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PATENT 

ATTORNEY DOCKET NO. 50125/107001 



Certificate of Mailing 

Date of Deposit: December 6. 2006 Label Number: EV 919881964 US 



I hereby certify under 37 C.F.R. § 1 .10 that this correspondence Is being deposited with the United States Postal Service as 
"Express Mail Post Office to Addressee" with sufficient postage on the datejindica^d abo\^e and ^ addressed to Mail Stop POT, 
Commissioner for Patents, P.O. Box 1450. Alexandria, VA 22313-1450. 



Josh Wheeler 



Printed name of person mailing con-espondence yg^ature of person mailing correspondence 



IN THE UNITED STATES PATENT AND TRADEMARK OFFICE 

Applicant: Giulio Superti-Fuga et al. Confirmation No.: 2727 

Serial No.: 10/555,896 Art Unit: Not Yet Assigned 

Filed: November 7, 2005 Examiner: Not Yet Assigned 

Customer No.: 21559 

Title: PROCESS FOR THE IDENTIFICATION OF NEW MEDICAL TARGETS 

Mail Stop PCT 
Commissioner for Patents 
P.O. Box 1450 
Alexandria, VA 223 13-1450 

REPLY TO NOTIFICATION OF MISSING REOUIREMENTS 

In reply to the Notification of Missing Requirements that was mailed in coimection 

with the above-captioned application on September 28, 2006, a copy of which is 

enclosed, applicant, as a large entity, submits the following: 

A Combined Declaration and Power of Attorney in compliance with 37 C.F.R. § 
1.497. 

A Preliminary Amendment. 



Enclosed is a Petition to extend the period for replying to the Notification for one 
month, to and including December 28, 2006, and a check in payment of the required 
extension fee. 

If there are any additional charges or any credits, please apply them to Deposit 
Account No. 03-2095. 



Clark & Elbing LLP 
101 Federal Street 
Boston, MA 021 10 
Telephone: 617-428-0200 
Facsimile: 617-428-7045 



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Page 1 of 2 




United States R\tent and TkAPEMARK QmcE 



UNITED STATES DEPARTMENT OF COMMERCE 
United Stotes Patent and Trademark OOice 

»: COMMISSIONER FOR PATENTS 
P.O. BokUSO 

Alexandna, Vuginia 22313>14S0 

WWW.IU]]t0.gOV 



U.S. APPLICATION NUMBER NO. 



FIRST NAMED APPLICANT 



ATTY. DOCKET NO. 



10/555,896 



21 559 

CLARK & ELBING LLP 
101 FEDERAL STREET 
BOSTON, MA 021 10 



Giulio Superti-Fuga 



50125/107001 



INTERNATIONAL APPLICATION NO. 



PCT/EP04/04883 

I 



l.A. FILING DATE 



PRIORITY DATE 



05/07/2004 



05/07/2003 



CONFIRMATION NO. 2727 
371 FORMALITIES LETTER 

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♦OC00000002061 2775* 



Date Mailed: 09/28/2006 

NOTIFICATION OF MISSING REQUIREMENTS UNDER 35 U.S.C. 371 IN THE UNITED 
STATES DESIGNATED/ELECTED OFFICE (DO/EO/US) 

The following items have been submitted by the applicant or the IB to the United States Patent and Trademark 
Office as a Designated / Elected Office (37 CFR 1.495). 



Copy of the International Application filed on 11/07/2005 

Copy of the International Search Report filed on 11/07/2005 

Oath or Declaration filed on 1 1/07/2005 

Request for Immediate Examination filed on 11/07/2005 

U.S. Basic National Fees filed on 11/07/2005 

Priority Documents filed on 11/07/2005 

Specification filed on 11/07/2005 

Claims filed on 11/07/2005 

Abstracts filed on 1 1/07/2005 



ACTION DUESS^^;^^^ 

DUE DATEA\:afi^3iXl^ 

ESP__3v2S_aaco — 

INITIALS jniyi^ 



The applicant needs to satisfy supplemental fees problems indicated below. 

The following items MUST be furnished within the period set forth below in order to complete the requirements for 
acceptance under 35 U.S.C. 371: 

• 6ath or declaration of the inventors, in compliance with 37 CFR 1 .497(a) and (b), identifying the application 
by the International application number and intemational filing date. The current oath or declaration does 
not comply with 37 CFR 1.497(a) and (b) in that it: 

■ is not executed in accordance with either 37 CFR 1 .66 or 37 CFR 1 .68. 

• To avoid abandonment, a surcharge (for late submission of filing fee, search fee, examination fee or oath 
or declaration) as set forth in 37 CFR 1 .492(h) of $130 for a non-small entity, must be submitted with the 
missing items identified in this letter. 



SUMMARY OF FEES DUE: 



Page 2 of 2 



Total additional fees required for this application is $130 for a Large Entity: 
• $130 Surcharge. 

ALL OF THE ITEMS SET FORTH ABOVE MUST BE SUBMITTED WITHIN TWO (2) MONTHS FROM THE 
DATE OF THIS NOTICE OR BY 32 MONTHS FROM THE PRIORITY DATE FOR THE APPLICATION, 
WHICHEVER IS LATER. FAILURE TO PROPERLY RESPOND WILL RESULT IN ABANDONMENT. 

The time period set above may be extended by filing a petition and fee for extension of time under the provisions 
of 37 CFR 1.136(a). 

Applicant is reminded that any communications to the United States Patent and Trademark Office must be mailed 
to the address given in the heading and include the U.S. application no. shown above (37 CFR 1.5) 

A copy of this notice MUST be returned with the response. 

PAULETTE R KID WELL 



Telephone: (703) 308-9140 EXT 216 
PART 1 - ATTORNEY/APPLICANT COPY 




10/555,896 



PCT/EP04/04883 



50125/107001 



FORM PCT/DO/EO/905 (371 Formalities Notice)