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( ) \)i^^PfgiSBI0a: SubsUUite for form 1449A/PTO 

3 0700^ 



NtiQRMATION DISCLOSURE 
TEMENT BY APPLICANT 

ft^se as many sheets as necessary) 



Complete if Known 



Application Number 



Filing Date 



First Named Inventor 



Art Unit 



Examiner Name 



09/804,625 



March 9, 2001 



Wang 



1647 



D. Romeo 



1 



of 



18 



Attorney Docket Number 



08702.0039-02000 



U.S. PATENTS AND PUBLISHED U.S. PATENT APPLICATIONS 



Examiner 
Initials' 


Cite 
No.' 


Document Number 


issue or 
Publication 
Date 
MM-DD-YYYY 


Name of Patentee or 
Applicant of Cited 
Document 


Pages. Columns, Lines, 

Where 
Relevant Passages or 
Relevant 
Figures Appear 


Number-Kind 
Code^ (if known) 






2,465.357 


29 Mar 1949 


Correll et al. 








3,955,719 


11 May 1976 


Pheulpin 










4,191.747 A 


04 Mar 1980 


Scheicher 










4,294.753 


13 Oct 1981 


Urist 










4,394.370 


19 July 1983 


Jeffries 










4,399.216 


16 Aug 1983 


Axel et al. 










4,419.446 


06 Dec 1986 


Howley et al. 










4,434.094 


28 Feb 1984 


Seyedin et al. 










4.441.915 


10Apr1984 


Arndt et al. 










4.455.256 


19Jun1984 


Urist 










4,468,464 


28 Aug 1984 


Cohen et al. 










4,472.840 


25 Sept 1984 


Jefferies 










4,553,542 


19 Nov 1985 


Schenk et al. 










4,563,350 


07 Jan 1986 


Nathan et al. 










4,596.574 


24 June 1986 


Urist 










4,608,199 


26 Aug 1986 


Caplan et al. 








4,619,989 


28 Oct 1986 


Ufist 








4,627,982 


09 Dec 1986 


Seyedin et al. 








4,642,120 


10 Feb 1987 


Nevo et al. ^ 








4,662,884 


05 May 1987 


Stenaas 








4,681,763 


21 Jul 1987 


Nathanson 










4,703,008 


27 Oct 1987 


Lin 










4,727,028 


23 Feb 1988 


Santerre et al. 










4,737,578 


12 Apr 1988 


Evans 










4.758.233 


19 Jul 1988 


Phillips et al. 










4,761,471 


2 Aug 1988 


Urist 










4,766,067 


23 Aug 1988 


Biswas et al. 










4,767,628 


30 Aug 1988 


Hutchinson 










4,769.328 


06 Sept 1988 


Murray et al. 










4,774,228 


27 Sept 1988 


Seyedin et al. 










4,774.322 


27 Sept 1988 


Seyedin et al. 








4,784.055 


15 Nov 1988 


Langen et al. 





IDS Form PTO/SB/08: Substitute for form 1449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


Application Number 


09/804.625 


Filing Date 


March 9. 2001 


First Named Inventor 


Wang 


Aft Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 2 of | 18 


Attorney Docket Numt)er 


08702.0039-02000 



U.S. PATENTS AND PUBLISHED U.S. PATENT APPLICATIONS 



4^ 




4,789.732 


06 Dec 1988 


Urist 










4.795,804 


30 Jan 1989 


Urist 










4.798.885 


17 Jan 1989 


Mason 










4,804,744 


14 Feb 1989 


Sen 










4,810,691 


07 Mar 1989 


Seyedin 










4,828,990 


09 May 1998 


Naoki et al. 










4,843,063 


27 Jun1989 


Seyedin 










4,851.521 


25 Jul 1989 


Delia Vaile et al. 










4.868,161 


19 Sept 1989 


Roberts 










4,877,864 


31 Oct 1989 


Wang et al. 










4,886.747 


12 Dec 1989 


Deryncl< 










4,908,204 


13 Mar 1990 


Robinson et al. 










4,920.962 


1 May 1990 


Proulx 










4,923,805 


8 May 1990 


Reddy et al. 










4,955.892 


11 Sept 1990 


Daniloff et al. 










4,963.146 


16 Oct 1990 


Li 










4,968,590 


06 Nov 1990 


Kuberasampath et al. 










4,992.274 


12 Feb 1991 


Robinson et al. 










5,011,486 


30 Apr 1991 


Aebischer et al. 










5,011.691 


30 Apr 1991 


Oppermann 










5,013,649 


07 May 1991 


Wang et al. 










5,019,087 


28 May 1991 


Nichols 










5,024.841 


ISJun 1991 


Chu et al. 










5,026.381 


25 Jun 1991 


Li 










5,041.538 


20 Aug 1991 


Ling et al. 










5.071.834 


10 Dec 1991 


Burton et al. 










5,089.396 


18 Feb 1992 


Mason et al. 










5,102.807 


07 Apr 1992 


Burger et al. 










5,106.626 


21 Apr 1992 


Parsons et al. 










5,106.748 


21 Apr 1992 


Wozney et al. 










5,108.753 


28 Apr 1992 


Kuberasampath 










5,108.922 


28 Apr 1992 


Wang et al. 










5,115,738 


26 May 1992 


Wang et al. 










5,118.667 


2 June 1992 


Adams et al. 










5.124.316 


23 Jun 1992 


Antoniades et al 








5.141.905 


25 Aug 1992 


Rosen et al. 





IDS Fonm PTO/SB/OB: SubsUtute for form 1449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


Application Number 


09/804,625 


Filing Date 


March 9. 2001 


First Named Inventor 


Wang 


Art Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 1 3 


of 18 


Attorney Docket Number 


08702.0039-02000 



U.S. PATENTS AND PUBLISHED U.S. PATENT APPLICATIONS 



4k 




5,147.399 


15 Sept 1992 


Dellon et al. 








5,166.058 


24 Nov 1992 


Wang et at. 








5.166.190 


24 Nov 1992 


Mather et al. 








5.166.322 


24 Nov 1992 


Shaw et al. 








5.168,050 


01 Dec 1992 


Hammonds 










5,171.579 


15 Dec 1992 


Ron et al. 










5,187.076 


16 Feb 1993 


Wozney et al. 










5.187.263 


16 Feb 1993 


Murray et al. 










5.202.120 


13 Apr 1993 


Silver et al. 










5.206.028 


27 Apr 1993 


Li 










5.208.219 


04 May 1993 


Ogawa et al. 










5,215.893 


01 Jun 1993 


Mason et al. 










5,216.126 


01 Jun 1993 


Cox et al. 










5,217.867 


08 Jun 1993 


Evans et al. 










5,218,090 


08 Jun 1993 


Connors 










5,229.495 


20 July 1993 


Ichijo et al. 










5.256,418 


26 Oct 1993 


Kemp et al. 










5,258,494 


02 Nov 1993 


Oppennann et al. 










5,266.683 


30 Nov 1993 


Oppemiann et al. 










5,278,145 


11 Jan 1994 


Keller et al. 










5,284,756 


08 Feb 1994 


Grinna et al. 










5,286.654 


15 Feb 1994 


Cox et al. 










5,290,271 


01 Mar 1994 


Jernberg 










5,292.802 


08 Mar 1994 


Rhee et al. 










5.306,307 


26 Apr 1994 


Senter et al. 










5,308,889 


03 May 1994 


Rhee et al 










5,324.519 


28 Jun 1994 


Dunn et al. 










5.324.775 


28 Jun 1994 


Rhee et al. 










5,328.955 


12 Jul 1994 


Rhee et al. 










5,352.715 


4 Oct 1997 


McMullin et at. 










5,354.557 


11 Oct 1994 


Oppermann et al. 










5,356.629 


18 Oct 1994 


Sander et al. 










5.364.839 


15 Nov 1994 


Gerhart et al. 










5,366.875 


22 Nov 1994 


Wozney et al. 










5,399.346 


21 Mar 1995 


Anderson et al. 








5.399.677 


21 Mar 1995 


Wolfman et al. 





IDS Form PTO/SB/08: Substitute for form 1449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


ComplBte if Known 


Application Number 


09/804.625 


Filing Date 


Mardi 9, 2001 


First Named Inventor 


Wang 


Art Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 1 4 of 16 


Attorney Docket Number 


08702.0039-02000 



U.S. PATENTS AND PUBLISHED U.S. PATENT APPLICATIONS 


4k 




5,405,390 


11 Apr 1995 


O'Leary et al. 










5,411,941 


02 May 1995 


Grinna et al. 










5,413,989 


09 May 1995 


Ogawa et al. 










5,420,243 


30 May 1995 


Ogawa et al. 










5.422,340 


06 Jun 1995 


Ammann et al. 










5.447,725 


05 Sept 1995 


Damiani et al. 










5.455.041 


03 Oct 1995 


Genco et al. 










5.455,329 


03 Oct 1995 


Wingender 










5.457,047 


10 Oct 1995 


Wingender 










5,457,092 


10 Oct 1995 


Schulter 










5,459.047 


17 Oct 1995 


Wozney et al. 










5,464,440 


07 Nov 1995 


Johannsson 










5.508.263 


16 Apr 1996 


Grinna et al. 








5.516.654 


14 May 1996 


Israel 










5,520,923 


28 May 1996 


Tjia et al. 










5,538,892 


23 Jul 1996 


Dona hoe et al. 










5,543,394 


06 Aug 1996 


Wozney et al. 










5,545.616 


13 Aug 1996 


Woddruff 










5,547.854 


20 Aug 1996 


Donahoe et al. 










5.556.767 


17 Sept 1996 


Rosen et al. 










5,618.924 


08 Apr 1997 


Wang et al. 










5,631.142 


20 May 1997 


Wang et al. 










5,635.372 


3 Jun 1997 


Celeste et al. 










5,635,373 


03 Jun 1997 


Wozney et al. 










5,637,480 


10 Jun 1997 


Celeste et al. 










5,639.638 


17 Jun 1997 


Wozney et al. 










5,645,592 


08 Jul 1997 


Nicolais et al. 










5,648.467 


15 July 1997 


Kobayashi et al. 










5,650,494 


22 Jul 1997 


Cerletti et ai. 










5,658.882 


19 Aug 1997 


Celeste et al. 










5,661.007 


26 Aug 1997 


Wozney et al. 










5.674,292 


07 Oct 1997 


Tucker et al. 










5,688.678 


8 Nov 1997 


Hewick et al. 










5,693.779 


02 Dec 1991 


Moos, Jr. et al. 










5.700.664 


23 Dec 1997 


Bennett 










5.700.774 


23 Dec 1997 


Hattersley et al 





IDS Form PTO/SB/08: Substitute for form WQMPJO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


Application Number 


09/804.625 


Filing Data 


March 9, 2001 


First Named Inventor 


Wang 


Art Un it 


1647 


Examiner Name 


D. Romeo 


Sheet 5 of 18 


Attorney Docket Number 


08702.0039-02000 



U.S. PATENTS AND PUBLISHED U.S. PATENT APPLICATIONS 






5.700.911 


23 Dec 1997 


Wozney et al. 








5.703.043 


30 Dec 1997 


Celeste et al. 










5,728.679 


17 Mar 1998 


Celeste et al. 










5.750.651 


12 May 1998 


Opperman et al. 










5,752.974 


19 May 1998 


Rhee et al. 










5.756.457 


25 May 1998 


Wang et al. 










5.786.217 


28 Jul 1998 


Tube et al. 










5.813.411 


29 Sept 1998 


Van Bladel etal. 










5.827.733 


27 Oct 1998 


Lee et al. 










5.846,931 


08 Decig98 


Hattersley et al. 










5.849,880 


15 Dec 1998 


Wozney et al. 










5,866,364 


02 Feb 1999 


Israel et al. 










5.932,216 


03 Aug 1999 


Celeste et al. 










5,935.594 


10 Aug 1999 


Ringeisen et al. 










5,936.067 


10 Aug 1999 


Graham et al. 










5,939.323 


17 Aug 1999 


Valentin! et al. 










5,939,388 


17 Aug 1999 


Rosen et al. 










5.965.403 


12 Oct 1999 


Celeste et al. 










5.972,368 


26 Oct 1996 


MacKay 










5.986.058 


16 Nov 1999 


Lee et al. 










6.001.352 


14 Dec 1999 


Boyan et al. 










6.004.937 


21 Dec 1999 


Wood et al. 










6,027.919 


22 Feb 2000 


Celeste et al. 










6,034.061 


06 Mar 2000 


Rosen et al. 










6,034.062 


07 Mar 2000 


Thies et al. 










6,132,214 


17 Oct 2000 


Sohonen et al. 










6,150,328 


21 Nov 2000 


Wang et al. 










6,177,406 


23 Jan 2001 


Wang et al. 










6,187,742 


13 Feb 2001 


Wozney et al. 










6,190,880 


20 Feb 2001 


Israel et al. 










6,207,813 


26 Mar 2001 


Wozney et al. 










6,245,889 


12 Jun 2001 


Wang et al. 










6,284,872 


04 Sep 2001 


Celeste et al. 










6,287,816 


1 1 Sep 2001 


Rosen et aL 










6,291,206 


18 Sep 2001 


Wozney et al. 








6,331.612 


18 Dec 2001 


Celeste et al. 





IDS Forni PTO/SB/08: Substitute for form 144gA/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


Application Number 


09/804.625 


Filing Date 


March 9, 2001 


First Named Inventor 


Wang 


Art Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 1 6 of 1 ia 


Attomey Docket Numt)er 


08702.0039-02000 



U.S. PATENTS AND PUBLISHED U.S. PATENT APPLICATIONS 






6.340,668 


22 Jan 2002 


Celeste et al. 










6,432,919 


13 Aug 2002 


Wang et al. 










6.437,111 


20 Aug 2002 


Wozney et al. 










6.558,925 


06 May 2003 


Graham et al. 










6,586.388 


01 Jul 2003 


Oppermann et al. 










6.593.109 


15 Jul 2003 


Israel et al. 










6.610.513 


26 Aug 2003 


Wozney et al. 










6.613,744 


02 Sep 2003 


Wozney et al. 










6.623.934 


23 Sep 2003 


Celeste et al. 










6.699.471 


02 Mar 2004 


Radici et al. 




41 




6.719.968 


13 Apr 2004 


Celeste et al. 





Note: Copies of the U.S. Patent Documents are not Required In IDS filed after October 21 , 2004 



FOREIGN PATENT DOCUMENTS 



Exami 

ner 
Initials* 


Cite 


Foreign Patent Document 


Publication 
Date 


Name of Patentee 
or 

Applicant of Cited 
Document 


Pages. Columns. 
Lines. Where 

Relevant 
Passages or 
Relevant Figures 
Appear 


Translati 
on« 


Country Code^ Number* Kind 
Code* (if known) 








BP 0 052 510 


26 May 1982 














EP 0 058 481 


25 Aug 1982 














EPO 121 976 


17 Oct 1984 














EP0128 041 


12 Dec 1984 














EPO 148 155 


10 Jul 1985 














EPO 155.476 


25 Sep 1985 














EPO 169 016 


01/1986 














EPO 177 343 


09 Apr 1986 














EPO 212 474 


04 Mar 1987 














EP 0 222 491 


02 Oct 1986 














EP 0 241 809 


21 Oct 1987 














EPO 313 578 


28 Aug 1996 














EP 0 329 239 


23 Aug 1989 














EP 0 336 760 


06 Apr 1989 














EPO 394 418 


13 Oct 1990 














EP 0 401 055 


05 Dec 1990U 












EP 0 409 472 


23 Jan 1991 












EPO 416 578 


13 Mar 1991 









IDS Form PTO/SB/08: SubsUtute for fonn 1449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


Application Number 


09/804.625 


Filing Date 


March 9, 2001 


First Named Inventor 


Wang 


Art Unit 


1647 


Examiner Name 


0. Romeo 


Sheet 7 | of | 18 


Attorney Docket Number 


08702.0039-02000 



FOREIGN PATENT DOCUMENTS 






EP 0 429 570 


05Jun 1991 












EP 0 433 225 


19Jun 1991 












EP 0 512 844 


11 Nov 1992 












EP 0 530 804 


10 Mar 1993 












EP 0 531 448 


17 Nov 1994 












EP0 536 186 


21 Nov 2001 












EP 0 592 562 


07 Jan 1999 












EP 0 626 451 


30 Nov 1994 














EP 0 688 869 


27 Dec 1995 














EP0 741 187 


06 Nov 1996 














EP 0 831 884 


21 May 1996 














EP 1 061 940 


24 Feb 1999 














WO 84/01106 


29 Mar 1984 














WO 85/04173 


26 Sep 1985 














WO 86/00525 


30 Jan 1986 














WO 86/00639 


30 Jan 1986 














WO 87/00528 


29 Jan 1987 














WO 88/00205 


14 Jan 1988 














WO 89/09787 


19 Oct 1989 














WO 89/09788 


19 Oct 1989 














WO 89/10133 


02 Nov 1989 














WO 89/10409 


02 Nov 1989 














WO 90/03733 


19 Apr 1990 














WO 90/11366 


04 Oct 1990 














WO 91/02744 


07 Mar 1991 














WO 91/04274 


04 Apr 1991 














WO 91/05802 


02 May 1991 














WO 91/10444 


25 Jul 1991 














WO 91/17777 


28 Nov 1991 














WO 91/18047 


28 Nov 1991 














WO 91/18098 


28 Nov 1991 














WO 92/05198 


02/\pr 1992 














WO 92/05199 


02 Apr 1992 














WO 92/07004 


30 Apr 1 992 










\ 




WO 92/07073 


30 Apr 1992 








4^ 




WO 92/09697 


06 Nov 1992 









IDS Form PTO/SB/08: SubsUlute for roim 144gA/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


AppficaVon Number 


09/804,625 


Filing Date 


March 9, 2001 


First Named Inventor 


Wang 


Art Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 1 8 | of | 18 


Attorney Docket Number 


08702.0039-02000 



FOREIGN PATENT DOCUMENTS 








wo 92/14481 


03 Sept 1992 














WO 92/15323 


17 Sep 1992 














WO 92/20793 


26 Nov 1992 














WO 92/22319 


23 Dec 1992 














WO 93/00049 


07 Jan 1993 














WO 93/00050 


07 Jan 1993 














WO 93/00432 


07 Jan 1993 














WO 93/04692 


18 Mar 1993 














WO 93/05751 


01 Apr 1993 














WO 93/06872 


15 Apr 1993 














WO 93/09228 


13 May 1993 














WO 93/09229 


13 May 1993 














WO 93/09802 


27 May 1993 














WO 93/13206 


08 Jul 1993 














WO 93/16099 


19 Aug 1993 














WO 93/19177 


30 Sep 1993 














WO 93/20858 


28 Oct 1993 














WO 94/01557 


20 Jan 1994 




• 










WO 94/03200 


17 Feb 1994 














WO 94/06449 


31 Mar 1994 














WO 94/1 1502 


26 May 1994 














WO 94/15949 


21 Jul 1994 














WO 94/15965 


21 Jul 1994 














WO 94/15966 


21 Jul 1994 














WO 94/21681 


29 Sep 1994 














WO 94/24285 


27 Oct 1994 














WO 94/26892 


24 Nov 1994 














WO 94/26893 


24 Nov 1994 














WO 95/01801 


19 Jan 1995 














WO 95/01802 


19 Jan 1995 














WO 95/05846 


02 Mar 1995 














WO 95/07982 


23 Mar 1995 














WO 95/10539 


20 Apr 1995 














WO 95/10611 


20 Apr 1995 














WO 95/12664 


11 May 1995 












WO 95/15966 


15 Jun 1995 









IDS Form PTOySB/08: SubsUtute for form 1449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(UsB as many sheets as necessary) 


Complete if Known 


Application Number 


09/604.625 


Filing Date 


March 9. 2001 


First Named Inventor 


Wang 


Art Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 9 | of | 18 


Attorney Docket Number 


08702.0039-02000 



FOREIGN PATENT DOCUMENTS 






wo 95/16035 


15 Jun 1995 














WO 95/33830 


14 060 1995 














WO 96/01845 


25 Jan 1996 














WO 96/02559 


1 Feb 1996 














WO 96/36710 


21 Nov 1996 














WO 96/38570 


05 Dec 1996 














WO 96/39170 


12 Dec 1996 














WO 96/39203 


12 Dec 1996 














WO 96/40883 


19 Dec 1996 








/ 




WO 07/15321 


01 May 1997 












WO 97/22308 


26 Jun 1997 












WO 97/34626 


25 Sept 1997 












WO 97/40137 


30 Oct 1997 












WO 97/45532 


04 Dec 1997 








4— 




WO 97/48275 


24 Dec 1997 












WO 97/49412 


31 Dec 1997 












WO 98/16641 


23 Apr 1998 












WO 98/31788 


23 Jul 1998 












WO 98/34951 


13 Aug 1998 












WO 98/40113 


17 Sep 1998 












WO 98/49296 


5 Nov 1998 












WO 99/01159 


14 Jan 1999 












WO 99/24070 


20 May 1999 












WO 99/31120 


24 Jun 1 999 












WO 99/37320 


29 Jul 1999 












WO 99/38543 


05 Aug 1999 












WO 99/45949 


16 Sep 1999 












WO 00/37124 


29 Jun 2000 












WO 00/43781 A 


27 Jul 2000 












PAJ 03-345189 


20 Jul 1993 




Patent Abstracts of 
Japan: Application 








Non-English: 
JP. 05-123390. A2 


21 May 1993 












Non-English: 
JP. 05-277174, A2 


26 Oct 1993 












Non-English: 
JP. 63-181770. A 


1988(63) 









IDS Fofm PTO/SB/08: Substitute for form 1449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(Use as many sheets as necessary) 


Complete if Known 


Application Number 


09/804.625 


Filing Date 


March 9. 2001 


First Named inventor 


Wang 


Art Unit 


1647 


Examiner Name 


D. Romeo 


Sheet 1 10 of | 18 


Attorney Docket Number 


06702.0039-02000 



NON PATENT LITERATURE DOCUMENTS 


Examiner 
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Cite 
No.' 


Include name of the author (in CAPITAL LETTERS), title of the article (when 
appropriate), title of the item (book, magazine Journal, serial, symposium, 
catalog, etc.), date, page(s), volume-issue number(s), publisher, city and/or 
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Translation® 






Aioa et a!., olOOUt 9U,0»^>3-oUoU (l^iBf) 










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Auisano eiai., oe//, oo.yr-iuo \ 










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barres. d.a. et ai., ueveiopfnent, no.^oo-zyo (lyyo) 










uasier, i\. eiai., ue//, /o.bo/-AUz (lyyoj 










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4 






Creighton, T.E.. Proteins: Structure and Molecular Principles, W.H. Freeman and 
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NON PATENT LITERATURE DOCUMENTS 




\^ 




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Cinr>h t^i qI DKIAQ QA'€i77n C77C /HQQ*7\ 










rrisncnaur ei ai,, j, moi. oioi., i r u.o^/-o4^ (lyo^) 










rrommei ©i ai., j, moi. fcvo/., ^4.^00-^0/ (iyoo 










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4/1 




Harrison et al.. Exp. Cell Res., 92:340-345 (1991) 





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NON PATENT LITERATURE DOCUMENTS 






Hasimoto etal.. J. Biol. Chem., 267:7203-7206 (1992) 










Me ei at., u&vciop. uynafnicSt lycioo-i**^ \ lyyo^ 










noDQd ei 31., J. invesi. UBrrndioi., yi-H**u-*t*JD ^laooj 










neni ei ai., j. rieurouiOL, ^o. i4io-j**oo pyy*»; 










nernmaii-Dnnvaniou ei ai., /vait/re, ooy.Duy-Di*f ^ lyy^^ 










LJ-,oi-\i^i A^ ol / D/a/ r^ham 071 -Oft 111 Oft 1 '57 /I OQR\ 

noang ei ai., J. o/o/. i/nem. , j.^d loi-^Diof v*^^^/ 










noiinagGi 61 ai., i^aicincu 1 issuG iniit oo,*to\j ^iyyo/ 










nunKapiiier ei ai., Mein, cnzyrnoLt yi.oyy-*n*3 ^lyooj 










mouye ei ai., iwo/. oe//. cnuocnnoi., yu.i (lyy^; 










lia«A«*ALr: / O/a/ OI-»a»vi 071*iT1£Jn C /'1QQC\ 

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1^1 • ^1. 1 * AAA A ^A /AAAA\ 

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H 




Leslie M., Nurse Practitioner, 24:38. 41-8 (1999) 





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Sheet 1 13 of 18 


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NON PATENT LITERATURE DOCUMENTS 








Lewin, oc/ence, zof.iOfU \i\ioi) 










Leyns ei ai. , i/e//, oo. (**!•( do \ i »y f ) 










1 in ot a\ rail Rfl'77^.7RR /1QQ9\ 










Lin ei di., ocienc&, ^ou. i lou* i lo^ ^ \ xy^o) 










LlpcS 61 ai., r'/V/to, oD.yf U'f ^lyooj 










1 r^HicK cki ol A;fo/ ^^/i AiVt/ '^'^ PH \A/ l-l Proomsin Pn n9RR MQQ'^^ 

loqism 61 ai., MOi. L^eu o/o/., J cQ., vv.n. rrcernan « i^o., p^oo ^ i^^oy 










LOpBZ-LrOvieiia ei ai., */. rnysioi. rans., yz.«fDu-*foi pyyo^ 










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NON PATENT LITERATURE DOCUMENTS 






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NON PATENT LITERATURE DOCUMENTS 






rOipn ei ai., Odncer r\6S., o/.o4o pyr /; 




. j — 




Kaipn et ai., J. irnmunoi.^ i i4.oyo ^ly/ o; 








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— 




K6QQI, A. JoJo, oO-A.o 1-1 .o1 -oD JZUUI ; 




— 

i — 




KeOQI 61 ai., USWOpOfOSIS, ACauemlC rfeSSf pp. ^o1-^Of pyyoj 




1 — 




KeaQiexa!., r/VAo, oy.ioui ^lyf/j 




— J — 




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4^ 




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Sheet 16 1 of | 18 


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NON PATENT LITERATURE DOCUMENTS 






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Sheet 17 of | 18 


Attorney Docket Number 


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NON PATENT LITERATURE DOCUMENTS 






Urist et al., Science, 220:680-686 (1983) 








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IDS Form PTO/SB/OS: SubsUtute for form 1449A/PTO 

INFORMATION DISCLOSURE 
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fl/sd as many s/iee/s as necessa/yj 


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Application Number 


09/804,625 


Filing Data 


March 9, 2001 


First Named Inventor 


Wang 


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1647 


Examiner Name 


D. Romeo 


Sheet 1 18 1 of 18 


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08702.0039^2000 



NON PATENT LITERATURE DOCUMENTS 






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1> 




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