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SEQUENCE LISTING 



SEQ ID NO: 1 provides a primate MIP-3ot polynucleotide sequence. 

SEQ ID NO: 2 provides a primate MIP-3ct polypeptide sequence. 

SEQ ID NO: 3 provides a murine MIP-3a polynucleotide sequence. 

SEQ ID NO: 4 provides a murine (mouse) MIP-3a polypeptide sequence. 

SEQ ID NO: 5 provides a murine MIP-3oc polynucleotide sequence. 

SEQ ID NO: 6 provides a murine (rat) MIP-3a polypeptide sequence. 

SEQ ID NO: 7 provides a primate CCR6 polynucleotide sequence. 

SEQ ID NO: 8 provides a primate CCR6 polypeptide sequence. 



<110> Oldham, Elizabeth R. 
Homey, Bernhard 
Dieu-Nos jean, Marie Caroline 
Caux, Christophe 
Zlotnik, Albert 

<120> Chemokine Uses; Compositions; Methods 

<130> DX0934K1B US 

<150> US 09/503,219 
<151> 2000-02-02 

<150> US 60/118,335 
<151> 1999-02-03 



<160> 8 



<170> Patentln version 3.1 



<211> 291 
<212> DNA 
<213> Homo sapiens 

<220> 

<221> CDS 

<222> (1) . . (288) 

<223> 

<220> 

<221> mat_peptide 

<222> (79) . . () 
<223> 



<400> 1 

atg tgc tgt acc aag agt ttg etc ctg get get ttg atg tea gtg ctg 48 
Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
-25 -20 -15 

eta etc cac etc tgc ggc gaa tea gaa gca gca age aac ttt gac tgc 96 
Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
-10 -5 -11 5 

tgt ctt gga tac aca gac cgt att ctt cat cct aaa ttt att gtg ggc 144 
Cys Leu Gly Tyr Thr Asp Arg lie Leu His Pro Lys Phe lie Val Gly 
10 15 20 

ttc aca egg cag ctg gee aat gaa ggc tgt gac ate aat get ate ate 192 
Phe Thr Arg Gin Leu Ala Asn Glu Gly Cys Asp He Asn Ala He He 
25 30 35 

ttt cac aca aag aaa aag ttg tct gtg tgc gca aat cca aaa cag act 240 
Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gin Thr 
40 45 50 

tgg gtg aaa tat att gtg cgt etc etc agt aaa aaa gtc aag aac atg 288 
Trp Val Lys Tyr lie Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
55 60 65 70 

taa 291 



<210> 2 

<211> 96 

<212> PRT 

<213> Homo sapiens 

<400> 2 

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
-25 -20 -15 



Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
-10 -5 -11 5 



Cys Leu Gly Tyr Thr Asp Arg He Leu His Pro Lys Phe He Val Gly 
10 15 20 



Phe Thr Arg Gin Leu Ala Asn Glu Gly Cys Asp He Asn Ala He He 
25 30 35 



Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gin Thr 
40 45 50 



Trp Val Lys Tyr He Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
55 ' 60 65 70 



<210> 3 

<211> 291 

<212> DNA 

<213> Mus mus cuius 

<220> 

<221> CDS 

<222> (1) . . (288) 

<223> 



<220> 

<221> mat_peptide 

<222> (82) . . () 
<223> 



<400> 3 

atg gcc tgc ggt ggc aag cgt ctg etc ttc ctt get ttg gca tgg gta 48 
Met Ala Cys Gly Gly Lys Arg Leu Leu Phe Leu Ala Leu Ala Trp Val 
-25 -20 -15 

ctg ctg get cac etc tgc age cag gca gaa gca age aac tac gac tgt 96 
Leu Leu Ala His Leu Cys Ser Gin Ala Glu Ala Ser Asn Tyr Asp Cys 
-10 -5 -11 5 

tgc etc teg tac ata cag acg cca ctt cct tec aga get att gtg ggt 144 
Cys Leu Ser Tyr lie Gin Thr Pro Leu Pro Ser Arg Ala lie Val Gly 
10 15 20 

ttc aca aga cag atg gcc gat gaa get tgt gac att aat get ate ate 192 
Phe Thr Arg Gin Met Ala Asp Glu Ala Cys Asp lie Asn Ala lie lie 
25 30 35 

ttt cac acg aag aaa aga aaa tct gtg tgc get gat cca aag cag aac 240 
Phe His Thr Lys Lys Arg Lys Ser Val Cys Ala Asp Pro Lys Gin Asn 
40 45 50 

tgg gtg aaa agg get gtg aac etc etc age eta aga gtc aag aag atg 288 
Trp Val Lys Arg Ala Val Asn Leu Leu Ser Leu Arg Val Lys Lys Met 
55 60 65 

taa 291 



<210> 4 

<211> 96 

<212> PRT 

<213> Mus mus cuius 

<400> 4 

Met Ala Cys Gly Gly Lys Arg Leu Leu Phe Leu Ala Leu Ala Trp Val 
-25 -20 -15 



Leu Leu Ala His Leu Cys Ser Gin Ala Glu Ala Ser Asn Tyr Asp Cys 
-10 -5 -11 5 



Cys Leu Ser Tyr lie Gin Thr Pro Leu Pro Ser Arg Ala lie Val Gly 
10 15 20 

Phe Thr Arg Gin Met Ala Asp Glu Ala Cys Asp He Asn Ala He He 
25 30 35 

Phe His Thr Lys Lys Arg Lys Ser Val Cys Ala Asp Pro Lys Gin Asn 
40 45 50 

Trp Val Lys Arg Ala Val Asn Leu Leu Ser Leu Arg Val Lys Lys Met 
55 60 65 

<210> 5 

<211> 291 

<212> DNA 

<213> Rattus sp. 

<220> 

<221> CDS 

<222> (1) . . (288) 

<223> 

<220> 

<221> mat_peptide 

<222> (76).. () 
<223> 

<400> 5 

atg gcc tgc aag cat ctg ccc ttc ctg get ttg gcg ggg gta ctg ctg 48 

Met Ala Cys Lys His Leu Pro Phe Leu Ala Leu Ala Gly Val Leu Leu 

-25 -20 -15 -10 



get tac etc tgc age cag tea gaa gca gca age aac ttt gac tgc tgc 
Ala Tyr Leu Cys Ser Gin Ser Glu Ala Ala Ser Asn Phe Asp Cys Cys 
-5 -11 5 



96 



etc acg tac aca aag aac gtg tat cat cat gcg aga aat ttt gtg ggt 144 
Leu Thr Tyr Thr Lys Asn Val Tyr His His Ala Arg Asn Phe Val Gly 
10 15 20 

ttc aca aca cag atg gec gac gaa get tgt gac att aat get ate ate 192 
Phe Thr Thr Gin Met Ala Asp Glu Ala Cys Asp lie Asn Ala lie lie 
25 30 ~ 35 

ttt cac ctg aag teg aaa aga tec gtg tgc get gac cca aag cag ate 240 
Phe His Leu Lys Ser Lys Arg Ser Val Cys Ala Asp Pro Lys Gin lie 
40 45 50 55 

tgg gtg aaa agg att ttg cac etc etc age eta aga ace aag aag atg 288 
Trp Val Lys Arg lie Leu His Leu Leu Ser Leu Arg Thr Lys Lys Met 
60 65 70 

taa 291 



<210> 6 

<211> 96 

<212> PRT 

<213> Rattus sp. 

<400> 6 

Met Ala Cys Lys His Leu Pro Phe Leu Ala Leu Ala Gly Val Leu Leu 
-25 -20 -15 -10 



Ala Tyr Leu Cys Ser Gin Ser Glu Ala Ala Ser Asn Phe Asp Cys Cys 
-5 -11 5 



Leu Thr Tyr Thr Lys Asn Val Tyr His His Ala Arg Asn Phe Val Gly 
10 15 20 



Phe Thr Thr Gin Met Ala Asp Glu Ala Cys Asp lie Asn Ala lie lie 
25 30 " 35 



Phe His Leu Lys Ser Lys Arg Ser Val Cys Ala Asp Pro Lys Gin lie 
40 45 50 55 



Trp Val Lys Arg lie Leu His Leu Leu Ser Leu Arg Thr Lys Lys Met 
60 65 70 



* 7 



<210> 7 

<211> 1098 

<212> DNA 

<213> Homo sapiens 

<220> 

<221> CDS 

<222> (1) . . (1095) 

<223> 

<220> 

<221> misc_feature 

<222> (579) . . (579) 

<223> n may be a, c, g, or t 



<400> 7 

atg ttt teg act cca gtg aag att att ttg tgt cag tea ata ctt cat 48 
Met Phe Ser Thr Pro Val Lys lie lie Leu Cys Gin Ser lie Leu His 
15 10 15 

att act cag ttg att ctg aga tgt tac tgt get cct tgc agg agg tea 96 
lie Thr Gin Leu lie Leu Arg Cys Tyr Cys Ala Pro Cys Arg Arg Ser 
20 25 30 

ggc agt tct cca ggc tat ttg tac cga att gee tac tec ttg ate tgt 144 
Gly Ser Ser Pro Gly Tyr Leu Tyr Arg lie Ala Tyr Ser Leu lie Cys 
35 40 45 

gtt ctt ggc etc ctg ggg aat att ctg gtg gtg ate acc ttt get ttt 192 
Val Leu Gly Leu Leu Gly Asn lie Leu Val Val lie Thr Phe Ala Phe 
50 55 60 

tat aag aag gec agg tct atg aca gac gtc tat etc ttg aac atg gec 240 
Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met Ala 
65 70 75 80 

att gca gac ate etc ttt gtt ctt act etc cca ttc tgg gca gtg agt 288 
lie Ala Asp lie Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val Ser 
85 90 95 



cat gee act ggt gcg tgg gtt ttc age aat gec acg tgc aag ttg eta 



336 



' 8 



His Ala Thr Gly Ala Trp Val Phe Ser Asn Ala Thr Cys Lys Leu Leu 
100 105 110 

aaa ggc ate tat gec ate aac ttt aac tgc ggg atg ctg etc ctg act 384 
Lys Gly lie Tyr Ala lie Asn Phe Asn Cys Gly Met Leu Leu Leu Thr 
115 120 125 

tgc att age atg gac egg tac ate gee att gta cag gcg act aag tea 432 
Cys lie Ser Met Asp Arg Tyr lie Ala lie Val Gin Ala Thr Lys Ser 
130 135 140 

ttc egg etc cga tec aga aca eta ccg cgc age aaa ate ate tgc ctt 480 
Phe Arg Leu Arg Ser Arg Thr Leu Pro Arg Ser Lys lie lie Cys Leu 
145 150 155 160 

gtt gtg tgg ggg ctg tea gtc ate ate tec age tea act ttt gtc ttc 528 
Val Val Trp Gly Leu Ser Val He He Ser Ser Ser Thr Phe Val Phe 
165 170 175 

aac caa aaa tac aac acc caa ggc age gat gtc tgt gaa ccc aag tac 576 
Asn Gin Lys Tyr Asn Thr Gin Gly Ser Asp Val Cys Glu Pro Lys Tyr 
180 185 190 

can act gtc teg gag ccc ate agg tgg aag ctg ctg atg ttg ggg ctt 624 
Thr Thr Val Ser Glu Pro He Arg Trp Lys Leu Leu Met Leu Gly Leu 
195 200 205 

gag eta etc ttt ggt ttc ttt ate cct ttg atg ttc atg ata ttt tgt 672 
Glu Leu Leu Phe Gly Phe Phe He Pro Leu Met Phe Met He Phe Cys 
210 215 220 

tac acg ttc att gtc aaa acc ttg gtg caa get cag aat tct aaa agg 720 
Tyr Thr Phe He Val Lys Thr Leu Val Gin Ala Gin Asn Ser Lys Arg 
225 230 235 240 

cac aaa gee ate cgt gta ate ata get gtg gtg ctt gtg ttt ctg get 768 
His Lys Ala He Arg Val He He Ala Val Val Leu Val Phe Leu Ala 
245 250 255 

tgt cag att cct cat aac atg gtc ctg ctt gtg acg get get aat ttg 816 
Cys Gin He Pro His Asn Met Val Leu Leu Val Thr Ala Ala Asn Leu 
260 265 270 

ggt aaa atg aac cga tec tgc cag age gaa aag eta att ggc tat acg 864 
Gly Lys Met Asn Arg Ser Cys Gin Ser Glu Lys Leu He Gly Tyr Thr 
275 280 285 

aaa act gtc aca gaa gtc ctg get ttc ctg cac tgc tgc ctg aac cct 912 
Lys Thr Val Thr Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn Pro 
290 295 300 

gtg etc tac get ttt att ggg cag aag ttc aga aac tac ttt ctg aag 96 0 

Val Leu Tyr Ala Phe He Gly Gin Lys Phe Arg Asn Tyr Phe Leu Lys 
305 310 315 320 

ate ttg aag gac ctg tgg tgt gtg aga agg aag tac aag tec tea ggc 1008 



lie Leu Lys Asp Leu Trp Cys Val Arg Arg Lys Tyr Lys Ser Ser Gly 
325 330 335 

ttc tec tgt gec ggg agg tac tea gaa aac att tct egg cag acc agt 1056 
Phe Ser Cys Ala Gly Arg Tyr Ser Glu Asn lie Ser Arg Gin Thr Ser 
340 345 350 

gag acc gca gat aac gac aat gcg teg tec ttc act atg tga 1098 
Glu Thr Ala Asp Asn Asp Asn Ala Ser Ser Phe Thr Met 
355 360 365 



<210> 8 

<211> 365 

<212> PRT 

<213> Homo sapiens 

<220> 

<221> misc_feature 

<222> (579) . . (579) 

<223> n may be a, c, g, or t 

<400> 8 

Met Phe Ser Thr Pro Val Lys lie lie Leu Cys Gin Ser lie Leu His 
15 10 15 



lie Thr Gin Leu lie Leu Arg Cys Tyr Cys Ala Pro Cys Arg Arg Ser 
20 25 30 



Gly Ser Ser Pro Gly Tyr Leu Tyr Arg lie Ala Tyr Ser Leu lie Cys 
35 40 45 



Val Leu Gly Leu Leu Gly Asn He Leu Val Val He Thr Phe Ala Phe 
50 55 60 



Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met Ala 
65 70 75 80 



He Ala Asp He Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val Ser 
85 90 95 



10 



His Ala Thr Gly Ala Trp Val Phe Ser Asn Ala Thr Cys Lys Leu Leu 
100 105 110 



Lys Gly lie Tyr Ala lie Asn Phe Asn Cys Gly Met Leu Leu Leu Thr 
115 120 125 



Cys lie Ser Met Asp Arg Tyr lie Ala lie Val Gin Ala Thr Lys Ser 
130 135 140 



Phe Arg Leu Arg Ser Arg Thr Leu Pro Arg Ser Lys lie He Cys Leu 
145 150 155 160 



Val Val Trp Gly Leu Ser Val He He Ser Ser Ser Thr Phe Val Phe 
165 170 175 



Asn Gin Lys Tyr Asn Thr Gin Gly Ser Asp Val Cys Glu Pro Lys Tyr 
180 185 190 



Thr Thr Val Ser Glu Pro He Arg Trp Lys Leu Leu Met Leu Gly Leu 
195 200 205 



Glu Leu Leu Phe Gly Phe Phe He Pro Leu Met Phe Met He Phe Cys 
210 215 220 



Tyr Thr Phe He Val Lys Thr Leu Val Gin Ala Gin Asn Ser Lys Arg 

225 230 235 240 



His Lys Ala He Arg Val He He Ala Val Val Leu Val Phe Leu Ala 
245 250 255 



Cys Gin He Pro His Asn Met Val Leu Leu Val Thr Ala Ala Asn Leu 
260 265 270 



Gly Lys Met Asn Arg Ser Cys Gin Ser Glu Lys Leu He Gly Tyr Thr 
275 280 285 



Lys Thr Val Thr Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn Pro 
290 295 300 



Val Leu Tyr Ala Phe He Gly Gin Lys Phe Arg Asn Tyr Phe Leu Lys 
305 310 315 320 



11 



lie Leu Lys Asp Leu Trp Cys Val Arg Arg Lys Tyr Lys Ser Ser Gly 
325 330 335 

Phe Ser Cys Ala Gly Arg Tyr Ser Glu Asn He Ser Arg Gin Thr Ser 
340 345 350 

Glu Thr Ala Asp Asn Asp Asn Ala Ser Ser Phe Thr Met 
355 360 365