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PATENT ABSTRACTS OF JAPAN 

(11)Publication number : 06-263627 
(43)Date of publication of application : 20.09.1994 



(51)lnt.CI. S J/« 

v ' A61K 7/00 

A61K 35/78 



(21 Application number : 05-078870 (71 Applicant : SUNSTAR INC 
(22)Date of filing : 12.03.1993 (72)lnventor : TAKAHASHI AYUMI 

MATSUMOTO KUMIKO 
NAESHIRO HIDEKAZU 



(54) COSMETIC COMPOSITION FOR PREVENTING AGING OF SKIN 

(57)Abstract: 

PURPOSE: To obtain a cosmetic for preventing aging of skin, excellent in effects for 
preventing aging of skin (proliferation of epiderm, promotion of differentiation, turn over 
promotion of corneal layer, improvement of corneum, skin- beautifying effect, etc.). 
CONSTITUTION: A cosmetic composition for preventing aging of skin is obtained by blending 
extracts of a plant belonging to the genus Betula or Alnus of Betulaceae (e.g. Betula 
platyphylla or Alnus japonica). As the extracting solvents for plant extracts, benzene, ethyl 
ether, chloroform, methylene chloride, ethyl acetate, butyl acetate, acetone, methanol, ethanol 
or 1 ,3-butylene glycol and water, etc., are preferably used, though these solvents are not 
especially limited. These extracts are blended in amounts of 0.001 -2wt.% based on cosmetic 
composition. 



LEGAL STATUS 

[Date of request for examination] 27.05. 1 997 

[Date of sending the examiner's decision of 
rejection] 

[Kind of final disposal of application other than 
the examiner's decision of rejection or 
application converted registration] 

[Date of final disposal for application] 

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[Patent number] 2988803 

[Date of registration] 08.10.1999 

[Number of appeal against examiner's 
decision of rejection] 

[Date of requesting appeal against examiner's 
decision of rejection] 

[Date of extinction of right] 



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JP,06-263627,A [DETAILED DESCRIPTION] 



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* NOTICES * 

JPO and NCIPI are not responsible for any 
damages caused by the use of this translation. 

1 .This document has been translated by computer. So the translation may not reflect the original 
precisely. 

2 **** shows the word which can not be translated. 
3. In the drawings, any words are not translated. 

DETAILED DESCRIPTION 

[Detailed Description of the Invention] 
[0001] 

[Industrial Application] This invention relates to skin aging prevention cosmetics excellent in the skin 
aging prevention effectiveness (growth of an epidermal cell, promotion of differentiation, turnover 
promotion of a horny layer, a keratin improvement, beautiful skin effect, etc.) which contains the extract 
extractives of the vegetation belonging to Betula of Betulaceae, and an alder group as an active 
principle. 
[0002] 

[Description of the Prior Art] On the aging skin, it becomes the desiccation skin which the fall of the cell 
activity of epidermis and dermis is looked at, therefore the depression of a horny layer depends, and the 
skin without the resiliency by the depression of dermis fibrocyte. In order to recover the activity of such 
the aging skin, retrieval of a cell activator is performed and the matter with the growth promotion 
operation over dermis fibrocyte is proposed (placental extract, whey extract, etc.). However, the 
constituent which blended these also came out of the effectiveness as skin aging prevention cosmetics 
enough, there was nothing and retrieval of a more effective component was a technical problem. 
[0003] 

[Means for Solving the Problem] this invention persons continue retrieval about the activator of an 
epidermal cell. Also unexpectedly, Betula of Betulaceae, It discovers that the extract extractives of the 
vegetation belonging to an alder group have the operation which promotes growth of an epidermal cell 
notably. As a result of repeating examination wholeheartedly, these extractives improve the function of a 
horny layer. Further The skin cosmetics which come to blend the extract extractives of the vegetation 
belonging to Betula of Betulaceae and an alder group promote the turnover of the aging skin. It checks 
also discovering Mr. ** and a beautiful skin effect (admiration, a smooth feeling, a flare, and gloss being 
gently given to the skin) for a remarkable operation to a dry-rough-skin improvement effect and a 
keratin improvement effect, and came to complete this invention. That is, this invention is skin aging 
prevention cosmetics which come to blend the extract extractives of the vegetation belonging to Betula 
of Betulaceae, and an alder group. 

[0004] The Betula alba of Betula of Betulaceae used for this invention is well-known vegetation which 
exists in **** of Takayama of CHUBU ENGINEERING CORPORATION or a northern part in Japan. 
Moreover, it is the well-known vegetation to which the alder of the vegetation belonging to the alder 
group of the same family also exists in Japan. Although the vegetable extract extractives blended into 
the skin cosmetics of this invention are the extract extractives of the vegetation belonging to Betula of 
above-mentioned Betulaceae, and an alder group and especially an extracting solvent is not limited, 
benzene, ethyl ether, chloroform, a methylene chloride, ethyl acetate, butyl acetate, an acetone, a 
methanol, ethanol or 1, 3-butylene glycol, water, etc. are desirable, and chloroform, ethanol, and 
especially water are still more desirable. These extracting solvents can also mix and use two or more 
sorts. Extract operation is performed by the conventional method. That is, the xylem of these vegetation, 
a bark, a root, a leaf,. etc. are dried, or it breaks finely as it is, and is immersed in a desired extracting 



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solvent. Especially the immersed temperature is not limited. A solvent can be filtered out after 
immersion, it can condense by approaches, such as vacuum concentration, and extractives can be 
obtained. As for the loadings to the cosmetics of the extract extractives of the vegetation belonging to 
Betulaceae Betula and an alder group, it is desirable that it is 0.001 - 2.0 % of the weight. The skin aging 
prevention effectiveness made into the purpose for these loadings to be less than 0.001 % of the weight 
cannot demonstrate enough. On the other hand, even if it exceeds 2.0 % of the weight, the improvement 
in effectiveness corresponding to the increment is not obtained. Remarkable effectiveness is accepted, 
when the extract extractives of the vegetation belonging to these Betulaceae Betula and an alder group 
improve a skin function, restore or improve the function with which the skin is originally equipped, and 
maintain the skin at a healthy condition and it applies to especially the aging skin. According to the 
class, well-known components (a basis, coloring matter, perfume, antiseptics, a surfactant, a pigment, 
anti-oxidant, etc.) can be suitably blended with the skin cosmetics of this invention in the range which 
does not spoil the engine performance. 
[0005] 

[Example] Hereafter, this invention is explained to a detail based on the example of reference, and an 
example. 

[Production of extract extractives] 

Example 1 of reference: 11. water extracted lOOg of bark of the Betula alba twice. Subsequently, it 
hardened by drying, after carrying out vacuum concentration of 2 times of the extracts, and extract 
extractives 1.4g was obtained. (1.4% of yield) 

Example 2 of reference: lOOg of bark of the Betula alba was extracted twice by 11. ethanol. 
Subsequently, it hardened by drying, after carrying out vacuum concentration of 2 times of the extracts, 
and extract extractives 22g was obtained. (22% of yield) 

Example 3 of reference: 11. chloroform extracted lOOg of bark of the Betula alba twice. Subsequently, it 
hardened by drying, after carrying out vacuum concentration of 2 times of the extracts, and extract 
extractives 23g was obtained. (23% of yield) 

[0006] Example 4 of reference: 11. water extracted lOOg of bark of an alder twice. Subsequently, it 
hardened by drying, after carrying out vacuum concentration of 2 times of the extracts, and extract 
extractives l.Og was obtained. (1.0% of yield) 

Example 5 of reference: lOOg of bark of an alder was extracted twice by 11. ethanol. Subsequently, it 
hardened by drying, after carrying out vacuum concentration of 2 times of the extracts, and extract 
extractives 1 8g was obtained. (18% of yield) 

Example 6 of reference: 11. chloroform extracted lOOg of bark of an alder twice. Subsequently, it 
hardened by drying, after carrying out vacuum concentration of 2 times of the extracts, and extract 
extractives 23g was obtained. (23% of yield) 
[0007] [Cornification cell proliferation accelerated test] 

Cultured cell: The cornification cell used the SV40 transformation Homo sapiens keratinocyte 
established as a cultured cell. 

Test method: 2.5ml of fetal calf serum which sterilized in the clean bench, 75ml of keratinocyte basal 
media, and 0.8ml of antibiotics were put in, 1.6x106 cornification cells were scattered there, 3ml was 
poured distributively on each 6 hole plate, and it cultivated at 37 degrees C under the ambient 
atmosphere which contains 5% of carbon dioxide gas among a carbon-dioxide-gas incubator. Culture 
medium was removed 24 hours after, 1.5ml of keratinocyte basal media, the 1.5ml of the Dulbecco 
strange method eagle minimum nutrition culture media, 3micro.g potassium chloride 3micro[ of linolic 
acid ] g, antibiotic 30microg, and 30microg [/ml ] fatty-acid free cow serum albumin were put in, and it 
added so that the last concentration might become [ ml ] in O.lmicrog /, and the trial matter was 
cultivated for one week. Culture medium was removed after culture, and EDTA and phosphoric-acid 
****** of Dulbecco who subsequently contains a trypsin 0.25% were added 0.02%, and it exfoliated. 
Subsequently, these were removed, in each hole, 1ml was put in, Dulbecco's phosphoric-acid ****** 
was suspended, and the number of cells was measured by the erythrocytometer. It carried out based on 
the number of cells of the blank trial which used distilled water instead of vegetable extractives, the rate 



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of a breeding ratio was calculated by the following formulas, and it was shown in the 1st table. 

[0008] 

[Equation 1] 



[0009] 
[Table 11 







mma.m 






1.48 


x 9 j — ji> 


1.21 


? a v sit Jl A 


0.78 




A 


1.35 


x ? / - A, 
$ a D .-it J\y A 


...L.«._.l..l 

0 . 6 9 



[0010] [Organoleptics (beautiful skin effect trial)] 

Test method: The effectiveness three months after applying the cream which blended the Betula-alba 
extract extractives of an example 2 with 20 woman test subjects (his 30-40's) who appeal against the 
rough skin, ****** 5 the desiccation skin, etc. 2.0%, and Betula-alba extract extractives a non-blended 
cream (cream B) for three months in succession [ bis die (morning, evening) ] was evaluated. The 
wettability of the skin, flexibility, resiliency, and the number to which it replied to each item of gloss in 
five steps showed the test result. 
[0011] 
[Table 2] 

2 & : gffittft (£M%)%Um 





w m 


* IJ-AA 


■ 9 i; - a b 






9 (A) 


o (A) 






7 


1 


ffl 




3 


4 


ft 




1 


i 4 






0 


1 






1 0 


0 






5 


2 






4 


6 






1 


1 2 






0 


0 






7 


0 


a 




7 


1 


■h 




6 


3 


tt 




0 


1 6 






0 


0 






9 


0 






5 


2 






5 


3 






1 


1 4 






0 


1 



[0012] Test result: It was admitted that the Betula-alba extract extractives of this invention discovered a 



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beautiful skin effect (admiration, a smooth feeling, a flare, and gloss are gently given to the skin) so that 

clearly from the result of the 2nd table. 

[0013] 

Example 1 . face toilet Component Loadings (% of the weight) 

Betula-alba extract extractives (example 2 of reference) 0.05 A glycerol 6.0 Ethanol 8.0 
Polyoxyethylene hydrogenated castor oil 0.8 Methyl parahydroxybenzoate 0.05 A citric acid 0.05 
sodium citrate 0.07 Perfume 0.1 Purified water Remainder Sum total A glycerol, a citric acid, and a 
sodium citrate are dissolved in 100 purified water. Betula-alba extract extractives, polyoxyethylene 
hydrogenated castor oil (60E.O), the methylparaben, and perfume were separately dissolved in ethanol, 
in addition to the aforementioned purified water solution, it solubilized and filtered, and face toilet was 
obtained. 
[0014] 

Example 2. cream Component Loadings (% of the weight) 
Component (A) 

Betula-alba extract extractives (example 1 of reference) 2.0 Ascorbyl stearatel.O White beeswax 4.0 
Cetanol 2.0 Stearin acid 1.0 Myristic-acid isopropyl 5.0 Lanolin 2.0 liquid paraffin 9.0 self- 
emulsification mold monostearin acid glyceryl 3.0 Monostearin acid Polyoxyethylene sorbitan (20E.O) 
1.5 Propyl parahydroxybenzoate 0.1 Component (B) 

Methyl parahydroxybenzoate 0.2 Propylene glycol 5.0 Perfume 0,2 Purified water Remainder Sum total 
The heating dissolution of the 100 components (A) is carried out, and it holds at 80 degrees C. Having 
carried out the heating dissolution of the component (B) except perfume independently, having kept at 
80 degrees C, and stirring said component (A) to this, in addition, it cooled, perfume was added, it 
cooled further, and the cream was obtained. 
[0015] 

Oil for example 3. makeup Component Loadings (% of the weight) 

Betula-alba extract extractives (example 3 of reference) 1.0 Stearin acid cholesteryl 1.0 Olive oil 2.0 
Squalene Remainder Sum total Other components were dissolved in 100 squalane at homogeneity, and 
the oil for makeup was obtained. 

[0016] It changes into the Betula-alba extract extractives of examples 1-3, and the cosmetics which 
blended the extract extractives of the alder shown in the examples 4-6 of reference can be prescribed 
similarly. These cosmetics were used for the woman test subject who appeals against the rough skin, 
******, the desiccation skin, etc., and all obtained good evaluation to each item of the wettability of the 
skin, flexibility, resiliency, and gloss. 
[0017] 

[Effect of the Invention] The skin cosmetics of this invention have effectiveness, such as growth of an 
epidermal cell, promotion of differentiation, turnover promotion of a horny layer, a keratin 
improvement, and a beautiful skin effect, improve a skin function, and demonstrate the effectiveness 
excellent in aging prevention of the skin. 



[Translation done.] 



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