 1988. 

Wertz PW, Downing DT: Hydroxyacid derivatives in mammalian epidermis. Joint Meeting of the 
American Society for Biochemistry and Molecular Biology and the American Society for Cell 
Biology, 1989. J Cell Biol 107:361a, 1988. 

Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Morphologic and biochemical lipid 
markers of terminal differentiation in cultured keratinocytes. Joint Meeting of the American 
Society for Biochemistry and Molecular Biology and the American Society for Cell Biology, 

1989. J Cell Biol 107:361a, 1988. 

Abraham PW, Wertz PW, Downing DT: Transformation of stratum corneum lipid liposomes into 
lamellar sheets. Joint Meeting of the American Society for Biochemistry and Molecular 
Biology and the American Society for Cell Biology, 1989. J Cell Biol 107:356a, 1988. 

Downing DT, Swartzendruber DC, Wertz PW, Madison KC: Molecular models of the extracellular 
membranes in mammalian stratum corneum. Joint Meeting of the American Society for 
Biochemistry and Molelcular biology and the Amrican Society for Cell Biology, 1989. J Cell 
Biol 107:356a, 1988. 

Swartzendruber DC, Madison KC, Wertz PW, Downing DT: Transmission electron microscopy 
(TEM) visualization of stratum corneum lipid lamellae after ruthenium tetroxide fixation. 
Joint Meeting fo the American Society for Biochemistry and Molecular Biology and the 
American Society for Cell Biology, 1989. J Cell Biol 107:357a, 1988. 

Abraham W, Wertz PW, Landmann L, Downing DT: O-Acylglucosylceramides and O- 

acylceramides cause aggregation and stacking of stratum corneum lipid liposomes. Annual 
meeting of the Society for Investigative Dermatology, 1987. Clin Res 35:665A, 1987. 

Downing DT, Swartzendruber DC, Madison KC, Wertz PW: The corneocyte plasma membrane is 
a chemically bound lipid envelope. Annual meeting of the Society for Investigative 
Dermatology, 1987. Clin Res 35:680A, 1987. 

Swartzenbdruber DC, Wertz PW, Madison KC, Downing DT: Demonstration of intercellular 
lamellae in intact and desquamated stratum corneum. Annual meeting of the Society for 
Investigative Dermatology, 1987. Clin Res 35:720A, 1987. 



Faculty Professional Biography 



-27- 



Philip Wesley Wertz 



Wertz PW, Melton JC, Swartzendruber DC, Downing DT: Effects of essential fatty acid deficiency 
on the structure and function of epidermal lipids. Annual meeting of the Society for 
Investigative Dermatology, 1987. Clin Res 35:724A, 1987. 

Abraham W, Wertz PW, Landmann L, Downing DT: Preparation of liposomes and lamellar sheets 
from stratum corneum lipids. Annual meeting of the Society for Investigative Dermatology, 
1986. Clin Res 34:733 A, 1986. 

Burken RR, Wertz PW, Abraham W, Downing DT: The occurrence of "molecular rivets" in 
epidermis from different orders of vertebrates. Annual meeting of the Society for 
Investigative Dermatology, 1986. Clin Res 34:741 A, 1986. 

Wertz PW, Downing DT: Linoleic acid in epidermal acylglucosylceramide from newborn, growing 
and mature mice. Annual meeting of the Society for Investigative Dermatology, 1985. Clin 
Res 34:787A, 1986. 

Madison KC, Wertz PW, Downing DT, Strauss JS: Lipid composition of cultured murine 

keratinocytes. Annual meeting of the Society for Investigative Dermatology, 1986. Clin Res 
34:765A, 1986. 

Squier CA, Cox P, Lesch CA, Wertz PW: Identification of lipids in successive epithelial strata of 
skin and oral mucosa. International Association for Dental Research meeting, 1985. 

Stewart ME, Wertz PW, Grahek MO, Downing DT: Relationship between sebum secretion rates 
and the concentration of linoleate in sebum and epidermal lipids. Annual meeting of the 
Society for Investigative Dermatology, 1985. Clin Res 33:684 A, 1985. 

Ranasinghe AW, Wertz PW, Mackenzie IC, Downing DT, Strauss JS : The role of lipids in 

corneocyte cohesion and desquamation in mouse ear skin. Annual meeting of the Society for 
Investigative Dermatology, 1985. Clin Res 33:677A, 1985. 

Abraham W, Wertz PW, Downing DT: Linoleate-rich polar lipids of epidermis: structure 

determination by proton magnetic resonance. Annual meeting of the Society for Investigative 
Dermatology, 1985. Clin Res 33:621 A, 1985. 

Long SA, Wertz PW, Strauss JS, Downing DT: Human stratum corneum polar lipids before and 
after desquamation. Annual meeting of the Society for Investigative Dermatology, 1983. Clin 
Res32:599A, 1984. 

Landmann L, Wertz PW, Downing DT: Acylglucosylceramide causes flattening and stacking of 
liposomes: an analogy for assembly of the epidermal permeability barrier. Annual meeting of 
the Society for Investigative Dermatology, 1984. Clin Res 32:596A, .1984. 

Wertz PW, Downing DT: The role of glycolipids in assembly of extracellular membranes in the 
skin. Annual meeting of the Iowa Academy of Science, 1984. 



Faculty Professional Biography 



-28- 



Philip Wesley Wertz 



Landmann L, Wertz PW, Downing DT: Acylglucosylceramide and the epidermal permeability 
barrier: a liposome reconstitution study. Annual meeting of the European Anatomical 
Society, 1984, Acta Anatomica 120:241-242, 1984. 

Cox PS, Wertz PW, Downing DT, Squier C A: Changes in lipid composition between consecutive 
sections through pig epidermis. Annual meeting of the British Society for Investigative 
Dermatology, 1984. 

Downing DT, Stewart ME, Wertz PW, Colton SW 6th: Analysis of waxes from vertebrate skin. 
Annual meeting of the American Oil Chemists Society, 1984. J Amer Oil Chem Soc 61:666, 
1984. 

Clancey CJ, Van Orden DE, Zlatnik FJ, Wertz PW, Dowining DT: Quantitation of amniotic fluid 
phospholipids: A novel determination of disaturated lecithins (SPC). Annual meeting of the 
Society for Gynecologic Investigation, 1983. 

Wertz PW, Downing DT: Epidermal sphingolipids: strucutres and possible functions in the 

epidermal water barrier. Annual meeting of the Society for Investigative Dermatology, 1983. 
Clin Res 3 1:608 A, 1983. 

Wertz PW, Downing DT: Studies on the role of glycolipids in the assembly and maintenance of the 
extracellular membranes in the skin of terrestrial vertebrates. Twelfth International Congress 
of Biochemistry, 1982. 

Wertz PW, Downing DT: The structures and physiological role of lipids in the epidermal barrier to 
percutaneous water loss. Annual scientific meeting of the Society of Cosmetic Chemists, 
1982. 

Wertz PW, Mueller GC: A role for protein alkylation in phorbol ester action. Annual meeting of 
the American Association for Cancer Research, 1981 . Proc Amer Assoc Cancer Res 22:137, 
1981. 

Wertz PW, Mueller GC: Activation of CTP:phosphorylcholine cytidyl transferase by 12-0- 
tetradecanoylphorbol- 13 -acetate (TP A) in bovine lymphocytes. Annual meeting of the 
American Association for Cancer Research, 1 980. Proc Amer Assoc Cancer Res 21:511, 
1980. 

Wertz PW, Mueller GC: 5,8,1 1,1 4-Eicosatetraynoic acid (ETYA) inhibits the biological action of 
12-0-tetradecanoylphorbol-13-acetate (TPA) in bovine lymphocytes. Annual meeting of the 
American Association for Cancer Research, 1979. Proc Amer Assoc Cancer Res 20:949, 
1979. 

Mueller GC, Kensler TW, Wertz PW, Kwong CH: Retinoic acid inhibition of phorbol ester 

mediated comitogenesis, phospholipid metabolism and capping in bovine lymphocytes. Cold 
Spring Harbor Symposium on Phorbol Esters, 1 978. 



faculty Professional Biography 



-29- 



Philip Wesley Wertz 



Wertz PW, Mueller GC: 12-0-Tetradecanoylphorbol-13-acetate stimulates phosphatidyl choline 
metabolism in bovine lymphocytes. Annual meeting of the American Society of Biological 
Chemists, 1978. Fed Proc 37:1494, 1978. 

Wertz PW: A computer assisted kinetic analysis of the tautomerization and complex mutarotation 
of D-galactose. Doctoral dissertation, University of Wisconsin, Madison (1976). Dissertation 
Abstracts International 37:4450-B, 1977. 

Anderson L, Wertz PW: Correlation between the complex mutarotation of an aldose and the 

kinetics of its tautomerization. Centennial meeting of the American Chemical Society, 1976. 

5. Invited External Presentations and Lectures 

Presented an invited lecture titled "Regional variation in lipids and barrier function in keratinizing 
epithelia" at the conference on Perspectives on Percutaneous Penetration in Leiden, September, 
1998. 

Seminars at the University of Modena, University of Leiden, University of South Carolina, Medical 
University of South Carolina, University of California at San Francisco and University of Iowa 
College of Dentistry and College of Medicine, 1998. 

Invited speaker at the Gordon Conference on the Barrier Function of Mammalian Skin, New 
Hampshire, 1997. 

Invited speaker at the World Congress of Dermatology, Sydney, Australia, 1997. 

Presented an invited lecture titled "Skin lipids in health and disease" at Catholic University, Seoul, 
Korea, August, 1996 

Presented an invited lecture titled "Effects of lipids on the cosmetic properties of the skin" at Pacific 
Research and Development Center, Seoul, Korea, August, 1996 

Presented an invited lecture titled "Lipids and the epidermal permeability barrier" at the annual 
meeting of the Korean Society for Investigation of the Barrier Function of the Stratum Corneum, 
Seoul, Korea, August, 1 996 

Presented an invited lecture titled "Chemistry and composition of lipids from the skin surface, 
stratum corneum and hair" at Amway Research Center, Grand Rapids, MI, October 1995 

Presented an invited lecture titled "Lipids and the epidermal permeability barrier" at ALZA 
Corporation, Palo Alto, CA, September 1995 

Invited speaker at the Gordon Conference on Barrier Function of Mammalian Skin. Also co- 
directed an afternoon workshop on the ROLES OF LIPIDS IN BARRIER FUNCTION. 

Presented an invited lecture titled "Lipids and the epidermal permeability barrier" at the annual 
scientific meeting of the Society of Cosmetic Chemists, New York, 8-9 December, 1994. 



Faculty Professional Biography 



-30- 



Philip Wesley Wertz 



Presented an invited lecture titled "Antimicrobial lipids from the skin surface" at ConvaTec, a 
subsidiary of Bristol-Myers Squibb, Princeton, NJ, December 1994. 

Served as co-chairman at the Dental Student Research Conference, 1990, 1992 & 1994. 

Presented an invited lecture titled "Epidermal lipids — opportunities for transdermal drug delivery 
and improved skin adhesives" at ConvaTec, a subsidiary of Bristol-Myers Squibb, Princeton, NJ, 
October 1993. 

Presented an invited lecture titled "Skin lipids in health and disease" at The 6th International 
Colloquium on Phospholipids, Hamburg, Germany, 24-27 October, 1993. 

Presented an invited lecture titled "The epidermal permeability barrier -- biochemical and 
ultrastructural considerations" Second Annual New Technologies Workshop: Skin Toxicology And 
Pharmacology - In Vitro And Clinical Techniques, Microbiological Associates, Inc., Bethesda, 
MD, 9- 1 0 September 1 993 . 

Presented an invited lecture titled "Roles of lipids in formation and function of the epidermal 
permeability barrier and the influence of skin surface lipids on adherence of Candida albicans" at the 
ConvaTec Skin Care Symposium, Princeton, NJ, 14 May 1993 

Presented an invited lecture titled "Composition, structure and organization of lipids in stratum 
corneum" at The Winter Workshop (The Physical Organization of Stratum Corneum Lipid) held at 
the University of British Columbia, Vancouver, Canada, February 28 - March 2, 1993 

Served as a judge of the Max Smith Award competition at the 1992 annual meeting of the Iowa 
Chapter of the American Association for Dental Research 

Speaker at conference on the effects of aging on oral mucosa and skin held in Iowa City, May 1992. 

Presented an invited lecture titled "Lipid nature of the epidermal permeability barrier" at ConvaTec, 
a subsidiary of Bristol-Myers Squibb, Princeton, NJ, 1991. 

Speaker and session chairman at International Conference on Liposome Dermatics in Bad 
Griesbach, Germany, October 1991. 

Presented invited lecture titled "Essential fatty acids and epidermal integrity" at the 36th Annual 
Symposium on the Biology of the Skin sponsored by the Cutaneous Biology Foundation, Inc., 
Salishan Lodge, Oregon, 1986. 

Presentations on epidermal lipids at Vicks Research Center, Shelton, CT, in 1982, 1983 and 1984. 

Presented and invited lecture title "Strucutre and function of the polar lipids of epidermis" at the 
Gordon Conference on Epithelial Differentiation and Keratinization, 1983. 



Faculty Professional Biography 



-31- 



Philip Wesley Wertz 



Presented invited lecture titled "The structure and physiological role of lipids in the epidermal 
barrier to percutaneous water loss" at the annual meeting of the Society of Cosmetic Chemists, 
New York. 1982. 

6. Other: Exhibits, films, tapes, special presentations 



XHL Student Mentoring : 

1. Graduate Theses Directed: 



Degree Year 



Candidate 



Title 



M.S. 1993 Sandra Law 
(Co-Directed with Pete Fotos) 



M.S. 



M.S. 



1992 Albert Manganaro 



1997 Patricio Jarpa 



Adherence of Candida albicans to porcine stratum 
corneum in vitro. 

Effects of permeabilizers on penetration of propranolol 
through buccal epithelium in vitro. 

Variations of pH, nicotine levels and mutagenicity of 
smokeless tobacco products from U.S., India and 
Venezuela 



Faculty Professional Biography -32- 
I have served or am serving on the thesis committees of: 



Philip Wesley Wertz 



Deborah Vezeau 
David Rolf 
Thomas Poore 
Riaz Ali 
Bruce Ringdahl 
Hudda Hamaddi 
Mike Huberman 
Joseli Alves 
Deena Kuempel 
Earnest Lam 
Kaaren Vargas 
Heather Reid 
Xiobing Du 

2. Other Graduate Committee Service : 

Degree Year Candidate Title 



3. Predoctoral Student Research Mentorship : 

Student Year Awards Received by Student 



Bennedicte van den Bergh 1998 
(Dutch Ph.D. student) 

Jennifer Garza 1 997- Dows Award 



NIDR Award 



Matt Howard 



1998- 



NIDR Award 



Manal Ahmad 



1997- 



DRA 



Rebecca Guo 



1998 - 



Dows Award 



Shannon Li 



1998 - 



DRA 



Kevin Ortale 



1994-1997 



Max Smith Award 
NIDR Awards 



Janet Hoogstraate 1994 
(Dutch PhD student) 



Sara Whittle 1995-1998 



NIDR Awards 



Faculty Professional Biography 



- j j - 



Philip Wesley Wertz 



Trace Lund 1994-1997 
(David Drake Co-Mentor) 

MattGrau 1996 
(Kevin Donly Co-Mentor) 

DougSquier 1995- 

(predental 1995, dental student 1996- ) 

Delon Gilbert 1996-1997 
(Predental, dental student 1997-) 



Keith Slaymaker 
(Predental) 

Matt Abraham 
(Predental) 

P. Bayati 



Ajanet Mclain 
(SSTP) 

GGell 

Candace Wright 
(SSTP) 

Aima Ahonkai 
(SSTP) 

Felicia Chang 

Niki Holbrook 
(SSTP) 

Harry Fang 



1996-1998 
1996 

1993-1995 

1994 

1993-1995 
1993 

1993 

1991-1994 
1992 

1992 



DRA 



Director's Award 



Dows Award 
DRA 

Howard Hughs Fellowship 
Dows Award 
AADS Gies Award 



Director's Award 
Dows Award 



Dows Award 



Dows Awards 



(local high school student; Science Research 91 :86) 

Nate Stevens 1991 
(Predental) 



William B Shade II 1991 
(SSTP, CA Squier Co-Mentor) 



Faculty Professional Biography 

Karen N. Ekpenyong 1991 
(SSTP, CA Squier Co-Mentor) 



-34- 



Philip Wesley Wertz 



Sofia F. Betancourt 1991 
(SSTP, David Drake Co-Mentor) 

Jennifer Haake 1991 
(local high school student; Science Research 91:86) 



Jeffrey T Bortz 
(Medical Student) 



1990 



Christopher L Hedberg 
(Medical Student) 



1989 



Kathy M Perisho 
(Medical Student) 

Mark A Wix 
(Medical Student) 

Jeffrey C Melton 
(Medical Student) 



1988 



1987 



1987 



Russel R Burken 
(Medical Student) 



1983-1984 



Susan Rubes 
(Medical Student) 

Paul M Stover 
(Medical Student) 



1986 



1986 



Saundrett Gibbs 
(Medical Student) 



1985 



Dan Johnson 
(Medical Student) 

Marianne C Miethke 
(Medical Student) 

Sherri Long 



1985 



1985 



1985 



Best Basic Science Presentation 
Best Clinical Presentation 
Best Presentation in Dermatology 
All at the 1986 Medical Student 
Research Symposium at Galviston 



Faculty Professional Biography 



-35- 



Philip Wesley Wertz 



Richard T Schoephoerster 1985 
(Undergraduate) 

Mark L Frost 1984 
(Medical Student) 

Craig Birkby 1982 
(Medical Student) 



XIV. Continuing Education (sponsored by the University; presented during the past five years most recent 
first) 

Presentations qualifying for continuing education credit at: 
Dermatology meetings & symposia 20 
Clinical research meeting 1 
Seminars 2 

XVI. Teaching Activities (Include the past five years; most recent first; provide narrative describing 
responsibility in each course) 

1 . Classroom . Seminar , or Teaching Laboratory 

Year Course Title and No. No. registered length of course 

1996- Systemic Disease Manifestations 75 16wks 

86:155 

facilitator for problem based learning 

1993- Pathophysiology of Skin & 9 16wks 

Mucosa 112:251 

1992-95 Dental Biochemistry 

99:161 70 16wks 

1991- Dental Science Research 

Methodology 151:210 31 8 wks 

Course Director 



1991- Research Seminar Series 15 16 wks 100% 

151:200 
Director 



1991- 



Pathophysiology of Salivary 



12 



16 wks 10% 



T 



Faculty Professional Biography .-36- Philip Wesley Wertz 

Glands 112:254 

1990-91 Dental Science Research 25 8 wks 10% 

Methodology 112:210 

1982-90 Basic Science for Dermatology 12 16 wks 25% 

College of Medicine 

1982-90 Research in Dermatology 6 16 wks 35% 

62:4 

2. Clinical Teaching (undergraduate, graduate and direct patient care) 
Year Where Occurred weeks/year hrs/wk 

Students supervised: 

2 local high school students 
7 SSTP students 

6 University of Iowa undergraduates 
14 medical students 
14 dental students 

3 College of Dentistry MS students 

1 high school science teacher 

2 postdoctoral associates 
2 Dutch PhD students 

see pages 25-32 for details.