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o//5r 

y CRF Errors Corroctod by tho STIC SysfWis Branch / j 

Saria. W. lm h.r: Ol/WV Ul Ej\l T P O C rN"™^I»^ 

| | Changed a (il/ from non-ASCII to ASCII ^ [J'orlflod by: f d I? (STIC staff) 

| | Changed the margins in cases where the seqiA^cS'tejrwas \vrapped" down to the next line. 

[ [ Edited a format error in the Current Application Data section. specrficaJly: 

| | Edited the Current Application Data section with the aduaJ current number. The number inputted by the 
applicant was O the prior application data; or Q other . 

| | Added the mandatory heading and subheadings (or "Current Application Data". 

| | Edited tho 'Number of Sequences" field. The applicant spelled out a number'instead of using an integer. 

| | Changed tho spelling of a mandatory field (the headings or subheadings), specifically; 

| | Corrected the 'SEQ ID NO when obviously incorrect. The sequence numbers that were edited were: 

| | Inserted or corrected a nucleic number at tho end of a nucleic line. SEO ID NO's edited: 

| ] Corrected subheading placement. All responses must be on tho same line as each subheading. If tho 

applicant placed a response below tho subheading, this was moved to its appropriate place. 

| J Inserted colons after headings/subheadings. Headings edited included: . 

| J Deleted extra, invalid, headings used by an applicant, specrficaJly: 

[ | Deleted: □ non-ASCII "garbage" at the beginning/end of files; O secretary initials/filename at end of file; 

□ page numbers throughout text; □ other invalid text, such as . . 

| | Inserted mandatory headings, specifically: „ ... 

I 1 Corrected an obvious error in the response, specifically: 



I | Edited identifiers where upper case is used but lower case is required, or vice versa. 

[ | Corrected an error in tho Number of Sequences field, specifically: 

1 1 A "Hard Page Break" code was inserted by the applicant. All occurrences had to be deleted. 

[ 1 / Deleted ending stop codon in amino acid sequences and adjusted the "(A)Length:" field accordingly (error 
due to a Patentln bug). Sequences corrected: 



Other: 



'Examiner: The above corrections must be communicated to the applicant in the first Office 
Actfon. DO NOT send a copy of this form. 3/1/95 



Page 1 of 7 



RAW SEQUENCE LISTING 

PATENT APPLICATION: US/09/848,616 



DATE: 05/27/2001 
TIME: 17:48:05 



Input Set : A:\Pto.amc 

Output Set: C:\CRF3\05272001\I848616.raw 



5 
6 
7 
8 



4 <110> 



APPLICANT: Sebbel, Peter 
Dunant, Nicolas 
Bachmann, Martin 
Tissot, Alain 
Lechner, Franziska 




10 <120> TITLE OF INVENTION: Molecular Antigen Array 

13 <130> FILE REFERENCE: 1700.0180002 
C~> 15 <140> CURRENT APPLICATION NUMBER: US/09/848,616 
C~> 16 <141> CURRENT FILING DATE: 2001-05-05 

18 <160> NUMBER OF SEQ ID NOS : 186 
20 <170> SOFTWARE: Patentln Ver. 2.1 

22 <210> SEQ ID NO: 1 

23 <211> LENGTH: 41 

24 <212> TYPE: DNA 

25 <213> ORGANISM: Artificial Sequence 

27 <220> FEATURE: 

28 <223> OTHER INFORMATION: Primer 

30 <400> SEQUENCE: 1 

31 ggggacgcgt gcagcaggta accaccgtta aagaaggcac c 41 

34 <210> SEQ ID NO: 2 

35 <211> LENGTH: 44 

36 <212> TYPE: DNA 

37 <213> ORGANISM: Artificial Sequence 

39 <220> FEATURE: 

40 <223> OTHER INFORMATION: Primer 

42 <400> SEQUENCE: 2 

43 cggtggttac ctgctgcacg cgttgcttaa gcgacatgta gcgg 4 4 

46 <210> SEQ ID NO: 3 

47 <211> LENGTH: 20 

48 <212> TYPE: DNA 

49 <213> ORGANISM: Artificial Sequence 

51 <220>' FEATURE: 

52 <223> OTHER INFORMATION: Primer 

54 <400> SEQUENCE: 3 

55 ccatgaggcc tacgataccc 20 

58 <210> SEQ ID NO: 4 

59 <211> LENGTH: 25 

60 <212> TYPE: DNA 

61 <213> ORGANISM: Artificial Sequence 

63 <220> FEATURE: 

64 <223> OTHER INFORMATION: Primer 

66 <4 00> SEQUENCE: 4 

67 ggcactcacg gcgcgcttta caggc 25 

70 <210> SEQ ID NO: 5 

71 <211> LENGTH: 47 

72 <212> TYPE: DNA 

73 <213> ORGANISM: Artificial Sequence 



file://C:\Crf3\Outhold\VsrI848616.htm 



5/27/01 



Page 2 of 7 



RAW SEQUENCE LISTING DATE : 05/27/2001 

PATENT APPLICATION: US/09/848,616 TIME: 17:48:05 

Input Set : A:\Pto.amc 

Output Set: C:\CRF3\05272001\I848616.raw 

75 <220> FEATURE: 

76 <223> OTHER INFORMATION: Primer 

78 <400> SEQUENCE: 5 

79 ccttctttaa cggtggttac ctgctggcaa ccaacgtggt tcatgac 47 

82 <210> SEQ ID NO: 6 

83 <211> LENGTH: 40 

84 <212> TYPE: DNA 

85 <213> ORGANISM: Artificial Sequence 

87 <220> FEATURE: 

88 <223> OTHER INFORMATION: Primer 

90 <400> SEQUENCE: 6 

91 aagcatgctg cacgcgtgtg cggtggtcgg atcgcccggc 4 0 

94 <210> SEQ ID NO: 7 

95 <211> LENGTH: 90 

96 <212> TYPE: DNA 

97 <213> ORGANISM: Artificial Sequence 

99 <220> FEATURE: 

100 <223> OTHER INFORMATION: Primer 

102 <400> SEQUENCE: 7 

103 gggtctagat tcccaaccat tcccttatcc aggctttttg acaacgctat gctccgcgcc 60 

104 catcgtctgc accagctggc ctttgacacc • 90 

107 <210> SEQ ID NO: 8 

108 <211> LENGTH: 108 

109 <212> TYPE: DNA 

110 <213> ORGANISM: Artificial Sequence 

112 <220> FEATURE: 

113 <223> OTHER INFORMATION: Primer 

115 <400> SEQUENCE: 8 

116 gggtctagaa ggaggtaaaa aacgatgaaa aagacagcta tcgcgattgc agtggcactg '60 

117 gctggtttcg ctaccgtagc gcaggccttc ccaaccattc ccttatcc 108 

120 <210> SEQ ID NO: 9 

121 <211> LENGTH: 31 

122 <212> TYPE: DNA 

123 <213> ORGANISM: Artificial Sequence 

125 <220> FEATURE: 

126 <223> OTHER INFORMATION: Primer 

128 <400> SEQUENCE: 9 

129 cccgaattcc tagaagccac agctgccctc c 31 

132 <210> SEQ ID NO: 10 

133 <211> LENGTH: 24 

134 <212> TYPE: DNA 

135 <213> ORGANISM: Artificial Sequence 

137 <220> FEATURE: 

138 <223> OTHER INFORMATION: Primer 

140 <400> SEQUENCE: 10 

141 cctgcggtgg tctgaccgac accc 24 

144 <210> SEQ ID NO: 11 

145 <211> LENGTH: 41 

146 <212> TYPE: DNA 



file://C:\Crf3\Outhold\VsrI848616.htm 



5/27/01 



Page 3 of 7 



RAW SEQUENCE LISTING DATE:' 05/27/2001 

PATENT APPLICATION: US/09/848,616 TIME: 17:48:05 

Input Set : A:\Pto.amc 

Output Set: C:\CRF3\05272001\I848616.raw 

147 <213> ORGANISM: Artificial Sequence 

14 9 <220> FEATURE: 

150 <223> OTHER INFORMATION: Primer 

152 <400> SEQUENCE: 11 

153 ccgcggaaga gccaccgcaa ccaccgtgtg ccgccaggat g 41 

156 <210> SEQ ID NO: 12 

157 <211> LENGTH: 33 

158 <212> TYPE: DNA 

159 <213> ORGANISM: Artificial Sequence 

161 <220> FEATURE: 

162 <223> OTHER INFORMATION: Primer 

164 <400> SEQUENCE: 12 

165 -ctatcatcta gaatgaatag aggattcttt aac 33 

168 <210> SEQ ID NO: 13 

169 <211> LENGTH: 15 

170 <212> TYPE: DNA 

171 <213> ORGANISM: Artificial Sequence 

173 <220> FEATURE: 

174 <223> OTHER INFORMATION: Modified ribosome 

175 binding site 

177 <400> SEQUENCE: 13 

178 aggaggtaaa aaacg 15 

181 <210> SEQ ID NO: 14 

182 <211> LENGTH: 21 

183 <212> TYPE: PRT 

184 <213> ORGANISM: Artificial Sequence 

186 <220> FEATURE: 

187 <223> OTHER INFORMATION: signal peptide 

189 <400> SEQUENCE: 14 

190 Met Lys Lys Thr Ala He Ala He Ala Val Ala Leu Ala Gly Phe Ala 

191 15 10 15 

193 Thr Val Ala Gin Ala 

194 20 

197 <210> SEQ ID NO: 15 

198 <211> LENGTH: 46 

199 <212> TYPE: PRT 

200 <213> ORGANISM: Artificial Sequence 

202 <220> FEATURE: 

203 <223> OTHER INFORMATION: modified Fos 

204 construct 

206 <400> SEQUENCE: 15 

207 Cys Gly Gly Leu Thr Asp Thr Leu Gin Ala Glu Thr Asp Gin Val Glu 

208 1 5 10 15 

210 Asp Glu Lys Ser Ala Leu Gin Thr Glu He Ala Asn Leu Leu Lys Glu 

211 20 25 30 

213 Lys Glu Lys Leu Glu Phe He Leu Ala Ala His Gly Gly Cys 

214 35 40 45 

217 <210> SEQ ID NO: 16 

218 <211> LENGTH: 6 



file://C:\Crf3\Outhold\VsrI848616.htm 



5/27/01 



Page 4 of 7 



RAW SEQUENCE LISTING 

PATENT APPLICATION: US/09/848,616 



DATE: 05/27/2001 
TIME: 17:48:05 



Input Set : A:\Pto.amc 

Output Set: C:\CRF3\05272001\I848616.raw 



219 <212> TYPE: PRT. 

220 <213> ORGANISM: Artificial Sequence 

222 <220> FEATURE: 

223 <223> OTHER INFORMATION: peptide linker 

225 <400> SEQUENCE: 16 

226 Ala Ala Ala Ser Gly Gly 

227 1 5 

230 <210> SEQ ID NO: 17 

231 <211> LENGTH: 6 

232 <212> TYPE: PRT 

233 <213> ORGANISM: Artificial Sequence 

235 <220> FEATURE: 

236 <223> OTHER INFORMATION: peptide linker 

238 <400> SEQUENCE: 17 

239 Gly Gly Ser Ala Ala Ala 

240 1 5 

243 <210> SEQ ID NO: 18 

244 <211> LENGTH: 256 

245 <212> TYPE: DNA 

246 <213> ORGANISM: Artificial Sequence 
24 8 <220> FEATURE: 

249 <223> OTHER INFORMATION: Fos fusion construct 

251 <400> SEQUENCE: 18 

252 gaattcagga ggtaaaaaac gatgaaaaag acagctatcg cgattgcagt ggcactggct 60 

253 ggtttcgcta ccgtagcgca ggcctgggtg ggggcggccg cttctggtgg ttgcggtggt 120 

254 ctgaccgaca ccctgcaggc ggaaaccgac caggtggaag acgaaaaatc cgcgctgcaa 180 

255 accgaaatcg cgaacctgct gaaagaaaaa gaaaagctgg agttcatcct ggcggcacac 240 

256 ggtggttgct aagctt 256 

259 <210> SEQ ID NO: 19 

260 <211> LENGTH: 52 

261 <212> TYPE: PRT 

262 <213> ORGANISM: Artificial Sequence 

264 <220> FEATURE: 

265 <223> OTHER INFORMATION: Fos fusion construct 

267 <400> SEQUENCE: 19 

268 Ala Ala Ala Ser Gly Gly Cys Gly Gly Leu Thr Asp Thr Leu Gin Ala 

269 5 10 15 

271 Glu Thr Asp Gin Val Glu Asp Glu Lys Ser Ala Leu Gin Thr Glu He 

272 20 25 30 

274 Ala Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe He Leu Ala Ala 

275 35 40 45 

277 His Gly Gly Cys 

278 50 

282 <210> SEQ ID NO: 20 

283 <211> LENGTH: 261 

284 <212> TYPE: DNA 

285 <213> ORGANISM: Artificial Sequence 

287 <220> FEATURE: 

288 <223> OTHER INFORMATION: Fos fusion ' 



file://C:\Crf3\Outhold\VsrI848616.htm 



5/27/01 



RAW SEQUENCE LISTING DATE: 05/27/2001 

PATENT APPLICATION: US/09/848,616 TIME: 17:48:05 

Input Set : A:\Pto.amc 

Output Set: C:\CRF3\05272001\I848616.raw 

289 construct 

291 <220> FEATURE: 

292 <221> NAME /KEY : CDS 

293 <222> LOCATION: (22) . . (240) 
295 <400> SEQUENCE: 20 



296 


gaattcagga ggtaaaaaac g 


atg 


aaa 


aag 


aca 


get 


ate 


gcg 


att 


gca 


gtg 


51 


297 














Met 


Lys 


Lys 


Thr 


Ala 


He 


Ala 


lie 


Ala 


Val 




298 














1 








5 










10 




300 


gca 


ctg 


get 


ggt 


ttc 


get 


acc 


gta 


gcg 


cag 


gee 


tgc 


ggt 


ggt 


ctg 


acc 


99 


301 


Ala 


Leu 


Ala 


Gly 


Phe 


Ala 


Thr 


Val 


Ala 


Gin 


Ala 


Cys 


Gly 


Gly 


Leu 


Thr 




302 










15 










20 










25 






304 


gac 


acc 


ctg 


cag 


gcg 


gaa 


acc 


gac 


cag 


gtg 


gaa 


gac 


gaa 


aaa 


tec 


gcg 


147 


305 


Asp 


Thr 


Leu 


Gin 


Ala 


Glu 


Thr 


Asp 


Gin 


Val 


Glu 


Asp 


Glu 


Lys 


Ser 


Ala 




306 








30 










35 










40 








308 


ctg 


caa 


acc 


gaa 


ate 


gcg 


aac 


ctg 


ctg 


aaa 


gaa 


aaa 


gaa 


aag 


ctg 


gag 


195 


309 


Leu 


Gin 


Thr 


Glu 


He 


Ala 


Asn 


Leu 


Leu 


Lys 


Glu 


Lys 


Glu 


Lys 


Leu 


Glu 




310 






45 










50 










55 










312 


ttc 


ate 


ctg 


gcg 


gca 


cac 


ggt 


ggt 


tgc 


ggt 


ggt 


tct 


gcg 


gee 


get 




240 


313 


Phe 


He 


Leu 


Ala 


Ala 


His 


Gly 


Gly 


Cys 


Gly 


Gly 


Ser 


Ala 


Ala 


Ala 






314 




60 










65 










70 













316 gggtgtgggg atatcaagct t 261 

319 <210> SEQ ID NO: 21 

320 <211> LENGTH: 73 

321 <212> TYPE: PRT 

322 <213> ORGANISM: Artificial Sequence 

324 <220> FEATURE: 

325 <223> OTHER INFORMATION: Fos fusion 

326 construct 
328 <400> SEQUENCE: 21 



329 


Met 


Lys Lys 


Thr 


Ala 


He 


Ala 


He 


Ala 


Val 


Ala 


Leu 


Ala 


Gly 


Phe 


Ala 


330 


1 






5 










10 










15 




332 


Thr 


Val Ala 


Gin 


Ala 


Cys 


Gly 


Gly 


Leu 


Thr 


Asp 


Thr 


Leu 


Gin 


Ala 


Glu 


333 






20 










25 










30 






335 


Thr 


Asp Gin 


Val 


Glu 


Asp 


Glu 


Lys 


Ser 


Ala 


Leu 


Gin 


Thr 


Glu 


He 


Ala 


336 




35 










40 










45 








338 


Asn 


Leu Leu 


Lys 


Glu 


Lys 


Glu 


Lys 


Leu 


Glu 


Phe 


He 


Leu 


Ala 


Ala 


His 


339 




50 








55 










60 










341 


Gly 


Gly Cys 


Gly 


Gly 


Ser 


Ala 


Ala 


Ala 
















342 


65 








70 























346 <210> SEQ ID NO: 22 

347 <211> LENGTH: 196 

348 <212> TYPE: DNA 

349 <213> ORGANISM: Artificial Sequence 

351 <220> FEATURE: 

352 <223> OTHER INFORMATION: Fos fusion 

353 construct 

355 <220> FEATURE: 

356 <221> NAME/KEY: CDS 

357 <222> LOCATION: (34).. (189) 

<J> . - 1 

Please Note: 

Use of n and/or Xaa have been detected in the Sequence Listing. Please review the 
Sequence Listing to ensure that a corresponding explanation is presented in the <220> to 
<223> fields of each sequence which presents at .least ne n or Xaa. 

fiie://C:\Crf3\Outhold\VsrI848616.htm 



VERIFICATION SUMMARY DATE: 05/27/2001 

PATENT APPLICATION: US/09/848,616 TIME: 17:48:06 



Input Set : A:\Pto.amc 

Output Set: C:\CRF3\05272001\I848616.raw 

L:15 M:270 C: Current Application Number differs, Replaced Application Number 
L:16 M:271 C: Current Filing Date differs, Replaced Current Filing Date 
L:381 M:-283 W: Missing Blank Line separator, <220> field identifier 
L:2378 M:341 W: (46) "n" or "Xaa" used, for SEQ ID#:111 



file://C:\Crf3\Outhold\VsrI848616.htm