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t * 

INFORMATION DISCLOSURE CITATION 



FILE COPY 

OMB No. 0651-0011 




Atty. Docket No. 08702.0039-02000 



Appln. No. 09/804,625 



RECE I VED 



Applicant 



WANG et al. 



Filing Date 



March 9, 2001 



4r/\ Group: 



1647 



FEB 2,8 2003 



TECH CENTER 16003$ 



U.S. PATENT DOCUMENTS 



Examiner 
Initial* 




Document 
Number 


Issue Date 


Name 


Class 


Sub 
Class 


Filing Date 
If Appropriate 






4,804,744 


2/14/89 


Sen 


530 


350 










4,774,228 


9/27/88 


Seyedin 


514 


21 










4,774,322 


9/27/88 


Seyedin 


530 


353 










4,434,094 


2/28/84 


Seyedin and 
Thomas 


530 


416 










4,627,982 


12/9/86 


Seyedin and 
Thomas 


424 


95 










4,563,350 


1/7/86 


Nathan 


424 


95 










4,294,753 


10/31/81 


Urist 


530 


395 










4,455,256 


6/19/84 


Urist 


530 


350 










4,968,590 


11/6/90 


Kuberasampath 
and Rueger 


530 


326 










4,761,471 


08/02/88 


Urist 


530 


350 










4,789,732 


12/6/88 


Urist 


530 


350 










4,608,199 


8/26/86 


Caplan and 
Syftestad 


530 


414 










4,681,763 


7/21/87 


Nathanson 


424 


95 










4,737,578 


4/12/88 


Evans 


530 


350 










4,798,885 


1/17/89 


Mason 


530 


350 










4,810,691 


3/7/89 


Seyedin 


514 


2 




< 






4,843,063 


6/27/89 


Seyedin 


514 


2 








5,011,691 


4/30/91 


Opperman 


424 


423 




Examiner ^ a „ e 


Date Considered /o f tsl o^> 



'Examiner: Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line 
through citation if not in conformance and not considered. Include copy of this form with next 
communication to applicant. 



Form PTO 1449 



Patent and Trademark Office - U.S. Department of Commerce 



Page 1 of 3 



01? £o. EPUoYi 



INFORMATION DISCLOSURE CITATION 



Atty. Docket No. 08702.0039-02000/^0 


Appln. No. 09/804,625 H bz CEIVED 


Applicant WANG et al. [ FEB 2 7 2MB r. FFR 9. a onm 


V ^ 
Filing Date March 9, 2001 \^ 


Group: 1647 

1 f '/it i nriwpin i fMA*M 



U.S. PATENT DOCUMENTS 






4,886,747 


12/12/89 


Derynck 


435 


69.5 










5,108,753 


4/28/92 


Kubserasampath 


424 


422 










5,106,626 


4/21/92 


Parsons et al. 


424 


423 










4,619,989 


10/1986 


Urist 


530 


417 










4,795,804 


1/1989 


Urist 


530 


350 








5,168,050 


12/01/92 


Hammonds 


435 


69.1 





FOREIGN PATENT DOCUMENTS 






Document 
Number 


Publication 
Date 


Country 


Class 


Sub 
Class 


Translation 
Yes or No 






4 165 78A2 


05/09/90 


EPO 








f 




4 094 72 A1 


1 1/07/90 


EPO 














33 6760 


06/04/89 


EPO 














2 017 466 


05/24/90 


Canada 














WO 91/18047 ^ 


1 1/28/91 


WIPO 














WO 89/09787 


10/29/89 


WIPO 














WO 89/09788 / 


10/19/89 


WIPO 














WO 90/03733 


04/19/90 


WIPO 














WO 91/02744 ^/j 


03/07/91 


WIPO 












WO 91/05802 


05/02/81 


WIPO 









OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 




Urist eh^. t "Bone Cell Differentiation and Growth Factors," Science, 220\ 680-686 (1983) 




Luyten et si, "Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating 
Bone Differentiation," J. Biol. Chem. 264: 13377-13380 (August 15, 1989) 


Examiner ^o^->— "f^^iy^j 


Date Considered 10 ft f /o ^ 


'Examiner: Initial if reference considered ■ whether or not citation is in conformance with MPEP 609; draw line 
through citation if not in conformance and not considered. Include copy of this form with next 
communication to applicant. 


Form PTO 1449 


Patent and Trademark Office - U.S. Department of Commerce 



Page 2 of 3 



OMB No. 0651-0011 



INFORMAI1QU DISCLOSURE CITATION 



Atty. Docket No. 08702.0039-02000 



Applicant 



WANG et al. 



gi ^Appln. No. 

M 



09/804.625 RFHFIVFn 



TIB 8,8 2003 



Filing Date 



March 9, 2001 



Group: 



1647 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 




Sampath, et al., "Isolation of osteogenin, an extracellular matrix-associated, bone-inductive 
protein, by heparin affinity chromatography," Proc. Natl Acad; Sci, 84: 7109-7113 (1987) 






Ozkaynak et al, "OP-1 cDNA encodes an osteogenic protein in the TGF-fi family," EMBO Journal, 
v.y no./, ^uoo-^uyo (iyyu; 






Maniatis, T. et a/., Molecular Cloning, A Laboratory Mammal, Cold Spring Harbor Laboratory, CSH. 
N Y 






Suggs, S.V. et al., "Use of synthetic oligonucleotides as hybridization probes: Isolation of cloned 
cDNA sequences for human (^-microglobulin," Proc. Natl. Acad. Sci. USA., 501 78: pp. 6617 
'(1981) 






Hammonds, et al. "Bone-inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b 
Precursor," Mol. Endocrinol. 5: 149-155 (1991) 






Bowie, et al., "Deciphering the message in protein sequences: tolerance to amino acid 
substitutions," Science, 247:1306-10 (16 March 1990) 




\ 


Alberts, et al. Mol. Biol. Cell, Garland Publishing, New York, NY: pages 1 142-1 145 (Jan 1994) 




Sato et al., "Bone morphogenetic protein-induced cartilage development in tissue culture." 
^ClinicalOrthopaedics and Related Research, 183: 1 80-7 (Mar 1 994) 



Examiner 




Date Considered ££> [ *Lt j O V 


*Examiner: 


Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line 
through citation if not in conformance and not considered. Include copy of this form with next 
communication to applicant. 


Form PTO 144S 


> Patent and Trademark Office - U.S. Department of Commerce 



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