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Full text of "USPTO Patents Application 09804625"

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Application No.: 09/804,625 Customer No.: 2529 1 

Inventors: Elizabeth A. Wang et al. 
Docket No.: GI5160C C2 
For: NOVEL BMP PRODUCTS 



'V' * FIGURE 1 



(1) 15 ' 30 45 

GGC CAC GAT GGG AAA' GGA CAC CCT CTC CAC AGA AGA GAA AAG CGG 
GHDGKGHPLHRREKR 

60 75 90 

CAA GCA AAA CAC AAA CAG CGG AAA CGC CTC AAG TCC AGC TGT AAG 
QAKHKQRKRLKSSCK 

(32) 105 120 135 

AGA CAC CCT TTA TAT GTG GAC TTC AGT GAT GTG GGG TGG AAT GAC 
RHPLYVDFSDVGWND 

150 165 180 

TGG ATC GTT GCA CCG CCG GGG TAT CAT GCC TTT TAG TGC CAT GGG 
WIVAPPGYH AFYCHG 

195 210 225 

GAG TGC CCT TTT CCC CTG GCC GAT CAC CTT AAC TCC ACG AAT CAT 
ECPFPLADHLNSTNH 

240 255 . 270 

GCC ATT CTC CAA ACT CTG GTC AAC TCA GTT AAC TCT AAG ATT CCC 
AIVQTLVNSVNSKIP 

385 300 315 

AAG GCA TGC TGT GTC CCA ACA GAG CTC AGC GCC ATC TCC ATG CTG 
KACCVPTE LSAI SML 



330 345 360 

TAG CTT GAT GAG AAT GAG AAG GTG GTA TTA AAG AAC TAT CAG GAC 
YLDENEKVVLK N Y Q D 

375 (129) 397 407 

ATG GTT GTC GAG GGT TGT GGG TGT CGT TAGCACAGCA AAATAAAATA 
M V V E G C G C R 

417 427 437 447 457 

TAAATATATA TATATATATA TTAGAAAAAC AGCAAAAAAA TCAAGTTGAC 

467 477 487 497 507 

ACTTTAATAT TTCCCAATGA AGACTTTATT TATGGAATGG AATGGAGAAA 

517 527 537 547 557 

AAGAAAAACA CAGCTATTTT GAAAACTATA TTTATATCTA CCGAAAAGAA 



567 577 587 

GTTGGGAAAA CAAATATTTT AATCAGAGAA TTATT 



Application No.: 09/804,625 Customer No.: 2 52^1 

^^Lnventors: Elizabeth A. Wang et al. 
^â– |)ocket No.: Gi5160CC2 
^^Tor: NOVEL BMP PRODUCTS 



FIGURE 2 

10 20 30 40 50 60 70 



80 90 100 110 120 130 140 



150 160 170 180 190 200 210 

ACiociOQQC cnox^ 



220 230 240 250 260 270 280 

QQGAGAAGGA QGAGQCAAAG AAAAQG^^ACG GACATI03CT 



290 300 310 320 330 340 350 



(1) 370 385 400 

CGACX: ATG_CTG GCC GQG_ACC CGC TGT CTT CTA_GCG TTGCTGCTT CCC CAG GTC 

METP Vai Ala Gly Ihr Arg Cys" Leu Leu Ala Leu Leu Leu Rro~Gln Val ' ' 

415 430 445 

CTC CIG GGC GGC GCG GOT GGC CTC GTT CCX^ GAG CTG GGC CGC AGG AAG TTC GCG 
Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys Phe Ala 

460 475 490 505 

GCG GCG TCG TCG GGC CGC CCC TCA TCC CAG CCC TCT GAC GAG GTC CTG AGC GAG 

Ala Ala Ser Ser Gly Arg Pro Ser Ser Gin Pro Ser Asp Glu Val Leu Ser Glu 

520 535 550 565 

TIC GAG TTG CGG CTG CTC AGC ATG TTC GGC CTG AAA CAG AGA CCC ACC CCC AGC 
Phe Glu Leu Arg Leu Leu Ser METT Phe Gly Leu Lys Gin Arg Pro Thr Pro Ser 

580 595 610 

AGG GAC GCC GTG GTG CCC CCC TAG ATG OTA GAC CTG TAT CGC AGG CAC TCA GGT 
Arg Asp Ala Val Val Pro Pro Tyr MET Leu Asp Leu Tyr Arg Arg His Ser Gly 

625 640 655 670 

CAG CCG GGC TCA CCC GCC CCA GAC CAC CGG TTG GAG AGG GCA GCC AGC CGA GCC 
Gin Pro Gly Ser Pro Ala Pro Asp His Arg Leu Glu Arg Ala Ala Ser Arg Ala 



685 700 715 

AAC ACT GTG CGC AGC TTC CAC CAT GAA GAA TCT TTG GAA GAA OTA CCA GAA ACG 
Asn Thr Val Arg Ser Phe His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Ihr 



Application No.: 09/804,625 Customer No.: 25291 

Inventors: Elizabeth A. Wang et al. ~ 
Docket No.: GI5160CC2 
For: NOVEL BMP PRODUCTS 



FIGURE 2A 



730 745 760 775 

AGT GOG AAA ACA ACC CX3G AGA TTC TTC ITT AAT TTA AGT TCT ATC CCC ACG GAG 

Ser Gly Lys Hir Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser lie Pro Thr Glu 

790 805 820 835 

GAG TTT ATC ACC TCA OCA GAG CTT CAG GTT TTC CGA GAA CAG ATG CAA GAT GCT 
Glu Phe He Thr Ser Ala Glu Leu Gin Val Phe Arg Glu Gin MET Gin Asp Ala 

850 865 880 

TTA GGA AAC AAT AQC AGT TTC CAT CAC CGA ATT AAT ATT TAT GAA ATC ATA AAA 
Leu Gly Asn Asn Ser Ser Phe His His Arg lie Asn He Tytr Glu He He Lys 

895 910 925 940 

CCr GCA ACA GCC AAC TCG AAA TTC CCC GTG ACC AGA CTT TIG GAC ACC AGG TTG 
Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Acg Leu Leu Asp Thr Arg Leu 

955 970 985 

GTG AAT CAG AAT GCA AGC AGG TGG GAA AGT TTT GAT GTC ACC CCC GCT GTG ATG 
Val Asn Gin Asn Ala Ser Arg Trp Glu Ser Phe Asp Val Thr Pro Ala Val MET 

1000 1015 1030 1045 

CGG TOG ACT GCA CAG GGA CAC GCC AAC CAT GGA TTC GIG GTG GAA GTG GCC CAC 

Arg Trp Thr Ala Gin Gly His Ala Asn His Gly Phe Val Val Glu Val Ala His 

1060 1075 1090 1105 

TTG GAG GAG AAA _CAA GCT CTC TCC AAG .?^^CAT GTT AGG ATA AGC AGG TCT TTG 
Leu Glu Glu Lys Gin Gly Val Ser Lys Arg His Val" Arg He Ser" Ar^' Ser Leu" 

1120 1135 1150 

CAC CAA GAT GAA CAC AGC TOG TCA CAG ATA AGG CCA TTG CTA CTA ACT TTT GGC 
His Gin Asp Glu His Ser Trp Ser Gin He Arg Pro Leu Leu Val Thr Phe Gly 

1165 1180 1195 1210 

CAT GAT GGA AAA GGG CAT CCT CTC CAC AAA AGA GAA AAA CCT CAA GCC AAA CAC 
His Asp Gly Lys Gly His Pro Leu His Lys Arg Glu Lys Arg Gin Ala Lys His 

1225 1240 (299)1255 

AAA CAG CGG AAA CGC CTT AAG TCC AGC TCT AAG AGA CAC CCT TTG TAC GTG GAC 
Lys Gin Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 

1270 1285 1300 1315 

TTC ACT GAC GTG GGG TOG AAT GAC TGG ATT GTG GCT CCC CCG GOG TAT CAC GCC 

Phe Ser Asp Val Gly Trp' Asn Asp Trp He Val Ala Pro Pro Gly Tyr His^Ala 

1330 1345 1360 1375 

TTT TAC TQC CAC GGA GAA TGC CCT TTT CCT CTG GCT GAT CAT CTG AAC TCC ACT 
Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 



1390 1405 1420 

AAT CAT GCC ATT GTT CAG ACG TTG GTC AAC TCT GTT AAC TCT AAG ATT CCT AAG 
Asn His Ala He Val Gin Thr Leu Val Asn Ser Val Asn Ser Lys He Pro Lys 



Application No.: 09/804,625 Customer No.: ^ 

Inventors: Elizabeth A. Wang et al. 
Docket No.: GI5160CC2 
For: NOVEL BMP PRODUCTS 



FIGURE 2B 



1435 1450 1465 1480 

GCA TQC TGT GTC CX^ ACA GAA CTC ACT GCT ATC TCG ATG CTG TAG CTT GAC GAG 
Ala Cys Cys Val Pro Thr Glu Leu Ser Ala lie Ser MET Ijeu Tyr Leu Asp Glu 

1495 1510 1525 

AAT GAA AAG GTT CTA TTA AAG AAC TAT GAG GAC ATG GIT GTG GAG GCT TGT GGG 
Asn Glu Lys Val Val Leu Lys Asn Tvr Gin Asp MET Val Val Glu Glv Cys Gly 

1540(396) 1553 1563 1573 1583 1593 1603 

TCT CX3C TACTACAGCA AAATTAAATA CATAAATATA TATATATATA TATATTTTAG AAAAAAGAAA 
cys Arg 



AAAA 



Application No.: 09/804,625 Customer No. 

Inventors: Elizabeth A. Wang et al. 

Docket No.: Gi5160CC2 

For: NOVEL BMP PRODUCTS 



FIGURE 3 



10 20 30 40 50 60 70 

CICTAGAQQG CAGAQGAQGA QQGAQQGA^ 



80 90 100 110 120 130 140 

QCATCCGM3C TGAQQGAa3C GAQCXJDGAGA CQCXDGCrQCr QCICCX3QOTG AGTATCTAQC TIGICTCCCC 



150 160 170 180 190 200 210 

GATQQGATTC CXCTGCAAGC TATCTCGM3C CTGCAGCX3CC ACPGICCCCG GOCXJTCGCCC AGCJCTCACTG 



220 230 240 250 260 270 280 

CAACXX3TTCA GAGGTCXXX:^ 



290 300 310 320 330 340 350 



360 370 380 390 400 (1) 

CTGTCAAGAA TCATQGACTG TTATTATATG CCTTGl'iTlC TGTCAAGACA CC ATG ATT CCT 
- - MEr~Ile Pro 



417 432 447 462 

GGT AAC CGA ATG CTG ATG GTC CTT TTA TTA TGC CAA GTC CTG CTA QGA GGC QCG 
Gly Asn Arg MET Leu MET Val Val Leu Leu Cys Gin Val Leu Leu Gly Gly Ala 

477 492 507 

AGC CAT GCT ACT TIG ATA CCT GAG ACG GGG AAG AAA AAA GTC GCC GAG ATT CAG 
Ser His Ala Ser Leu lie Pro Glu Thr Gly Lys Lys Lys Val Ala Glu lie Gin 

522 537 552 567 

GGC CAC GCG GGA GGA CGC CGC TCA GGG CAG AGC CAT GAG CTC CTG CGG GAC TTC 
Gly His Ala Gly Gly Arg Arg Ser Gly Gin Ser His Glu Leu Leu Arg Asp Phe 

582 597 612 627 

GAG GCG ACA CTT CTG CAG ATG TIT GGG CTG CGC CGC CGC CCG CAG CCT AGC AAG 
Glu Ala Thr Leu Leu Gin MET Phe Gly Leu Arg Arg Arg Pro Gin Pro Ser Lys 

642 657 672 

ACT GCC GTC ATT CCG GAC TAC ATG CGG GAT CTT TAC CGG CTT CAG TCT GGG GAG 
Ser Ala Val lie Pro Asp Tyr MET Arg Asp Leu Tyr Arg Leu Gin Ser Gly Glu 



687 702 717 732 

GAG GAG GAA GAG CAG ATC CAC AGC ACT GCT CTT GAG TAT CCT GAG CGC CCG GCC 
Glu Glu Glu Glu Gin He His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala 



Application No.: 09/804,625 Customer No., 

Inventors: Elizabeth A. Wang et al. 
Docket No.: GI5160CC2 
For: NOVEL BMP PRODUCTS 



FIGURE 3A 



747 762 777 

AGC OQG GCC AAC ACC GIG AGG AGO TIC CAC CAC GAA GAA CAT CTG GAG AAC ATC 
Ser Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn lie 

792 807 822 837 

CCA GOG ACC AGT GAA AAC TCP GCT TTT CGT TIC CTC TIT AAC CTC AGC AGC ATC 

Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu Ser Ser lie 

852 867 882 897 

CCT GAG AAC GAG GIG ATC TCX: TCT GCA GAG CTP CGG CTC TIC CGG GAG CAG GTG 
Pro Glu Asn Glu Val lie Ser Ser Ala Glu Leu Arg Leu Phe Arg Glu Gin Val 

912 927 942 

GAG CAG GGC CCT GAT TOG GAA AGG GGC TIC CAC CGT ATA AAC ATT TAT GAG GTT 
Asp Gin Gly Pro Asp Trp Glu Arg Gly Phe His Arg lie Asn lie Tyr Glu Val 

957 972 987 1002 

ATG AAG CCC CCA GCA GAA GTG GTG CCT GGG CAC CTC ATC ACA CGA CTA CTG GAC 
MET Lys Pro Pro Ala Glu Val Val Pro Gly His Leu lie Thr Arg Leu Leu Asp 

1017 1032 1047 

ACG AGA CTG GTC CAC CAC AAT GTG ACA CGG TOG GAA ACT TTT GAT GTG AGC CCT 
Thr Arg Leu Val His His Asn Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro 

1062 1077 1092 1107 

GCG GTC CTT CGC TOG ACC CGG GAG AAG CAG CCA AAC TAT GGG CTA GCC ATT GAG 

Ala"Val~Leu Arg Trp Thr Arg Glu Lys GInrPro~Asn T^r" Gly ^ Ala lie Glu 

1122 1137 1152 1167 

GTG ACT CAC CTC CAT CAG ACT CGG ACC CAC CAG GGC CAG CAT GTC AGG ATT AGC 
Val Thr His Leu His Gin Thr Arg Thr His Gin Gly Gin His Val Arg lie Ser 

1182 1197 1212 

CGA TOG TTA CCT CAA GGG ACT GGG AAT TGG GCC CAG CTC CGG CCC CTC CTG GTC 
Arg Ser Leu Pro Gin Gly Ser Gly Asn Trp Ala Gin Leu Arg Pro Leu Leu Val 

1227 1242 1257 1272 

ACC TTT GGC CAT GAT GGC COG GGC CAT GCC TTG ACC CGA CGC CGG AGG GCC AAG 
Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg Arg Ala Lys 

1287 1302 1317 

CCT A3C CCT AAG CAT CAC TCA CAG CGG GCC AGG AAG AAG AAT AAG AAC TQC CGG 
Arg Ser Pro Lys His His Ser Gin Arg Ala Arg Lys Lys Asn Lys Asn Cys Arg 

1332(311) 1347 1362 1377 

CGC CAC TCG CTC TAT GTG GAC TTC AGC GAT GTG GGC TOG AAT GAC TOG ATT GTG 

Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp lie Val 



1392 1407 1422 1437 

GCC CCA CCA GGC TAG CAG GCC TIC TAG TGC CAT GGG GAC TGC CCC TTT CCA CTG 
Ala Pro Pro Gly Tyr Gin Ala Phe Tyr Cys His Gly Asp Cys Pro Phe Pro Leu 



•Application No.: 09/804,625 Customer No.: 2^|^ 

[nventors: Elizabeth A. Wang at al. 
Docket No.: Gt5160C C2 



For: NOVEL BMP PRODUCTS 



FIGURE 3B 



1452 1467 1482 

GCT GAC CAC CTC AAC TCA ACC AAC CAT GOC ATT GTG CAG ACX: CTG GTC AAT TCT 
Ala Asp His Leu Asn Ser Thr Asn His Ala lie Val Gin Thr Leu Val Asn Ser 

1497 1512 1527 1542 

GTC AAT TCC AGT ATC CCC AAA GCC TGT TGT GTG CCC ACT GAA CTG AGT GCC ATC 
Val Asn Ser Ser lie Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala lie 

1557 1572 1587 

TCC ATG CTG TAG CTG GAT GAG TAT GAT AAG GTG GTA CTG AAA AAT TAT CAG GAG 
Ser MET Leu Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tvr Gin Glu 

1602 1617 (408) 1636 1646 1656 

ATG GTA GTA GAG GGA TGT GGG TGC CGC TGAGATCAGG CAGTCdTGA GGATAGACAG 
MET Val Val Glu Glv Cys Gly Cys Arg 



1666 1676 1686 1696 1706 1716 

1726 ATATACACAC CACACACACA CACCACATAC ACCACACACA CACXJCTCCCA TCCACTCACC 
CACACACTAC 



1736 1746 1756 1766 1776 . 1786 

1796 ACAGACTGCT TCCTTATAQC TQGACTTTTA TTTAAAAAAA AAAAAAAAAA AATQGAAAAA 
ATCCCTAAAC 



1806 1816 1826 1836 1846 1856 

1866 ATTCACCTTG ACCTTATTrA TGACTTTACG TQCAAATGTT TIGACCATAT TGATCATATA 
TITTGACAAA 



1876 1886 1896 1906 1916 1926 

1936 ATATATITAT AACTACGTAT TAAAAGAAAA AAATAAAATG AGTCATTATT TTAAAAAAAA 
AAAAAAAACT 



1946 

CTAGAGTCGA CQGAATTC