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Q Sterne Kessler 
Goldstein Fox 




LAW 



Robert Greene Sterne 
Edward J. Kessler 
Jorge A. Goldstein 
David K.S. Cornwell 
Robert W.Esmond 
Tracy-Gene G. Durkin 
Micnele A. Cimbala 
Michael B. Ray 
Robert E. Sofcohl 
Eric K. Steffe 
Michael Q. Lee 
Steven R. Ludwig 
John M. Covert 
Linda E. Alcorn 
Robert C. Millonig 
Lawrence B. Bugaisky 
Donald J. Featherstone 
Michael V. Messinger 



Judith U. Kim 
Timothy J. Shea, Jr. 
Patrick E. Garrett 
Jeffrey T.Hervey 
Heidi L Kraus 
Albert L Ferro* 
Donald R. Banowit 
Peter A. Jackman 
Teresa U. Medler 
Jeffreys. Weaver 
Kendrick P. Patterson 
Vincent L Capuano 
Eldora Ellison Floyd 
Thomas C. Fiala 
Brian J. Del Buono 
Virgil Lee Beaston 
Theodore A. Wood 
Elizabeth J. Haanes 



July 15, 2004 



Commissioner for Patents 

P.O. Box 1450 

Alexandria, VA 22313-1450 



Joseph S. Ostroff 
Frank R. Cottingham 
Christine M. Lhulier 
Rae Lynn Prengaman 
George S. Bardmesse* 
Daniel A. Klein* 
Jason D. Eisenberg 
Michael D. Specht 
Andrea J. Kamage 
Tracy L. Muller* 
LuAnne M. DeSantis 
Ann E. Summerfield 
Tiera S. Coston 
AricW.Ledford* 
Helene C. Carlson 
Timothy A. Doyle* 
Jessica L. Parezo 
Gaby L. Longsworth* 



Lori A. Gordon* 
Nicole D. Dretar* 
Ted J. Ebersole 
Jyoti C Iyer* 
Laura A. Vogel 

Registered Patent Agents * 
Karen R. Markowicz 
Nancy J. Leith 
Matthew J. Dowd 
Aaron L Schwartz 
Katrina Yuiian Pei Quach 
Bryan L. Skefton 
Robert A, Sctiwartzman 
Teresa A. Colella 
Jeffrey S. Lundgren 
Victoria S. Rutherford 
Michelle K. Holoubek 



Robert H. DeSelms 
Simon J. Elliott 
JulieA.Heider 
Mita Mukherjee 
Scott M. Woodhouse 
Michael G. Penn 
Christopher J.Walsh 



Kenneth C. Bass III 
Evan R. Smith 
Marvin C Guthrie 

* Ad mined only in Maryland 
+ Admitted only in Virginia 
•Practice Limited to 
Federal Agencies 



Writer 's Direct Number: 

(202) 772-8525 

Internet Address: 

BRIAND@SKGF.COM 

Art Unit 1648 



Re: U.S. Utility Patent Application 

Appl. No. 09/848,616; Filed: May 4, 2001 
For: Molecular Antigen Array 
Inventors: SEBBEL et al 
Our Ref: 1 700.01 80002/BJD/SJE 



Transmitted herewith for appropriate action are the following documents: 

1 . First Supplemental Information Disclosure Statement; 

2. Form PTO- 1 449 (62 sheets citing 1 95 documents); 

3 . 189 documents cited in Form PTO- 1 449 (attached); and 

4. One (1) return postcard. 

It is respectfully requested that the attached postcard be stamped with the date of filing of 
these documents, and that it be returned to our courier. In the event that extensions of time are 
necessary to prevent abandonment of this patent application, then such extensions of time are 
hereby petitioned. 

The U.S. Patent and Trademark Office is hereby authorized to charge any fee deficiency, 
or credit any overpayment, to our Deposit Account No. 19-0036. 

Respectfully submitted, 

Sterne, Kessler, Goldstein & Fox p.l.l.c. 

Brian J. Del Buono 
Attorney for Applicants 
Registration No. 42,473 

287535.1 



BJD/SJE/lam 
Enclosures 



Sterne, Kessler, Goldstein & Fox p.llc : 1100 New York Avenue, NW : Washington, DC 20005 : 202.371.2600 f 202.371.2540 : www.skgf.com 




HE UNITED STATES PATENT AND TRADEMARK OFFICE 



In re application of: 
Sebbel et al. 
Appl.No.: 09/848,616 
Filed: May 4, 2001 
For: Molecular Antigen Array 



Confirmation No.: 6018 



Art Unit: 1648 



Examiner: Mosher, M. 

Atty. Docket: 1 700.0 1 80002/B JD/S JE 



First Supplemental Information Disclosure Statement 
Under 37 C.F.R. § 1.97(b) 



Commissioner for Patents 

P.O. Box 1450 

Alexandria, VA 22313-1450 



Sir: 



Listed on accompanying Form PTO-1449 are documents that may be considered 
material to the examination of this application, in compliance with the duty of disclosure 
requirements of 37 C.F.R. §§ 1.56, 1.97 and 1.98. The numbering on this First 
Supplemental Information Disclosure Statement is a continuation of the numbering in 
Applicants' Information Disclosure Statement filed on May 7, 2002 in connection with 
the above-captioned application. 

Copies of documents AF2 to AK2 are not provided in accordance with the U.S. 
Patent and Trademark Office pre-OG notice of July 11, 2003, which states "[t]he Office 
hereby waives the requirement under 37 CFR 1.98 (a)(2)(i) for submitting a copy of each 
cited U.S. patent and each U.S. patent application publication for all U.S. national patent 
applications filed after June 30, 2003." Copies of the remaining documents are provided. 

The Examiner's attention is directed to the following copending applications 
directed to related technical subject matter: 

U.S. Application No. 10/622,064, Bachmann et aL, filed July 18, 2003, published 
as Published Application No. 2004/0059094 Al (Document AD1); 

U.S. Application No. 10/617,876, Bachmann et al., filed July 14, 2003, published 
as Published Application No. 2004/007661 1 Al (Document AE1); 



U.S. Application No. 10/622,087, Bachmann et al., filed July 18, 2003, pending 
(Document AT92); 



- 2 - SEBBEL et al. 

Appl. No. 09/848,616 

U.S. Application No. 10/622,124, Bachmann et al., filed July 18, 2003, published 
as Published Application No. 2004/0076645 Al (Document AF1); and 

U.S. Application No. 10/733,582, Renner et al., filed December 12, 2003 pending 
(Not Published), which is a continuation of U.S. Application No. 09/449,631, Renner et 
al., filed November 30, 1999, abandoned (Document AR93). 

In accordance with the recent Federal Circuit decision in Dayco Prods. , Inc. v. 
Total Containment, Inc. 329 F.3d 1358 (Fed. Cir. 2003), Applicants submit herewith 
Office Actions from related copending applications as Documents AS95-AS96. 

The identification of these U.S. Patent Applications and Office Actions is not to 
be construed as a waiver if secrecy as to those applications now or upon issuance of the 
present application as a patent. The Examiner is respectfully requested to consider the 
cited applications, Office Actions, and the art cited therein during examination of the 
present application. 

Document AR94 is an unverified English language abstract of non English- 
language Published International Patent Application No. 94/06472, which was submitted 
as Document AL2 in Applicants 1 Information Disclosure Statement filed on May 7, 
2002. 

Where the publication date of a listed document does not provide a month of 
publication, the year of publication of the listed document is sufficiently earlier than the 
effective U.S. filing date and any foreign priority date so that the month of publication is 
not in issue. Applicants have listed publication dates on the attached PTO-1449 based on 
information presently available to the undersigned. However, the listed publication dates 
should not be construed as an admission that the information was actually published on 
the date indicated. 

Applicants reserve the right to establish the patentability of the claimed invention 
over any of the information provided herewith, and/or to prove that this information may 
not be prior art, and/or to prove that this information may not be enabling for the 
teachings purportedly offered. 

This statement should not be construed as a representation that a search has been 
made, or that information more material to the examination of the present patent 
application does not exist. The Examiner is specifically requested not to rely solely on 
the material submitted herewith. 



-3- 



SEBBEL et al 
Appl. No. 09/848,616 



This Information Disclosure Statement is being filed before the mailing of a first 
Office Action after the filing of a request for continued examination under 37 C.F.R. 
§ 1.114. No statement or fee is required. 

It is respectfully requested that the Examiner initial and return a copy of the 
enclosed PTO-1449, and indicate in the official file wrapper of this patent application 
that the documents have been considered. 

The U.S. Patent and Trademark Office is hereby authorized to charge any fee 
deficiency, or credit any overpayment, to our Deposit Account No. 19-0036. 



Respectfully submitted, 



Sterne, Kessler, Goldstein & Fox p.l.l.c. 




Brian J. Del Buono 
Attorney for Applicants 
Registration No. 42,473 



Date: July 15. 2004 



1 100 New York Avenue, N.W. 
Washington, D.C. 20005-3934 
(202)371-2600 



285853.1 




Page 1 of 62 



^/FORM PTO-1449 



JRST SUPPLEMENTAL INFORMATION DISCLOSURE 
^^VTftTV>^ STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



APPLICATION NO. 
09/848,616 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF2 


5,143,726 


09/01/1992 


Thornton et al. 






11/20/1989 




AG2 


5,580,859 


12/03/1996 


Feigner et al. 






03/18/1994 




AH2 


5,935,821 


08/10/1999 


Chatterjee et al. 






11/21/1996 




AI2 


2004/0059094 


03/25/2004 


Bachmann et aL 






07/18/2003 




AJ2 


2004-0076611 


04/22/2004 


Bachmann et al. 






07/14/2003 




AK2 


2004-0076645 


04/22/2004 


Bachmann et al. 






07/18/2003 



U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN4 


WO 99/28478 


06/10/1999 


WIPO 






Yes 
No 




A04 


WO 99/57289 


11/11/1999 


WIPO 






Yes 
No 




AP4 


WO 00/50461 


08/31/2000 


WIPO 






Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



AS 



35 



Abraham, J.M., et al., "An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia 
coli," Proc Natl Acad Sci USA. 1985 Sep;82(17):5724-5727, National Academy Press (1985) 



AT 



35 



Abraham, S.N., etal., "Glycerol-induced unraveling of the tight helical conformation of Escherichia coli type 1 
fimbriae, " J Bacteriol. 1992 Aug;1 74(1 5):51 45-5148, American Society for Microbiology (1992) 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. 
and not considered. Include copy of this form with next communication to Applicant. 



Draw line through citation if not in conformance 



285541_1.DOC 



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Page 2 of 62 



% \^ " gbRMPTO-1449 

FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
STATEMENT ~ 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



U.S. PATENT DOCUMENTS 



C AM Ivl 1 IN C r\ 

INITIAL 




NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
MM 
















AD 
MD 
















ML* 
































AF 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL5 


EP0 385 610 A1 


05/09/1990 


Europe 






Yes 
No 




AM5 


EP0 385 610 B1 


03/16/1994 


Europe 






Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



36 



Arnon, R. t et a/., "A mimotope peptide-based vaccine against Schistosoma mansoni: synthesis and 
characterization, " Immunology. 2000 Dec;101(4):555-562, Blackwell Science, Ltd. (December 2000) 



AS 



36 



Bachmann, M.F., et al., "TRANCE, a tumor necrosis factor family member critical for CD40 ligand- 
independent T helper cell activation, " J Exp Med. 1999 Apr 5;189(7):1 025-1031, The Rockefeller University 
Press (1999) 



AT 



36 



Bass, S., and Yang, M., "Expressing cloned genes in Escherichia coli, " in Protein Function: A practical 
Approach, 2 nd ed., Creighton, T.E., ed., IRL Press, Oxford, Great Britain, pp. 29-55 (1997) 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



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/O 'SA 


\ S^V X g0RMPTO-1449 

FIR^.SUPPLEM^TTAL INFORMATION DISCLOSURE 
^r*TRf^ STATEMENT 


ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et a/. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


37 


Biomfield, I.C., et a/., "Type 1 fimbriation and fimE mutants of Escherichia coli K-12., " J Bacteriol. 1991 
Sep;173(17):5298~5307, American Society for Microbiology (1991) 




AS 


37 


Biomfield, I.C., etal., "Integration host factor stimulates both FimB-and FimE-mediated site-specific DNA 
inversion that controls phase variation of type 1 fimbriae expression in Escherichia coli, " Mol Microbiol. 1997 
Feb;23(4):705-717, Blackwell Science, Ltd. (1997) 




AT 


37 


Boder, ET., and Wittrup, K.D., "Yeast surface display for directed evolution of protein expression, affinity, and 
stability, " Methods Enzymol. 2000;328:430-444, Academic Press (October 2000) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



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Page 4 of 62 



a (># tfiORM PTO-1449 
tIRST SUPPLEMI 



AL INFORMATION DISCLOSURE 



STATEMENT 



ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel ef a/. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



NAME 



CLASS 



SUB-CLASS 



FILING DATE 



AA 



AB 



AC 



AD 



AE 



AF 



AG 



AH 



Al 



AJ 



AK 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



COUNTRY 



CLASS 



SUB-CLASS 



TRANSLATION 



AL 



Yes 
No 



AM 



Yes 
No 



AN 



Yes 
No 



AO 



Yes 
No 



AP 



Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 





AR 


38 


Bond, A., et al., "Relatedness and phytogeny within the family of periplasmic chaperones involved in the 
assembly of pili or capsule-like structures of gram-negative bacteria, u J Mol Evol. 1997 Mar;44(3):299-309, 
Springer Verlag New York Inc. 1997 




AS 


38 


Brinton, Jr., C.C., "the Structure, function, synthesis and genetic control of bacterial pili and a molecular 
model for DNA and RNA transport in gram negative bacteria, ° Trans. N.Y. Acad. Sci. 1965;27:1003-1054, 
New York Academy of Sciences (1965) 




AT 


38 


Brown, K.D., et a/., "A family of small inducible proteins secreted by leukocytes are members of a new 
superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators 
of various activation processes, " J Immunol. 1989 Jan 15;142(2):679-687, The American Association of 
Immunologists (1989) 


EXAMINER 


DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



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/x ? b t/^X Pa 9 e 5 of 62 


/ \ 

f ^ \ * ^ tjFORM PTO-1449 

VlRST SUPPLEMENTAL INFORMATION DISCLOSURE 
>»* . Tf r cS* / STATEMENT 


ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et a/. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


t AMIVI 1 IN t r\ 

INITIAL 




NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
MM 
















Ad 
















AO 
















An 
AU 
















A C 

At 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


39 


Brown, P.M., et a/., "A single-step purification of biologically active recombinant human interleukin-5 from a 
baculovirus expression system, u Protein Expr Purif. 1995 Feb;6(1):63-71, Academic Press, Inc. (1995) 




AS 


39 


Burger, J.A., et ai, "Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from 
spontaneous apoptosis through stromal cell-derived factor-1, * Blood. 2000 Oct;96(8):2655-63, The American 
Society of Hematology (October 2000) 




AT 


39 


Burghoff, R.L., ef a/., "Utilization of the mouse large intestine to select an Escherichia coli F-18 DNA 
sequence that enhances colonizing ability and stimulates synthesis of type 1 fimbriae, " Infect Immun. 1993 
Apr;61(4):1293-1300, American Society for Microbiology (1993) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



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FORM PTO-1449 

NTAL INFORMATION DISCLOSURE 
STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



FIRST NAMED INVENTOR 
Sebbel et at. 



FILING DATE 
May 4, 2001 



APPLICATION NO. 
09/848,616 



ART UNIT 
1648 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



NAME 



CLASS 



SUB-CLASS 



FILING DATE 



AA 



AB 



AC 



AD 



AE 



AF 



AG 



AH 



Al 



AJ 



AK 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



COUNTRY 



CLASS 



SUB-CLASS 



TRANSLATION 



AL 



Yes 
No 



AM 



Yes 
No 



AN 



Yes 
No 



AO 



Yes 
No 



AP 



Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 





AR 


40 


Daugherty, P.S. et al., "Development of an optimized expression system for the screening of antibody 
libraries displayed on the Escherichia coli surface, " Protein Eng. 1999 Jul; 12(7):61 3-621, Oxford University 
Press (July 1999) 




AS 


40 


Eisenstein, B.I., etal., "Phase variation of type 1 fimbriae in Escherichia coli is under transcriptional control, " 
Science. 1981 Oct 16;21 4(451 8):337-339, American Association for the Advancement of Science (1981) 




AT 


40 


Elisseeva, E.L., etal., "NMR studies of active N-terminal peptides of stromal cell-derived factor-1. Structural 
basis for receptor binding, u J Biol Chem. 2000 Sep 1 ;275(35):26799-26805, The American Society for 
Biochemistry and Molecular Biology Inc. (September 2000) 


EXAMINER 


DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



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* \ * ilFpRM PTO-1449 

5T SUPPLEMENTAL INFORMATION DISCLOSURE 
^ a TO^ S TATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



fcAAlvHlNfcK 

INITIAL 




NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




A A 

MA 
















Ab 
















AO 
















AU 
















AC 

At 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



41 



Fehr, T., etal., "T cell-independent type I antibody response against B cell epitopes expressed repetitively on 
recombinant virus particles, " Proc Natl Acad Sci USA. 1998 Aug 4; 95(1 6): 9477-9481, National Academy 
Press (1998) 



AS 



41 



Gaily, D.L., et a/., "Environmental regulation of the fim switch controlling type 1 fimbrial phase variation in 
Escherichia coli K-12: effects of temperature and media, " J Bacteriol. 1993 Oct; 1 75(1 9):61 86-61 93, 
American Society for Microbiology (1993) 



AT 



41 



Gaily, D.L., et a/., "Interaction of FimB and FimE with the fim switch that controls the phase variation of type 1 
fimbriae in Escherichia coli K-12, " Mol Microbiol. 1996 Aug;21(4):725-38, Blackwell Science Ltd: (1996) 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



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Page 8 of 62 


, 






l ^/FORM PTO-1449 

VlRST SUPPLEMENTAL INFORMATION DISCLOSURE 
a ™ rif^ STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/S J E 


APPLICATIONNO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


42 


Gherardi, E., etal., "A single-step procedure for cloning and selection of antibody-secreting hybridomas, " J 
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54 


Nieland, J.D., ef a/., "Chimeric papillomavirus virus-like particles induce a murine self-antigen-specific 
protective and therapeutic antitumor immune response, " J Cell Biochem. 1999 May 1;73(2): 145-1 52, Wiley- 
Liss Inc. (May 1999) 




AS 


54 


Nilsson, P., etal., "Mutations affecting mRNA processing and fimbrial biogenesis in the Escherichia coli pap 
operon, ° J Bacteriol. 1996 Feb;178(3):683-690, American Society for Microbiology (1996) 




AT 


54 


Olszewska, W., etal., "Protection against measles virus-induced encephalitis by anti-mimotope antibodies: 
the role of antibody affinity, u Virology. 2000 Jun 20;272(1):98-105, Academic Press (June 2000) 


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STATEMENT 



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09/848,616 


FIRST NAMED INVENTOR 




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1648 



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AR 



55 



Orndorff, P.E., and Falkow, S., "Identification and characterization of a gene product that regulates type 1 
piliation in Escherichia coli, " J Bacteriol. 1984 Oct;160(1):61-66, American Society for Microbiology (1984) 



AS 



55 



Orndorff, P.E., and Falkow, S., "Nucleotide sequence of pilA, the gene encoding the structural component of 
type 1 pili in Escherichia coli, " J Bacteriol. 1985 Apr;162(1 ):454-457, American Society for Microbiology 
(1985) 



AT 



55 



Pierson-Mullany, L.K., era/., "Characterization of polyclonal allergen-specific IgE responses by affinity 
distributions, " Mol Immunol. 2000 Aug;37(10):61 3-620, Elsevier Science Ltd (August 2000) 



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-«&\ 




ATTY. DOCKET NO. 
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pORM PTO-1449 


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a 

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56 


Ritter, A., et a/., "The Pai-associated leuX specific tRNAS(Leu) affects type 1 fimbriation in pathogenic 
Escherichia coli by control of FimB recombinase expression, " Mot Microbiol. 1997 Sep;25{5):871-882, 
Blackwell Science Ltd (1997) 




AS 


56 


Roesch, P.L., and Blomfield, I.C., "Leucine alters the interaction of the leucine-responsive regulatory protein 
(Lrp) with the fim switch to stimulate site-specific recombination in Escherichia coli, " Mol Microbiol. 1998 
Feb;27(4):751-761, Blackwell Science Ltd (1998) 




AT 


56 


Russell, P.W., and Orndorff, P.E., "Lesions in two Escherichia coli type 1 pilus genes alter pilus number and 
length without affecting receptor binding, u Bacteriol. 1992 Sep; 174(1 8): 5923-5935, American Society for 
Microbiology (1992) 


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"6 P ^\ Page 23 of 62 


/ ^ '«\ 

f \ <\ 10 1 &FORM PTO-1449 

FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
\"'. ( .^7 STATEMENT 


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APPLICATION NO. 
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FOREIGN PATENT DOCUMENTS 


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57 


Saulino, E.T., etal., "Ramifications of kinetic partitioning on usher-mediated pilus biogenesis, " EMBOJ. 1998 
Apr 15;17(8):2177-2185, Oxford University Press (1998) 




AS 


57 


Slepushkin, V.A., et a/., "Protection of mice against influenza A virus challenge by vaccination with 
bacuiovirus-expressed M2 protein, u Vaccine. 1995;13(15):1399-1402, Elsevier Science Ltd. (1995) 




AT 


57 


Slonim, L.N., et al., "Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone 
superfamily and essential in subunit recognition and assembly, ° EMBO J. 1992 Dec;11(13):4747-4756, 
Oxford University Press (1992) 


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/ ^ ^\ 


FORM PTO-1449 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
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( § 

\ FIRST SUPPLElOte 


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EYAMIMP D 
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INITIAL 




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UL^OUIVI t In I 

NUMBER 


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FOREIGN PATENT DOCUMENTS 


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OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


58 


Smyth, C.J., etal., "Fimbrial adhesins: similarities and variations in structure and biogenesis, " FEMS 
Immunol Med Microbiol. 1996 Dec 1;16(2):127-139, Elsevier (1996) 




AS 


58 


Striker, R.T., etal., "Stable fiber-forming and nonfiber-forming chaperone-subunit complexes in pilus 
biogenesis, " J Biol Chem. 1994 Apr 22;269(16):1 2233-1 2239, The American Society for Biochemistry and 
Molecular Biology Inc. (1994) 




AT 


58 


Thanassi, D.G., etal., "The PapC usher forms an oligomeric channel: implications for pilus biogenesis across 
the outer membrane, " Proc Natl Acad Sci USA. 1998 Mar 17;95(6):3146-3151 , National Academy Press 
(1998) 


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/^ rr \ 


ATTY. DOCKET NO. 
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APPLICATION NO. 
09/848,616 


FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
^/ STATEMENT 


FIRST NAMED INVENTOR 
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No 




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No 




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No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


59 


Walse, B., et al., "Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus 
subunit bound by the Escherichia coli PapD chaperone, " FEBS Lett. 1997 Jul 21 ;412(1):1 15-120, Elsevier 
Science B.V. (1997) 




AS 


59 


Wynne, S.A., et at., "The crystal structure of the human hepatitis B virus capsid, " Mol Cell. 1999 
Jun;3(6):771-780, Cell Press (June 1999) 




AT 


59 


Zuercher, A.W., etai, "Oral anti-lgE immunization with epitope-displaying phage, " Eur J Immunol. 2000 
Jan;30(1):128-135, Wiley-Vch Verlag GmbH (January 2000) 


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OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



60 



NCBI Entrez, GenBank Report, Accession No. P03153, from Seeger, C, et al. (January 1990) 



NCBI Entrez, GenBank Report, Accession No. X59397, from Jordan, C.T., et al. (November 1991) 



AS 



60 



NCBI Entrez, GenBank Report, Accession No. 711678A, from Shipolini, R.A., etat. (July 1992) 



AT 



60 



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OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


61 


NCBI Entrez, GenBank Report, Accession No. M27603, from Orndorff, P.E., and Falkow, S. (April 1993) 




AS 


61 


NCBI Entrez, GenBank Report, Accession No. M20706, from Nassal M. (April 1993) 




AT 


61 


NCBI Entrez, GenBank Report, Accession No. AAA37490, from Rouvier E. (July 1993) 


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r ^ 


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<£/ STATEMENT 


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AR 


62 


NCBI Entrez, GenBank Report, Accession No. M90520, from Kew, M.C., etal. (August 1993) 




AS 


62 


NCBI Entrez, GenBank Report, Accession No. X00981, from Klemm, P. (September 1993) 




AT 


62 


NCBI Entrez, GenBank Report, Accession No. VCBPQB, from Maita, T., and Konigsberg, W. (December 
1993) 


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JUL 1 5 2004 ^ rm 



5/ 



PTO-1449 



SUPPLEMENTAL INFORMATION DISCLOSURE 



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AR 


63 


NCBI Entrez, GenBank Report, Accession No. AAA16663, from Kozlovska, T.M., et al. (March 1994) 




AS 


63 


NCBI Entrez, GenBank Report, Accession No. X02514, from Yanisch-Perron, C, et al. (May 1994) 




AT 


63 


NCBI Entrez, GenBank Report, Accession No. X85256, from Lai, M.E., et al. (April 1995) 


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uj FORM PTO-1449 
J5IRST SUPPLEMENTAL INFORMATION DISCLOSURE 



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STATEMENT 



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AR 


64 


NCBI Entrez, GenBank Report, Accession No. X85259, from Lai, M.E., et al., (April 1995) 




AS 


64 


NCBI Entrez, GenBank Report, Accession No. X85260, from Lai, M.E., et al. (April 1995) 




AT 


64 


NCBI Entrez, GenBank Report, Accession No. X85272, from Lai, M.E., et al. (April 1995) 


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/o 

/ ^ .FORM PTO-1449 

FIRSTSfel)p^LEME[siTAL INFORMATION DISCLOSURE 
\^ ^"/STATEMENT 


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OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


65 


NCBI Entrez, GenBank Report, Accession No. X85275, from Lai, M.E., et al. (April 1995) 

f 




AS 


65 


NCBI Entrez, GenBank Report, Accession No. X85284, from Lai, M.E., et al. (April 1995) 




AT 


65 


NCBI Entrez, GenBank Report, Accession No. X85285, from Lai, M.E., et al. (April 1995) 


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( *0* ^| RM PTO * 1449 
firstKSu |MLe M E n Jal information disclosure 

V°, ^STATEMENT 


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FOREIGN PATENT DOCUMENTS 


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OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


66 


NCBI Entrez, GenBank Report, Accession No. X85286, from Lai, M.E., et al. (April 1995) 




AS 


66 


NCBI Entrez, GenBank Report, Accession No. X85287, from Lai, M.E., et al. (April 1995) 




AT 


66 


NCBI Entrez, GenBank Report, Accession No. X85291, from Lai, M.E. t et al. (April 1995) 


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285541_1.DOC 



SKGF Rev. 12/03/03 



N ? 1= ^ 



Page 33 of 62 



^ \ ^ £j FORM PTO-1449 

\RIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
nt£^ SWEMENT 



ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel ef a/. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



67 



NCBI Entrez, GenBank Report, Accession No. X85293, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85295, from Lai, M.E., etal. (April 1995) 



AS 



67 



NCBI Entrez, GenBank Report, Accession No. X85296, from Lai, M.E., etal. (April 1995) 



AT 



67 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 




? E 




Page 34 of 62 



<y t> TSSft g FORM PTO-1449 



ST SUPPLB-. 



NTAL INFORMATION DISCLOSURE 
STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



NAME 



CLASS 



SUB-CLASS 



FILING DATE 



AA 



AB 



AC 



AD 



AE 



AF 



AG 



AH 



Al 



AJ 



AK 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



COUNTRY 



CLASS 



SUB-CLASS 



TRANSLATION 



AL 



Yes 
No 



AM 



Yes 
No 



AN 



Yes 
No 



AO 



Yes 
No 



AP 



Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



68 



NCBI Entrez, GenBank Report, Accession No. X85297, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85298, from Lai, M.E., et al. (April 1995) 



AS 



68 



NCBI Entrez, GenBank Report, Accession No. X85299, from Lai, M.E., etal. (April 1995) 



AT 



68 



EXAMINER 


DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 1.DOC 



SKGF Rev. 12/03/03 









Page 35 of 62 




( JUL 1 5 2004 g FORMPTO-1449 

V^RST SUPPLEMENTAL INFORMATION DISCLOSURE 
\&> r ^/ STATEMENT 


ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et a/. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE ' 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


69 


NCBI Entrez, GenBank Report, Accession No. X85301, from Lai, M.E., etal. (April 1995) 




AS 


69 


NCBI Entrez, GenBank Report, Accession No. X85302, from Lai, M.E., etal. (April 1995) 




AT 


69 


NCBI Entrez, GenBank Report, Accession No. X85303, from Lai, M.E., etal. (April 1995) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGFRev. 12/03/03 



aPJ= 




Page 36 of 62 



FORM PTO-1449 



JUL \ S fflW £ 
^IRST SUPPLEMENTAL INFORMATION DISCLOSURE 



<&/ STATEMENT 



ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



70 



NCBI Entrez, GenBank Report, Accession No. X85305, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85307, from Lai, M.E., et al. (April 1995) 



AS 



70 



NCBI Entrez, GenBank Report, Accession No. X8531 1, from Lai, M.E., et al. (April 1995) 



AT 



70 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 









Page 37 of 62 


/ - »x 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


JUL 1 5 2004 a) FORMPTO " 1449 


FIRST NAMED INVENTOR 
Sebbel et at. 


YEIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
t .^y STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


21 


NCBI Entrez, GenBank Report, Accession No. X85314, from Lai, M.E., et al. (April 1995) 




AS 


Zi 


NCBI Entrez, GenBank Report, Accession No. X85315, from Lai, M.E., etal. (April 1995) 




AT 


21 


NCBI Entrez, GenBank Report, Accession No. X85316, from Lai, M.E., etal. (April 1995) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



Page 38 of 62 



JUL 1 5 2004 -FORM pto-1449 
"°~ ?st supplemIntal information disclosure 

%HA^ STATEMENT ~ 



ATTY. DOCKET NO. 
1700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



72 



NCBI Entrez, GenBank Report, Accession No. X85317, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85319, from Lai, M.E., etal. (April 1995) 



AS 



72 



NCBI Entrez, GenBank Report, Accession No. X80925, from Karayiannis, P. (December 1995) 



AT 



72 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGFRev. 12/03/03 



Page 39 of 62 



ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848,616 


FIRST NAMED INVENTOR 




Sebbel et al. 




FILING DATE 


ART UNIT 


May 4, 2001 


1648 



JUL \ 5 o FORM PTO-1 449 

it/ 

3BST SUPPLEMENTAL INFORMATION DISCLOSURE 
STATEMENT 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



73 



NCBI Entrez, GenBank Report, Accession No. AAC50341, from Yao, Z., et al. (January 1996) 



NCBI Entrez, GenBank Report, Accession No. X72702, from Preisler-Adams, S., et al. (February 1996) 



AS 



73 



NCBI Entrez, GenBank Report, Accession No. VCBPR7, from Weber, K M et at. (April 1996) 



AT 



73 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 







Page 40 of 62 


(** e \ 1 

YEIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
X& r STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


74 


NCBI Entrez, GenBank Report, Accession No. 1604193A, from Gomez, F., et al. (October 1996) 




AS 


74 


NCBI Entrez, GenBank Report, Accession No. B56338, from Hoffman, D.R. (May 1997) 




AT 


24 


NCBI Entrez, GenBank Report, Accession No. U95551, from Rao, B.S., et al. (June 1997) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1 .DOC SKGF Rev. 12/03/03 









Page 41 of 62 




ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


1 \ rnn» a nTA -\ A ACl 
\ ~ MA | 1 FORM P I U-1 44y 

JUL 1 5 20W s 


FIRST NAMED INVENTOR 
Sebbel et a/. 


WlRST SUPPLEI^ENTAL INFORMATION DISCLOSURE 
\^ ^/ STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



75 



NCBI Entrez, GenBank Report, Accession No. S14764, from Vandermeers, A., et al. (October 1997) 



NCBI Entrez, GenBank Report, Accession No. P03611, from Weber, K., era/. (November 1997) 



AS 



75 



NCBI Entrez, GenBank Report, Accession No. AAC14699, from Beekwilder, M.J., et al. (April 1998) 



AT 



75 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. 
and not considered. Include copy of this form with next communication to Applicant. 



Draw line through citation if not in conformance 



285541_1.DOC 



SKGF Rev. 12/03/03 



-r~pr-\ Page 42 of 62 


f jO*** f]p RMPTO - 1449 
RIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
STATEMENT 


ATTY. DOCKET NO. 
1 700.0 1 80002/BJ D/S J E 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



76 



NCBI Entrez, GenBank Report, Accession No. AAC14704, from Beekwilder, M.J., etal. (April 1998) 



NCBI Entrez, GenBank Report, Accession No. AF043593, from Gunther, S., etal. (May 1998) 



AS 



76 



NCBI Entrez, GenBank Report, Accession No. 1POC, from Scott, D.L., etal. (September 1998) 



AT 



76 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



/O Hb\ Page 43 of 62 


\ W FORM PTO-1449 

FtR^T^^eRfeeMENTAL INFORMATION DISCLOSURE 
■ — STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


77 


NCBI Entrez, GenBank Report, Accession No. CAA30374, from Inokuchi, Y., et al. (February 1999) 




AS 


77 


NCBI Entrez t GenBank Report, Accession No. X02496, from Bichko, V., etal. (April 1999) 




AT 


77 


NCBI Entrez, GenBank Report, Accession No. MFIV62, from Cox, N.J., etal. (July 1999) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through station if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 1.DOC 



SKGFRev. 12/03/03 



Page 44 of 62 


/ \FORM PTO-1449 

\FIROT SUPPLEMENTAL INFORMATION DISCLOSURE 
\^ ^/ STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



^SJKW^ U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


78 


NCBI Entrez, GenBank Report, Accession No. VCBPFR, from Wittmann-Liebold, B., et al. (July 1999) 




AS 


78 


NCBI Entrez, GenBank Report, Accession No. A59055, from Hoffman, D.R., and Schmidt, J.O. (August 1999) 




AT 


78 


NCBI Entrez, GenBank Report, Accession No. B59055, from Hoffman, D.R., and Schmidt, J.O. (August 1999) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 _1 .DOC SKGF Rev. 12/03/03 











Page 45 of 62 


/ 




ATTY. DOCKET NO. 


APPLICATION NO. 




( JUL 1 5 2004 


\ 


1 700.0 1 80002/B J D/S J E 


09/848,616 




£l?ORM PTO-1449 
<?/ 


FIRST NAMED INVENTOR 
Sebbel et al. 


R&ST SUPPLEM 


ENTAL INFORMATION DISCLOSURE 


FILING DATE 


ART UNIT 






/ STATEMENT 


May 4, 2001 


1648 





U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


79 


NCBI Entrez, GenBank Report, Accession No. AF051814, from Boyd, E.F., and Hartl, D.L. (September 1999) 




AS 


79 


NCBI Entrez, GenBank Report, Accession No. AF1 10999, from Chang, S.F., et al. (October 1999) 




AT 


79 


NCBI Entrez, GenBank Report, Accession No. AB033559, from Okamoto, H., et al. (October 1999) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



. Page 46 of 62 

/ ^ P F >v 


/° ' ^ 

( » ,5* | ORMPTO - m9 

FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
<*/ STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJ D/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Pate, Pertinent Pages, etc.) 



AR 



80 



NCBI Entrez, GenBank Report, Accession No. AB010289, from Koseki, T., et a!. (December 1999) 



NCBI Entrez, GenBank Report, Accession No. AJ132364, from Graupner, S., et at. (April 2000) 



AS 



80 



NCBI Entrez, GenBank Report, Accession No. AF237482, from Johnson, J.R., etat. (May 2000) 



AT 



80 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



? E 



Page 47 of 62 



r o\ FORM PTO-1449 

\UV * it] 
FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 

^ STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et a/. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



81 



NCBI Entrez, GenBank Report, Accession No. M32138, from Tong, S.P., et al. (July 2000) 



NCBI Entrez, GenBank Report, Accession No. AF229646, from Skerker, J.M., and Shapiro, L. (August 2000) 



AS 



81 



NCBI Entrez, GenBank Report, Accession No. M95589, from Shi, H. ( et a/. (January 2001) 



AT 



81 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 









Page 48 of 62 


1 4 t iu\/* pORM PTO-1449 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FfRST supplemejStal information disclosure 

^STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


82 


NCBI Entrez, GenBank Report, Accession No. VCBPM2, from Min Jou, W., et al. (January 2001) 




AS 


82 


NCBI Entrez, GenBank Report, Accession No. AF323080, from Steppan, CM., etai (January 2001 ) 




AT 


82 


NCBI Entrez, GenBank Report, Accession No. AF323081, from Steppan, CM., etal. (January 2001) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



C ./.X Page 49 of 62 

. o e £\ 


» 3 *• cJ FORMPTO-1449 

Y^IRST SUPR^MENTAL INFORMATION DISCLOSURE 
N <£*rRA0*5& >r STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


83 


NCBI Entrez, GenBank Report, Accession No. U14003, from Plunket, G., Ill, et al. (January 2001) 




AS 


83 


NCBI Entrez, GenBank Report, Accession No. AF121239, from Hannoun, C, et al. (February 2001) 




AT 


83 


NCBI Entrez, GenBank Report, Accession No. AF121240, from Hannoun, C, et al. (February 2001) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1 .DOC SKGF Rev. 1 2/03/03 



Page 50 of 62 


f 1^*0* febRMPTO-1449 

fIrst^jpplemeivtal information disclosure 
v2, .^statement 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbet et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


84 


NCBI Entrez, GenBank Report, Accession No. AF121242, from Hannoun, C, et al. (February 2001) 




AS 


84 


NCBI Entrez, GenBank Report, Accession No. X59795, from Lai, M.E., et al. (March 2001) 




AT 


84 


NCBI Entrez, GenBank Report, Accession No. X65257, from Lai, M.E., et al. (March 2001) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



Page 51 of 62 



FIR#^JSUPPLEMEI^/ 



F=pRM PTO-1449 



fAL INFORMATION DISCLOSURE 
STATEMENT 



ATTY. DOCKET NO. 
1 700.0 1 80002/BJ D/S J E 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et a/. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



85 



NCBI Entrez, GenBank Report, Accession No. X65258, from Lai f M.E., et al. (March 2001) 



NCBI Entrez, GenBank Report, Accession No. AF151735, from Gerner, P., et al. (April 2001) 



AS 



85 



NCBI Entrez, GenBank Report, Accession No. AJ000636, from Gousset, N., et al. (November 2001 ) 



AT 



85 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 









Page 52 of 62 


1 j\J\- » J cr/ FORM PTO-1449 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at. 


VEIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
^SV* rp *ttf*? / STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


86 


NCBI Entrez, GenBank Report, Accession No. AAB59424, from Kenten, J.H., et al. (February 2002) 




AS 


86 


NCBI Entrez, GenBank Report, Accession No. AAC06250, from Beekwilder, M.J., et al. (March 2002) 




AT 


86 


NCBI Entrez, GenBank Report, Accession No. L09137, from Yanisch-Perron, C, et al. (May 2002) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609, Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



^ Page 53 of 62 


/o *\ 

( ^TSf^ fp RMPTO ' 1449 

FIRSTJ!fel)pPLEME^tAL INFORMATION DISCLOSURE 
\ ^ j?/STATEMENT 


ATTY. DOCKET NO. 
1700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



^<l^^ U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


87 


NCBI Entrez, GenBank Report, Accession No. 009006, from Hromas, R., et al. (June 2002) 




AS 


87 


NCBI Entrez, GenBank Report, Accession No. P40224, from Nagasawa, T., et al. (June 2002) 




AT 


87 


NCBI Entrez, GenBank Report, Accession No. P34884, from Bernhagen, J., et al. (June 2002) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609, Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 







Page 54 of 62 


1 -*\ 

\\\V A J iUV) ^ ^FORM PTO-1449 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FfkST SUPPLEMENTAL INFORMATION DISCLOSURE 
X*/.-.^^ STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


88 


NCBI Entrez, GenBank Report, Accession No. P06821, from Winter, G., et al. (June 2002) 




AS 


88 


NCBI Entrez, GenBank Report, Accession No. P30904, from Sakai, M., et al. (June 2002) 




AT 


88 


NCBI Entrez, GenBank Report, Accession No. NP_040754, from Inokuchi, Y., et al. (June 2003) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 1.DOC S KG F Rev. 12/03/03 



Page 55 of 62 



\ 1^ g] FORM PTO-1449 



FIRST SUPL 



-MENTAL INFORMATION DISCLOSURE 
STATEMENT 



ATTY. DOCKET NO. 
1 700.0 180002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et al. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



89 



NCBI Entrez, GenBank Report, Accession No. NP_061354, from Ishikawa, S., etaL (September 2003) 



NCBI Entrez, GenBank Report, Accession No. NP_031804, from Lenda, D.M., etal. (September 2003) 



AS 



89 



NCBI Entrez, GenBank Report, Accession No. NP_006410, from Luther, S.A., et ai. (September 2003) 



AT 



89 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



V 



Page 56 of 62 



FORM PTO-1449 



FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 



STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et a/. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



NAME 



CLASS 



SUB-CLASS 



FILING DATE 



AA 



AB 



AC 



AD 



AE 



AF 



AG 



AH 



Al 



AJ 



AK 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



COUNTRY 



CLASS 



SUB-CLASS 



TRANSLATION 



AL 



Yes 
No 



AM 



Yes 
No 



AN 



Yes 
No 



AO 



Yes 
No 



AP 



Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 





AR 


90 


NCBI Entrez, GenBank Report, Accession No. NP_000748, from Yao, G.Q., et al. (September 2003) 




AS 


90 


NCBI Entrez, GenBank Report, Accession No. P03069, from Hinnebusch, A.G., et al. (September 2003) 




AT 


90 


NCBI Entrez, GenBank Report, Accession No. 000585, from Hromas, R., et al. (September 2003) 


EXAMINER 


DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



-At 



Page 57 of 62 



^V tV> " it FORM PTO-1449 
FII^T SUPPLEMENTAL INFORMATION DISCLOSURE 



STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJP/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et at. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



91 



NCBI Entrez, GenBank Report, Accession No. P14174, from Weiser, W.Y., et al. (September 2003) 



NCBI Entrez, GenBank Report, Accession No. P48061, from Spotita, L.D., etal. (September 2003) 



AS 



91 



NCBI Entrez, GenBank Report, Accession No. P80003, from Vandermeers, A., et al. (September 2003) 



AT 



91 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



°\ 






Page 58 of 62 


o FORM PTO-1449 

VfvlRST SUfcfc^EMENTAL INFORMATION DISCLOSURE 
^^J^ STATEMENT 


ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


92 


Swiss-Prot/TrEMBL, TN11_Mouse, Primary Accession No. 035235, entered in Swiss-Prot in October 2001 




AS 


92 


Swiss-Prot/TrEMBL, TN11_Human, Primary Accession No. 014788, entered in Swiss-Prot in October 2001 




AT 


92 


Copy of co-pending U.S. application 10/622,087, inventors Bachmann et al., filed July 18, 2003 (NOT 
PUBLISHED) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



?rr ^ 

EIRST SUPPLE 



Page 59 of 62 



ORM PTO-1449 

TAL INFORMATION DISCLOSURE 



STATEMENT 



ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et at. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



93 



Copy of co-pending U.S. Application No. 10/733,582, inventors Renner et a/., filed December 12, 2003 (NOT 
PUBLISHED) 



AS 



93 



Jegerlehner, A., et al., "A molecular assembly system that renders antigens of choice highly repetitive for 
induction of protective B cell responses," Vaccine 20:3104-3112, Elsevier Science, Ltd. (August 2002) 



AT 



93 



NCBI Entrez, PubMed Abstract, PMID: 2205968, Diallo, A., et al., "Morbillivirus group: genome organization 
and proteins," Vet. Microbiol. 23:155-163 (1990) 



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ATTY. DOCKET NO. 


ArKLlOAl 1UN NO. 


1 700 .0 1 80002/B J D/S J E 


09/848,616 


FIRST NAMED INVENTOR 




Sebbel et al. 




FILING DATE 


ART UNIT 


May 4, 2001 


1648 



if 

B < NTA 



RM PTO-1449 



FlftS^SUPPLEMqNTAL INFORMATION DISCLOSURE 
^/^Tj^j^ STATEMENT ~~ 



U.S. PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



NAME 



CLASS 



SUB-CLASS 



FILING DATE 



AA 



AB 



AC 



AD 



AE 



AF 



AG 



AH 



Al 



AJ 



AK 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 



DOCUMENT 
NUMBER 



DATE 



COUNTRY 



CLASS 



SUB-CLASS 



TRANSLATION 



AL 



Yes 
No 



AM 



Yes 
No 



AN 



Yes 
No 



AO 



Yes 
No 



AP 



Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 





AR 


94 


Dialog File 351, Accession No. 1994-111516, Derwent WPI English language abstract for FR 2695563 




AS 


94 


International Search Report for International Application No. PCT/IB02/00168 mailed on November 4, 2002 




AT 


94 


International Search Report for International Application No. PCT/IB02/00166 mailed on October 29, 2002 


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/O ^ FORM PTO-1 449 | , , a] 

/ fa a* * \ ^ m 

FIRST aifPRLEMENTAL INFORMATION DISCLOSURE./ 
\ ^ V ill STATEMENT N&j, .^X 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 





^ U.S. PATENT DOCUMENTS 


EXAMINER — 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


95 


International Search Report for International Application No. PCT/IB02/00166, mailed January 31, 2003 




AS 


95 


Copy of Office Action mailed June 6 t 2001 , for United States Patent Application No. 09/449,631, Renner et 
aL, filed November 30, 1999. 




AT 


95 


Copy of Office Action mailed February 27, 2002, for United States Patent Application No. 09/449,631 , Renner 
et a/., filed November 30, 1999. 


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*\RST SUPPLEM, 



jORM PTO-1449 

fAL INFORMATION DISCLOSURE 



STATEMENT 



ATTY. DOCKET NO. 
1 700 .0 1 80002/BJ D/S J E 



APPLICATION NO. 
09/848,616 



FIRST NAMED INVENTOR 
Sebbel et at. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



96 



Copy of Office Action mailed November 14, 2002, for United States Patent Application No. 09/449,631, 
Renner et a/., filed November 30, 1999. 



AS 



96 



Copy of Office Action mailed March 1 , 2004, for United States Patent Application No. 10/050,902, Renner et 
at., filed January 18, 2002. 



AT 



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