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I 1 

RAW SEQUENCE LISTING 



The Biotechnology Systems Branch of the Scientific and Technical 
Information Center (STIC) no errors detected. 



Application Serial Number: 
Source: 

Date Processed by STIC: 




ENTERED 



RAW SEQUENCE LISTING DATE: 03/01/ 

PATENT APPLICATION: US/09/804 , 625A TIME: 07:59 



Input Set : A:\87023902.app 

Output Set: N:\CRF4\03012005\l804625A.raw 

3 <110> APPLICANT: WANG, ELIZABETH A. 

4 WOZNEY, JOHN M. 

5 ROSEN, VICKI A. 

7 <12 0> TITLE OF INVENTION: NOVEL BMP PRODUCTS 
9 <130> FILE REFERENCE: 08702.003 9-02 000 

11 <140> CURRENT APPLICATION NUMBER: 09/804, 625A 

12 <141> CURRENT FILING DATE: 2001-03-09 

14 <150> PRIOR APPLICATION NUMBER: 08/925,779 

15 <151> PRIOR FILING DATE: 1997-09-09 

17 <150> PRIOR APPLICATION NUMBER: 07/721,847 

18 <151> PRIOR FILING DATE: 1991-06-14 

20 <150> PRIOR APPLICATION NUMBER: 07/493,272 

21 <151> PRIOR FILING DATE: 1990-03-14 

23 <150> PRIOR APPLICATION NUMBER: 07/406,217 

24 <151> PRIOR FILING DATE: 1989-09-12 

26 <150> PRIOR APPLICATION NUMBER: 07/655,579 

27 <151> PRIOR FILING DATE: 1991-03-18 

29 <150> PRIOR APPLICATION NUMBER: 07/179,100 

30 <151> PRIOR FILING DATE: 1988-04-08 

32 <150> PRIOR APPLICATION NUMBER: 07/028,285 

33 <151> PRIOR FILING DATE: 1987-03-20 

35 <150> PRIOR APPLICATION NUMBER: 06/943,332 

36 <151> PRIOR FILING DATE: 1986-12-17 

38 <150> PRIOR APPLICATION NUMBER: 06/880,776 

39 <151> PRIOR FILING DATE: 1986-07-01 

41 <150> PRIOR APPLICATION NUMBER: PCT/US87/01537 

42 <151> PRIOR FILING DATE: 1987-06-30 
44 <160> NUMBER OF SEQ ID NOS : 23 

46 <170> SOFTWARE: PatentIn Ver. 3.3 

48 <210> SEQ ID NO: 1 

49 <211> LENGTH: 592 

50 <212> TYPE: DNA 

51 <213> ORGANISM: Bos taurus 

53 <220> FEATURE: 

54 <221> NAME/KEY: CDS 

55 <222> LOCATION: (1) . . (387) 

57 <400> SEQUENCE: 1 

58 ggc cac gat ggg aaa gga cac cct etc cac aga aga gaa aag egg eaa 

59 Gly His Asp Gly Lys Gly His Pro Leu His Arg Arg Glu Lys Arg Gin 

60 1 5 10 15 

62 gca aaa cac aaa cag egg aaa ege etc aag tec age tgt aag aga cac 

63 Ala Lys His Lys Gin Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His 

64 20 25 30 



file://C:\CRF4\Outhold\VsrI804625A.htm 



RAW SEQUENCE LISTING DATE: 03/01/2005 

PATENT APPLICATION: US/09/804 , 62 5A TIME: 07:59:37 



Input Set : A:\87023902.app 

Output Set: N:\CRF4\03012005\l804625A.raw 

66 cct tta tat gtg gac ttc agt gat gtg ggg tgg aat gac tgg ate gtt 144 
6 7 Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp lie Val 
68 35 40 45 

70 gca ccg ccg ggg tat cat gcc ttt tac tgc cat ggg gag tgc cct ttt 192 

71 Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe 

72 50 55 60 

74 ccc ctg gcc gat cac ctt aac tec aeg aat eat gcc att etc caa act 240 

75 Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala lie Leu Gin Thr 

76 65 70 75 80 

78 ctg gtc aac tea gtt aac tct aag att ccc aag gca tgc tgt gtc cca 288 

79 Leu Val Asn Ser Val Asn Ser Lys lie Pro Lys Ala Cys Cys Val Pro 

80 85 90 95 

82 aca gag etc age gcc ate tec atg ctg tac ctt gat gag aat gag aag 336 

83 Thr Glu Leu Ser Ala lie Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys 

84 100 105 110 

86 gtg gta tta aag aac tat cag gac atg ggt gtc gag ggt tgt ggg tgt 384 

87 Val Val Leu Lys Asn Tyr Gin Asp Met Gly Val Glu Gly Cys Gly Cys 

88 115 120 125 

90 egt tageaeagca aaataaaata taaatatata tatatatata ttagaaaaac 437 

91 Arg 

93 ageaaaaaaa tcaagttgae aetttaatat ttceeaatga agactttatt tatggaatgg 497 
95 aatggagaaa aagaaaaaca cagctatttt gaaaactata tttatateta ccgaaaagaa 557 
97 gttgggaaaa caaatatttt aatcagagaa ttatt 592 

100 <210> SEQ ID NO: 2 

101 <211> LENGTH: 129 

102 <212> TYPE: PRT 

103 <213> ORGANISM: Bos taurus 

105 <400> SEQUENCE: 2 

106 Gly His Asp Gly Lys Gly His Pro Leu His Arg Arg Glu Lys Arg Gin 

107 15 10 15 

109 Ala Lys His Lys Gin Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His 

110 20 25 30 

112 Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp lie Val 

113 35 40 45 

115 Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe 

116 50 55 60 

118 Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala lie Leu Gin Thr 

119 65 70 75 80 

121 Leu Val Asn Ser Val Asn Ser Lys lie Pro Lys Ala Cys Cys Val Pro 

122 85 90 95 

124 Thr Glu Leu Ser Ala lie Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys 

125 100 105 110 

12 7 Val Val Leu Lys Asn Tyr Gin Asp Met Gly Val Glu Gly Cys Gly Cys 
128 115 120 125 

130 Arg 

135 <210> SEQ ID NO: 3 

136 <211> LENGTH: 1607 

137 <212> TYPE: DNA 

138 <213> ORGANISM: Homo sapiens 



file://C:\CRF4\OuthoId\VsrI804625A.htm 



Page 3 of 8 



RAW SEQUENCE LISTING DATE: 03/01/2005 

PATENT APPLICATION: US/09/804 , 625A TIME: 07:59:37 

Input Set : A:\87023902.app 

Output Set: N:\CRF4\03012005\I804625A.raw 



140 


<22 0> FEATURE: 




























141 


<221> NAME/KEY: 


CDS 


























142 


<222> LOCATION: 


(356) . . 


(1543) 




















144 


<400> SEQUENCE: 


3 


























145 


gtcgactcta gagtgtgtgt cagcacttgg 


ctggggaett 


cttgaacttg eagggagaat 


60 


147 


aacttgcgca ccccactttg cgccggtgcc 


tttgeeccag 


cggagcctgc ttcgecatet 


120 


149 


ccgagcccca ccgcccctcc actcctcggc 


cttgeccgae 


aetgagacgc tgttcceagc 


180 


151 


gtgaaaagag agactgcgcg gccggcaccc 


ggg^g^^gg^ 


ggaggeaaag aaaaggaacg 


240 


153 


gacattcggt ccttgcgcca ggtcctttga 


ecagagtttt 


tccatgtgga cgctctttca 


300 


155 


atggacgtgt ccccgcgtgc ttcttagacg 


gactgcggte 


tectaaaggt cgace atg 


358 


156 
































Met 




157 
































1 




159 


gtg 


gcc 


ggg 


acc 


egc 


tgt 


ett 


eta 


gcg 


ttg 


ctg 


ett 


ccc 


cag 


gte 


etc 


406 


160 


Val 


Ala 


Gly 


Thr 


Arg 


Cys 


Leu 


Leu 


Ala 


Leu 


Leu 


Leu 


Pro 


Gin 


Val 


Leu 




161 








5 










10 










15 








163 


ctg 


ggc 


ggc 


gcg 


get 


ggc 


etc 


gtt 


ccg 


gag 


ctg 


ggc 


egc 


agg 


aag 


ttc 


454 


164 


Leu 


Gly 


Gly 


Ala 


Ala 


Gly 


Leu 


Val 


Pro 


Glu 


Leu 


Gly 


Arg 


Arg 


Lys 


Phe 




165 






20 










25 










30 










167 


gcg 


gcg 


gcg 


teg 


teg 


ggc 


cgc 


ccc 


tea 


tec 


cag 


ccc 


tct 


gac 


gag 


gte 


502 


168 


Ala 


Ala 


Ala 


Ser 


Ser 


Gly 


Arg 


Pro 


Ser 


Ser 


Gin 


Pro 


Ser 


Asp 


Glu 


Val 




169 




35 










40 










45 












171 


ctg 


age 


gag 


ttc 


gag 


ttg 


egg 


ctg 


etc 


age 


atg 


ttc 


ggc 


ctg 


aaa 


cag 


550 


172 


Leu 


Ser 


Glu 


Phe 


Glu 


Leu 


Arg 


Leu 


Leu 


Ser 


Met 


Phe 


Gly 


Leu 


Lys 


Gin 




173 


50 










55 










60 










65 




175 


aga 


ccc 


ace 


ccc 


age 


agg 


gac 


gee 


gtg 


gtg 


ccc 


ccc 


tac 


atg 


eta 


gac 


598 


176 


Arg 


Pro 


Thr 


Pro 


Ser 


Arg 


Asp 


Ala 


Val 


Val 


Pro 


Pro 


Tyr 


Met 


Leu 


Asp 




177 










70 










75 










80 






179 


ctg 


tat 


cge 


agg 


eac 


tea 


ggt 


cag 


ccg 


ggc 


tea 


ccc 


gee 


cca 


gac 


cae 


646 


180 


Leu 


Tyr 


Arg 


Arg 


His 


Ser 


Gly 


Gin 


Pro 


Gly 


Ser 


Pro 


Ala 


Pro 


Asp 


His 




181 








85 










90 










95 








183 


egg 


ttg 


gag 


agg 


gca 


gee 


age 


cga 


gee 


aac 


act 


gtg 


cgc 


age 


ttc 


cac 


694 


184 


Arg 


Leu 


Glu 


Arg 


Ala 


Ala 


Ser 


Arg 


Ala 


Asn 


Thr 


Val 


Arg 


Ser 


Phe 


His 




185 






100 










105 










110 










187 


cat 


gaa 


gaa 


tct 


ttg 


gaa 


gaa 


eta 


cca 


gaa 


acg 


agt 


ggg 


aaa 


aca 


ace 


742 


188 


His 


Glu 


Glu 


Ser 


Leu 


Glu 


Glu 


Leu 


Pro 


Glu 


Thr 


Ser 


Gly 


Lys 


Thr 


Thr 




189 




115 










120 










125 












191 


egg 


aga 


tte 


ttc 


ttt 


aat 


tta 


agt 


tct 


ate 


ccc 


acg 


gag 


gag 


ttt 


ate 


790 


192 


Arg 


Arg 


Phe 


Phe 


Phe 


Asn 


Leu 


Ser 


Ser 


He 


Pro 


Thr 


Glu 


Glu 


Phe 


He 




193 


130 










135 










140 










145 




195 


acc 


tea 


gca 


gag 


ett 


eag 


gtt 


tte 


cga 


gaa 


cag 


atg 


caa 


gat 


get 


tta 


838 


196 


Thr 


Ser 


Ala 


Glu 


Leu 


Gin 


Val 


Phe 


Arg 


Glu 


Gin 


Met 


Gin 


Asp 


Ala 


Leu 




197 










150 










155 










160 






199 


gga 


aac 


aat 


age 


agt 


ttc 


eat 


eac 


cga 


att 


aat 


att 


tat 


gaa 


ate 


ata 


886 


200 


Gly 


Asn 


Asn 


Ser 


Ser 


Phe 


His 


His 


Arg 


He 


Asn 


He 


Tyr 


Glu 


He 


He 




201 








165 










170 










175 








203 


aaa 


ect 


gca 


aca 


gee 


aac 


teg 


aaa 


ttc 


ccc 


gtg 


acc 


aga 


ett 


ttg 


gac 


934 


204 


Lys 


Pro 


Ala 


Thr 


Ala 


Asn 


Ser 


Lys 


Phe 


Pro 


Val 


Thr 


Arg 


Leu 


Leu 


Asp 




205 






180 










185 










190 










207 


acc 


agg 


ttg 


gtg 


aat 


eag 


aat 


gca 


age 


agg 


tgg 


gaa 


agt 


ttt 


gat 


gte 


982 



file://C:\CRF4\Outhold\VsrI804625A.htm 



3/1/05 



Page 4 of 8 



RAW SEQUENCE LISTING DATE: 03/01/2005 

PATENT APPLICATION: US/09/804 , 625A TIME: 07:59:37 



Input Set : A:\87023902.app 

Output Set: N:\CRF4\03012005\l804625A.raw 



208 


Thr 


Arg 


Leu 


val 


Asn 


Gin 


Asn 


Ala 


Ser 


Arg 


Trp 


Glu 


Ser 


Pne 


Asp 


vai 




209 




195 










200 










205 












211 


acc 


ece 


get 


gtg 


atg 


egg 


tgg 


act 


gca 


eag 


gga 


cac 


gee 


aac 


cat 


gga 


103 0 


212 


Thr 


Pro 


Ala 


Val 


Met 


Arg 


Trp 


Thr 


Ala 


Gin 


Gly 


His 


Ala 


Asn 


His 


Gly 




213 


210 










215 










220 










22 5 




215 


ttc 


gtg 


gtg 


gaa 


gtg 


gcc 


cac 


ttg 


gag 


gag 


aaa 


eaa 


ggt 


gte 


tee 


aag 


1078 


216 


Phe 


Val 


Val 


Glu 


Val 


Ala 


His 


Leu 


Glu 


Glu 


Lys 


Gin 


Gly 


Val 


Ser 


Lys 




217 










230 










235 










240 






219 


aga 


cat 


gtt 


agg 


ata 


age 


agg 


tct 


ttg 


cac 


eaa 


gat 


gaa 


cac 


age 


tgg 


1126 


220 


Arg 


His 


Val 


Arg 


He 


Ser 


Arg 


Ser 


Leu 


His 


Gin 


Asp 


Glu 


His 


Ser 


Trp 




221 








245 










250 










255 








223 


tea 


cag 


ata 


agg 


eca 


ttg 


eta 


gta 


act 


ttt 


ggc 


cat 


gat 


gga 


aaa 


ggg 


1174 


224 


Ser 


Gin 


He 


Arg 


Pro 


Leu 


Leu 


Val 


Thr 


Phe 


Gly 


His 


Asp 


Gly 


Lys 


Gly 




225 






260 










265 










270 










227 


cat 


eet 


etc 


cac 


aaa 


aga 


gaa 


aaa 


egt 


eaa 


gcc 


aaa 


cac 


aaa 


eag 


egg 


1222 


228 


His 


Pro 


Leu 


His 


Lys 


Arg 


Glu 


Lys 


Arg 


Gin 


Ala 


Lys 


His 


Lys 


Gin 


Arg 




229 




275 










280 










285 












231 


aaa 


cge 


ctt 


aag 


tee 


age 


tgt 


aag 


aga 


cac 


eet 


ttg 


tae 


gtg 


gac 


ttc 


1270 


232 


Lys 


Arg 


Leu 


Lys 


Ser 


Ser 


Cys 


Lys 


Arg 


His 


Pro 


Leu 


Tyr 


Val 


Asp 


Phe 




233 


290 










295 










300 










305 




235 


agt 


gae 


gtg 


ggg 


tgg 


aat 


gae 


tgg 


att 


gtg 


get 


ccc 


ccg 


ggg 


tat 


cac 


1318 


236 


Ser 


Asp 


Val 


Gly 


Trp 


Asn 


Asp 


Trp 


He 


Val 


Ala 


Pro 


Pro 


Gly 


Tyr 


His 




237 










310 










315 










32 0 






239 


gcc 


ttt 


tac 


tge 


cac 


gga 


gaa 


tge 


eet 


ttt 


eet 


etg 


get 


gat 


eat 


etg 


1366 


240 


Ala 


Phe 


Tyr 


Cys 


His 


Gly 


Glu 


Cys 


Pro 


Phe 


Pro 


Leu 


Ala 


Asp 


His 


Leu 




241 








325 










330 










335 








243 


aac 


tec 


act 


aat 


cat 


gee 


att 


gtt 


eag 


acg 


ttg 


gte 


aac 


tct 


gtt 


aac 


1414 


244 


Asn 


Ser 


Thr 


Asn 


His 


Ala 


He 


Val 


Gin 


Thr 


Leu 


Val 


Asn 


Ser 


Val 


Asn 




245 






340 










345 










350 










247 


tct 


aag 


att 


eet 


aag 


gca 


tge 


tgt 


gte 


ccg 


aca 


gaa 


etc 


agt 


get 


ate 


1462 


248 


Ser 


Lys 


He 


Pro 


Lys 


Ala 


Cys 


Cys 


Val 


Pro 


Thr 


Glu 


Leu 


Ser 


Ala 


He 




249 




355 










360 










365 












251 


teg 


atg 


etg 


tae 


ctt 


gac 


gag 


aat 


gaa 


aag 


gtt 


gta 


tta 


aag 


aac 


tat 


1510 


252 


Ser 


Met 


Leu 


Tyr 


Leu 


Asp 


Glu 


Asn 


Glu 


Lys 


Val 


Val 


Leu 


Lys 


Asn 


Tyr 




253 


370 










375 










380 










385 




255 


eag 


gac 


atg 


gtt 


gtg 


gag 


ggt 


tgt 


ggg 


tgt 


cge 


tagtacagea aaattaaata 


1563 


256 


Gin 


Asp 


Met 


Val 


Val 


Glu 


Gly 


Cys 


Gly 


Cys 


Arg 














257 










390 










395 
















259 


eataaatata tatatatata tatattttag aaaaaagaaa 


aaaa 








1607 


262 


<210> SEQ ID NO; 


: 4 


























263 


<211> LENGTH: 396 


























264 


<212> TYPE: 


PRT 




























265 


<213> ORGANISM: 


Homo sapiens 




















267 


<400> SEQUENCE: 


4 


























268 


Met 


Val 


Ala 


Gly 


Thr 


Arg 


Cys 


Leu 


Leu 


Ala 


Leu 


Leu 


Leu 


Pro 


Gin 


Val 




269 


1 








5 










10 










15 






271 


Leu 


Leu Gly Gly Ala Ala 


Gly 


Leu 


Val 


Pro 


Glu 


Leu 


Gly Arg Arg 


Lys 




272 








20 










25 










30 








274 


Phe 


Ala 


Ala 


Ala 


Ser 


Ser Gly Arg 


Pro 


Ser 


Ser 


Gin 


Pro 


Ser Asp 


Glu 





file://C:\CRF4\Outhold\VsrI804625A.htm 



3/1/05 



Page 5 of 8 



RAW SEQUENCE LISTING 

PATENT APPLICATION: US/09/804 , 625A 



DATE: 03/01/2005 
TIME: 07:59:37 



Input Set : 
Output Set : 



A:\87023902.app 
N:\CRF4\03012005\l804625A.raw 



275 



35 



40 



45 



2 77 Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
278 50 55 60 

280 Gin Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 

281 65 70 75 80 

283 Asp Leu Tyr Arg Arg His Ser Gly Gin Pro Gly Ser Pro Ala Pro Asp 

284 85 90 95 

286 His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 

287 100 105 110 

289 His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 

290 115 120 125 

2 92 Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser lie Pro Thr Glu Glu Phe 
293 130 135 140 

2 95 lie Thr Ser Ala Glu Leu Gin Val Phe Arg Glu Gin Met Gin Asp Ala 
296 145 150 155 160 

298 Leu Gly Asn Asn Ser Ser Phe His His Arg lie Asn lie Tyr Glu lie 

299 165 170 175 

301 lie Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 

302 180 185 190 

3 04 Asp Thr Arg Leu Val Asn Gin Asn Ala Ser Arg Trp Glu Ser Phe Asp 
305 195 200 205 

3 07 Val Thr Pro Ala Val Met Arg Trp Thr Ala Gin Gly His Ala Asn His 
308 210 215 220 

310 Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gin Gly Val Ser 

311 225 230 235 240 
'313 Lys Arg His Val Arg lie Ser Arg Ser Leu His Gin Asp Glu His Ser 
314 245 250 255 

316 Trp Ser Gin lie Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 

317 260 265 270 

319 Gly His Pro Leu His Lys Arg Glu Lys Arg Gin Ala Lys His Lys Gin 

320 275 280 285 

322 Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 

323 290 295 300 

325 Phe Ser Asp Val Gly Trp Asn Asp Trp lie Val Ala Pro Pro Gly Tyr 

326 305 310 315 320 
32 8 His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
329 325 330 335 

331 Leu Asn Ser Thr Asn His Ala lie Val Gin Thr Leu Val Asn Ser Val 

332 340 345 350 

334 Asn Ser Lys lie Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 

335 355 360 365 

337 lie Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 

338 370 375 380 

340 Tyr Gin Asp Met Val Val Glu Gly Cys Gly Cys Arg 

341 385 390 395 

345 <210> SEQ ID NO: 5 

346 <211> LENGTH: 1954 

347 <212> TYPE: DNA 

348 <213> ORGANISM: Homo sapiens 



file://C:\CRF4\Outhold\VsrI804625A.htm 



3/1/05 



Page 6 of 8 



RAW SEQUENCE LISTING ERROR SUMMARY 
PATENT APPLICATION: US/09/804 , 625A 



DATE: 03/01/2005 
TIME: 07:59:38 



Input Set : A:\87023902.app 

Output Set: N:\CRF4\03012005\l804625A.raw 



Please Note: 

Use of n and/or Xaa have been detected in the Sequence Listing. Please review the 
Sequence Listing to ensure that a corresponding explanation is presented in the <220> 
to <223> fields of each sequence which presents at least one n or Xaa. 

Seq#:14; Xaa Pos . 6 
Seq#:15; N Pos . 3 
Seq#:16; N Pos . 12,15 



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VERIFICATION SUMMARY DATE: 03/01/2005 

PATENT APPLICATION: US/09/804 , 625A TIME: 07:59:38 



Input Set : A:\87023902.app 

Output Set: N:\CRF4\03012005\l804625A.raw 



L:653 M:341 W 
L:671 M:341 W 
L:693 M:341 W 



(46) "n" or 
(46) "n" or 
(46) "n" or 



"Xaa" used, 
"Xaa" used, 
"Xaa" used, 



for SEQ ID#:14 
for SEQ ID#:15 
for SEQ ID#:16 



after pos . : 0 
after pos . : 0 
after pos . : 0 



file://C:\CRF4\Outhold\VsrI804625A.htm 



3/1/05