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J^Ras'dPCryPTO 07 NOV 2005 



Certificate of Mailing 

Date of Deoosit* November 7 200*5 Label Number EV 768764408 US 

1 hereby certify under 37 C.F.R. § 1.10 that this correspondence is being deposited with the United States Postal Service as 
"Express Mail Post Office to Addressee" with sufficient postage on the date indjeaied above and is addressed to Mail Stop 
PCT, Commissioner for Patents, P.O. Box 1450, Alexandria, VA 22313 : 1450. /' /) /~\ JL 

Elvis DeLaCruz W I X (f /OV")* 


Printed name of person mailing correspondence Signature of p srson mailing corfesponc 








Substitute Form PTO 1390 U.S. Department of Commerce Patent and Trade maVk^ffice 

TRANSMITTAL Lb I I bR TO THE UNITED STATES 

DESIGNATED/ELECTED OFFICE (DO/EO/US) 
CONCERNING A FILING UNDER 35 U.S.C. § 371 


Attorney Docket Number: 
50125/107001 
U.S. /toplicatiorvy umber 
Not ^Q^ifeeS 5 


896 


INTERNATIONAL APPLICATION NUMBER 


INTERNATIONAL FILING DATE 


PRIORITY DATE CLAIMED 


PCT/EP2004/004883 


May 7, 2004 


May 7, 2003 


TITLE OF INVENTION: 


PROCESS FOR THE IDENTIFICATION OF NEW MEDICAL TARGETS 


APPLICANTS FOR DO/EO/US: 


Giulio SUPERTI-FUGA; Ulrich KRUSE; Vladimir RYBIN; Gitte NEUBAUER 


Applicant herewith submits to the United States Designated/Elected Office (DO/EO/US) the following items and other information: 


1. 


a This is a FIRST submission of items concerning a filing under 35 U.S.C. § 371 . 


2. 


□ This is a SECOND or SUBSEQUENT submission of items concerning a filing under 35 U.S.C. § 371. 


3. 


a This is an express request to begin national examination procedures (35 U.S.C. § 371(f)). 


4. 


a The U.S. has been elected. 


5. 


A copy of the International Application (35 U.S.C. § 371(c)(2)). 

h a. is transmitted herewith (required only if not transmitted by the International Bureau). 

□ b. has been transmitted by the International Bureau. 

□ c. Is not required, as the application was filed with the United States Receiving Office (RO/US). 


6. 


An English language translation of the International Application into English (35 U.S.C. § 371(c)(2)). 

□ a. is transmitted herewith. 

□ b. has been previously submitted under 35 U.S.C. 154(d)(4). 


7. 


Amendments to the claims of the International Application under PCT Article 1 9 (35 U.S.C. § 371 (c)(3)). 

□ a. are transmitted herewith (required only if not transmitted by the International Bureau), 
a b. have been transmitted by the International Bureau. 

□ c. have not been made; however, the time limit for making such amendments has NOT expired. 
h d. have not been made and will not be made. 


8. 


□ An English language translation of the amendments to the claims under PCT Article 19 (35 U.S.C. § 371(c)(3)). 


9. 


h An oath or declaration of the inventors (35 U.S.C. § 371(c)(4)). (unsigned) 


10. 


o An English language translation of the annexes to the International Preliminary Examination Report under PCT Article 
36 (35 U.S.C. §371 (c)(5). 


11. 


□ An Information Disclosure Statement under 37 C.F.R. §§ 1.97 and 1.98. 


12. 


o An assignment for recording. A separate cover sheet in compliance with 37 C.F.R. §§ 3.28 and 3.31 is included. 


13. 


□ A preliminary amendment. 


14. 


□ A substitute specification. 


15. 


□ A power of attorney and/or change of address letter. 


16. 


□ Request for Deferred Examination. 


17. 


a Application Data Sheet. 


18. 


a Other items or information: Postcard, PCT/RO/105, PCT/IB/304, PCT/ISA/206, PCT/IB/301, PCT/IB/308 (First Notice), 
PCT/IB/308 (Second and Supplementary Notice), PCT/IB/345 


19. 


a The following fees are submitted: 



10/555896 

JC14 Rec'd PCT/PTO 0 7 NOV 2005 



Basic National Stage Fee: $300 


$300 




National Stage Search Fee 

If the written opinion prepared by ISA/US or the international preliminary 
examination report prepared by IPEA/US indicates all claims satisfy provisions of 
PCT Article 33(1 H4): $0 

Search fee (37 C.F.R. § 1.445(a)(2)) has been paid on the international 
application to the USPTO as an International Search Authority: $100 

International Search Report prepared by an ISA other than the US and provided to 
the Office or previously communicated to the US by the IB: $400 

All other situations: $500 


$400 




National Stage Examination Fee 

If the written opinion prepared by ISA/US or the international preliminary 
examination report prepared by IPEA/US indicates all claims satisfy provisions of 
PCT Article 33(1 )-(4): $0 

All other situations: $200 


$200 




Surcharge of $1 30 for furnishing any of the search fee, examination fee, or the 
oath or declaration after the date of commencement of the national stage (37 
C.F.R. § 1.492(h)). 


$ 
v 




CLAIMS 


NUMBER FILED 


NUMBER EXTRA 


RATE 






Total claims 


16-20 = 




x $50 


$ 




Independent claims 


2-3 = 




x $200 


$ 




Multiple dependent claims (if applicable) 


+ $360 


$ 




Application Size Fee: Additional fee for specification and drawings in paper over 
100 sheets (excluding sequence listing or computer program listing filed in an 
electronic medium). The fee is $250 for each additional 50 sheets of paper or 
fraction thereof. 






TOTAL 
SHEETS 


EXTRA 
SHEETS 


Number of each additional 50 
sheets or fraction thereof (round 
up to a whole number) 


RATE 


$ 




-100= 


/50= 




X$250 


TOTAL OF ABOVE CALCULATIONS = 


$ 




Reduction of 1/2 for filing by small entity, if applicable. ["Applicant claims small 
entity status under 37 C.F.R. § 1.27"] 


$ 




SUBTOTAL = 


$ 




Processing fee of $130.00 for furnishing the English translation later than 30 
months from the earliest claimed priority date (37 C.F.R. § 1 .492(0). + 


$ 




TOTAL NATIONAL FEE = 


$ 




Fee for recording the enclosed assignment (37 C.F.R. 1 .21(h)). The assignment 
must be accompanied by an appropriate cover sheet (37 C.F.R. §§ 3.28, 3.31 ). 
$40.00 per property. + 


$ 




TOTAL FEES ENCLOSED = 


$ 






Amount to be 
refunded 


$ 




charged 


$ I 


□ a. Enclosed is a check for $["AMOUNT"] to cover the total fees. 

b b. Enclosed is a check for $300 to cover the basic national stage fee; no other fees are being paid at this time. 

□ c. Please charge my Deposit Account No. 03-2095 in the amount of $[**] to cover the above fees. 

b d. The Commissioner is hereby authorized to charge any additional fees which may be required, or credit any 
overpayment to Deposit Account No. 03-2095. 


NOTE: Where an appropriate time limit under 37 C.F.R. §§ 1.494 or 1.495 has not been met, a petition to revive (37 C.F.R. § 
1 . 1 37(a) or (b) must be filed and granted to restore the application to pending status. 



SEND ALL CORRESPONDENCE TO: 

Kristina Bieker-Brady, Ph.D. Telephone: 617-428-0200 
Clark & Elbing LLP Facsimile: 61 7-428-7045 
101 Federal Street Customer No.: 21559 
Boston, MA 02110-2214 










Signatu 
KrisW 
Reg. Nfc 


e 

Bieker-Brad 
.39.109 I 




3 h.D. 









J. Cooper McDonald, Ph.D. 
Patent Agent 

Reg. No. 52,01 1