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"<l&j^0in re Application of 



Docket No.: 50229-435 
1-0 fi 



IN THE UNITED STATES PATENT AND TRADEMARK OFFICE 



Customer Number: 20277 



PATENT 



Jeffrey A. MOSCOW, et al. 



Confirmation Number: 7209 



Application No. : 1 0/849,55 1 



Group Art Unit: 1645 



Filed: May 20, 2004 



Examiner: Not yet assigned 



For: AN ORGANIC CATION TRANSPORTER PREFERENTIALLY EXPRESSED IN 
HEMATOPOIETIC CELLS 



Mail Stop Amendment 
Commissioner for Patents 
P.O. Box 1450 
Alexandria, VA 22313-1450 

Dear Sir: 

In accordance with the provisions of 37 C.F.R. 1 .56, 1 .97 and 1 .98, the attention of the 
Patent and Trademark Office is hereby directed to the documents listed on the attached form PTO- 
1449. It is respectfully requested that the documents be expressly considered during the prosecution 
of this application, and that the documents be made of record therein and appear among the 
"References Cited' 1 on any patent to issue therefrom. 

This Information Disclosure Statement is being filed within three months of the U.S. filing 
date OR before the mailing date of a first Office Action on the merits. No certification or fee is 
required. 



INFORMATION DISCLOSURE STATEMENT 



^10/8*49,551 

Please charge any shortage in fees due in connection with the filing of this paper, 
including extension of time fees, to Deposit Account 500417 and please credit any excess fees to 
such deposit account. 



Respectfully submitted, 
McDERMOTT WILL & EMERY LLP 




Thomas A. Haag, Ph.D., Esq. 
Registration No. 47,621 



600 13 Street, N.W. Please recognize our Customer No. 20277 

Washington, DC 20005-3096 as our correspondence address. 

Phone: 202.756.8000 TAH:blg 
Facsimile: 202.756.8087 
Date: December 16, 2004 



2 




DEC 1 6-2004- 



c. 



SHEET 1 OF 1 



INFORMATf^gJ^LOSURE 
CITATION IN AN 
APPLICATION 



(PTO-1449) 



ATTY. DOCKET NO. 
50229-435 



SERIAL NO. 
10/849,551 



APPLICANT 

Jeffrey A. MOSCOW, et al. 



FILING DATE 
May 20, 2004 



GROUP 
1645 



U.S. PATENT DOCUMENTS 



EXAMINER'S 
INITIALS 



CITE 
NO. 



Document Number 
Number-Kind Code2 (it known) 



Publication Date 
MM-DD-YYYY 



Name of Patentee or Applicant of Cited 
Document 



Pages, Columns, Lines, Where 
Relevant Passages or Relevant 
Figures Appear 



US 



FOREIGN PATENT DOCUMENTS 



EXAMINER'S 
INITIALS 


CITE 
NO. 


Foreign Patent Document 
Country Code3 -Number 4 -Kind 
Codes (if known) 


Publication Date 
MM-DD-YYYY 


Name of Patentee or 
Applicant of Cited Document 


Pages, Columns, Lines 
Where Relevant 
Figures Appear 


Translation 
Yes No 














I 



OTHER ART (Including Author, Title, Date, Pertinent Pages, Etc.) 



EXAMINER'S 
INITIALS 



CITE 
NO. 



Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of the item (book, magazine, 
journal, serial, symposium, catalog, etc.), date, page(s), volume-issue number(s), publisher, city and/or country where 
published. 



Biochem. Pharmacol. "Short Communications" Vol. 11: pp. 1233-1234, Pergamon Press Ltd., 1962 



Moscow, et al., "Isolation of a Gene Encoding a Human Reduced Folate Carrier (RFC1) and Analysis of Its 
Expression in Transport-deficient, Methotrexate-resistant Human Breast Cancer Cells" Cancer Res. 55: pp. 3790- 

3794, 1995 



Moscow et al., "Reduced Folate Carrier Gene (RFC1) Expression and Anti-Folate Resistance in Transfected and Non- 
Selected Cell Lines" Int J Cancer. 72: pp. 184-190, 1997 



Koepsell et al., "Organic Cation Transporters in Intestine, Kidney, Liver, and Brain" Ann. Rev. Physiol. 60: pp. 243- 

266, 1998 



Burckhardt, et al., "Structure of renal organic anion and cation transporters" Am J Physiol Renal Physiol. 278: pp. 

F853-66., 2000 



Wu, et al., "Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (uptake 2 ) 
and Evidence for the Expression of the Transporter in the Brain" J Biot Chem. 273: pp. 32776-86, 1998 



Dhillon et at. Clin Pharmacol Then 65: p. 205, 1996 



Koyama et al., "CD63, a Member of Tetraspan Transmembrane Protein Family, Induces Cellular Spreading by 
Reaction with Monoclonal Antibody on Substrata" Biochem Biophys Res Commun. 246: pp. 841-846, 1998 



Moscow, J. A., Schneider, E. S., Ivy, S. P., and Cowan, K. H. "Multidrug resistance" In: H. M. Pinedo, D. L. Longo, and 
B. A. Chabner (eds.), Cancer chemotherapy and biological response modifiers. Annual 17. New York: Elsevier, pp. 

139-177, 1997 



GenBank AF268892 



GenBank AC002464 



GenBank AI040384 



GenBank AA033971 



GenBank H70190 



EXAMINER 



DATE CONSIDERED 



•EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not considered. 
Include copy of this form with next communication to applicant. 

1 Applicant's unique citation designation number (optional). 2 Applicant is to place a check mark here if English language Translation is attached.