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Full text of "USPTO Patents Application 09773351"

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SECTION I. (AMENDMENTS TO THE CLAIMS) 



Following is a list of claims 1-20 as amended herein, with markings to show changes made: 

1 . (Currently amended) A composition for topical application to the skin comprising a» 
integral amixture of cholesterol sulfate or salts thereof present in an amount between 
0.05 to about 5.00 percent , int e gral with an exfoliant present in an amount between 0.1 to 
about 10.0 percent by weight of the composition in a cosmetically or pharmaceutically 
acceptable vehicle. 

2. (Canceled). 

3. (Original) The composition of claim 1 wherein the composition contains a salt of 
cholesterol sulfate. 

4. (Original) The composition of claim 3 wherein the salt is potassium. 

5. (Original) The composition of claim 1 wherein the exfoliant is an amino sugar selected 
from the group consisting of N-acetyl-D-glucosamine, N-acetylgalactosamine, and a 
combination thereof. 

6. (Original) The composition of claim 1 further comprising at least one fatty acid selected 
from the group consisting of butyric acid, caproic acid, octanoic acid, decanoic acid, 
dodecanoic acid, tetradecanoic acid, palmitic acid, stearic acid, linoleic acid and oleic 
acid. 

7. (Original) The composition of claim 6 wherein said fatty acid is linoleic acid. 

8. (Original) The composition of claim 1 further comprising cholesterol. 



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9. (Original) The composition of claim 1 further comprising both linoleic acid and 

cholesterol. 



10. (Original) The composition of claim 1 further comprising sclareolide. 

1 1 . (Original) The composition of claim 1 further comprising a protease inhibitor selected 
from the group consisting of white birch extract, silver birch extract, Boswellia extract, 
bearberry extract, Centella asiatica extract, and Pygeum africanum extract. 

12. (Previously presented) The composition of claim 1 further comprising both sclareolide 
and white birch extract. 

1 3 . (Currently amended) A cosmetic or pharmaceutical formulation for topical application of 
a composition to the skin, the formulation containing a mixture comprising an integral 
mixture of cholesterol sulfate or salts thereof in an amount from about 0.05 to about 5.00 
percent, and from about 0.1 to about 10.0 percent by weight of an amino sugar selected 
from the group consisting of N-acetyl-D-glucosamine, N-acetylgalactosamine, and a 
combination thereof by weight of the composition being int e gral with on e another in a 
cosmetically or pharmaceutically acceptable vehicle. 

14. (Original) The formulation of claim 13 further comprising both cholesterol and a fatty 
acid selected from the group consisting of butyric acid, caproic acid, octanoic acid, 
decanoic acid, dodecanoic acid, tetradecanoic acid, palmitic acid, stearic acid, linoleic 
acid and oleic acid. 

15. (Original) The formulation of claim 14 wherein the fatty acid is linoleic acid present in an 
amount less than 1 percent and the cholesterol is present in an amount less than 1 percent. 

16. (Currently amended) A method for improving or maintaining a healthy skin barrier which 
comprises adding an effective amount of an integral amixture to a cosmetically or 
pharmaceutically acceptable vehicle wherein said int e gral mixture comprises cholesterol 



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sulfate or salts thereof in an amount from about 0.05 to about 5.00 percent by weight of 
the composition, and from about 0.1 to 10.0 percent by weight of the composition an 
amino sugar selected from the group consisting of N-acetyl-D-glucosamine, N- 
acetylgalactosamine, and a combination thereof, and applying said vehicle containing 
said mixture to the skin. 

17. (Original) The method of claim 16 in which the mixture comprises from about 0.1 to 
about 2.0 percent cholesterol sulfate. 

18. (Previously presented) The method of claim 1 6 in which the composition comprises 
about 0.04 to about 1.0 percent cholesterol sulfate. 

1 9. (Currently amended) A method of treating or reducing damage to the skin, wherein the 
damage is associated with a reduction or loss of skin barrier function, which comprises 
adding an effective amount of an integral amixture to a cosmetically or pharmaceutically 
acceptable vehicle wherein said mixture comprises cholesterol sulfate or salts thereof in 
an amount from about 0.05 to about 5.00 percent by weight of the composition, and about 
0.1 to about 10.0 percent of an amino sugar selected from the group consisting of N- 
acetyl-D-glucosamine, N-acetylgalactosamine, and a combination thereof by weight of 
the composition, and applying said vehicle containing said mixture to the skin. 

20. (Previously presented) The method of claim 1 9 further comprising cholesterol sulfate or 
salts thereof in an amount of about 0.1 to 2.0 percent, about 0.5 to 8.0 percent of N- 
acetyl-D-glucosamine, cholesterol in an amount of about 0.2 to 1.0 percent, linoleic acid 
in an amount of about 0.2 to 1.0 percent by weight of the composition, sclareolide in an 
amount of about 0.001 to about 1.000 percent, and white birch extract in an amount of 
about 0.001 to about 1.000 percent. 



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