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OIPE 



RAW SEQUENCE LISTING 

PATENT APPLICATION: US/09/84 8,616 



DATE: 05/16/2001 
TIME: 13:46:54 




tea 



5 
6 
7 
8 



4 <110> 



APPLICANT: Sebbel, Peter 
Dunant, Nicolas 
Bachmann , Martin 
Tissot, Alain 
Lechner , Franz iska 



Input Set : A:\seqlist 1700 0180002.txt 
Output Set: N:\CRF3\05162001\I848616.raw 




10 <120> TITLE OF INVENTION: Molecular Antigen Array 

13 <130> FILE REFERENCE: 1700.0180002 
C--> 15 <140> CURRENT APPLICATION NUMBER: US/09/848,616 
C--> 16 <141> CURRENT FILING DATE: 2001-05-04 

18 <160> NUMBER OF SEQ ID NOS : 186 
20 <170> SOFTWARE: Patentln Ver . 2.1 

22 <210> SEQ ID NO: 1 

23 <211>" LENGTH: 41 

24 <212> TYPE: DNA 

25 <213> ORGANISM: Artificial Sequence 

27 <220> FEATURE: 

28 <223> OTHER INFORMATION: Primer 

30 <400> SEQUENCE: 1 

31 ggggacgcgt gcagcaggta accaccgtta aagaaggcac c 41 

34 <210> SEQ ID NO: 2 

35 <211> LENGTH: 44 

36 <212> TYPE: DNA 

37 <213> ORGANISM: Artificial Sequence 

39 <220> FEATURE: 

40 <223> OTHER INFORMATION: Primer 
42 <400> SEQUENCE: 2 

4 3 cggtggttac ctgctgcacg cgttgcttaa gcgacatgta gcgg 44 

46 <210> SEQ ID NO: 3 

47 <211> LENGTH: 20 

48 <212> TYPE: DNA 

49 <213> ORGANISM: Artificial Sequence 

51 <220> FEATURE: 

52 <223> OTHER INFORMATION: Primer 

54 <400> SEQUENCE: 3 

55 ccatgaggcc tacgataccc 20 

58 <210> SEQ ID NO: 4 

59 <211> LENGTH: 25 

60 <212> TYPE: DNA 

61 <213> ORGANISM: Artificial Sequence 

63 <220> FEATURE: 

64 <223> OTHER INFORMATION: Primer 

66 <400> SEQUENCE: 4 

67 ggcactcacg gcgcgcttta caggc 25 

70 <210> SEQ ID NO: 5 

71 <211> LENGTH: 47 

72 <212> TYPE: DNA 

73 <213> ORGANISM: Artificial Sequence 



file://C:\CRF3\Outhold\VsrI848616.htm 



5/16/01 



Page 2 of 7 



RAW SEQUENCE LISTING DATE: 05/16/2001 

PATENT APPLICATION: US/09/848, 616 TIME: 13:46:54 

Input Set : A:\seqlist 1700 0180002.txt 
Output Set: N:\CRF3\05162001\I848616.raw 

75 <220> FEATURE: 

76 <223> OTHER INFORMATION: Primer 

78 <400> SEQUENCE: 5 

79 ccttctttaa cggtggttac ctgctggcaa ccaacgtggt tcatgac 47 

82 <210> SEQ ID NO: 6 

83 <211>. LENGTH: 40 

84 <212> TYPE: DNA 

85 <213> ORGANISM: . Artificial Sequence 

87 <220> FEATURE: 

88 <223> OTHER INFORMATION: Primer 

90 <400> SEQUENCE: 6 

91 aagcatgctg cacgcgtgtg cggtggtcgg atcgcccggc 40 

94 <210> SEQ ID NO : 7 

95 <211> LENGTH: 90 

96 <212> TYPE: DNA 

97 <213> ORGANISM: Artificial Sequence 

99 <220> FEATURE: 

100 <223> OTHER INFORMATION: Primer 

102 <400> SEQUENCE: 7 

103 gggtctagat tcccaaccat tcccttatcc aggctttttg acaacgctat gctccgcgcc 60 

104 catcgtctgc accagctggc ctttgacacc 90 

107 <210> SEQ ID NO: 8 

108 <211> LENGTH: 108 

109 <212> TYPE: DNA 

110 <213> ORGANISM: Artificial Sequence 

112 <220> FEATURE: 

113 <223> OTHER INFORMATION': Primer 

115 <400> SEQUENCE: 8 

116 gggtctagaa ggaggtaaaa aacgatgaaa aagacagcta tcgcgattgc agtggcactg 60 

117 gctggtttcg ctaccgtagc gcaggccttc ccaaccattc ccttatcc 108 

120 <210> SEQ ID NO: 9 

121 <211> LENGTH: 31 

122 <212> TYPE: DNA 

123 <213> ORGANISM: Artificial Sequence 

125 <220> FEATURE: 

126 <223> OTHER INFORMATION: Primer 

128 <400> SEQUENCE: 9 

129 cccgaattcc tagaagccac agctgccctc c 31 

132 <210> SEQ ID NO: 10 

133 <211> LENGTH: 24 

134 <212> TYPE: DNA 

135 <213> ORGANISM: Artificial Sequence 

137 <220> FEATURE: 

138 <223> OTHER INFORMATION: Primer 

140 <400> SEQUENCE: 10 

141 cctgcggtgg tctgaccgac accc 24 

144 <210> SEQ ID NO: 11 

145 <211> LENGTH: 41 

146 <212> TYPE: DNA 



file://C:\CRF3\Outhold\VsrI848616.htm 



5/16/01 



RAW SEQUENCE LISTING DATE: 05/16/2001 

PATENT APPLICATION: US/09/848,616 TIME: 13:46:54 



Input Set : A:\seqlist 1700 0180002.txt 
Output Set: N:\CRF3\05162001\l848616.raw 



147 
149 
150 
152 
153 



<213> ORGANISM: Artificial Sequence 
<220> FEATURE: 

<223> OTHER INFORMATION: Primer 
<400> SEQUENCE: 11 

ccgcggaaga gccaccgcaa ccaccgtgtg ccgccaggat g 



41 



156 <210> SEQ ID NO: 12 

157 <211> LENGTH: 33 

158 <212> TYPE: DNA 

159 <213> ORGANISM: Artificial Sequence 

161 <220> FEATURE: 

162 <223> OTHER INFORMATION: Primer 

164 <400> SEQUENCE: 12 

165 ctatcatcta gaatgaatag aggattcttt aac 33 

168 <210> SEQ ID NO: 13 

169 <211> LENGTH: 15 

170 <212> TYPE: DNA 

171 <213> ORGANISM: Artificial Sequence 

173 <220> FEATURE: 

174 <223> OTHER INFORMATION: Modified ribosome 

175 binding site 
177 <400> SEQUENCE: 13 

17 8 aggaggtaaa aaacg 15 

181 <210> SEQ ID NO: 14 

182 <211> LENGTH: 21 

183 <212> TYPE: PRT 

184 <213> ORGANISM: Artificial Sequence 

186 <220> FEATURE: 

187 <223> OTHER INFORMATION: signal peptide 

189 <400> SEQUENCE: 14 

190 Met Lys Lys Thr Ala lie Ala lie Ala Val Ala Leu Ala Gly Phe Ala 

191 15 10 15 

193 Thr Val Ala Gin Ala 

194 20 

197 <210> SEQ ID NO: 15 

198 <211> LENGTH: 46 

199 <212> TYPE: PRT 

200 <213> ORGANISM: Artificial Sequence 

202 <220> FEATURE: 

203 <223> OTHER INFORMATION: modified Fos 

204 construct 

206 <400> SEQUENCE: 15 

207 Cys Gly Gly Leu Thr Asp Thr Leu Gin Ala Glu Thr Asp Gin Val Glu 

208 1 5 10-15 

210 Asp Glu Lys Ser Ala Leu Gin Thr Glu lie Ala Asn Leu Leu Lys Glu 

211 20 25 30 

213 Lys Glu Lys Leu Glu Phe lie Leu Ala Ala His Gly Gly Cys 

214 • 35' 40 45 

217 <210> SEQ ID NO: 16 

218 <211> LENGTH: 6 



file://C:\CRF3\Outhold\VsrI848616.htm 



RAW SEQUENCE LISTING DATE: 05/16/2001 

PATENT APPLICATION: US/09/84 8,616 TIME: 13:46:54 



Input Set : A:\seqlist 1700 0180002.txt 
Output Set: N:\CRF3\05162001\I848616.raw 



219 <212> TYPE: PRT 

220 <213> ORGANISM: Artificial Sequence 

222 <220> FEATURE: 

223 <223> OTHER INFORMATION: peptide linker 

225 <400> SEQUENCE: 16 

226 Ala Ala Ala Ser Gly Gly 

227 1 5 

230 <210> SEQ ID NO: 17 

231 <211> LENGTH: 6 

232 <212> TYPE: PRT 

233 <213> ORGANISM: Artificial Sequence 

235 <220> FEATURE: 

236 <223> OTHER INFORMATION: peptide linker 

238 <400> SEQUENCE: 17 

239 Gly Gly Ser Ala Ala Ala 

240 1 5 

243 <210> SEQ ID NO: 18 

244 <211> LENGTH: 256 

245 <212> TYPE: DNA 

246 <213> ORGANISM: Artificial Sequence 
24 8 <220> FEATURE: 

249 <223> OTHER INFORMATION: Fos fusion construct 

251 <400> SEQUENCE: 18 

252 gaattcagga ggtaaaaaac gatgaaaaag acagctatcg cgattgcagt ggcactggct 60 

253 ggtttcgcta ccgtagcgca ggcctgggtg ggggcggccg cttctggtgg ttgcggtggt 120 

254 ctgaccgaca ccctgcaggc ggaaaccgac caggtggaag acgaaaaatc cgcgctgcaa 180 

255 accgaaatcg cgaacctgct gaaagaaaaa gaaaagctgg agttcatcct ggcgaGacac 240 



259 <210> SEQ ID NO: 19 

260 <211> LENGTH: 52 

261 <212> TYPE: PRT 

262 <213> ORGANISM: Artificial Sequence 

264 <220> FEATURE: 

265 <223> OTHER INFORMATION: Fos fusion construct 

267 <400> SEQUENCE: 19 

268 Ala Ala Ala Ser Gly Gly Cys Gly Gly Leu Thr Asp Thr Leu Gin Ala 

269 5 10 15 

271 Glu Thr Asp Gin Val Glu Asp Glu Lys Ser Ala Leu Gin Thr Glu lie 

272 20 25 30 

274 Ala Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe lie Leu Ala Ala 

275 35 40 45 

277 His Gly Gly Cys 

278 50 

282 <210> SEQ ID NO: 20 

283 <211> LENGTH: 261 

284 <212> TYPE: DNA 

285 <213> ORGANISM: Artificial Sequence 

287 <220> FEATURE: 

288 <223> OTHER INFORMATION: Fos fusion 



256 




ggtggtt< 




aagctt 



file://C:\CRF3\Outhold\VsrI8486 1 6.htm 



RAW SEQUENCE LISTING 

PATENT APPLICATION: US/09/848 f 616 



DATE: 05/16/2001 
TIME: 13:46:54 



Input Set : A:\seqlist 1700 0180002.txt 
Output Set: N:\CRF3\05162001\I848616.raw 



TOO 


construct 


























l 


<220> FEATURE: 


























z y z 


<221> NAME/KEY: 


CDS 
























z y j 


<222> LOCATION: 


(22) 


. . (240) 




















one 

zy b 


<400> SEQUENCE: 


20 
























z y d 


gaattcagga ggtaaaaaac g 


atg 


aaa 


aag 


aca 


get 


o +- r> 


gcg 


a +■ +■ 
all 


gca 


9tg 


zy / 








Met 


Lys 


Lys 


Thr 


Ala 


lie 


Ala 


lie 


Ala 

Ala 


vai 


zy o 








i 








5 










1U 


JUU 


gca ctg get ggt 


ttc 


get 


acc 




gcg 


cag 


gee 


tgc 


ggt 


99~t 


ctg 


acc 


301 


Ala Leu Ala Gly 


Phe 


Ala. 


Thr 


Val 


A 1 — 

Ala 


Gin 


Ala 


Cys 


Gly 


Gly 


Leu 


Thr 


302 




15 










20 










2 D 




304 


gac acc ctg cag 


gcg 


gaa 


acc 


gac 


cag 


gtg 


gaa 


gac 


gaa 


aaa 


tec 


gcg 


one 

JUS 


Asp Thr Leu Gin 


Ala 


Glu 


Thr 


Asp 


Gin 


Val 


Glu 


Asp 




Lys 


Ser 


Ala 


one 


30 










35 
















o rt o 
30o 


ctg caa acc gaa 


ate 


gcg 


aac 


ctg 


ctg 


aaa 


gaa 


aaa 


gaa 


aag 


ctg 


gag 


309 


Leu Gin Thr Glu 


He 


Ala 


Asn 


Leu 


Leu 


Lys 


Glu 


Lys 


Glu 


Lys 


Leu 


Glu 


310 


45 








50 










DO 








312 


ttc ate ctg gcg 


gca 


cac 


ggt 


ggt 


tgc 


ggt 


ggt 


tct 


gcg 


gec 


get 




313 


Phe lie Leu Ala 


Ala 


His 


Gly 


Gly 


Cys 


Gly Gly 


Ser 


Ala 


Ala 


Ala 




314 


60 






65 










70 










316 


gggtgtgggg atatcaagct t 






















319 


<210> SEQ ID NO 


21 
























320 


<211> LENGTH: 7 3 
























321 


<212> TYPE: PRT 


























322 


<213> ORGANISM: 


Artificial Sequence 
















j z4 


<220> FEATURE: 


























325 


<223> OTHER INFORMATION 


Fos fusion 
















326 


construct 


























328 


<400> SEQUENCE: 


21 
























329 


Met Lys Lys Thr 


Ala 


He 


Ala 


He 


Ala 


Val 


Ala 


Leu 


Ala 


Gly 


Phe 


A 1 

Ala 


3 30 


1 


5 










10 










lo 




332 


Thr Val Ala Gin 


Ala 


Cys 


Gly 


Gly 


Leu 


Thr 


Asp 


Thr 


Leu 


Gin 


Ala 


Glu 


0 0*3 

3 3 3 


20 










25 










3U 






*J o c 

3 35 


Thr Asp Gin Val 


Glu 


Asp 


Glu 


Lys 


Ser 


Ala 


Leu 


Gin 


Thr 


Glu 


T 1 a 

lie 


Ala 


336 


35 








40 










45 








"3 O Q 

j Jo 


Asn Leu Leu Lys 


Glu 


Lys 


Glu 


Lys 


Leu 


Glu 


Phe 


lie 


Leu 


Ala 


Ala 


His 


3 3 y 


50 






55 










D u 










341 


Gly Gly Cys Gly 


Gly 


Ser 


Ala 


Ala 


Ala 
















342 


65 




70 






















346 


<210> SEQ ID NO 


22 
























347 


<211> LENGTH: 196 
























348 


<212> TYPE: DNA 


























349 


<213> ORGANISM: 


Artificial Sequence 
















351 


<220> FEATURE: 


























352 


<223> OTHER INFORMATION: 


Fos 


fusion 
















353 


construct 


























355 


<220> FEATURE: 


























356 


<221> NAME/KEY: 


CDS 
























357 


<222> LOCATION: 


(34) 


. .(189) 





















51 



99 



147 



195 



240 



261 



Please Note: 

Use fnand/ r Xaa have been detect d in the Sequence Listing. Please review the 
S ?i Ue " C ?_. L,stlng to ensure that a c rr «sponding explanati n is presented in the <220> to 
<223> fields f each sequence which presents at least ne n rXaa. 



file://C:\CRF3\Outhold\VsrI8486 1 6.htm 



Page 6 of 7 



VERIFICATION SUMMARY DATE: 05/16/2001 

PATENT APPLICATION: US/09/848,616 TIME: 13:46:55 

Input Set : A:\seqlist 1700 0180002.txt 
Output Set: N:\CRF3\05162001\I848616.raw 

L:15 M:270 C: Current Application Number differs, Replaced Application Number 
L:16 M:271 C: Current Filing Date differs, Replaced Current Filing Date 
L:381 M:283 W: Missing Blank Line separator, <220> field identifier 
L:2378 M:341 W: (46) "n" or "Xaa" used, for SEQ ID# : 111 



file://C:\CRF3\Outhold\VsrI8486 1 6.htm 



5/16/01