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Ml IMRPR 


HATP 


MA MP 




ci acq 


Pit IMf^ HATP 




AA 
















AB 
















AC 
















AD 
















AE 














Ml" 


AF2 


5,143,726 


09/01/1992 


Thornton ef al. 






11/20/1989 






AG2 


5,580,859 


12/03/1996 


Feigner ef a/. 






03/18/1994 






AH2 


5.935,821 


08/10/1999 


Chatterjee ef a/. 






11/21/1996 






AI2 


2004/0059094 


03/25/2004 


Bach man n et al 






07/18/2003 






AJ2 


2004-0076611 


04/22/2004 


Bachmann et al. 






07/14/2003 


\ 




AK2 


2004-0076645 


04/22/2004 


Bachmann et al. 






07/18/2003 



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No 




AM 












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No 


MM 


AN4 


WO 99/28478 


06/10/1999 


WlPO 






Yes 
No 






A04 


WO 99/57289 


11/11/1999 


WIPO 






Yes 
No 




/ 


AP4 


WO 00/50461 


08/31/2000 


WlPO 






Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



AS 



35 



Abraham, J.M., et a/., "An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia 
coli," Proc Natl Acad Sci USA. 1985 Sep;82(17):5724-5727, National Academy Press (1985) 



AT 



35 



Abraham, S.N., ef at., "Glycerol-induced unraveling of the tight helical conformation of Escherichia coli type 1 
fimbriae, " J Bacten'ot. 1992 Aug;174<15):5145-5148, American Society for Microbiology (1992) 



sideredTwtbther or not dtationls in conformance with MPEP 60S. 



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* \ * gORM PTO-1449 

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RRST SUPPLEMENTAL INFORMATION DISCLOSURE 
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ATTY. DOCKET NO. 


APPLICATION NO. 


1700.0180002/BJD/SJE 


09/648,616 


FIRST NAMED INVENTOR 
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FILING DATE 
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AL5 


EP 0 385 610 A1 


05/09/1990 


Europe 






Yes 
No 




AM5 


EP0 385 610B1 


03/1671994 


Europe 






Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


36 


Anion, R., ef a/., "A mimotope peptide-based vaccine against Schistosoma mansoni: synthesis and 
characterization, " Immunology. 2000 Dec;101(4):555-562, Biackwell Science, Ltd. (December 2000) 






AS 


36 


Bachmann, M.F., ef a/., "TRANCE, a tumor necrosis factor family member critical for CD40 ligand- 
independent T helper cell activation, " J Exp Med. 1999 Apr 5; 189(7): 1025-1 031, The Rockefeller University 
Press (1999) 7 


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AT 


36 


Bass. S„ and Yang, M.. "Expressing cloned genes in Escherichia coli, " in Protein Function: A practical 
Approach, 2 nd ed., Creighton, T.E., ed M IRL Press, Oxford, Great Britain, pp. 29-55 (1997) 


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285541_1.DOC 



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FlftgT.,SUPPLEMB 



^RM PTO-1449 

fAL INFORMATION DISCLOSURE 



STATEMENT 



ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 



FIRST NAMED INVENTOR 
Sebbel et a/. 



APPLICATION NO. 
09/848,616 



FILING DATE 
May 4. 2001 



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AL 



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No 



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Yes 
No 



AP 



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No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



fAf^ 


AR 


37 


Blomfield, I.C., et a/.. "Type 1 fimbriation and fimE mutants of Escherichia coli K-12., " J Bacterid. 1991 
Sep; 1 73(1 7);5298-5307, American Society for Microbiology (1991 ) 






AS 


22 


Blomfield, I.C., eta/., "Integration host factor stimulates both FimB-and FimE-mediated site-specific DNA 
inversion that controls phase variation of type 1 fimbriae expression in Escherichia coli, " Mot Microbiol, 1997 
Feb;23(4):705-717, Blackwell Science. Ltd. (1997) 


\ 


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AT 


37 


Boder, E.T., and Wittrup, K.D., "Yeast surface display for directed evolution of protein expression, affinity, and 
stability. * Methods Enzymot. 2000;328:430-444, Academic Press (October 2000) 


EXAMINER 


DATE CONSIDERED 


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I * * US* SflORMPTO-1449 
I ^ M 

FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
\i v. STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et el. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
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DOCUMENT 
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DATE 


NAME 


PI A9^ 


Ol ID pi AQQ 






AA 
















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FOREIGN PATENT DOCUMENTS 


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No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


38 


Bond, A., et al., "Related ness and phytogeny within the family of periplasm ic chaperones involved in the 
assembly of pili or capsule-like structures of gram-negative bacteria, tt J Mot Evol. 1997 Mar,44(3):299-309, 
Springer Veriag New York Inc. 1997 






AS 


38 


Brinton, Jr., C.C., *the Structure, function, synthesis and genetic control of bacterial pili and a molecular 
model for DNA and RNA transport in gram negative bacteria, " Trans. N.Y. Acad, Sci. 1965:27:1003-1054, 
New York Academy of Sciences ( 1 965) 


\ 


/ 


AT 


38 


Brown, K.D., et a/., "A family of small inducible proteins secreted by leukocytes are members of a new 
superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators 
of various activation processes, " J Immunol. 1 989 Jan 1 5;142(2):679-687, The American Association of 
Immunologists (1989) 


EXAMINER DATE CONSIDERED 


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/ \ ? t ^eX Pa 9© 5 of 62 


( ^ \ * ^ iHFORM PTO-1449 

VlRST SUPPLEMENTAL INFORMATION DISCLOSURE 
STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPUCATION NO. ~" 
09/648,616 


FIRST NAMED INVENTOR 
Sebbel ef a/. 


FILING DATE 
May 4. 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
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DATE 


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FOREIGN PATENT DOCUMENTS 


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AM 












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No 




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No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 


r 


A) 


AR 


39 


Brown, P.M., et a/., "A single-step purification of biologically active recombinant human interieukin-5 from a 
baculovirus expression system, • Protein ExprPurif. 1995 Feb;6(1):63-71, Academic Press, Inc. (1995) 






AS 


39 


Burger, J.A., etai, "Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from 
spontaneous apoptosis through stromal cell-derived factor-1, " Blood. 2000 Oct;96(8):2655-63, The American 
Society of Hematology (October 2000) 


\ 




AT 


39 


Burghoff, R.L., et a/., "Utilization of the mouse large Intestine to select an Escherichia coli F-1 8 DNA 
sequence that enhances colonizing ability and stimulates synthesis of type 1 fimbriae, " infect Immun. 1993 
Apr;61(4):1293-1300, American Society for Microbiology (1993) 


EXAMINER DATE CONSIDERED 


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285541_1.DOC 



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ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848.616 


FIRST NAMED INVENTOR 




Sebbel et ai 




FILING DATE 


ART UNIT 


May 4. 2001 


1648 



\^ L it 



Trstsuppl. 



0/ FORM PTO-1449 



ENTAL INFORMATION DISCLOSURE 
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AB 



AC 



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AK 



FOREIGN PATENT DOCUMENTS 



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CLASS 



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AL 



Yes 
No 



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Yes 
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AN 



Yes 
No 



AO 



Yes 
No 



AP 



Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 





AR 


40 


Daugherty, P.S. et at., "Development of an optimized expression system for the screening of antibody 
libraries displayed on the Escherichia coli surface, " Protein Eng. 1999 Jul; 12(7):61 3-621 , Oxford University 
Press (July 1999) 




AS 


40 


Eisenstein, B.I., era/., "Phase variation of type 1 fimbriae in Escherichia coli is under transcriptional control, * 
Science. 1981 Oct 16;214(4518):337-339, American Association for the Advancement of Science (1981) 




AT 


40 


Elisseeva, E.L., etal. t "NMR studies of active N-termlnal peptides of stromal cell-derived factor-1. Structural 
basis for receptor binding, " J Biol Chem. 2000 Sep 1;275(35): 26799-26805, The American Society for 
Biochemistry and Molecular Biology Inc. (September 2000) 


EXAMINER 


DATE CONSIDERED 


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A? b *\ , 




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( *pRM PTO-1449 

FIRST SUPPLEMEiWTAL INFORMATION DISCLOSURE 
\^ rfiTr ^ STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et a/. 


FILING DATE 
May 4. 2001 


ART UNIT 
1648 



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AC 
















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FOREIGN PATENT DOCUMENTS 


EXAMINER 
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Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




P 


AR 


11 


Fehr, T. t et at., "T cell-independent type 1 antibody response against B cell epitopes expressed repetitively on 
recombinant virus particles, " Proc Natl Acad Sci USA. 1998 Aug 4;95(16):9477-9481 t National Academy 
Press (1998) 






AS 


41 


Gaily, D.L., et at., "Environmental regulation of the fim switch controlling type 1 fimbrial phase variation in 
Escherichia coli K-12: effects of temperature and media, " J Bacterid. 1993 Oct;175(19):6186-6193, 
American Society for Microbiology (1993) 


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/ 


AT 


41 


Gaily, D.L., et a/. ( "Interaction of FimB and FimE with the fim switch that controls the phase variation of type 1 
fimbriae in Escherichia coli K-12, u Mot Microbiol. 1996 Aug;21(4):725-38, Blackwell Science Ltd: (1996) 


EXAMINER DATE CONSIDERED 


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285541J.DOC 



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/V V ^ ^CX Pa Se 8 of 62 


\ JfcO ^JFORM PTO-1449 

FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
<Arr „ TP uS^X STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPUCATION.NO. 
09/848.616 


FIRST NAMED INVENTOR 
Sebbel ef a/. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


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INITIAL . 




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DATE 


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SUB-CLASS 


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AA 
















AB 
















AC 
















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AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


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CLASS 


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AL 












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No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 


ft? 




AR 


42 


Gherardr, E., etaf. t "A single-step procedure for cloning and selection of antibody-secreting hybridomas, " J 
Immunol Methods. 1990 Jan 24; 1 26(1 ):6 1-68, Elsevier (1990) 






AS 


42 


Hanes, J. ( et a/., "Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by 
ribosome display, " Nat Biotechnol. 2000 Dec; 18(1 2): 1287-1292, Nature Publishing Company (December 
2000) 


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AT 




Hanson, M.S., et al., "Purification of the Escherichia coli type 1 ptlin and minor pilus proteins and partial 
characterization of the adhesin protein, " J Bacteriol. 1988 Aug;170(8):3350-3358, American Society for 
Microbiology (1988) 


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Pa 9© 9 of 62 


/ c i£]FORM PTO-1449 

\FIRST supplemental information disclosure 

x ^ STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















At 
















AJ 
















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FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


< 

TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


43 


Hanson, M.S., and Brinton, Jr., C.C., "Identification and characterization of E. coli type-1 pilus tip adhesion 
protein, " Nature. 1988 Mar 17;332(6161):265-8, Nature Publishing Group (1988) 






AS 


43 


Harrison, J.L., et a/.. "Screening of phage antibody libraries, " Methods Enzymol. 1996;267:83-109, Macmillan 
Publisher Ltd. (1996) 




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/ 

AT 


43 


Hirel, P.-H.. et a/., "Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the 
side-chain length of the penultimate amino acid, " Proc Natl Acad Sci USA. 1989 Nov;86(21):8247-8251, 
National Academy Press (1989) 


EXAMINER DATE CONSIDERED 


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( JlSL ^ ^ ^j FORM PTO-1449 
VlRST SUPPLEWHZNTAL INFORMATION DISCLOSURE 
V ^ iu l*^ STATEMENT 


ATTY. DOCKET NO. 
1 700.0 180002/BJD/SJE 


APPLICATION NO. — 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel etai 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL * 




DOCUMENT 
NUMBER 


DATE 


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CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















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AE 
















AF 
















AG 
















AH 
















Al 
















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FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


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AL 












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No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


44 

t 


Holmgren, A. f ef al., "Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in 
bacteria, * EMBO J. 1992 Apr; 1 1(4): 161 7- 1622, Oxford University Press (1992) 






AS 


44 


Holmgren, A., and Branden, C.-l., "Crystal structure of chaperone protein PapD reveals an immunoglobulin 
fold, " Nature. 1989 Nov 16;342(6247):248-251, Nature Publishing Group (1989) 


\ 


J 


AT 


44 


Hultgren, S.J., et a/., "PapD and superfamily of periplasmic immunoglobulin-like pilus chaperones, " 
Adv Protein Chem. 1993;44:99-123, Academic Press Inc. (1993) 


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/* x?r \ j 


ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848,616 


( ^ ^ £J 0RM PT °- 1449 


FIRST NAMED INVENTOR 
Sebbel et al. 


FIRST SUPPLEIvUEMTAL INFORMATION DISCLOSURE 
VA, a£/ STATEMENT 


FILING DATE 
May 4, 2001 


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FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


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AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 


3S 
tnSg 


AR 


45 


Hultgren, S.J., et a/., "Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition, " 
Celt. 1993 Jun 4;73(5):887-901 , Cell Press (1993) 


Sim 

s < m 


AS 


45 


Hultgren, S.J., et ai , "Bacterial Adhesins and Their Assembly, " in Escherichia co// and Salmonella. 
Neidhardt, F.C.. et al., eds., ASM Press, Washington, D.C. pp. 2730-2756 (1996) 




AT 


45 


Hung, D.L., et a/., "Molecular basis of two subfamilies of immunoglobulin-like chaperones, " 
EMBOJ. 1996 Aug 1;15(15):3792-3805. Oxford University Press (1996) 


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( *0< u M ORM PTO " 1449 
\FIR^slfPPLEM&/rAL INFORMATION DISCLOSURE 
\ W STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


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expression systems, " Eur J Biochem. 1991 Mar 28;196(3):623-629, Blackwell Science Ltd. (1991 ) 


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WYE.M0SH 
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Microbiol Lett. 1994 Oct 1;1 22(3 ):28 1-287. Elsevier (1994) 



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the role of antibody affinity. " Virology. 2000 Jun 20;272(1):98-105, Academic Press (June 2000) 


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piliation in Escherichia coli, " J Bacteriol. 1984 Oct; 160(1): 61 -66, American Society for Microbiology (1984) 


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TRANSLATION 




AL 












Yes 
No 




AM 












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AN 












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No 




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Yes 
No 



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AR 



57 



Saulino, E.T., etal., "Ramifications of kinetic partitioning on usher-mediated pilus biogenesis, ' EMBOJ. 1998 
Apr 15;17(8):2177-2165, Oxford University Press (1998) 



AS 



57 



Slepushkin, V.A., ef at., "Protection of mice against influenza A virus challenge by vaccination with 
baculovirus-expressed M2 protein, " Vaccine. 1995; 13(1 5): 1399- 1402, Elsevier Science Ltd. (1995) 



m 33 
39 



AT 



57 



Slonim, L.N., etal., "Interactive surface In the PapD chaperone cleft is conserved in pilus chaperone 
superfamily and essential in subunit recognition and assembly, " EMBO J. 1992 Dec;1 1 (1 3):4747-4756, 
Oxford University Press (1 992) 



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AR 


58 


Smyth. C.J., et a/., 'Fimbria! adhesins: similarities and variations in structure and biogenesis, " FEMS 
Immunol Med Microbiol. 1996 Dec 1;16(2):127-139, Elsevier (1996) 


lAARY E.M0S 
GROUP 181 


AS 


5S 


Striker, R.T., et a/., "Stable fiber-forming and nonfiber-forming chaperone-subunit complexes in pilus 
biogenesis, " J Biol Chem. 1994 Apr 22,269(16): 12233- 12239, The American Society for Biochemistry and 
Molecular Biology Inc. (1994) 


HER 
MNER 


AT 


58 


Thanassi, D.G., ef al. t The PapC usher forms an oligomeric channel: implications for pilus biogenesis across 
the outer membrane, * Proc Natl Acad Set USA. 1998 Mar 17;95(6):31 46-31 51, National Academy Press 
(1998) 



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AR 



59 



Walse, B. p et al., "Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus 
subunit bound by the Escherichia coli PapD chaperone, " FEBS Lett. 1997 Jul 21;412(1):1 15-120, Elsevier 
Science B.V. (1997) 



AS 



59 



Wynne, S.A., et a/., "The crystal structure of the human hepatitis B virus caps id, " Mol Cell. 1999 
Jun;3(6):771-780, Cell Press (June 1999) 



AT 



52 



Zuercher, A.W., et a/., "Oral anti-lgE immunization with epitope-displaying phage, " Eur J Immunol. 2000 
Jan;30(1):12a-135, Wiley-Vch Verlag GmbH (January 2000) 



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No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



as 

«5S 



AR 



60 



NCBI Entrez, GenBank Report, Accession No. P03153, from Seeger, O, et al. (January 1990) 



NCBI Entrez, GenBank Report, Accession No. X59397, from Jordan, C.T., et at. (November 1991 ) 



AS 



60 



NCBI Entrez, GenBank Report, Accession No. 71 1678A, from Shipolini, R.A.. era/. (July 1992) 



AT 



60 



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OTHER (Including Author, Title, Pate, Pertinent Pages, etc.) 



3 



AR 



61 



NCBI Entrez, GenBank Report, Accession No. M27603, from Orndorff, P.E., and Falkow, S. (April 1993) 



NCBI Entrez, GenBank Report. Accession No. M20706. from Nassal M. (April 1993) 



AS 



61 



NCBI Entrez, GenBank Report, Accession No. AAA37490, from Rouvler E. (July 1993) 



AT 



61 



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e-<rn 
if ° 



AR 



62 



NC8I Entrez, GenBank Report, Accession No. M90520, from Kew f M.C., et al. (August 1993) 



NCBI Entrez, GenBank Report, Accession No. X00981, from Klemm, P. (September 1993) 



AS 



62 



AT 



62 



NCBI Entrez, GenBank Report, Accession No. VCBPQ8, from Maita, T„ and Konigsberg, W. (December 
1993) 



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— / Q \pr,\ 




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I JUL 1 5 MO* I^rmpto.1449 


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pi i iMf^ nATP 




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AR 


63 


NCBI Entrez, GenBank Report, Accession No. AAA16663, from Kozlovska, T.M., et al. (March 1994) 




AS 


63 


NCBI Entrez, GenBank Report, Accession No. X02514, from Yanisch-Perron, C, ef a/. (May 1994) 




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63 


NCBI Entrez, GenBank Report, Accession No. X85256, from Lai, M.E., ef a/. (April 1995) 


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/ '6' rr \ 1 


ATTY. DOCKET NO. 
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( 4 e m(U vu] FORM PTO-1449 

JUL 1 5 2004 g 
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AR 


64 


NCBI Entrez. GenBank Report, Accession No. X85259, from Lai, M.E., et al., (April 1995) 


is 


AS 


64 


NCBI Entrez, GenBank Report, Accession No. X85260. from Lai, M.E., ef at. (April 1995) 




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No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



3 



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AR 



AS 



AT 



65 



65 



§1 



NCBI Entrez, GenBank Report, Accession No. X85275, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85284, from Lai, M.E., et al. (April 1995) 



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AR 




NCBI Entrez. GenBank Report, Accession No. X85286, from Lai, M.E., et al. (April 1995) 


ARYE.MOSHE 
MARYEXAMIN 
GROUP 1800 


AS 


66 


NCBI Entrez, GenBank Report, Accession No. X85287, from Lai, M.E., et at. (April 1995) 




AT 


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S£v 1 




I 


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OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


62 


NCBI Entrez, GenBank Report, Accession No. X85293, from Lai, M.E., et al. (April 1995) 


e= ■< r° 


AS 


67 


NCBI Entrez, GenBank Report, Accession No. X85295, from Lai, M.E., ef a/. (April 1995) 




AT 


67 


NCBI Entrez, GenBank Report, Accession No. X85296, from Lai, M.E., etat. (April 1995) 


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£ FORM PTO-1449 

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AR 


68 


NCBI Entrez, GenBank Report, Accession No. X85297, from Lai, M.E., et al. (April 1995) 




AS 


68 


NCBI Entrez, GenBank Report, Accession No. X85298, from Lai, M.E., et at. (April 1995) 




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69 



NCBI Entrez, GenBank Report. Accession No. X85301, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85302, from Lai, M.E., etai. (April 1995) 



AS 



69 



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3* 



NCBI Entrez, GenBank Report, Accession No. X85303, from Lai, M.E., et at. (April 1995) 



AT 



69 



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AA 
















AB 
















AC 
















AD 


• 














AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



70 



NCBI Entrez, GenBank Report, Accession No. X85305, from Lai, M.E., et al. (April 1995) 



2*8 



NCBI Entrez, GenBank Report, Accession No. X85307, from Lai, M.E., et al. (April 1995) 



AS 



70 



3 



NCBI Entrez, GenBank Report, Accession No. X85311, from Lai, M.E., et al. (April 1995) 



AT 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial If reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not In conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 







Page 37 of 62 


7*^% 1 


ATTY. DOCKET NO. 
1700.01800027 BJD/SJE 


APPLICATION NO. 
09/846.616 


I JUI 1 ^ 2004 S) FORM PTO-1449 


FIRST NAMED INVENTOR 
Sebbel et al. 


YSIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
N^W ^7 STATEMENT 


FILING DATE 
May 4. 2001 


ART UNIT 
1648 



EXAMINER 
IMITIAI 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















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U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



Iff 

cz *< pi 
•Dm, 



AR 



71 



NCBI Entrez, Gen Bank Report, Accession No. X85314, from Lai, M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85315, from Lai, M.E., et al. (April 1995) 



AS 



21 



NCBI Entrez, GenBank Report, Accession No. X85316, from Lai, M.E., et al. (April 1995) 



AT 



21 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 1.DOC 



SKGF Rev. 12/03/03 




Page 38 of 62 



JUL 1 5 2004 juWrMPTO-1449 
3RST SUPPLEM ENTAL INFORMATION DISCLOSURE 



ATTY. DOCKET NO.. 
1 700.01 80002/BJD/SJE 



APPLICATION NO. 
09/848.616 



FIRST NAMED INVENTOR 
Sebbel ef at. 



FILING DATE 
May 4, 2001 



ART UNIT 
1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



no rn 9 



AR 



72 



NCBI Entrez, GenBank Report, Accession No. X85317, from Lai. M.E., et al. (April 1995) 



NCBI Entrez, GenBank Report, Accession No. X85319, from Lai, M.E., eta!. (April 1995) 



AS 



72 




NCBI Entrez, GenBank Report, Accession No. X80925, from Karayiannis, P. (December 1995) 



AT 



72 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation Is in conformance with MPEP 609. 
and not considered. Include copy of this farm with next communication to Applicant 



Draw line through citation if not in conformance 



285541_1.DOC 



SKGF Rev. 12/03/03 







Page 39 of 62 


1 

( JUL \ 5 2D04 SJformpto-1449 

\&RST SUPPLEMENTAL INFORMATION DISCLOSURE 
^ STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848.616 


FIRST NAMED INVENTOR 
Sebbel ef a/. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CA 

VjL/AOO 


OUD"vLnOO 


CM (Mf* r*ATC 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


73 


NCBI Entrez, GenBank Report, Accession No. AAC50341, from Yao, 2., et al. (January 1996) 


IARYE.MOSHE 
IMARYEXAMIh 
GROUP 1800 


AS 


73 


NCBI Entrez, GenBank Report, Accession No. X72702, from Preisler-Adams. S., ef a/. (February 1996) 




AT 


73 


NCBI Entrez, GenBank Report, Accession No. VCBPR7, from Weber, K., ef a/. (April 1996) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant 



285541_1.DOC 



SKGF Rev. 12/03/03 



/* \ 1 




Page 40 of 62 


( ittL ^ * ^ c) F0RM PT °^ ug 

VtaRST SUPPLEMENTAL INFORMATION DISCLOSURE 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbe! et al. 


r .^y STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


74 


NCBJ Entrez. GenBank Report, Accession No. 1604193A, from Gomez, F., et al. (October 1996) 


ARYLMOSHER 
MARY EXAMINEF 
GROUP 1800 


AS 


74 


NCBI Entrez, GenBank Report, Accession No. B56338, from Hoffman, D.R. (May 1997) 




AT 


74 


NCBI Entrez, GenBank Report, Accession No. U 95551. from Rao, B.S.. et at. (June 1997) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 1.DOC 



SKGF Rev. 12/03/03 



/6^p^X i 




I 


3 age41 of 62 


/ A 

( - \ FORM PTO-1449 

JUL 1 5 2004 g] 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at. 


WlRST SUPPLEMENTAL INFORMATION DISCLOSURE 
j& STATEMENT 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FIL INfi DATE 
i ii_imw unit 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMEN 1 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


25 


NCBI Entrez, GenBank Report, Accession No. S14764, from Vandermeers, A., et al. (October 1997) 


S ll 


AS 


21 


NCBI Entrez. GenBank Report, Accession No. P0361 1, from Weber, K., et ah (November 1997) 




AT 


75 


NCBI Entrez, GenBank Report, Accession No. AAC14699, from Beekwilder, M.J., et al. (April 1998) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial If reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not In conformance 
and not considered. Include copy of this form with next communication to Applicant 



285541_1.DOC 



SKGFRev. 12/03/03 







Page 42 of 62 


( \>O s1BVl f]p RMPTO " 1449 

k\Rs\ SUPPLEMENTAL INFORMATION DISCLOSURE 
^7 STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel ef eA 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



-~ U.S. PATENT DOCUMENTS 


EXAMINER 

IKIITIAI 

UNI 1 IMl_ 




DOCUMENT 

Ml IMOCD 


DATF 


NAMF 

IN Ml VIC 


PI ACQ 


CI ID f 1 ACC 


rILINo L/Al t 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 


aa 


AR 


26 


NCBI Entrez, GenBank Report, Accession No. AAC 14704, from Beekwilder, M.J., etal. (April 1998) 


MARYLMOSI 
RIMARY EXAM 
GROUP 1801 


AS 


76 


NCBI Entrez, GenBank Report, Accession No. AF043593. from Gunther. S., etal. (May 1998) 


|S 


AT 


76 


NCBI Entrez, GenBank Report, Accession No. 1POC, from Scott, D.L, et ai (September 1998) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is In conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541J.DOC 



SKGF Rev. 12/03/03 



yb^ ^ 






Page 43 of 62 




ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848.616 


\ 4c/ FORM PTO-1449 

f^t^^rr^Imental information disclosure 
^ " statement 


FIRST NAMED MENTOR 
Sebbel of at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 




FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 




j 








Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


22 


NCBI Entrez, GenBank Report, Accession No. CAA30374, from Inokuchi, Y., et al. (February 1999) 


UW £♦ MOSHEF 
AARY EXAMINE 
3ROUP180O 


AS 


77 


NCBI Entrez, GenBank Report, Accession No. X02496, from Bichko. V., et al (April 1999) 




AT 


22 


NCBI Entrez, GenBank Report, Accession No. MFIV62, from Cox, N.J., ere/. (July 1999) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through -citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



Page 44 of 62 


/° \ 

( \FORM PTO-1449 

\ FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
V^v STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848.616 


FIRST NAMED INVENTOR 
Sebbel ef at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1646 



^£IR£i!>^ U.S. PATENT DOCUMENTS 


EXAMINER 

IKI l"T"l A 1 

INITIAL 




DOCUMENT 

Ml IMDCD 


HATE 


IMAMt 


ULAOO 


CI id r*t ACQ 


ri| IKIf* nATC 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


78 


NCBI Entrez, GenBank Report, Accession No. VCBPFR, from Wittmann-Liebold. B., et al. (July 1999) 




AS 


13. 


NCBI Entrez, GenBank Report, Accession No. A59055, from Hoffman, D.R., and Schmidt, J.O. (August 1999) 




AT 


28 


NCBI Entrez, GenBank Report, Accession No. B59055, from Hoffman, D.R., and Schmidt, J.O. (August 1999) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant 



285541 jl .DOC SKGF Rev. 12/03/03 









Page 45 of 62 


JUL 1 5 2DW gffORM PTO-1449 

RRST SUPPLEMENTAL INFORMATION DISCLOSURE 
^>»^f/ STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et at 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 

INI \ l/M_ 




DOCUMENT 

Ml IRARPD 
INUMDtK 




hi AMP 


r>t ACQ 




rILINo UAI t 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


79 


NCBI Entrez, GenBank Report, Accession No. AF051814, from Boyd. E.F., and Hartl. D.L (September 1999) 


IP 

si" 


AS 


22 


NCBI Entrez, GenBank Report, Accession No. AF1 10999, from Chang, S.F., ef a/. (October 1999) 




AT 


29 


NCBI Entrez, GenBank Report, Accession No. AB033559. from Okamoto, H, era/. (October 1999) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial If reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation If not In conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



. Page 46 of 62 


/ \ 

/ oflflL uHORM PTO-1449 

FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
\fc o^/ STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel ef a/. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



^£jnQ^ u s PATENT DOCUMENTS 


EXAMINER 

IKIITIAI 

IINI 1 l/-\L_ 




DOCUMENT 

Ml 1MRPR 


DATE 








r ILIINo UM 1 e 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 






V 






Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


80 


NCBI Entrez, GenBank Report, Accession No. AB010289. from Koseki, T., et af. (December 1999) 


AARYE.M0SH 
UMARY EXAMI 
GROUP 1600 


AS 


80 


NCBI Entrez, GenBank Report, Accession No. AJ 132364, from Graupner, S., et al. (April 2000) 




AT 


80 


NCBI Entrez. GenBank Report, Accession No. AF237482, from Johnson, J.R., et al (May 2000) 


EXAMINER DATE CONSIDERED 


EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 




FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
<5Z STATEMENT 



Page 47 of 62 


ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848,616 


FIRST NAMED INVENTOR 




Sebbel etat. 




FILING DATE 


ART UNIT 


May 4, 2001 


1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



AR 



51 



NCBI Entrez, GenBank Report, Accession No. M32138, from Tong, S.P., et al. (July 2000) 



C -< F 5 
•D m » 



NCBI Entrez, GenBank Report, Accession No. AF229646, from Skerker, J.M., and Shapiro, L (August 2000) 



AS 



81 



NCBI Entrez, GenBank Report, Accession No. M95589, from Shi, H., eta!. (January 2001 ) 



AT 



51 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation Is In conformance with MPEP 609. Draw line through citation tf not in conformance 
and not considered. Include copy of this form with next communication to Applicant 



285541_1.DOC 



SKGF Rev. 12/03/03 




Page 48 of 62 



ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848.616 


FIRST NAMED INVENTOR 




Sebbel et al. 




FILING DATE 


ART UNIT 


May 4, 2001 


1648 



j&l ^ * ^ «^ RM PTO * 1449 

FfRST SUPPLEMENTAL INFORMATION DISCLOSURE 
VKk .^STATEMENT 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 


t 










Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



-^St- 



ar 



82 



NCBI Entrez, GenBank Report. Accession No. VCBPM2. from Min Jou, W.. et al. (January 2001) 



NCBI Entrez, GenBank Report. Accession No. AF323080, from Steppan, CM., et at. (January 2001) 



AS 



82 



NCBI Entrez, GenBank Report, Accession No. AF323081 , from Steppan, CM., et al. (January 2001 ) 



AT 



S2 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation Is In conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541_1.DOC 



SKGF Rev. 12/03/03 



i\P c Page 49 of 62 


JUL |) FORMPTO-1449 

v-O C>/ 

\ftHRST SUPRBBMENTAL INFORMATION DISCLOSURE 
^4 FR^O^ STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848.616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 

IMITIAI 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 


aag£.. 


AR 


83 


NCBI Entrez, GenBank Report, Accession No. U 14003, from Piunket. G., III. et al. (January 2001) 


gf 3 

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AS 


83 


NCBI Entrez, GenBank Report, Accession No. AF121239, from Hannoun, C, et al. (February 2001) 




AT 




NCBI Entrez, GenBank Report, Accession No. AF121240, from Hannoun, C, et al. (February 2001) 


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RM PTO-1449 



fIrst^jpple menyAl INFORMATION DISCLOSURE 



ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848,616 


FIRST NAMED INVENTOR 




Sebbel et al 




FILING DATE 


ART UNIT 


May 4, 2001 


1648 



EXAMINER 

IMITIA! 
ii >ii i irM. 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 






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AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc) 




AR 



84 



NCBI Entrez, GenBank Report, Accession No. AF 121 242, from Hannoun, C, et al. (February 2001) 



NCBI Entrez, GenBank Report, Accession No. X59795, from Lai, M.E., et al. (March 2001) 



AS 



84 



NCBI Entrez, GenBank Report, Accession No. X65257. from Lai, M.E., et al. (March 2001) 



AT 



84 



EXAMINER 



DATE CONSIDERED 



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1 




Page 51 of 62 


\ ^ ^)RM PTO-1449 

FIR^£UPPLEMEt$TAL INFORMATION DISCLOSURE 
TR ,o^ STATEMENT 


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APPLICATION NO. 
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FILING DATE 
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ART UNIT 
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U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 

iiU ivi D^r\ 


DATE 


NAME 




SUB-PI A^ 


Fit INA DATF 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















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AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 


-a 

33 5 


AR 




NCBI Entrez. GenBank Report, Accession No. X65258, from Lai, M.E., et al. (March 2001) 


oSfe 

3§1 

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AS 


85 


NCBI Entrez, GenBank Report, Accession No. AF151735, from Gerner, P., et al. (April 2001) 




AT 


SI 


NCBI Entrez, GenBank Report, Accession No. AJ000636, from Gousset, N., et al. (November 2001 ) 


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1 A S TDQ* "J form PTO-1449 

\%IRST SUPPLEMENTAL INFORMATION DISCLOSURE 
mfrtfi^ STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
09/848.616 


FIRST NAMED INVENTOR 
Sebbel et al. 




FILING DATE 
May 4. 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


MAMF 




OU D'vLnOO 


ril_IINV3 Unlu 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


86 


NCBI Entrez, GenBank Report, Accession No. AAB59424, from Kenten, J.H., et al. (February 2002) 


/£. MOSHER 
RY EXAMINER 
0UP1800 


AS 


86 


NCBI Entrez, GenBank Report, Accession No. AAC06250, from Beekwilder, M.J., et al. (March 2002) 




AT 


86 


NCBI Entrez, GenBank Report, Accession No. L09137, from Yanisch-Perron, C, etal. (May 2002) 


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x ^rr>^ 

/o *\ 

UsT?5kuVpLEMEr3TAL INFORMATION DISCLOSURE 
\^ ^/STATEMENT 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/648,616 


FIRST NAMED INVENTOR 
Sebbel etaL 


FILING DATE 
May 4. 2001 


ART UNIT 
1646 



^LSJS^ U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
Nil JMRFR 


DATE 


NAME 




CI JR_f > l ACQ 


CM |Mf2 nATP 
rlLimO UnIC 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


cmss 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


87 


NCBI Entrez, GenBank Report, Accession No. O09006, from Hromas, R., et al. (June 2002) 




AS 


82 


NCBI Entrez, GenBank Report, Accession No. P40224, from Nagasawa, T.. et al. (June 2002) 




AT 


87 


NCBI Entrez, GenBank Report, Accession No. P34884, from Bernhagen, J. ( et al. (June 2002) 


EXAMINER DATE CONSIDERED 


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Page 54 of 62 


1 

1 )\SV. ^ * ^ gJORMPTO-1449 
W&ST SUPPLEMENTAL INFORMATION DISCLOSURE 
^ZtmtStfy STATEMENT 


ATTY. DOCKET NO. 
17G0.0180002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel et al. 


FILING DATE 
May 4. 2001 


ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 

IMITIAI 




DOCUMENT 

Ml IMRPR 


nATF 


MAMC 




OUD*uLMOO 


pii iKiri nATP 

i 1 LIINO L/nIC 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


88 


NCBI Entrez, GenBank Report, Accession No. P06821, from Winter, G.. et al. (June 2002) 


-* 


AS 


88 


NCBI Entrez, GenBank Report, Accession No. P30904, from Sakai, M., et al. (June 2002) 




AT 


S8 


NCBI Entrez, GenBank Report, Accession No. NP_040754, from Inokuchi, Y. f et al. (June 2003) 


EXAMINER DATE CONSIDERED 


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I 


Page 55 of 62 


^ %r 1 

^ \ S 15^ ^| FORM PTO-1449 

* FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
Nft^.u.rfty STATEMENT 


ATTY. DOCKET NO. 
1700.0180002/BJD/SJE 


APPLICATION NO. 
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FIRST NAMED INVENTOR 
Sebbel et at. 


FILING DATE 
May 4, 2001 


ART UNIT 
1646 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


OU D*wU\Ow 


cm iMft OATF 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


89 


NCBI Entrez, GenBank Report, Accession No. NP_061354, from Ishikawa, S. f et al. (September 2003) 




AS 


89 


NCBI Entrez, GenBank Report, Accession No. NP_031804, from Lenda, D.M.. et al. (September 2003) 




AT 


89 


NCBI Entrez, GenBank Report, Accession No. NP_00641Q, from Luther, S.A., et al. (September 2003) 


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"9 fc ^C?X Page 56 of 62 


vV \ ^ gl FORM PTO-1449 

\ FIRST SUPPLEMENTAL INFORMATION DISCLOSURE 
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ATTY. DOCKET NO. 
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APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbal et al. 


FILING DATE 
May 4, 2001 


ART UNIT 
1646 



U.S. PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 




Fll IMf5 DATP 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


2Q 


NCBI Entrez, GenBank Report, Accession No. NPJX)0748, from Yao, G.Q., et al. (September 2003) 


-s||- 


AS 


90 


NCBI Entrez, GenBank Report, Accession No. P03069, from Hinnebusch, A.G., et al. (September 2003) 




AT 


2Q 


NCBI Entrez, GenBank Report, Accession No. 000585, from Hromas, R., et al. (September 2003) 


EXAMINER DATE CONSIDERED 


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Page 57 of 62 






ATTY. DOCKET NO. 


APPLICATION NO. 




: j FORMPTO-1449 


1 700.01 80002/BJD/SJE 


09/848,616 




FIRST NAMED INVENTOR 






ENTAL INFORMATIQN pi§PL,OSURf= 


Sebbel et at. 




\RR%T SUPPLE^ 


FILING DATE 


ART UNIT 




STATEMENT 


May 4. 2001 


1648 



U.S. PATENT DOCUMENTS 


EXAMINER 

IMITIAI 
I IN I I IML 




DOCUMENT 

Ml IMRFR 


HATF 


NAMF 


f*l A9.C; 


CMD.pl ACC 


Pll IMfi nATF 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 





AR 


91 


NCBI Entrez, GenBank Report, Accession No. P14174, from Weiser, W.Y., et al. (September 2003) 




AS 


21 


NCBI Entrez, GenBank Report, Accession No, P48061, from Spotita, L.D., etal. (September 2003) 




AT 


21 


NCBI Entrez, GenBank Report, Accession No. P80003, from Vandermeers, A., et al. (September 2003) 


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fa &\ Page 58 of 62 


^ v £/ F0RM PT °- 1449 

VfcfRST SUfcf&EMENTAL INFORMATION DISCLOSURE 
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ATTY. DOCKET NO. 
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APPLICATION NO. 
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FIRST NAMED INVENTOR 
Sebbelefa/. 


FILING DATE 
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ART UNIT 
1648 



U.S. PATENT DOCUMENTS 


EXAMINER 

I IN I I IML 




DOCUMENT 

Ml IMDCf? 
fNUIVlDCrx 


nATP 

L/M 1 C 


MAMC 
INMtVIC 


r*i ACQ 


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AF 
















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AH 
















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AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


92 


Swiss-Prot/TrEMBL, TN1 1_Mouse t Primary Accession No. 035235, entered in Swiss-Prot in October 2001 


IMARYEXAMI 
GROUP 180C 


AS 


92 


Swiss-Prot/TrEMBL. TN11_Human, Primary Accession No. 01478B, entered in Swiss-Prot in October 2001 


as m 


AT 


22 


Copy of co-pending U.S. application 10/622,087, inventors Bachmann et al., filed July 18, 2003 (NOT 
PUBLISHED) 


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" ~~ SUPPLE 



ORM PTO-1449 

TAL INFORMATION DISCLOSURE 



Page 59 of 62 


ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848,616 


FIRST NAMED INVENTOR 




Sebbel et a/. 




FILING DATE 


ART UNIT 


May 4. 2001 


1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



3 £ 

IS)|§ 

4 



AR 



93 



Copy of co-pending U.S. Application No. 10/733,582, inventors Renner et at., filed December 12, 2003 (NOT 
PUBLISHED) 



S 



AS 



93 



Jegeriehner, A., et al., "A molecular assembly system that renders antigens of choice highly repetitive for 
induction of protective B cell responses," Vaccine 20:3104-31 1 2, Elsevier Science, Ltd. (August 2002) 



AT 



93 



NCBI Entrez, PubMed Abstract, PMID: 2205968, Diallo, A., et al., "Morbillivirus group: genome organization 
and proteins," Vet. Microbiol. 23:155-163 (1990) 



EXAMINER 



DATE CONSIDERED 



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285541_1.DOC 



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Page 60 of 62 



iRM PTO-1449 



FIF 



RSUPPLEMSNtAL INFORMATION DISCLOSURE 
^Ta^SS>^ STATEMENT 



ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/848,616 


FIRST NAMED INVENTOR 




Sebbel et at. 




FILING DATE 


ART UNIT 


May 4, 2001 


1648 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
NO 




AO 












Yes 
No 




AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



— 



AR 



24 



Dialog File 351, Accession No. 1994-111516, DerwentWPI English language abstract for FR 2695563 



International Search Report for International Application No. PCT/IB02/00168 mailed on November 4, 2002 



AS 



94 



International Search Report for International Application No. PCT/IB02/00166 mailed on October 29, 2002 



AT 



24 



EXAMINER 



DATE CONSIDERED 



EXAMINER: initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
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285541J1.DOC 



SKGF Rev. 12/03/03 





/O J FORMPTO-1449 f ^ $ T8$» gj 

( FIRST SU-fa P^8e M ENTAL INFORMATION DISCLOSURE? 
V ^ £7 STATEMENT ^^f/ 


ATTY. DOCKET NO. 
1 700.01 80002/BJD/SJE 


APPLICATION NO. 
09/848,616 


FIRST NAMED INVENTOR 
Sebbel etal. 


FILING DATE 
May 4, 2001 


ART UNIT 
164B 





& U.S. PATENT DOCUMENTS 


INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 




Pll INfi DATP 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 














FOREIGN PATENT DOCUMENTS 


EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 




AP 












Yes 
No 


OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 




AR 


95 


International Search Report for International Application No. PCT/IB02/00166, mailed January 31, 2003 


ill 


AS 


95 


Copy of Office Action mailed June 6, 2001 , for United States Patent Application No. 09/449,631 , Renner et 
a/., filed November 30, 1999. 




AT 


95 


Copy of Office Action mailed February 27, 2002, for United States Patent Application No. 09/449,631 , Renner 
ef a/., filed November 30, 1999. 


EXAMINER DATE CONSIDERED 


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285541JI.DOC 



SKGF Rev. 12/03/03 




Page 62 of 62 



ATTY. DOCKET NO. 


APPLICATION NO. 


1 700.01 80002/BJD/SJE 


09/648,616 


FIRST NAMED INVENTOR 




Sebbel et at. 




FILING DATE 


ART UNIT 


May 4. 2001 


1646 



\IRST SUPPLEMfi 



ORM PTO-1449 

AL INFORMATION DISCLOSURE 



STATEMENT 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


NAME 


CLASS 


SUB-CLASS 


FILING DATE 




AA 
















AB 
















AC 
















AD 
















AE 
















AF 
















AG 
















AH 
















Al 
















AJ 
















AK 















U.S. PATENT DOCUMENTS 



FOREIGN PATENT DOCUMENTS 



EXAMINER 
INITIAL 




DOCUMENT 
NUMBER 


DATE 


COUNTRY 


CLASS 


SUB-CLASS 


TRANSLATION 




AL 












Yes 
No 




AM 












Yes 
No 




AN 












Yes 
No 




AO 












Yes 
No 


S*- 


AP 












Yes 
No 



OTHER (Including Author, Title, Date, Pertinent Pages, etc.) 



Sen 
Ssx 



AR 



96 



Copy of Office Action mailed November 14, 2002, for United States Patent Application No. 09/449,631, 
Renner et a/., filed November 30, 1999. 



3 



AS 



96 



Copy of Office Action mailed March 1, 2004, for United States Patent Application No. 10/050,902, Renner et 
a/., filed January 18, 2002. 



AT 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance 
and not considered. Include copy of this form with next communication to Applicant. 



285541 1.DOC 



SKGF Rev. 12/03/03