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The Biotechnology Systems Branch of the Scientific and Technical 
Information Center (STIC) no errors detected. 

Application Serial Number: /O/g^/^ f 
Source: 'llfc PUJ O 

Date Processed by STIC: [0-?J^ -0^ 



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Page 1 of 8 




IFWO 



RAW SEQUENCE LISTING DATE: 10/26/2004 

PATENT APPLICATION: US/10/849,551 TIME: 16:46:0.9 

Input Set : D:\US Utility 50229-435 Sequence Listing.txt 
Output Set: N: \CRF4\10262004\J849551, raw 

3 <110> APPLICANT: University of Kentucky Research Foundation 

4 Moscow, Jeffrey A. 

5 Jordan, Craig 

6 Xin, Lu 

8 <120> TITLE OF INVENTION: AN ORGANIC. CATION TRANSPORTER PREFERENTIALLY EXPRESSED IN 

9 HEMATOPOIETIC CELLS 

11 <130> FILE REFERENCE: 050229-435 

13 <140> CURRENT APPLICATION NUMBER: 10/849,551 

14 <141> CURRENT FILING DATE: 2 004-05-20 

16 <150> PRIOR APPLICATION NUMBER: 60/471,709 

17 <151> PRIOR FILING DATE: 2003-05-20 
19 <160> NUMBER OF SEQ ID NOS : 14 

21 <170> SOFTWARE: Patentin version 3.3 

23 <210> SEQ ID NO: 1 

24 <211> LENGTH: 1734 

25 <212> TYPE: DNA 

26 <213> ORGANISM: Homo sapiens 

28 <400> SEQUENCE: 1 

29 atggggtccc gccacttcga ggggatttat gaccacgtgg ggcacttcgg cagattccag 60 
31 agagtcctct atttcatatg tgccttccag aacatctctt gtggtattca ctacttggct 120 
33 tctgtgttca tgggagtcac ccctcatcat gtctgcaggc ccccaggcaa tgtgagtcag 180 
35 gttgttttcc ataatcactc taattggagt ttggaggaca ccggggccct gttgtcttca 24 0 
37 ggccagaaag attatgttac ggtgcagttg cagaatggtg agatctggga gctctcaagg 3 00 
39 tgtagcagga ataagaggga gaacacatcg agtttgggct atgaatacac tggcagtaag 36 0 
41 aaagagtttc cttgtgtgga tggctacata tatgaccaga acacatggaa aagcactgcg 42 0 
43 gtgacccagt ggaacctggt ctgtgaccga aaatggcttg caatgctgat ccagccccta 480 
45 tttatgtttg gagtcctact gggatcggtg acttttggct acttttctga caggctagga 540 
47 cgccgggtgg tcttgtgggc cacaagcagt agcatgtttt tgtttggaat agcagcggcg 600 
49 tttgcagttg attattacac cttcatggct gctcgctttt ttcttgccat ggttgcaagt 660 
51 ggctatcttg tggtggggtt tgtctatgtg atggaattca ttggcatgaa gtctcggaca 720 
53 tgggcgtctg tccatttgca ttcctttttt gcagttggaa ccctgctggt ggctttgaca 780 
55 ggatacttgg tcaggacctg gtggctttac cagatgatcc tctccacagt gactgtcccc 840 
57 tttatcctgt gctgttgggt gctcccagag acaccttttt ggcttctctc agagggacga 900 
59 tatgaagaag cacaaaaaat agttgacatc atggccaagt ggaacagggc aagctcctgt 960 
61 aaactgtcag aacttttatc actggaccta caaggtcctg ttagtaatag ccccactgaa 102 0 
63 gttcagaagc acaacctatc atatctgttt tataactgga gcattacgaa aaggacactt 1080 
65 accgtttggc taatctggtt cactggaagt ttgggattct actcgttttc cttgaattct 1140 
67 gttaacttag gaggcaatga atacttaaac ctcttcctcc tgggtgtagt ggaaattccc 1200 
69 gcctacacct tcgtgtgcat cgccacggac aaggtcggga ggagaacagt cctggcctac 1260 
71 tctcttttct gcagtgcact ggcctgtggt gtcgttatgg tgatccccca gaaacattat 1320 
73 attttgggtg tggtgacagc tatggttgga aaatttgcca tcggggcagc atttggcctc 13 8 0 
75 atttatcttt atacagctga gctgtatcca accattgtaa gatcgctggc tgtgggaagc 1440 
77 ggcagcatgg tgtgtcgcct ggccagcatc ctggcgccgt tctctgtgga cctcagcagc 1500 



file://C:\CRF4\Outhold\VsrJ84955 1 .htm 



10/26/04 



Page 2 of 8 



RAW SEQUENCE LISTING DATE: 10/26/2004 

PATENT APPLICATION: US/10/849,551 TIME: 16:46:09 

Input Set : D:\US Utility 50229-435 Sequence Listing.txt 
Output Set: N:\CRF4\10262004\J849551.raw 

79 atttggatct tcataccaca gttgtttgtt gggactatgg ccctcctgag tggagtgtta 1560 

81 acactaaagc ttccagaaac ccttgggaaa cggctagcaa ctacttggga ggaggctgca 162 0 

83 aaactggagt cagagaatga aagcaagtca agcaaattac ttctcacaac taataatagt 168 0 

85 gggctggaaa aaacggaagc gattaccccc agggattctg gtcttggtga ataa 1734 

88 <210> SEQ ID NO: 2 

89 <211> LENGTH: 578 

90 <212> TYPE: PRT 

91 <213> ORGANISM: Homo sapiens 

94 <22 0> FEATURE: 

95 <221> NAME/KEY: misc_feature 

96 <222> LOCATION: (264) . . (264) 

97 <223> OTHER INFORMATION: Xaa can be any naturally occurring amino acid 

99 <220> FEATURE: 

100 <221> NAME/KEY: misc_feature 

101 <222> LOCATION: (268) .. (269) 

102 <223> OTHER INFORMATION: Xaa can be any naturally occurring amino acid 

104 <220> FEATURE: 

105 <221> NAME/KEY: misc_feature 

106 <222> LOCATION: (274) . . (275) 

107 <223> OTHER INFORMATION: Xaa can be any naturally occurring amino acid 

109 <220> FEATURE: 

110 <221> NAME/KEY: misc_feature 

111 <222> LOCATION: (410) .. (410) 

112 <223> OTHER INFORMATION: Xaa can be any naturally occurring amino acid 
114 <4 00> SEQUENCE: 2 



116 


Met 


Gly 


Ser 


Arg 


His 


Phe 


Glu 


Gly 


He 


Tyr 


Asp 


His 


Val 


Gly 


His 


Phe 


117 


1 








5 










10 










15 




120 


Gly 


Arg 


Phe 


Gin 


Arg 


Val 


Leu 


Tyr 


Phe 


He 


Cys 


Ala 


Phe 


Gin 


Asn 


He 


121 








20 










25 










30 






124 


Ser 


Cys 


Gly 


He 


His 


Tyr 


Leu 


Ala 


Ser 


Val 


Phe 


Met 


Gly 


Val 


Thr 


Pro 


125 






35 










40 










45 








128 


His 


His 


Val 


Cys 


Arg 


Pro 


Pro 


Gly Asn 


Val 


Ser 


Gin 


Val 


Val 


Phe 


His 


129 




50 










55 










60 










13,2 


Asn 


His 


Ser 


Asn 


Trp 


Ser 


Leu 


Glu Asp 


Thr 


Gly 


Ala 


Leu 


Leu 


Ser 


Ser 


133 


65 










70 










75 










80 


136 


Gly 


Gin 


Lys 


Asp 


Tyr 


Val 


Thr 


Val 


Gin 


Leu 


Gin 


Asn 


Gly 


Glu 


He 


Trp 


137 










85 










90 










95 




140 


Glu 


Leu 


Ser 


Arg 


Cys 


Ser 


Arg 


Asn 


Lys 


Arg 


Glu 


Asn 


Thr 


Ser 


Ser 


Leu 


141 








100 










105 










110 






144 


Gly 


Tyr 


Glu 


Tyr 


Thr 


Gly Ser 


Lys 


Lys 


Glu 


Phe 


Pro 


Cys 


Val 


Asp 


Gly 


145 






115 










120 










125 








148 


Tyr 


He 


Tyr 


Asp 


Gin 


Asn 


Thr 


Trp 


Lys 


Ser 


Thr 


Ala 


Val 


Thr 


Gin 


Trp 


149 




130 










135 










140 










152 


Asn 


Leu 


Val 


Cys 


Asp 


Arg 


Lys 


Trp 


Leu 


Ala 


Met 


Leu 


He 


Gin 


Pro 


Leu 


153 


145 










150 










155 










160 


156 


Phe 


Met 


Phe 


Gly 


Val 


Leu 


Leu 


Gly 


Ser 


Val 


Thr 


Phe 


Gly 


Tyr 


Phe 


Ser 


157 










165 










170 










175 




160 


Asp 


Arg 


Leu 


Gly 


Arg 


Arg 


Val 


Val 


Leu 


Trp 


Ala 


Thr 


Ser 


Ser 


Ser 


Met 


161 








180 










185 










190 







file://C:\CRF4\Outhold\VsrJ84955 1 .htm 



10/26/04 



Page 3 of 8 



RAW SEQUENCE LISTING DATE: 10/26/2004 

PATENT APPLICATION: US/10/849,551 TIME: 16:46:09 

Input Set : D:\US Utility 50229-435 Sequence Listing.txt 
Output Set: N:\CRF4\10262004\J849551.raw 





164 


Phe 


Leu 


Phe 


Gly 


He 


Ala 


Ala 


Ala 


Phe 


Ala 


Val 


Asp 


Tyr 


Tyr 


Thr 


Phe 




165 






195 










200 










205 










168 


Met 


Ala Ala Arig 


Phe 


Phe 


Leu 


Ala 


Met 


Val 


Ala 


Ser 


Gly 


Tyr 


Leu 


Val 




169 




210 










215 










220 












172 


Val 


Gly Phe Val 


Tyr 


Val 


Met 


Glu 


Phe 


He 


Gly 


Met 


Lys 


Ser 


Arg 


Thr 




173 


225 










230 










235 










240 




176 


Trp 


Ala 


Ser 


Val 


His 


Leu 


His 


Ser 


Phe 


Phe 


Ala 


Val 


Gly 


Thr 


Leu 


Leu 




177 










245 










250 










255 




w--> 


180 

181 


Val 


Ala 


Leu 


Thr 

260 


Gly 


Tyr 


Leu 


Xaa 


Arg 

265 


Thr 


Trp 


Xaa 


Xaa 


Tyr 

270 


Gin 


Met 


w--> 


184 

185 


lie 


Xaa 


Xaa 

275 


Ser 


Thr 


Val 


Thr 


Val 

280 


Pro 


Phe 


He 


Leu 


Cys 

285 


Cys 


Trp 


Val 




188 


Leu 


Pro 


Glu 


Thr 


Pro 


Phe 


Trp 


Leu 


Leu 


Ser 


Glu 


Gly 


Arg 


Tyr 


Glu 


Glu 




189 




290 










295 










300 












192 


Ala 


Gin 


Lys 


He 


Val 


Asp 


He 


Met 


Ala 


Lys 


Trp 


Asn 


Arg 


Ala 


Ser 


Ser 




193 


305 










310 










315 










320 




196 


Cys 


Lys 


Leu 


Ser 


Glu 


Leu 


Leu 


Ser 


Leu 


Asp 


Leu 


Gin 


Gly 


Pro 


Val 


Ser 




197 










325 










330 










335 






200 


Asn 


Ser 


Pro 


Thr 


Glu 


Val 


Gin 


Lys 


His 


Asn 


Leu 


Ser 


Tyr 


Leu 


Phe 


Tyr 




201 








340 










345 










350 








204 


Asn 


Trp 


Ser 


He 


Thr 


Lys 


Arg 


Thr 


Leu 


Thr 


Val 


Trp 


Leu 


He 


Trp 


Phe 




205 






355 










360 










365 










208 


Thr 


Gly 


Ser 


Leu 


Gly 


Phe 


Tyr 


Ser 


Phe 


Ser 


Leu 


Asn 


Ser 


Val 


Asn 


Leu 




209 




370 










375 










380 












212 


Gly 


Gly Asn Glu 


Tyr 


Leu 


Asn 


Leu 


Phe 


Leu 


Leu 


Gly 


Val 


Val 


Glu 


He 




213 


385 










390 










395 










400 


w--> 


216 

217 


Pro 


Ala 


Tyr 


Thr 


Phe 

405 


Val 


Cys 


He 


Ala 


Xaa 
410 


Asp 


Lys 


Val 


Gly 


Arg 

415 


Arg 




22 0 


Thr 


Val 


Leu 


Ala 


Tyr 


Ser 


Leu 


Phe 


Cys 


Ser 


Ala 


Leu 


Ala 


Cys 


Gly 


Val 




221 








420 










425 










430 








224 


Val 


Met 


Val 


He 


Pro 


Gin 


Lys 


His 


Tyr 


He 


Leu 


Gly 


Val 


Val 


Thr 


Ala 




225 






435 










440 










445 










228 


Met 


Val 


Gly Lys 


Phe 


Ala 


He 


Gly 


Ala 


Ala 


Phe 


Gly 


Leu 


He 


Tyr 


Leu 




229 




450 










455 










460 












232 


Tyr 


Thr 


Ala 


Glu 


Leu 


Tyr 


Pro 


Thr 


He 


Val 


Arg 


Ser 


Leu 


Ala 


Val 


Gly 




233 


465 










470 










475 










480 




236 


Ser 


Gly Ser Met 


Val 


Cys 


Arg 


Leu 


Ala 


Ser 


He 


Leu 


Ala 


Pro 


Phe 


Ser 




237 










485 










490 










495 






240 


Val 


Asp 


Leu 


Ser 


Ser 


He 


Trp 


He 


Phe 


He 


Pro 


Gin 


Leu 


Phe 


Val 


Gly 




241 








500 










505 










510 








244 


Thr 


Met 


Ala 


Leu 


Leu 


Ser 


Gly 


Val 


Leu 


Thr 


Leu 


Lys 


Leu 


Pro 


Glu 


Thr 




245 






515 










520 










525 










248 


Leu 


Gly Lys Arg 


Leu 


Ala 


Thr 


Thr 


Trp 


Glu 


Glu 


Ala 


Ala 


Lys 


Leu 


Glu 




249 




530 










535 










540 












252 


Ser 


Glu 


Asn 


Glu 


Ser 


Lys 


Ser 


Ser 


Lys 


Leu 


Leu 


Leu 


Thr 


Thr 


Asn 


Asn 




253 


545 










550 










555 










560 




256 


Ser 


Gly Leu Glu 


Lys 


Thr 


Glu 


Ala 


He 


Thr 


Pro 


Arg 


Asp 


Ser 


Gly 


Leu 




257 










565 










570 










575 






260 


Gly 


Glu 































file://C:\CRF4\Outhold\VsrJ84955 1 .htm 



10/26/04 



Page 4 of 8 



RAW SEQUENCE LISTING DATE: 10/26/2004 

PATENT APPLICATION: US/10/849 , 551 TIME: 16:46:09 

Input Set : D:\US Utility 50229-435 Sequence Listing.txt 
Output Set: N:\CRF4\10262004\J849551.raw 



264 <210> SEQ ID NO: 3 

265 <211> LENGTH: 123805 

266 <212> TYPE: DNA 

267 <213> ORGANISM: Homo sapiens 

269 <400> SEQUENCE: 3 

270 aagcttgtcc aacccatggc ccacgggcca catgtggcct aagatggctt tgaatgcagc 60 
272 ccaacacaaa tttgtaaact ttcttaaagc attgagatat ttttgcaatt ttctttttta 120 
274 gctcatcagc tatcgttagt gttagtgtat tttatatgtg gtgcaagaca attcgtcttc 180 
276 ttccaatgtg gcccagggaa gccaaaagat tggacacccc gtgagatctt ctaggcgact 240 
2 78 ggcccccagt gaaattgtga tcacggagga tagtagagtc ccggtagtac acataggaga 3 00 
280 tgttccacaa actccatatg atcagcaccg ttttcgggag gccccacact gtgccgaaca 360 
282 tcatgaatca gtgagggttt aggaagcaca tcaacctccc agtgtttggg agctgctgtt 420 
284 ttaagaaggt cccgtttacc attctactgc ccacatgaag agtgaagact -aatccgtgga 480 
286 caggatgcct ctccagtcta gctgtgcccc gctccctctt tctcatctaa atcgaaccct 540 
288 tttcctgtgg attgagatga aaagtccttg aacgcaccac cttgtgctgc taggtcagtc 600 
290 tagacaatat taagtcacat ccattaagtt ttccttaaag aaaatgtttg aaatatttct 660 
292 tccttcagtt cgatactaag tgtattttgc cacaagacac ttcctgatga cccaatttca 720 
294 ggtccccatt cttttatcta tgtgagaatt ctccactttc agactctgct taatttaact 780 
296 ctctctgaaa atgtgcaagt tcataaaaga aggtgaaata attactacgg tacatacaaa 840 

2 98 gaggtgaaca tttctttttt atgtacaaat tgtgtgttac cccaagtgga ctttcctggg 900 
300 cccgcctcct ccttctgtcc caggatcctg gcccagctct gtcccccaat gaactgcaga 960 

3 02 ggtagagggg taaagaagag cagttgagtg gctcagattg ctgcctgaac tctggaccga 102 0 
304 ggagcaatca cgagtaaccc caaaaactgc ccattggttt gcgcactcat agcatgaaaa 1080 
306 caagttccgt tcttttgtgc tgtcctggaa catcagccag ctcttaagtc acgttgcccg 1140 
308 gattcatgtg ctcctgcaat gaaaggccct attgtcaaca aggctggtca acaaggcaaa 1200 
310 gcaaagtttg acccgtgcat caaaacctgg aacatcctga cttgttacgt gctgagaaat 1260 
312 gtgtgcttag tattgtatta aagtaaatgg ggaggggcag tgtctttaaa aatacccaaa 132 0 
314 gcaaagaaaa atagatacta tctgctcaat gtcccagagt agaagttttt aaaatgacct 1380 
316 gagaaatagg tttattgctt tcattgcttc cttccttctt cttcctcctt ctctgacatt 1440 
318 tggccctcct ctctaaaaac ttcccctcat agtgacccca ggctcctgtt gggaagtctc 1500 
320 acccactgtg tgggtgaaca agcaaagcaa ctgttaaaag tgttcagata acatggacaa 1560 
322 aaaacacatg gaaaagctga tatcgagttc cattgggttt ggagtggttc ttgcgggcaa 1620 
324 aggatgcagt gagctgaaca tacattaaaa atacaaaccc ttaagagctg actgggtaag 1680 
326 acttaagccc agtatctttc agagatgagt gtctaggtgc atcacccaga tcttagcctg 1740 
328 cctgagtgta ccagtgaacc tgcccaggtt ttagtttcct tttctataaa atgatagctt 1800 
330 ggttctgatg atcttcaggc tcccttggga ggtccttgag gcttcagctc aaaccctagc 1860 
332 tctgctatct acctcttctt ggtgctgaga ttccatgata tccttcaatt attgtgggac 1920 
334 tgacttagta gaaggcatca gagggaatgg aagcctctac attatcaatg cagaaattga 1980 
33 6 ggcaagaggc caacattatt gcacaaaaca tggcagatgt tggaatgaag aagacagtga 2 04 0 
338 gacacaggca gcaacagagc ctccttaatc tctgacccaa aagagtcttg acttgaagtt 2100 
340 ccccaagctc cttcttttct cccaggcact cactgctttc aaagcgactt caatctcaag 2160 
342 ttgggagatg tggcccagtt cagggtctgc cgcagactca ggcaccatcc cttctcctat 2220 
344 ctcagtttct tcactggcaa atggaaggta tacaattaga tgatttttaa agccaagctc 2280 
346 agagctaaca tccacaattc caggaattcc aggaaatgca cactaaaact aaggttctga 2340 
348 aacaagtaaa aaaacagacc aaatgttcga accaacgatt ttcagacatt ggagcacagg 2400 
350 tggcacagga aacaagtgag gtgagtcctg tgattgcccc agcttgctgc ctggagagac 2460 
352 tttccaggcc atggaacagg gacatggaat acaggtggag cacagccata tccctgtgta 2520 
354 gaaggatggg gctggggtcc cagggacact tgtgcaccta gaactcacag gagagaatac 2580 
356 tggagagaag aaagctgcac acggagagaa ctctgggctc tgcagagtgt catctttggg 2640 



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RAW SEQUENCE LISTING DATE: 10/26/2 004 

PATENT APPLICATION: US/10/849 , 551 TIME: 16:46:09 

Input Set : D:\US Utility 50229-435 Sequence Listing.txt 
Output Set: N:\CRF4\10262004\J849551.raw 

358 tcttcagcaa agtattgatc agcacatgca tgtgaggaaa agaaatgagg ccagaaaaag 2700 

360 aatcacccaa aaagattaga gggaaccatt cctagagctc ccaccagcca gagaatagcc 2760 

362 cctgtggcca ccaaccacag ttgaaaacct tctaattcat cgggcactga gtagaacact 282 0 

364 ctgagtattg tctcagtaat gcagcccaat tcagcttact ctaaagtctc ctgtggtccc 2880 

366 tcctgacaag gcttaaaagc aagtcttggc tggcacggtg gtgcgtgcct gcagtcccag 2940 

368 ctatccagga gggtgagggc tgaggcagca tgacgactgt tcaagccagg agttcaagac 3000 

370 cagcctgggc aacatagtga gattctgtat cttttttttt tttttttttt tttaaaaaaa 3060 

372 aaggccgggc acggtgtgtc aaccctgtaa tcccagcact ttgggaggcc gaggtgggta 3120 

374 gatcatctga ggtcgggagt ttgagacaag cctgaccaac atggagaaac cctgtctcta 3180 

376 ctaaaaacac aaaattagtc gggcgtggtg gcacaggcca gtaatcccag ctactcgcga 3240 

378 ggctgcggca ggagaatcgc ttgaacctag gaggcagagg ttgcagtgaa tggagatcgc 3300 

3 80 gcatcgctgt ccagcctggg caacaagagg gaaactccat ctaaaaaaca aaacaaacaa 3360 

382 acaaacaaaa aacaagtcat gaaaggatcg aactgttttc aagtaaatta actgtgttct 3420 

384 agaacaacac tcaaaagttt ttttgtgtgt ttgtttgttt tttaaagaat atccaggcca 3480 

386 ggcatggtgg ctcacaccta taatcccagc actttgggag accgaggaag gtggatcact 3540 
388 tgaggttagg attttgagac cagactggcc tcaaacatgg tgaaactctg tgtcttctaa ' 3600 

390 aaatacaaaa attagccagg tgtggtgggg gaggtgctgt agtcccagtt actcaggagg 3660 

3 92 ctgaggcagg agaatcgttt gaacctggga ggaagaggtt atactgagct gagattacgc 3 72 0 

3 94 cactgaactc cagcctggga gacaaagtga gactccgtct caaaaaaata aaaagaaaaa 3780 

3 96 gaatatccag cactcagcaa gataaaattc aagcaagaga aacatgaagg aaattataac 3840 

398 aagacacatc ataatcaaat tgctcaatac cagtgataaa gagaaaatct taaaattaac 3900 

400 aacaggaaaa aaattatgtt agaaacagga gaacaaagat aagaatggca gcagagttca 3 960 

402 tgtcagaagc aagcaagtga gaagacagag gaacaataat ctttaaagta atcagagaaa 4 02 0 

404 aatattgtca acctagaatt ctaggttttt gggtgttttt ttttttttgt ctttcacatg 4080 

406 aaatggccac taattctata cccagcaaaa atgtctttca aaaacaaatg caaaatactt 4140 

408 tttcaaacat acaaaagctt aaaaaatgat cctctgagga cctatactat aagaaatgtt 4200 

410 aagggatgtc cttcaagcag aaggacaatg ataccagata aaattctggc tctacaaaaa 42 6 0 

412 gaatgaagag ttctggaagt ggaacttcaa ctactctaaa catgcaacaa gctatgaatg 4320 

414 gggagtcttt ctgtggaggc ttccaiggacc caaaagtgag gacagagaag tactctttgc 43 80 

416 ctgagctgac acccaccaga gctgagaacc aaggattcct aagaggtgac atatgtggct 4440 

418 gtgttaccgc caactccacc ttctacccag taagactggg aaggagggag agagagaaat 4500 

420 aagtctaagg gtcactggag cacaggacgt gtgaggagag gggacttcct gcccttcctg 4560 

422 tggttatggg aaatggggtg gctgtgcttt cctccctagt aaggttctaa taaaatgatt 4620 

424 ccacaaatat tggaatgtaa agtagctccc ctgttggaca tttgattagg aaaaggattt 4680 

426 gctggcttat tcatacatca ttagggatag aggagggtct tggagaaaga agaaagggca 4740 

428 caaagaagag ctgcaggggc agtctgaact cacccagttg gtcagggcca gaaaacgcat 4800 

430 ttcctgcagt tcaagtggat gctacttaga aggcagctgg atttgttcca tccctacccc 4860 

432 aacagggttc tctctcctat ttaccgggga gctcaaagag tccgtagagt acatatccag 4920 

434 tcatgggagt tgaggggcat ggaggtggtt gagcctggat ttaccatatc cgtgccctgc 4980 

436 aagtctctct aaaagaaccc agatgtgtct tccagagaag gctagcacgt cgatgcctgc 5040 

438 ctcacagcca gtcccagtgg gacaccgcta gagagaaggc taccactaga gagaaggcta 5100 

440 ccactagaga gaaggctacc gctgccctgt tagtttacga ccctctgccc tttctctgtc 5160 

442 ctacctctca gcccagcgca ctagaggaac tatttcccaa agcggaaagc gagagtggag 5220 

444 gagtgtccca gaaatagacc tccctcattc agggtccagg tccaagcttg cactggaccg 52 80 

446 ggagagggca gtggcgctgg gagatgaggt gagagtagaa tcgtttggaa ttaatgtttt 5340 

448 aaagtggact gagggttaat acctgaaaac agtggtaaaa ttttggaccc gcccaagatg 5400 

450 taattaacag atctgctacc ctctggataa ggttgagcac atttgaaagg gcttcagaaa 5460 

452 atgaaaaagc cttttctgtc tttaagaaaa caaacaaaca aaaaaaaaca aaacaaaaga 552 0 

454 acaaaaaacc tgtcttcccc caacaggcac aattacattt gtaaagatgg ttcccagcag 5580 



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Page 6 of 8 



RAW SEQUENCE LISTING ERROR SUMMARY DATE: 10/26/2004 

PATENT APPLICATION: US/10/849 , 551 TIME: 16:46:10 

Input Set : D:\US Utility 50229-435 Sequence Listing.txt 
Output Set: N:\CRF4\10262004\J849551.raw 



Please Note; 

Use of n and/or Xaa have been detected in the Sec[uence Listing. Please review the 
Sequence Listing to ensure that a corresponding explanation is presented in the <220> 
to <223> fields of each sequence whyCclvy presents at least one n or Xaa. 

Seq# : 2 ; Xaa Pos . 





file://C:\CRF4\Outhold\VsrJ849551.htm 



10/26/04 



VERIFICATION SUMMARY DATE: 10/26/2004 

PATENT APPLICATION: US/10/849 , 551 TIME: 16:46:10 



Input Set : D:\US Utility 50229-435 Sequence Listing.txt 

Output Set: N:\CRF4\10262004\J849551.raw 

L:180 M:341 W: (46) "n" or "Xaa" used, for SEQ ID#:2 after pos.:256 

L:184 M:341 W: (46) "n" or "Xaa" used, for SEQ ID#:2 after pos,:272 

L:216 M:341 W: (46) "n" or "Xaa" used, for SEQ ID# : 2 after pos.:400 



file://C:\CRF4\Outholcl\VsrJ84955 1 .htm