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Full text of "USPTO Patents Application 09919224"

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FIG 1 



Rhesus PBMC Proliferation 

35000 -, ! 



30000 




O.Sug/mJ 1.0ug/n,I 5.0 us/ml lOug/ml 50 ug/ml 
ConA CooA ConA ConA ConA 



Mar 



05 



FIG2A 



0PF, CB 



7 ^0 



77 "/o,vs 




FIG 2C 




-Mock 
I -rhCMVIL-10 
I -rhCMVlL-10+AB 



FIG 2B 



3/14 



c 200 
.g 

2 150 
4? 

100 

o. 

e 50 
a> 

? o 

CU 

o -50 

-100 J 



rh:CMV 0.-10 



rhlL-10 



FIG3A 



200 
150 
100 
50 
0 
-50 
-100 



HCMVIL-10 Human IL-10 



FIG 3B 




FIG 4 





FIG 5B 



6/14 




0.25 0.5 1 



PHA (ng/ml) 

■ Mock 

• HCMV IL-10 
o rtiCMV IL-10 
a Human IL-10 



FIG 5C 



7/14 



■ Mock 

• HiCMVIL-10 




0.25 0.5 1 

PHA Cug/ml) 
FIG6A 



400 




100 



LPS (ug/mQ 

FIG 6B 



8/14 



IL-1<* 




LPS (ng/ml) 
FIG7A 



■ Mock 

• rhCMVIL-10 

# rhlL-10 




Mock 

rhCMV IL-10 
rhlL-10 



LPS (ng/ml) 
FIG7B 




0.25 0.5 1.0 o rhlL-10 

PHA (ng/ml) 

FIG 7C 



8000 
6000 
4000 




■ Mock 

• rhCMVIL-10 

• rhiL-10 



0.01 0.1 1 



LPS (^g/ml) 
FIG 7D 




FIG8A 



90 
60 




-MOCX 
■HCMVIL-10 
•fMl-10 



FIG 8B 




BOOO 




LPS (ug/ml) 



12/14 



CD54 HLA-A,B,C HLA-DR HLA-G 



Mock 



CMV 
IL-10 



284 



127 



io u io' io* io J io q io u io' iq' nr io H io u 10' io £ itr io s io u io' 10* icr io 



87 



29 





10 u 10' 10* 10° 10^ 10 u 10 1 10* 10 HT 10* 





FIG 9 



Control 



CD14 



CD54 



HCMV IL-10 

8 



™ 10* 10° 10 1 10? 10? io' 



HLA-A 




C054PE° 10 10 " 1°' ^ 10 * 10" 



HLA-DR 



10 w 10* 10* 10T 10' 

Anli-HLA-DRPE 



FIG 10 



13/14 




RPM lOOng/ml lng/ml 



p|6 'I A 



lOpg/ml lOOpg/ml lpg/mi 



T ^ x 



mill iihi 
iiiiiiiiiii 



RPMI lOOng/ml 



lng/ml 



lOpg/ml 



lOOpg/ml lpg/ml 



FIG 11B 



14/14 





Cytokine concentration 
FIG 12B